GT200500086A - Bioconversion estereoselectiva de dinitrilos alifaticos en acidos cianocarboxilicos. - Google Patents
Bioconversion estereoselectiva de dinitrilos alifaticos en acidos cianocarboxilicos.Info
- Publication number
- GT200500086A GT200500086A GT200500086A GT200500086A GT200500086A GT 200500086 A GT200500086 A GT 200500086A GT 200500086 A GT200500086 A GT 200500086A GT 200500086 A GT200500086 A GT 200500086A GT 200500086 A GT200500086 A GT 200500086A
- Authority
- GT
- Guatemala
- Prior art keywords
- dinitrils
- cyanocarboxyl
- alifatic
- acids
- bioconversion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/207497—Molecular oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
LA PRESENTE INVENCION ESTA DIRIGIDA A UNA BIOCONVERSION REIO Y ESTEREOSELECTIVA DE DINITRILOS ALIFATICOS SELECCIONADOS EN LOS CORRESPONDIENTES ACIDOS CIANOCARBOXILICOS. MAS PARTICULARMENTE, LA PRESENTE INVENCION PORPORCIONA METODS PARA LA CONVERSION DE 2ISOBUTILSUCCINONITRILO EN ACIDO (S)3CIANO5METILHEXANOICO, EL CUAL ES UN PRODUCTO INTERMEDIO UTIL EN LA SINTESIS DE ACIDO (S)3(AMINOMETIL)5METILHEXANOICO (PREGABALINA). LA PREGABALINA PUEDE USARSE PARA TRATAR CIERTAS ENFERMEDADES CEREBRALES, POR EJEMPLO, EN EL TRATAMIENTO Y PREVENCION DE TRASTORNOS REPENTINOS, DOLOR, Y TRASTORNOS PSICOTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56213304P | 2004-04-14 | 2004-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200500086A true GT200500086A (es) | 2006-01-10 |
Family
ID=34962755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200500086A GT200500086A (es) | 2004-04-14 | 2005-04-13 | Bioconversion estereoselectiva de dinitrilos alifaticos en acidos cianocarboxilicos. |
Country Status (44)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| AT412092B (de) * | 2003-02-27 | 2004-09-27 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung chiraler alpha-hydroxycarbonsäuren durch enzymatische hydrolyse von chiralen cyanhydrinen |
| WO2006108151A1 (en) | 2005-04-06 | 2006-10-12 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of pregabalin |
| US7488846B2 (en) | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| KR20070118305A (ko) | 2005-05-10 | 2007-12-14 | 테바 파마슈티컬 인더스트리즈 리미티드 | 3-카르바모일메틸-5-메틸 헥산산의 광학 분할 |
| MX2007000525A (es) | 2005-05-10 | 2007-03-28 | Teva Pharma | Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella. |
| ATE486841T1 (de) | 2005-05-10 | 2010-11-15 | Teva Pharma | Verfahren zur herstellung von pregabalin und salzen daraus |
| KR20080034205A (ko) | 2005-09-19 | 2008-04-18 | 테바 파마슈티컬 인더스트리즈 리미티드 | (ｓ)-프레가발린의 신규한 합성을 위한 주요 중간체인 키랄3-카르바모일메틸-5-메틸 헥산산 |
| US20070141684A1 (en) * | 2005-12-21 | 2007-06-21 | Pfizer Inc | Preparation of gamma-amino acids having affinity for the alpha-2-delta protein |
| WO2007139933A2 (en) | 2006-05-24 | 2007-12-06 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof |
| KR20080036060A (ko) * | 2006-05-31 | 2008-04-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린의 중간체의 제조에 효소 분할을 이용하는 방법 |
| EP1881077A1 (en) * | 2006-07-19 | 2008-01-23 | Solvay Organics GmbH | Process for the production of fluorine containing a-hydroxy carboxylic acids |
| TW200846308A (en) | 2007-03-22 | 2008-12-01 | Teva Pharma | Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid |
| WO2009087650A2 (en) * | 2007-10-15 | 2009-07-16 | V.B. Medicare Pvt. Ltd. | A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin |
| KR20110025917A (ko) | 2008-05-21 | 2011-03-14 | 산도즈 아게 | ５－메틸－３－니트로메틸－헥산산 에스테르의 입체선택적 효소 가수분해 방법 |
| US8614081B2 (en) | 2009-07-23 | 2013-12-24 | Codexis, Inc. | Nitrilase biocatalysts |
| WO2011141923A2 (en) | 2010-05-14 | 2011-11-17 | Lupin Limited | Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin |
| US8604062B2 (en) * | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| JP6482465B2 (ja) * | 2012-11-07 | 2019-03-13 | ハイカル リミテッド | プレガバリンの調製方法 |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| CN105017072B (zh) * | 2015-06-30 | 2017-10-03 | 河北诚信有限责任公司 | 异丁基琥珀腈的合成方法 |
| CN105176955B (zh) | 2015-08-27 | 2018-11-02 | 浙江工业大学 | 来源于高山南芥的腈水解酶、基因、载体、工程菌及其应用 |
| CN108424900B (zh) * | 2018-02-09 | 2020-11-03 | 浙江工业大学 | 一种腈水解酶突变体及其构建方法和应用 |
| CN114164197B (zh) * | 2020-01-13 | 2023-08-18 | 浙江工业大学 | 一种热稳定性和活力提高的腈水解酶突变体及其应用 |
| CN113651717A (zh) * | 2021-08-05 | 2021-11-16 | 浙江工业大学 | 一种光学纯异丁基丁二腈的消旋方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593871A (en) * | 1990-09-20 | 1997-01-14 | E. I. Du Pont De Nemours And Company | Process for the preparation of enantiometric 2-alkanoic acid amides from nitriles |
| JP3218133B2 (ja) * | 1993-02-03 | 2001-10-15 | 三菱レイヨン株式会社 | フェニル基を有する光学活性α−ヒドロキシカルボン酸の製造法 |
| US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| US5858736A (en) * | 1996-05-17 | 1999-01-12 | E. I. Du Pont De Nemours And Company | Preparation of lactams from aliphatic α,ω-dinitriles |
| CN1138755C (zh) * | 1997-10-27 | 2004-02-18 | 沃尼尔·朗伯公司 | 作为药物的环状氨基酸及其衍生物 |
| US6642398B2 (en) * | 1999-06-10 | 2003-11-04 | Warner-Lambert Company | Mono-and disubstituted 3-propyl gamma-aminobutyric acids |
| US6551804B2 (en) | 1999-07-12 | 2003-04-22 | E. I. Du Pont De Nemours And Company | Process for preparing 4-cyanopentanoic acid |
| US20040014195A1 (en) * | 1999-12-29 | 2004-01-22 | Diversa Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
| AU777046B2 (en) * | 2000-01-27 | 2004-09-30 | Warner-Lambert Company Llc | Asymmetric synthesis of pregabalin |
| FR2824823A1 (fr) * | 2001-05-21 | 2002-11-22 | Aventis Animal Nutrition Sa | Procede de preparation d'acides carboxyliques aliphatiques par hydrolyse enzymatique de composes nitriles aliphatiques |
| WO2004111256A1 (en) * | 2003-06-19 | 2004-12-23 | Pfizer Products Inc. | Biocatalytic preparation of 1-cyanocyclohexaneacetic acid |
-
2005
- 2005-01-04 UA UAA200610837A patent/UA82292C2/uk unknown
- 2005-04-01 WO PCT/IB2005/000873 patent/WO2005100580A1/en active Application Filing
- 2005-04-01 DE DE602005017027T patent/DE602005017027D1/de active Active
- 2005-04-01 BR BRPI0509908-0A patent/BRPI0509908A/pt not_active Application Discontinuation
- 2005-04-01 US US10/599,899 patent/US7727749B2/en not_active Expired - Fee Related
- 2005-04-01 ES ES05718347T patent/ES2331140T3/es active Active
- 2005-04-01 JP JP2007507859A patent/JP4051082B2/ja not_active Expired - Fee Related
- 2005-04-01 DO DO2005000055A patent/DOP2005000055A/es unknown
- 2005-04-01 NZ NZ549698A patent/NZ549698A/en not_active IP Right Cessation
- 2005-04-01 AU AU2005233371A patent/AU2005233371B2/en not_active Ceased
- 2005-04-01 DK DK05718347T patent/DK1745136T3/da active
- 2005-04-01 PL PL05718347T patent/PL1745136T3/pl unknown
- 2005-04-01 KR KR1020067021286A patent/KR100887777B1/ko not_active IP Right Cessation
- 2005-04-01 RS RSP-2009/0451A patent/RS50994B/sr unknown
- 2005-04-01 CA CA2563307A patent/CA2563307C/en not_active Expired - Fee Related
- 2005-04-01 AT AT05718347T patent/ATE445019T1/de active
- 2005-04-01 EP EP05718347A patent/EP1745136B1/en active Active
- 2005-04-01 PT PT05718347T patent/PT1745136E/pt unknown
- 2005-04-01 EA EA200601574A patent/EA010305B1/ru not_active IP Right Cessation
- 2005-04-01 GE GEAP20059657A patent/GEP20084530B/en unknown
- 2005-04-01 SI SI200530805T patent/SI1745136T1/sl unknown
- 2005-04-01 ME MEP-2009-320A patent/ME01107B/me unknown
- 2005-04-01 AP AP2006003764A patent/AP2301A/xx active
- 2005-04-01 CN CN2005800109287A patent/CN1942587B/zh not_active Expired - Fee Related
- 2005-04-12 AR ARP050101423A patent/AR048690A1/es not_active Application Discontinuation
- 2005-04-12 HN HN2005000162A patent/HN2005000162A/es unknown
- 2005-04-12 MY MYPI20051622A patent/MY144296A/en unknown
- 2005-04-12 UY UY28851A patent/UY28851A1/es not_active Application Discontinuation
- 2005-04-12 PE PE2005000405A patent/PE20060252A1/es not_active Application Discontinuation
- 2005-04-13 PA PA20058629801A patent/PA8629801A1/es unknown
- 2005-04-13 GT GT200500086A patent/GT200500086A/es unknown
- 2005-04-13 NL NL1028762A patent/NL1028762C2/nl not_active IP Right Cessation
- 2005-04-13 TW TW094111638A patent/TWI304095B/zh not_active IP Right Cessation
- 2005-04-14 SV SV2005002085A patent/SV2005002085A/es active IP Right Grant
-
2006
- 2006-09-06 IL IL177918A patent/IL177918A/en not_active IP Right Cessation
- 2006-09-07 ZA ZA200607476A patent/ZA200607476B/en unknown
- 2006-10-10 EC EC2006006917A patent/ECSP066917A/es unknown
- 2006-10-12 CR CR8686A patent/CR8686A/es unknown
- 2006-10-13 MA MA29391A patent/MA28536B1/fr unknown
- 2006-10-13 TN TNP2006000329A patent/TNSN06329A1/fr unknown
- 2006-11-10 NO NO20065181A patent/NO335624B1/no not_active IP Right Cessation
-
2007
- 2007-09-25 HK HK07110403.3A patent/HK1105215A1/xx not_active IP Right Cessation
-
2009
- 2009-10-21 HR HR20090562T patent/HRP20090562T1/xx unknown
- 2009-10-30 CY CY20091101131T patent/CY1109556T1/el unknown
-
2010
- 2010-04-20 US US12/763,570 patent/US8304252B2/en not_active Expired - Fee Related
-
2011
- 2011-06-22 CR CR20110356A patent/CR20110356A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GT200500086A (es) | Bioconversion estereoselectiva de dinitrilos alifaticos en acidos cianocarboxilicos. | |
| UY28860A1 (es) | Procedimiento para el tratamiento de trastornos premenstruales y otros trastornos sexuales femeninos | |
| HK1117824A1 (en) | Acyloxyalkyl carbamate prodrugs of tranexamic acid and use | |
| WO2006120682A3 (en) | Compositions and methods for treating hyperproliferative epidermal diseases | |
| ATE453642T1 (de) | Substituierte phenylaminopyrimidine | |
| ECSP088969A (es) | Amino-imidazolones y su uso como medicamento para tratar deficiencias cognitivas, enfermedad de alzheimer, neurodegeneración y demencia | |
| BR0312232A (pt) | Inibidores de caspases e seus usos | |
| DE60320095D1 (de) | Zusammensetzungen zur behandlung von hauterkrankungen | |
| NO20064982L (no) | 1,3,4-oksadiazol-2-oner som PPAR delta modulatorer og anvendelse derav | |
| WO2009150408A3 (en) | Topical antimuscarinic formulations | |
| EP1778186A4 (en) | PROCESS FOR PREPARING POLY-ICLC AND USES THEREOF | |
| UA86399C2 (ru) | Применение 2,5 дигидроксибензолсульфоновой кислоты для изготовления лекарства, которые применяют для лечения болезней, зависимых от ангиогенеза | |
| TW200510308A (en) | Isophthalic acid derivatives | |
| DE60015508D1 (de) | C-16 ungesätigte fp-selektive prostaglandin analoge | |
| WO2007022642A3 (en) | Anti-inflammatory molecules and their uses | |
| BRPI0407693A (pt) | uso de esteróides para preparação de formulações utilizáveis no tratamento de pessoas sofrendo de distúrbios oculares, bem como formulação assim obtidos | |
| WO2007025229A3 (en) | Compositions and their uses directed to hsp27 | |
| BRPI0511125A (pt) | usos de ácido 5,6,7-triidroxieptanóico seus e análogos | |
| ATE508749T1 (de) | Antidepressiva zur prophylaxe und therapie von zystischer fibrose | |
| BR0306855A (pt) | Método para o tratamento de distúrbios cognitivos | |
| UY28226A1 (es) | Derivados del ácido 3-(1-(3-(1,3-benzotiazol-6-il)propilcarbamoil)cicloalquil)propanoico como inhibidores de nep | |
| EA200501865A1 (ru) | Аналоги тиовольфраматов и их применение | |
| NO20073610L (no) | Nye substituerte tiofenpyrimidinonderivater som inhibitorer for 17 β-hydroksysteroiddehydrogenase | |
| BR0313922A (pt) | Compostos de piperidina de benzoìla | |
| DOP2003000728A (es) | Compuestos de tiazol para el tratamiento de trastornos neurodegenetivos |