DE60222031D1 - Stereoselektives verfahren zur herstellung von nukleosidderivaten - Google Patents

Stereoselektives verfahren zur herstellung von nukleosidderivaten

Info

Publication number
DE60222031D1
DE60222031D1 DE60222031T DE60222031T DE60222031D1 DE 60222031 D1 DE60222031 D1 DE 60222031D1 DE 60222031 T DE60222031 T DE 60222031T DE 60222031 T DE60222031 T DE 60222031T DE 60222031 D1 DE60222031 D1 DE 60222031D1
Authority
DE
Germany
Prior art keywords
preparation
nucleoside derivatives
stereoselective process
stereoselective
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60222031T
Other languages
English (en)
Other versions
DE60222031T2 (de
Inventor
Qing Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Shire BioChem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire BioChem Inc filed Critical Shire BioChem Inc
Application granted granted Critical
Publication of DE60222031D1 publication Critical patent/DE60222031D1/de
Publication of DE60222031T2 publication Critical patent/DE60222031T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D411/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DE60222031T 2001-06-15 2002-06-14 Stereoselektives verfahren zur herstellung von nukleosidderivaten Expired - Lifetime DE60222031T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29807901P 2001-06-15 2001-06-15
US298079P 2001-06-15

Publications (2)

Publication Number Publication Date
DE60222031D1 true DE60222031D1 (de) 2007-10-04
DE60222031T2 DE60222031T2 (de) 2008-05-21

Family

ID=23148927

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60222031T Expired - Lifetime DE60222031T2 (de) 2001-06-15 2002-06-14 Stereoselektives verfahren zur herstellung von nukleosidderivaten
DE60208202T Expired - Lifetime DE60208202T2 (de) 2001-06-15 2002-06-14 Stereoselektives verfahren zur herstellung von nukleosidanaloga

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60208202T Expired - Lifetime DE60208202T2 (de) 2001-06-15 2002-06-14 Stereoselektives verfahren zur herstellung von nukleosidanaloga

Country Status (29)

Country Link
US (2) US7109334B2 (de)
EP (2) EP1406896B8 (de)
JP (1) JP4542776B2 (de)
KR (1) KR100832617B1 (de)
CN (1) CN1297553C (de)
AP (1) AP1559A (de)
AT (2) ATE313542T1 (de)
AU (2) AU2002344862C1 (de)
BR (2) BRPI0210444B1 (de)
CA (1) CA2449338C (de)
CO (1) CO5550497A2 (de)
CY (1) CY1107805T1 (de)
DE (2) DE60222031T2 (de)
DK (2) DK1406896T3 (de)
EA (1) EA006372B1 (de)
ES (2) ES2293445T3 (de)
HK (1) HK1070652A1 (de)
HR (1) HRP20031021B1 (de)
IL (2) IL159139A0 (de)
MX (1) MXPA03011627A (de)
NO (1) NO326135B1 (de)
NZ (1) NZ529906A (de)
OA (1) OA12628A (de)
PL (2) PL218777B1 (de)
PT (1) PT1632490E (de)
RS (1) RS50868B (de)
SI (2) SI1406896T1 (de)
WO (1) WO2002102796A1 (de)
ZA (1) ZA200309307B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501514B1 (en) 2003-10-15 2009-03-10 Shire Biochem, Inc. Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides
JP4653966B2 (ja) * 2004-04-19 2011-03-16 ダイセル化学工業株式会社 2−ベンゾイルオキシアセトアルデヒド誘導体の製造法
US8318934B2 (en) * 2007-09-28 2012-11-27 Avexa Limited Process for chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes
US20130165350A1 (en) * 2011-12-22 2013-06-27 Affymetrix, Inc. Surface linkers for array synthesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR840001591A (ko) * 1981-09-29 1984-05-07 구라바야시 이꾸시로 당케탈류의 제조방법
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
JP2960164B2 (ja) * 1990-11-13 1999-10-06 バイオケム ファーマ インコーポレイテッド 抗ウイルス特性を有する置換1,3−オキサチオラン類および置換1,3−ジチオラン類
US5532349A (en) * 1993-07-20 1996-07-02 Mitsui Toatsu Chemicals, Inc. Process for producing 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives
KR100856416B1 (ko) * 1998-08-12 2008-09-04 길리애드 사이언시즈, 인코포레이티드 1,3-옥사티올란 뉴클레오시드의 제조 방법

Also Published As

Publication number Publication date
WO2002102796A8 (en) 2003-09-18
SI1632490T1 (sl) 2008-02-29
DE60222031T2 (de) 2008-05-21
NO326135B1 (no) 2008-10-06
ES2293445T3 (es) 2008-03-16
IL159139A0 (en) 2004-06-01
OA12628A (en) 2006-06-13
CN1297553C (zh) 2007-01-31
SI1406896T1 (sl) 2006-04-30
EP1632490A1 (de) 2006-03-08
DE60208202T2 (de) 2006-08-17
EA006372B1 (ru) 2005-12-29
EP1406896B8 (de) 2006-11-15
US20060183899A1 (en) 2006-08-17
CA2449338A1 (en) 2002-12-27
US20030135048A1 (en) 2003-07-17
CA2449338C (en) 2012-02-07
JP2004535428A (ja) 2004-11-25
NO20035556D0 (no) 2003-12-12
AU2002344862B2 (en) 2008-05-01
PL215267B1 (pl) 2013-11-29
CY1107805T1 (el) 2013-06-19
EP1406896B1 (de) 2005-12-21
ATE370945T1 (de) 2007-09-15
AP1559A (en) 2006-01-24
CN1543463A (zh) 2004-11-03
AU2002344862C1 (en) 2009-02-19
AU2008203443A1 (en) 2008-08-21
HRP20031021A2 (en) 2004-06-30
HRP20031021B1 (en) 2007-09-30
RS50868B (sr) 2010-08-31
US7109334B2 (en) 2006-09-19
KR100832617B1 (ko) 2008-05-27
JP4542776B2 (ja) 2010-09-15
US7230100B2 (en) 2007-06-12
ZA200309307B (en) 2005-02-23
NZ529906A (en) 2006-03-31
DK1406896T3 (da) 2006-05-08
EA200400042A1 (ru) 2004-06-24
DE60208202D1 (de) 2006-01-26
KR20040017233A (ko) 2004-02-26
PL218777B1 (pl) 2015-01-30
HK1070652A1 (en) 2005-06-24
BRPI0210444B1 (pt) 2017-06-20
AU2008203443B2 (en) 2011-06-16
DK1632490T3 (da) 2008-01-28
WO2002102796A1 (en) 2002-12-27
PT1632490E (pt) 2007-11-07
BR0210444A (pt) 2004-08-17
IL159139A (en) 2010-04-15
YU97503A (sh) 2006-05-25
EP1632490B1 (de) 2007-08-22
CO5550497A2 (es) 2005-08-31
ES2254695T3 (es) 2006-06-16
ATE313542T1 (de) 2006-01-15
PL401835A1 (pl) 2013-02-18
PL366907A1 (en) 2005-02-07
MXPA03011627A (es) 2005-03-07
EP1406896A1 (de) 2004-04-14

Similar Documents

Publication Publication Date Title
DE60119283D1 (de) Verfahren zur herstellung von 3-hydroxypicolinsäure-derivaten
DE60323192D1 (de) Verfahren zur Herstellung von Hydroxyalkylstärkederivaten
DE50201891D1 (de) Verfahren zur herstellung von 1-octen
DE60223070D1 (de) Verfahren zur herstellung von dihalogenadamantanen
DE60019747D1 (de) Verfahren zur herstellung von fluorolefinen
DE60208738D1 (de) Verfahren zur Herstellung von Chlorfluorpolyoxyalkylenolen
DE60219193D1 (de) Verfahren zur herstellung von silylorganomercaptanen
DE50103049D1 (de) Verfahren zur Herstellung von Aminodiphenylaminen
DE60233589D1 (de) Verfahren zur herstellung von echinocandinderivaten
DE50311721D1 (de) Verfahren zur Herstellung von Aryl-aminopropanolen
DE60108668D1 (de) Verfahren zur herstellung von phenethylamin-derivaten
DE50210487D1 (de) Verfahren zur Herstellung von 1-Amino-4-hydroxyanthrachinonen
DE60024372D1 (de) Verfahren zur Herstellung von Tetraorganooxysilanen
DE60322356D1 (de) Verfahren zur herstellung von 2-aminoindanderivaten
DE60209171D1 (de) Verfahren zur Herstellung von Bromfluorenen
DE60222806D1 (de) Verfahren zur herstellung von (1,4,5)-oxadiazepinderivaten
DE60031231D1 (de) Verfahren zur Herstellung von 2-Alkyl-4-Isothiazolin-3-onen
DE60004119D1 (de) Verfahren zur Herstellung von Pentaacetyl-beta-D-Glucopyranose
DE60301444D1 (de) Verfahren zur Herstellung von Polyalkylphenoxyaminoalkanen
DE60143437D1 (de) Katalytisches verfahren zur herstellung von thiazolderivaten
DE60222031D1 (de) Stereoselektives verfahren zur herstellung von nukleosidderivaten
DE60019763D1 (de) Verfahren zur herstellung von thiazolderivaten
DE50207073D1 (de) Verfahren zur Herstellung von Acyloxybenzolsulfonaten
DE50003603D1 (de) Verfahren zur Herstellung von Bistrifluormethylbenzylaminen
DE50001772D1 (de) Verfahren zur Herstellung von Nitrodiphenylaminen

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SHIRE BIOCHEM INC., VILLE ST-LAURENT, QUEBEC, CA

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SHIRE CANADA INC., VILLE ST.-LAURENT, QUEBEC, CA