BR0210444A - Processo estéreosseletivo para a preparação de análogos de nucleosìdeos - Google Patents

Processo estéreosseletivo para a preparação de análogos de nucleosìdeos

Info

Publication number
BR0210444A
BR0210444A BR0210444-0A BR0210444A BR0210444A BR 0210444 A BR0210444 A BR 0210444A BR 0210444 A BR0210444 A BR 0210444A BR 0210444 A BR0210444 A BR 0210444A
Authority
BR
Brazil
Prior art keywords
formula
nucleoside analogs
preparation
stereoselective process
pyrimidine base
Prior art date
Application number
BR0210444-0A
Other languages
English (en)
Inventor
Qing Yu
Original Assignee
Shire Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc
Publication of BR0210444A publication Critical patent/BR0210444A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

"PROCESSO ESTéREOSSELETIVO PARA A PREPARAçãO DE ANáLOGOS DE NUCLEOSìDEOS". A presente invenção refere-se a um processo para produção de nucleosídeos predominantemente cis ou análogos de nucleosídeos e derivados de fórmula (A): onde R1 é uma base pirimidina ou um seu derivado farmaceuticamente aceitável e Q é oxigênio, carbono ou enxofre, compreendendo uma etapa de acoplamento da base pirimidina com uma molécula de fórmula (B) aqui descrita em um apropriado solvente de acoplamento, na presença de quantidades catalíticas de um elemento ou combinação de elementos de grupo IB ou IIB da tabela periódica, uma amina terciária e um ácido de Lewis para obter um intermediário de fórmula (D) que é desprotegido na etapa subseq³ente para gerar o produto de fórmula (A).
BR0210444-0A 2001-06-15 2002-06-14 Processo estéreosseletivo para a preparação de análogos de nucleosìdeos BR0210444A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29807901P 2001-06-15 2001-06-15
PCT/CA2002/000899 WO2002102796A1 (en) 2001-06-15 2002-06-14 Stereoselective method for the preparation of nucleoside analogues

Publications (1)

Publication Number Publication Date
BR0210444A true BR0210444A (pt) 2004-08-17

Family

ID=23148927

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0210444-0A BRPI0210444B1 (pt) 2001-06-15 2002-06-14 Stereo-relevant process for the preparation of nucleosidal analogs
BR0210444-0A BR0210444A (pt) 2001-06-15 2002-06-14 Processo estéreosseletivo para a preparação de análogos de nucleosìdeos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0210444-0A BRPI0210444B1 (pt) 2001-06-15 2002-06-14 Stereo-relevant process for the preparation of nucleosidal analogs

Country Status (29)

Country Link
US (2) US7109334B2 (pt)
EP (2) EP1406896B8 (pt)
JP (1) JP4542776B2 (pt)
KR (1) KR100832617B1 (pt)
CN (1) CN1297553C (pt)
AP (1) AP1559A (pt)
AT (2) ATE313542T1 (pt)
AU (2) AU2002344862C1 (pt)
BR (2) BRPI0210444B1 (pt)
CA (1) CA2449338C (pt)
CO (1) CO5550497A2 (pt)
CY (1) CY1107805T1 (pt)
DE (2) DE60222031T2 (pt)
DK (2) DK1632490T3 (pt)
EA (1) EA006372B1 (pt)
ES (2) ES2293445T3 (pt)
HK (1) HK1070652A1 (pt)
HR (1) HRP20031021B1 (pt)
IL (2) IL159139A0 (pt)
MX (1) MXPA03011627A (pt)
NO (1) NO326135B1 (pt)
NZ (1) NZ529906A (pt)
OA (1) OA12628A (pt)
PL (2) PL215267B1 (pt)
PT (1) PT1632490E (pt)
RS (1) RS50868B (pt)
SI (2) SI1632490T1 (pt)
WO (1) WO2002102796A1 (pt)
ZA (1) ZA200309307B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501514B1 (en) 2003-10-15 2009-03-10 Shire Biochem, Inc. Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides
JP4653966B2 (ja) * 2004-04-19 2011-03-16 ダイセル化学工業株式会社 ２−ベンゾイルオキシアセトアルデヒド誘導体の製造法
IN2015DN02599A (pt) * 2007-09-28 2015-09-18 Avexa Ltd
US20130165350A1 (en) * 2011-12-22 2013-06-27 Affymetrix, Inc. Surface linkers for array synthesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR840001591A (ko) * 1981-09-29 1984-05-07 구라바야시 이꾸시로 당케탈류의 제조방법
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
AU8864191A (en) * 1990-11-13 1992-06-11 Biochem Pharma Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US5532349A (en) * 1993-07-20 1996-07-02 Mitsui Toatsu Chemicals, Inc. Process for producing 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives
EP1535921A1 (en) * 1998-08-12 2005-06-01 Gilead Sciences, Inc. Method of manufacture of 1,3-oxathiolane nucleosides

Also Published As

Publication number Publication date
EP1406896B1 (en) 2005-12-21
CY1107805T1 (el) 2013-06-19
WO2002102796A1 (en) 2002-12-27
DE60222031T2 (de) 2008-05-21
NO326135B1 (no) 2008-10-06
EP1632490A1 (en) 2006-03-08
ES2293445T3 (es) 2008-03-16
ES2254695T3 (es) 2006-06-16
EP1632490B1 (en) 2007-08-22
EA006372B1 (ru) 2005-12-29
EP1406896A1 (en) 2004-04-14
NO20035556D0 (no) 2003-12-12
NZ529906A (en) 2006-03-31
YU97503A (sh) 2006-05-25
PL401835A1 (pl) 2013-02-18
CN1297553C (zh) 2007-01-31
DE60222031D1 (de) 2007-10-04
CA2449338C (en) 2012-02-07
PL215267B1 (pl) 2013-11-29
DK1632490T3 (da) 2008-01-28
DE60208202D1 (de) 2006-01-26
AU2002344862C1 (en) 2009-02-19
AU2008203443A1 (en) 2008-08-21
EP1406896B8 (en) 2006-11-15
US7230100B2 (en) 2007-06-12
HK1070652A1 (en) 2005-06-24
US20060183899A1 (en) 2006-08-17
JP2004535428A (ja) 2004-11-25
SI1632490T1 (sl) 2008-02-29
IL159139A (en) 2010-04-15
US20030135048A1 (en) 2003-07-17
US7109334B2 (en) 2006-09-19
HRP20031021B1 (en) 2007-09-30
DK1406896T3 (da) 2006-05-08
CO5550497A2 (es) 2005-08-31
WO2002102796A8 (en) 2003-09-18
IL159139A0 (en) 2004-06-01
DE60208202T2 (de) 2006-08-17
KR100832617B1 (ko) 2008-05-27
ATE313542T1 (de) 2006-01-15
ZA200309307B (en) 2005-02-23
SI1406896T1 (sl) 2006-04-30
BRPI0210444B1 (pt) 2017-06-20
AP1559A (en) 2006-01-24
RS50868B (sr) 2010-08-31
OA12628A (en) 2006-06-13
PT1632490E (pt) 2007-11-07
MXPA03011627A (es) 2005-03-07
CN1543463A (zh) 2004-11-03
AU2008203443B2 (en) 2011-06-16
EA200400042A1 (ru) 2004-06-24
ATE370945T1 (de) 2007-09-15
PL218777B1 (pl) 2015-01-30
JP4542776B2 (ja) 2010-09-15
CA2449338A1 (en) 2002-12-27
HRP20031021A2 (en) 2004-06-30
AU2002344862B2 (en) 2008-05-01
PL366907A1 (en) 2005-02-07
KR20040017233A (ko) 2004-02-26

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: SHIRE BIOCHEM INC. (CA)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070139839/RJ DE 03/10/2007.

B25D Requested change of name of applicant approved

Owner name: SHIRE CANADA INC. (CA)

Free format text: ALTERADO DE: SHIRE BIOCHEM INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 409/04, C07D 411/04

Ipc: C07D 409/04 (2011.01), C07D 411/04 (2011.01), A61P

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)