RS50868B - Stereoselektivni postupak za dobijanje nukleozidnih analoga - Google Patents
Stereoselektivni postupak za dobijanje nukleozidnih analogaInfo
- Publication number
- RS50868B RS50868B YUP-975/03A YUP97503A RS50868B RS 50868 B RS50868 B RS 50868B YU P97503 A YUP97503 A YU P97503A RS 50868 B RS50868 B RS 50868B
- Authority
- RS
- Serbia
- Prior art keywords
- formula
- iodo
- bromo
- fluoro
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Stereoselektivni postupak za dobijanje pretežno cis nukleozida ili nukleozidnih analoga i derivata formule (A), naznačen time, što :Rl predstavlja pirimidinsku bazu ili njen farmaceutski prihvatljivi derivat; i Q predstavlja ugljenik, kiseonik ili sumpor, gde je Q po mogućstvu kiseonik; koji se sastoji od faze spajanja (kuplovanja) jedinjenja formule (B):u kojoj jeR2 C7-10 aralkil, C1-6 acil ili Si (Z1) (Z2) (Z3), gde su Z1, Z2 i Z3 svaki za sebe nezavisno odabrani iz grupe koju čine vodonik; C1-20 alkil po slobodnom izboru supstituisan sa fluoro, bromo, hloro, jodo, C1-6 alkoksi ili C6-20 ariloksi; C7-20aralkil po slobodnom izboru supstituisan sa halogenom, C1-20 alkil ili C1-20 alkoksi; C6-20 aril po slobodnom izboru supstituisan sa fluoro, bromo, hloro, jodo, C1-20 alkil ili C1-20 alkoksi; trialkilsilil, fluoro, bromo; hloro i jodo;sa bazom Rl, pirimidinskom bazom ili njenim farmaceutski prihvatljivim derivatom; u rastvaraču sa C1-10 atoma ugljenika u kojem se vrši reakcija spajanja, u prisustvu katalitičkih količina elemenata ili kombinacije elemenata iz grupe IB ili IIB; tercijalnog amina i Luisove kiseline da bi se dobio intermedijer formule (D):u kojoj su Rl, R2 i Q ranije definisani, idruge faze u kojoj se vrši skidanje zaštitne grupe intermedijera formule (D) da bi se dobili cis nukleozidi ili nukleozidni analozi formule (A)gde se faza spajanja po mogućstvu odigrava na temperaturi koja je jednaka ili manja od 30 stepeni Celzijusa.Prijava sadrži još 9 patentnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29807901P | 2001-06-15 | 2001-06-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU97503A YU97503A (sh) | 2006-05-25 |
| RS50868B true RS50868B (sr) | 2010-08-31 |
Family
ID=23148927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-975/03A RS50868B (sr) | 2001-06-15 | 2002-06-14 | Stereoselektivni postupak za dobijanje nukleozidnih analoga |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7109334B2 (sr) |
| EP (2) | EP1406896B8 (sr) |
| JP (1) | JP4542776B2 (sr) |
| KR (1) | KR100832617B1 (sr) |
| CN (1) | CN1297553C (sr) |
| AP (1) | AP1559A (sr) |
| AT (2) | ATE370945T1 (sr) |
| AU (2) | AU2002344862C1 (sr) |
| BR (2) | BR0210444A (sr) |
| CA (1) | CA2449338C (sr) |
| CO (1) | CO5550497A2 (sr) |
| CY (1) | CY1107805T1 (sr) |
| DE (2) | DE60222031T2 (sr) |
| DK (2) | DK1632490T3 (sr) |
| EA (1) | EA006372B1 (sr) |
| ES (2) | ES2254695T3 (sr) |
| HK (1) | HK1070652A1 (sr) |
| HR (1) | HRP20031021B1 (sr) |
| IL (2) | IL159139A0 (sr) |
| MX (1) | MXPA03011627A (sr) |
| NO (1) | NO326135B1 (sr) |
| NZ (1) | NZ529906A (sr) |
| OA (1) | OA12628A (sr) |
| PL (2) | PL215267B1 (sr) |
| PT (1) | PT1632490E (sr) |
| RS (1) | RS50868B (sr) |
| SI (2) | SI1632490T1 (sr) |
| WO (1) | WO2002102796A1 (sr) |
| ZA (1) | ZA200309307B (sr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7501514B1 (en) | 2003-10-15 | 2009-03-10 | Shire Biochem, Inc. | Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides |
| JP4653966B2 (ja) * | 2004-04-19 | 2011-03-16 | ダイセル化学工業株式会社 | ２−ベンゾイルオキシアセトアルデヒド誘導体の製造法 |
| IN2015DN02599A (sr) * | 2007-09-28 | 2015-09-18 | Avexa Ltd | |
| US20130165350A1 (en) * | 2011-12-22 | 2013-06-27 | Affymetrix, Inc. | Surface linkers for array synthesis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR840001591A (ko) | 1981-09-29 | 1984-05-07 | 구라바야시 이꾸시로 | 당케탈류의 제조방법 |
| US5587480A (en) * | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
| ES2091948T3 (es) * | 1990-11-13 | 1996-11-16 | Iaf Biochem Int | 1,3-oxatiolanos sustituidos con propiedades antiviricas. |
| US5532349A (en) | 1993-07-20 | 1996-07-02 | Mitsui Toatsu Chemicals, Inc. | Process for producing 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives |
| EP1104415B1 (en) | 1998-08-12 | 2004-11-10 | Gilead Sciences, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
-
2002
- 2002-06-14 CA CA2449338A patent/CA2449338C/en not_active Expired - Fee Related
- 2002-06-14 MX MXPA03011627A patent/MXPA03011627A/es active IP Right Grant
- 2002-06-14 RS YUP-975/03A patent/RS50868B/sr unknown
- 2002-06-14 DE DE60222031T patent/DE60222031T2/de not_active Expired - Lifetime
- 2002-06-14 CN CNB028159624A patent/CN1297553C/zh not_active Expired - Fee Related
- 2002-06-14 DE DE60208202T patent/DE60208202T2/de not_active Expired - Lifetime
- 2002-06-14 KR KR1020037016301A patent/KR100832617B1/ko not_active IP Right Cessation
- 2002-06-14 US US10/170,418 patent/US7109334B2/en not_active Expired - Fee Related
- 2002-06-14 DK DK05017130T patent/DK1632490T3/da active
- 2002-06-14 AT AT05017130T patent/ATE370945T1/de active
- 2002-06-14 AP APAP/P/2003/002948A patent/AP1559A/en active
- 2002-06-14 EP EP02742572A patent/EP1406896B8/en not_active Expired - Lifetime
- 2002-06-14 DK DK02742572T patent/DK1406896T3/da active
- 2002-06-14 OA OA1200300329A patent/OA12628A/en unknown
- 2002-06-14 SI SI200230631T patent/SI1632490T1/sl unknown
- 2002-06-14 AT AT02742572T patent/ATE313542T1/de active
- 2002-06-14 IL IL15913902A patent/IL159139A0/xx unknown
- 2002-06-14 BR BR0210444-0A patent/BR0210444A/pt not_active IP Right Cessation
- 2002-06-14 ES ES02742572T patent/ES2254695T3/es not_active Expired - Lifetime
- 2002-06-14 WO PCT/CA2002/000899 patent/WO2002102796A1/en active IP Right Grant
- 2002-06-14 AU AU2002344862A patent/AU2002344862C1/en not_active Ceased
- 2002-06-14 ES ES05017130T patent/ES2293445T3/es not_active Expired - Lifetime
- 2002-06-14 NZ NZ529906A patent/NZ529906A/xx not_active IP Right Cessation
- 2002-06-14 PL PL366907A patent/PL215267B1/pl unknown
- 2002-06-14 EA EA200400042A patent/EA006372B1/ru not_active IP Right Cessation
- 2002-06-14 BR BRPI0210444-0A patent/BRPI0210444B1/pt unknown
- 2002-06-14 JP JP2003506269A patent/JP4542776B2/ja not_active Expired - Fee Related
- 2002-06-14 PT PT05017130T patent/PT1632490E/pt unknown
- 2002-06-14 SI SI200230273T patent/SI1406896T1/sl unknown
- 2002-06-14 EP EP05017130A patent/EP1632490B1/en not_active Expired - Lifetime
- 2002-06-14 PL PL401835A patent/PL218777B1/pl unknown
-
2003
- 2003-11-28 ZA ZA2003/09307A patent/ZA200309307B/en unknown
- 2003-12-01 IL IL159139A patent/IL159139A/en not_active IP Right Cessation
- 2003-12-09 HR HR20031021A patent/HRP20031021B1/xx not_active IP Right Cessation
- 2003-12-12 NO NO20035556A patent/NO326135B1/no not_active IP Right Cessation
-
2004
- 2004-01-14 CO CO04002061A patent/CO5550497A2/es active IP Right Grant
-
2005
- 2005-04-18 HK HK05103299A patent/HK1070652A1/xx not_active IP Right Cessation
-
2006
- 2006-04-07 US US11/399,502 patent/US7230100B2/en not_active Expired - Fee Related
-
2007
- 2007-11-15 CY CY20071101481T patent/CY1107805T1/el unknown
-
2008
- 2008-08-01 AU AU2008203443A patent/AU2008203443B2/en not_active Ceased
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