RS49841B - Biorazgradivi alginatni gelovi sa kontinualnim oslobađanjem - Google Patents

Biorazgradivi alginatni gelovi sa kontinualnim oslobađanjem

Info

Publication number
RS49841B
RS49841B YUP-694/00A YU69400A RS49841B RS 49841 B RS49841 B RS 49841B YU 69400 A YU69400 A YU 69400A RS 49841 B RS49841 B RS 49841B
Authority
RS
Serbia
Prior art keywords
biodegradable
alginate gels
biodegradable sustained
biologically active
release alginate
Prior art date
Application number
YUP-694/00A
Other languages
English (en)
Inventor
Merrill Seymour GOLDENBERG
Jian Hua GU
Original Assignee
Amgen Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc., filed Critical Amgen Inc.,
Publication of YU69400A publication Critical patent/YU69400A/sh
Publication of RS49841B publication Critical patent/RS49841B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Kompozicija u obliku gela sa odloženim kontinualnim oslobađanjem, naznačen time, što se sastoji od: a) biorazgradivog anjonskog polisaharida; b) biološki aktivnog proteina; i c) najmanje jednog vezanog polivalentnog jona metala, gde biološki aktivan agens sadrži protein i i što dati biorazgradiv anjonski polisaharid je alginatni estar koji je jonski umrežen obezbeđujući biorazgradiv, biokompatibilian hidrogel alginatnog estra koji se može injektirati.
YUP-694/00A 1998-05-18 1999-05-14 Biorazgradivi alginatni gelovi sa kontinualnim oslobađanjem RS49841B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/080,832 US6432449B1 (en) 1998-05-18 1998-05-18 Biodegradable sustained-release alginate gels

Publications (2)

Publication Number Publication Date
YU69400A YU69400A (sh) 2003-02-28
RS49841B true RS49841B (sr) 2008-08-07

Family

ID=22159900

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-694/00A RS49841B (sr) 1998-05-18 1999-05-14 Biorazgradivi alginatni gelovi sa kontinualnim oslobađanjem

Country Status (25)

Country Link
US (2) US6432449B1 (sr)
EP (1) EP1079811B1 (sr)
JP (1) JP2002515419A (sr)
KR (1) KR20010025023A (sr)
CN (1) CN1309556A (sr)
AT (1) ATE343378T1 (sr)
AU (1) AU3993999A (sr)
BG (1) BG65397B1 (sr)
BR (1) BR9910553A (sr)
CA (1) CA2331446C (sr)
CY (1) CY1105944T1 (sr)
DE (1) DE69933763T2 (sr)
DK (1) DK1079811T3 (sr)
EA (1) EA003670B1 (sr)
ES (1) ES2275341T3 (sr)
HU (1) HUP0101895A3 (sr)
IL (1) IL139617A0 (sr)
NO (1) NO20005564L (sr)
NZ (1) NZ507943A (sr)
PL (1) PL199499B1 (sr)
PT (1) PT1079811E (sr)
RS (1) RS49841B (sr)
SK (1) SK16752000A3 (sr)
WO (1) WO1999059549A1 (sr)
ZA (1) ZA200006299B (sr)

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Also Published As

Publication number Publication date
CN1309556A (zh) 2001-08-22
AU3993999A (en) 1999-12-06
BR9910553A (pt) 2001-01-30
EP1079811A1 (en) 2001-03-07
CA2331446C (en) 2004-03-16
YU69400A (sh) 2003-02-28
NO20005564D0 (no) 2000-11-03
CA2331446A1 (en) 1999-11-25
PL344337A1 (en) 2001-11-05
CY1105944T1 (el) 2011-04-06
EP1079811B1 (en) 2006-10-25
JP2002515419A (ja) 2002-05-28
NZ507943A (en) 2003-08-29
BG104943A (en) 2001-07-31
WO1999059549A1 (en) 1999-11-25
HUP0101895A3 (en) 2004-01-28
SK16752000A3 (sk) 2001-09-11
EA003670B1 (ru) 2003-08-28
US20020168406A1 (en) 2002-11-14
EA200001200A1 (ru) 2001-04-23
ES2275341T3 (es) 2007-06-01
DE69933763D1 (de) 2006-12-07
DK1079811T3 (da) 2007-02-26
HUP0101895A2 (hu) 2001-10-28
ATE343378T1 (de) 2006-11-15
US6432449B1 (en) 2002-08-13
NO20005564L (no) 2001-01-18
PT1079811E (pt) 2007-01-31
ZA200006299B (en) 2001-05-30
DE69933763T2 (de) 2007-10-04
IL139617A0 (en) 2002-02-10
KR20010025023A (ko) 2001-03-26
PL199499B1 (pl) 2008-09-30
BG65397B1 (bg) 2008-06-30

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