RS50112B - Derivati izosorbid mononitrata i njihova upotreba kao vazodilatacionih agensa sa redukovanom tolerancijom - Google Patents

Derivati izosorbid mononitrata i njihova upotreba kao vazodilatacionih agensa sa redukovanom tolerancijom

Info

Publication number
RS50112B
RS50112B YUP-252/01A YUP25201A RS50112B RS 50112 B RS50112 B RS 50112B YU P25201 A YUP25201 A YU P25201A RS 50112 B RS50112 B RS 50112B
Authority
RS
Serbia
Prior art keywords
group
derivatives
vasidolatator
utilization
agents
Prior art date
Application number
YUP-252/01A
Other languages
English (en)
Inventor
Moliner Jose Repolles
Coy Pubill
Llorente Cabeza
Banus Carbo
Rofes Negrie
Riudavets Cerda
Siso Ferrer
Marek Radomski
Perez-Rasilla Salas
Bonnin Juan Martinez
Original Assignee
Lacer S.A.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer S.A., filed Critical Lacer S.A.,
Publication of RS50112B publication Critical patent/RS50112B/sr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Jedinjenja koja su derivati izosorbid mononitrata, i njegove farmaceutski prihvatljive soli, naznačena time, što odgovaraju sledećoj opštoj formuli (I) u kojoj A i B nezavisno predstavljaju bilo koju od grupa gde je Z atom kiseonika ili atom sumpora, R je alkil C1-C4 grupa, aril grupa ili aralkil grupa, ili grupa U kojoj je R1 vodonik ili alkil C1-C4 grupa, aril grupa ili aralkil grupa, sa uslovom da je: (a) jedno od A ili B uvek -ONO2, ali nikad oba u isto vreme; (b) kada je Z atom sumpora R je alkil C1-C4 grupa, aril grupa ili aralkil grupa, i (c) kada je Z atom kiseonika R je grupa u kojoj R1 predstavlja gore naznačene grupe. Prijava sadrži još 9 patentnih zahteva.
YUP-252/01A 1998-10-07 1999-10-04 Derivati izosorbid mononitrata i njihova upotreba kao vazodilatacionih agensa sa redukovanom tolerancijom RS50112B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802076A ES2142773B1 (es) 1998-10-07 1998-10-07 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
PCT/ES1999/000316 WO2000020420A1 (es) 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida

Publications (1)

Publication Number Publication Date
RS50112B true RS50112B (sr) 2009-03-25

Family

ID=8305360

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-252/01A RS50112B (sr) 1998-10-07 1999-10-04 Derivati izosorbid mononitrata i njihova upotreba kao vazodilatacionih agensa sa redukovanom tolerancijom

Country Status (40)

Country Link
US (2) US20010051735A1 (sr)
EP (1) EP1120419B1 (sr)
JP (1) JP4659214B2 (sr)
KR (1) KR100641801B1 (sr)
CN (1) CN1096465C (sr)
AP (1) AP1555A (sr)
AR (1) AR020538A1 (sr)
AT (1) ATE323707T1 (sr)
AU (1) AU762724B2 (sr)
BG (1) BG65135B1 (sr)
BR (1) BR9914355B1 (sr)
CA (1) CA2346010C (sr)
CO (1) CO5180544A1 (sr)
CU (1) CU23162A3 (sr)
CZ (1) CZ294551B6 (sr)
DE (2) DE19983612T1 (sr)
DK (1) DK1120419T3 (sr)
EA (1) EA003360B1 (sr)
EE (1) EE04374B1 (sr)
ES (2) ES2142773B1 (sr)
GB (1) GB2359810B (sr)
GE (1) GEP20043162B (sr)
GT (1) GT199900173A (sr)
HR (1) HRP20010256B1 (sr)
HU (1) HUP0103937A3 (sr)
ID (1) ID29946A (sr)
IL (2) IL142391A0 (sr)
IS (1) IS2312B (sr)
NO (1) NO328584B1 (sr)
NZ (1) NZ510855A (sr)
OA (1) OA11661A (sr)
PA (1) PA8483901A1 (sr)
PE (1) PE20001083A1 (sr)
PL (1) PL200028B1 (sr)
PT (1) PT1120419E (sr)
RS (1) RS50112B (sr)
TR (1) TR200100961T2 (sr)
WO (1) WO2000020420A1 (sr)
YU (1) YU25201A (sr)
ZA (1) ZA200102836B (sr)

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ES2258365B1 (es) 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) * 2007-01-23 2010-10-21 Lacer, S.A. Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
JP5587790B2 (ja) 2008-01-09 2014-09-10 アミュラ セラピューティクス リミティド 化合物
US8003811B2 (en) * 2008-02-07 2011-08-23 Nicox S.A. Nitric oxide donor compounds
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) * 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) * 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
ES2423939T3 (es) * 2009-09-10 2013-09-25 Cognis Ip Management Gmbh Derivados de isosorburo gliceril éter y su empleo en aplicaciones de uso doméstico
CA2822747A1 (en) * 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
CN102241687A (zh) * 2011-05-23 2011-11-16 中国人民解放军第四军医大学 抗缺血/再灌注损伤的药物
CN103687843B (zh) 2011-10-24 2016-11-16 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物
KR20150123324A (ko) * 2013-03-05 2015-11-03 아처 다니엘 미드랜드 캄파니 이소헥시드 모노트리플레이트 및 이의 합성 방법
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN104650108B (zh) * 2013-11-18 2017-05-24 富力 连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用

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FR1356374A (fr) 1963-02-12 1964-03-27 Machine à fonctions multiples pour le travail du bois
AU465217B2 (en) 1971-04-29 1975-09-18 American Home Products Corporation Mononitrte esters of 1,4:3, 6-dianhydro-d-glucitol
US3886196A (en) 1973-02-07 1975-05-27 Phillips Petroleum Co Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles
DE3028289C2 (de) * 1980-07-25 1986-11-27 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE3248548A1 (de) 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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CA2014520C (en) 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
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FR2680173A1 (fr) * 1991-08-07 1993-02-12 Hoechst Lab Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
DE69321596T2 (de) * 1992-07-30 1999-04-22 Cal International Ltd Ester und kombinationen von einem organischen nitrat und einem salicyclat
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HUP0103937A3 (en) 2003-11-28
JP4659214B2 (ja) 2011-03-30
CA2346010A1 (en) 2000-04-13
WO2000020420A1 (es) 2000-04-13
IL142391A (en) 2007-07-24
US20010051735A1 (en) 2001-12-13
EE04374B1 (et) 2004-10-15
GB2359810A (en) 2001-09-05
IS2312B (is) 2007-11-15
CZ20011257A3 (cs) 2001-08-15
YU25201A (sh) 2003-04-30
NZ510855A (en) 2004-02-27
OA11661A (en) 2004-12-08
ES2257871T3 (es) 2006-08-01
PA8483901A1 (es) 2000-09-29
CA2346010C (en) 2010-01-12
US20030225134A1 (en) 2003-12-04
GEP20043162B (en) 2004-01-26
HUP0103937A2 (hu) 2002-02-28
ATE323707T1 (de) 2006-05-15
DE69930949T2 (de) 2006-12-28
US6858632B2 (en) 2005-02-22
AR020538A1 (es) 2002-05-15
BR9914355A (pt) 2001-06-26
DE69930949D1 (de) 2006-05-24
ID29946A (id) 2001-10-25
KR20010088848A (ko) 2001-09-28
AP2001002128A0 (en) 2001-06-30
BG65135B1 (bg) 2007-03-30
GT199900173A (es) 2001-03-30
PL347030A1 (en) 2002-03-11
ES2142773A1 (es) 2000-04-16
CU23162A3 (es) 2006-07-18
IL142391A0 (en) 2002-03-10
BR9914355B1 (pt) 2014-10-21
CO5180544A1 (es) 2002-07-30
CN1322205A (zh) 2001-11-14
AU762724B2 (en) 2003-07-03
JP2002526544A (ja) 2002-08-20
BG105417A (en) 2001-12-29
DE19983612T1 (de) 2001-09-27
GB2359810B (en) 2003-12-03
EE200100207A (et) 2002-06-17
AU6204199A (en) 2000-04-26
CN1096465C (zh) 2002-12-18
PE20001083A1 (es) 2000-11-28
IS5910A (is) 2001-03-29
EP1120419A1 (en) 2001-08-01
HRP20010256B1 (en) 2009-08-31
DK1120419T3 (da) 2006-07-03
EA003360B1 (ru) 2003-04-24
PT1120419E (pt) 2006-07-31
NO328584B1 (no) 2010-03-22
PL200028B1 (pl) 2008-11-28
TR200100961T2 (tr) 2003-02-21
KR100641801B1 (ko) 2006-11-02
AP1555A (en) 2006-01-18
HRP20010256A2 (en) 2002-04-30
EA200100422A1 (ru) 2001-10-22
ZA200102836B (en) 2002-09-25
NO20011778D0 (no) 2001-04-06
EP1120419B1 (en) 2006-04-19
CZ294551B6 (cs) 2005-01-12
NO20011778L (no) 2001-04-06
ES2142773B1 (es) 2001-01-01
GB0111172D0 (en) 2001-06-27

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