RO91186B - Procedeu pentru prepararea unor peptide cu actiune asupra functiei glandei pituitare - Google Patents

Procedeu pentru prepararea unor peptide cu actiune asupra functiei glandei pituitare

Info

Publication number
RO91186B
RO91186B RO114739A RO11473984A RO91186B RO 91186 B RO91186 B RO 91186B RO 114739 A RO114739 A RO 114739A RO 11473984 A RO11473984 A RO 11473984A RO 91186 B RO91186 B RO 91186B
Authority
RO
Romania
Prior art keywords
protecting group
leu
arg
ala
gln
Prior art date
Application number
RO114739A
Other languages
English (en)
Other versions
RO91186A (ro
Inventor
Jean E. F. Rivier
Joachim Spiess
Wylie W. Vale Jr.
Original Assignee
The Salk Institute For Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Salk Institute For Biological Studies filed Critical The Salk Institute For Biological Studies
Publication of RO91186A publication Critical patent/RO91186A/ro
Publication of RO91186B publication Critical patent/RO91186B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/843—Digestive system
    • Y10S530/845—Pancreas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Machine Tool Sensing Apparatuses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Prostheses (AREA)

Abstract

Inventia se refera la un procedeu penru prepararea unor peptide cu actiune asupra functiei glandei pituitoare cu formula generala I:H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arf-Lys-Val-Leu-D-Ala-Glu-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Glu-Gyn-Y, în care Y este -COOH sau CINh2, caracterizat prin aceea ca formeaza o peptida care are cel putin o grupa protectoare cu formula generala II:X1-Tyr(X2)-Ala-Asp(X3)-Ala-Ile-Phe-Thr(X4)-Asn(X5)-Ser(X4)-Tyr(X2)-Arg(X6)-Lys(X7)-Val-Leu-D-Ala-Gln(X5)-Leu-Ser(X4)-Ala-Arg(X6)-Lys(X7)-Leu-Leu-Gln(X5)-Asp(X3)-Ile-Met-Ser-(X4)-Arg(X6)-Gln(X6)-Gly(X6), în care X1 reprezinta hidrogen sau t-butiloxicarbanil ca grupa protectoare pentru alfa - amino, X2 reprezinta hidrogen sau 2,6-diclorbenzil ca grupa protectoare pentru hidroxilul fenolic al yr; X3 reprezinta hidrogen sau benziloxi ca grupa protectoare pentru grupa carboxil din Asp sau lu; X4 reprezinta hidrogen sau benzil cu grupa protectoare pentru hidroxilul alcoolic din Ser si Thr, X5 reprezinta hidrogen sau Xan ca grupa protectoare pentru radicalul guanidino din Arg, X6 reprezinta toluensulfonil ca grupa protectoare pe grupa amino din Lys, X8 reprezinta -NH rasina suport, se scindeaza grupa sau grupele protectoare cu HF la temperaturi între -20 degree C ... 100 degree C si cu acid trifluoracetic în CH2 Cl2 la temperaturi între 0 degree C si temperatura camerei si daca se doreste se transfera peptida rezultata într-o sare de aditie metalica.
RO114739A 1982-10-04 1984-06-01 Procedeu pentru prepararea unor peptide cu actiune asupra functiei glandei pituitare RO91186B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/432,663 US4563352A (en) 1982-10-04 1982-10-04 Human pancreatic GRF

Publications (2)

Publication Number Publication Date
RO91186A RO91186A (ro) 1987-07-30
RO91186B true RO91186B (ro) 1987-07-31

Family

ID=23717095

Family Applications (1)

Application Number Title Priority Date Filing Date
RO114739A RO91186B (ro) 1982-10-04 1984-06-01 Procedeu pentru prepararea unor peptide cu actiune asupra functiei glandei pituitare

Country Status (25)

Country Link
US (1) US4563352A (ro)
EP (1) EP0105759B1 (ro)
JP (1) JPS59501951A (ro)
KR (1) KR900006712B1 (ro)
AT (1) ATE24919T1 (ro)
AU (1) AU566180B2 (ro)
CA (1) CA1243016A (ro)
DE (1) DE3369144D1 (ro)
DK (1) DK269284D0 (ro)
ES (1) ES8606399A1 (ro)
FI (1) FI83660C (ro)
GR (1) GR79698B (ro)
HU (1) HU191263B (ro)
IE (1) IE56175B1 (ro)
IL (1) IL69897A (ro)
MX (1) MX7701E (ro)
NO (1) NO167866C (ro)
NZ (1) NZ205745A (ro)
PH (1) PH20333A (ro)
PT (1) PT77453B (ro)
RO (1) RO91186B (ro)
SU (1) SU1426455A3 (ro)
WO (1) WO1984001379A1 (ro)
YU (1) YU45575B (ro)
ZA (1) ZA837208B (ro)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
US4703035A (en) * 1982-10-04 1987-10-27 The Salk Institute For Biological Studies Human pancreatic GRF amidated fragments
US4581168A (en) * 1983-02-21 1986-04-08 Sanofi Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
ZA844380B (en) * 1983-07-05 1985-01-30 Salk Inst For Biological Studi Dna encoding a grf precursor
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
EP0189673B1 (en) * 1984-12-24 1990-09-26 Sumitomo Pharmaceuticals Company, Limited Stable growth hormone releasing factor preparation
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
FR2599038B1 (fr) * 1986-05-26 1990-06-29 Sanofi Sa Procede de preparation de nonacosapeptides et peptides intermediaires
IL84758A (en) * 1987-01-13 1992-03-29 Salk Inst For Biological Studi Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
USRE33699E (en) * 1987-07-09 1991-09-24 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
US4801456A (en) * 1987-07-09 1989-01-31 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
AU637316B2 (en) * 1988-01-28 1993-05-27 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5153175A (en) * 1989-05-25 1992-10-06 University Of Tennesee Research Corporation Method of inducing sleep with GHRH complementary peptide compositions
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
IL98638A (en) * 1990-06-29 1995-07-31 Hoffmann La Roche Analogs of the factor that releases human growth hormone, their preparation and pharmaceutical preparations that contain them
ATE119916T1 (de) * 1990-12-10 1995-04-15 Hoffmann La Roche Verfahren zur enzymatischen herstellung von grf(1-44)nh2.
CA2084061A1 (en) * 1991-04-09 1992-10-10 Arthur M. Felix Growth hormone releasing factor analogs
US5246920A (en) * 1992-06-15 1993-09-21 University Of South Florida Treatment of hyperprolactinemia
US5811074A (en) * 1992-06-29 1998-09-22 University Of South Florida Method of diagnosing pituitary dependent growth hormone deficiency
US5631225A (en) * 1994-10-13 1997-05-20 Novo Nordisk A/S Pharmaceutical formulation
EP0880969A1 (en) * 1997-05-28 1998-12-02 Applied Research Systems ARS Holdings N.V. Pharmaceutical compositions of peptides having low solubility in physiological medium
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
EA006484B1 (ru) * 2001-02-02 2005-12-29 Конджачем, Инк. Долгоживущие производные рилизинг-фактора гормона роста
BR0314619A (pt) * 2002-09-18 2005-08-02 Univ Montreal Ct Hospitalier Chum Análogos de ghrh
WO2009009727A2 (en) * 2007-07-12 2009-01-15 Akela Pharma Srl Ghrh analogs and therapeutic uses thereof
CN107936090B (zh) * 2017-12-08 2021-09-24 陕西慧康生物科技有限责任公司 一种低成本合成ARK-Cu的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904753A (en) * 1970-02-20 1975-09-09 Research Corp Clinically active bovine growth hormone fraction
US3664925A (en) * 1970-02-20 1972-05-23 Martin Sonenberg Clinically active bovine growth hormone fraction
US3853833A (en) * 1971-04-27 1974-12-10 Hormone Res Foundation Synthetic human growth-promoting and lactogenic hormones and method of producing same
US4056520A (en) * 1972-03-31 1977-11-01 Research Corporation Clinically active bovine growth hormone fraction
PH14681A (en) * 1977-11-30 1981-11-10 Pfizer Phenylglycinamides useful in the treatment of ischaemic heart disease

Also Published As

Publication number Publication date
NO842148L (no) 1984-05-30
JPS59501951A (ja) 1984-11-22
FI83660C (fi) 1991-08-12
IE56175B1 (en) 1991-05-08
SU1426455A3 (ru) 1988-09-23
WO1984001379A1 (en) 1984-04-12
PT77453B (en) 1986-02-26
US4563352A (en) 1986-01-07
DK269284A (da) 1984-05-30
ES8606399A1 (es) 1986-04-16
IL69897A0 (en) 1984-01-31
YU45575B (sh) 1992-07-20
MX7701E (es) 1990-09-20
NZ205745A (en) 1987-07-31
KR900006712B1 (ko) 1990-09-17
AU566180B2 (en) 1987-10-08
HU191263B (en) 1987-01-28
PT77453A (en) 1983-11-01
AU2126983A (en) 1984-04-24
NO167866B (no) 1991-09-09
EP0105759B1 (en) 1987-01-14
GR79698B (ro) 1984-10-31
IL69897A (en) 1986-12-31
DE3369144D1 (en) 1987-02-19
RO91186A (ro) 1987-07-30
ZA837208B (en) 1984-05-30
DK269284D0 (da) 1984-05-30
FI83660B (fi) 1991-04-30
EP0105759A3 (en) 1985-05-08
PH20333A (en) 1986-12-02
ES526201A0 (es) 1986-04-16
IE832333L (en) 1984-04-04
FI842166L (fi) 1984-05-30
NO167866C (no) 1991-12-18
YU200083A (en) 1986-06-30
ATE24919T1 (de) 1987-01-15
FI842166A0 (fi) 1984-05-30
KR850003417A (ko) 1985-06-17
CA1243016A (en) 1988-10-11
EP0105759A2 (en) 1984-04-18

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