RO91186B - Procedeu pentru prepararea unor peptide cu actiune asupra functiei glandei pituitare - Google Patents
Procedeu pentru prepararea unor peptide cu actiune asupra functiei glandei pituitareInfo
- Publication number
- RO91186B RO91186B RO114739A RO11473984A RO91186B RO 91186 B RO91186 B RO 91186B RO 114739 A RO114739 A RO 114739A RO 11473984 A RO11473984 A RO 11473984A RO 91186 B RO91186 B RO 91186B
- Authority
- RO
- Romania
- Prior art keywords
- ala
- gln
- leu
- ser
- gly
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 206010062767 Hypophysitis Diseases 0.000 title 1
- 210000003635 pituitary gland Anatomy 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical group C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/845—Pancreas
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Prostheses (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Machine Tool Sensing Apparatuses (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Inventia se refera la un procedeu penru prepararea unor peptide cu actiune asupra functiei glandei pituitoare cu formula generala I:H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arf-Lys-Val-Leu-D-Ala-Glu-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Glu-Gyn-Y, în care Y este -COOH sau CINh2, caracterizat prin aceea ca formeaza o peptida care are cel putin o grupa protectoare cu formula generala II:X1-Tyr(X2)-Ala-Asp(X3)-Ala-Ile-Phe-Thr(X4)-Asn(X5)-Ser(X4)-Tyr(X2)-Arg(X6)-Lys(X7)-Val-Leu-D-Ala-Gln(X5)-Leu-Ser(X4)-Ala-Arg(X6)-Lys(X7)-Leu-Leu-Gln(X5)-Asp(X3)-Ile-Met-Ser-(X4)-Arg(X6)-Gln(X6)-Gly(X6), în care X1 reprezinta hidrogen sau t-butiloxicarbanil ca grupa protectoare pentru alfa - amino, X2 reprezinta hidrogen sau 2,6-diclorbenzil ca grupa protectoare pentru hidroxilul fenolic al yr; X3 reprezinta hidrogen sau benziloxi ca grupa protectoare pentru grupa carboxil din Asp sau lu; X4 reprezinta hidrogen sau benzil cu grupa protectoare pentru hidroxilul alcoolic din Ser si Thr, X5 reprezinta hidrogen sau Xan ca grupa protectoare pentru radicalul guanidino din Arg, X6 reprezinta toluensulfonil ca grupa protectoare pe grupa amino din Lys, X8 reprezinta -NH rasina suport, se scindeaza grupa sau grupele protectoare cu HF la temperaturi între -20 degree C ... 100 degree C si cu acid trifluoracetic în CH2 Cl2 la temperaturi între 0 degree C si temperatura camerei si daca se doreste se transfera peptida rezultata într-o sare de aditie metalica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/432,663 US4563352A (en) | 1982-10-04 | 1982-10-04 | Human pancreatic GRF |
Publications (2)
Publication Number | Publication Date |
---|---|
RO91186A RO91186A (ro) | 1987-07-30 |
RO91186B true RO91186B (ro) | 1987-07-31 |
Family
ID=23717095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO114739A RO91186B (ro) | 1982-10-04 | 1984-06-01 | Procedeu pentru prepararea unor peptide cu actiune asupra functiei glandei pituitare |
Country Status (25)
Country | Link |
---|---|
US (1) | US4563352A (ro) |
EP (1) | EP0105759B1 (ro) |
JP (1) | JPS59501951A (ro) |
KR (1) | KR900006712B1 (ro) |
AT (1) | ATE24919T1 (ro) |
AU (1) | AU566180B2 (ro) |
CA (1) | CA1243016A (ro) |
DE (1) | DE3369144D1 (ro) |
DK (1) | DK269284D0 (ro) |
ES (1) | ES8606399A1 (ro) |
FI (1) | FI83660C (ro) |
GR (1) | GR79698B (ro) |
HU (1) | HU191263B (ro) |
IE (1) | IE56175B1 (ro) |
IL (1) | IL69897A (ro) |
MX (1) | MX7701E (ro) |
NO (1) | NO167866C (ro) |
NZ (1) | NZ205745A (ro) |
PH (1) | PH20333A (ro) |
PT (1) | PT77453B (ro) |
RO (1) | RO91186B (ro) |
SU (1) | SU1426455A3 (ro) |
WO (1) | WO1984001379A1 (ro) |
YU (1) | YU45575B (ro) |
ZA (1) | ZA837208B (ro) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
US4703035A (en) * | 1982-10-04 | 1987-10-27 | The Salk Institute For Biological Studies | Human pancreatic GRF amidated fragments |
US4581168A (en) * | 1983-02-21 | 1986-04-08 | Sanofi | Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides |
ZA844380B (en) * | 1983-07-05 | 1985-01-30 | Salk Inst For Biological Studi | Dna encoding a grf precursor |
AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
FR2567524B1 (fr) * | 1984-07-10 | 1987-11-27 | Sanofi Sa | Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires |
US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
EP0189673B1 (en) * | 1984-12-24 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Stable growth hormone releasing factor preparation |
US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
IL84758A (en) * | 1987-01-13 | 1992-03-29 | Salk Inst For Biological Studi | Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them |
US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
US4801456A (en) * | 1987-07-09 | 1989-01-31 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
US4880777A (en) * | 1987-09-01 | 1989-11-14 | Eastman Kodak Company | Synthetic peptides having growth hormone releasing activity |
EP0400051B1 (en) * | 1988-01-28 | 1995-05-10 | Polygen Holding Corporation | Polypeptide compounds having growth hormone releasing activity |
US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
US5153175A (en) * | 1989-05-25 | 1992-10-06 | University Of Tennesee Research Corporation | Method of inducing sleep with GHRH complementary peptide compositions |
US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
AU656144B2 (en) * | 1990-06-29 | 1995-01-27 | F. Hoffmann-La Roche Ag | Histidine substituted growth hormone releasing factor analogs |
DK0490249T3 (da) * | 1990-12-10 | 1995-05-29 | Hoffmann La Roche | Fremgangsmåde til enzymatisk fremstilling af GRF(1-44)-NH2 |
WO1992018531A1 (en) * | 1991-04-09 | 1992-10-29 | F. Hoffmann-La Roche Ag | Growth hormone releasing factor analogs |
US5246920A (en) * | 1992-06-15 | 1993-09-21 | University Of South Florida | Treatment of hyperprolactinemia |
US5811074A (en) * | 1992-06-29 | 1998-09-22 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
EP0880969A1 (en) * | 1997-05-28 | 1998-12-02 | Applied Research Systems ARS Holdings N.V. | Pharmaceutical compositions of peptides having low solubility in physiological medium |
EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
BR0206919A (pt) * | 2001-02-02 | 2004-07-06 | Conjuchem Inc | Derivados de fator de liberação de hormÈnio de crescimento de longa duração |
CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
CN107936090B (zh) * | 2017-12-08 | 2021-09-24 | 陕西慧康生物科技有限责任公司 | 一种低成本合成ARK-Cu的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3664925A (en) * | 1970-02-20 | 1972-05-23 | Martin Sonenberg | Clinically active bovine growth hormone fraction |
US3904753A (en) * | 1970-02-20 | 1975-09-09 | Research Corp | Clinically active bovine growth hormone fraction |
US3853833A (en) * | 1971-04-27 | 1974-12-10 | Hormone Res Foundation | Synthetic human growth-promoting and lactogenic hormones and method of producing same |
US4056520A (en) * | 1972-03-31 | 1977-11-01 | Research Corporation | Clinically active bovine growth hormone fraction |
PH14681A (en) * | 1977-11-30 | 1981-11-10 | Pfizer | Phenylglycinamides useful in the treatment of ischaemic heart disease |
-
1982
- 1982-10-04 US US06/432,663 patent/US4563352A/en not_active Expired - Lifetime
-
1983
- 1983-09-26 NZ NZ205745A patent/NZ205745A/en unknown
- 1983-09-27 ZA ZA837208A patent/ZA837208B/xx unknown
- 1983-10-03 PH PH29648A patent/PH20333A/en unknown
- 1983-10-03 WO PCT/US1983/001564 patent/WO1984001379A1/en active IP Right Grant
- 1983-10-03 IE IE2333/83A patent/IE56175B1/en not_active IP Right Cessation
- 1983-10-03 ES ES526201A patent/ES8606399A1/es not_active Expired
- 1983-10-03 JP JP83503459A patent/JPS59501951A/ja active Pending
- 1983-10-03 AU AU21269/83A patent/AU566180B2/en not_active Expired
- 1983-10-03 GR GR72605A patent/GR79698B/el unknown
- 1983-10-03 HU HU8497A patent/HU191263B/hu unknown
- 1983-10-04 PT PT77453A patent/PT77453B/pt not_active IP Right Cessation
- 1983-10-04 AT AT83306008T patent/ATE24919T1/de not_active IP Right Cessation
- 1983-10-04 EP EP83306008A patent/EP0105759B1/en not_active Expired
- 1983-10-04 MX MX831019U patent/MX7701E/es unknown
- 1983-10-04 CA CA000438354A patent/CA1243016A/en not_active Expired
- 1983-10-04 DE DE8383306008T patent/DE3369144D1/de not_active Expired
- 1983-10-04 YU YU200083A patent/YU45575B/sh unknown
- 1983-10-04 IL IL69897A patent/IL69897A/xx not_active IP Right Cessation
- 1983-10-26 KR KR1019830005067A patent/KR900006712B1/ko not_active IP Right Cessation
-
1984
- 1984-05-30 FI FI842166A patent/FI83660C/fi not_active IP Right Cessation
- 1984-05-30 NO NO84842148A patent/NO167866C/no not_active IP Right Cessation
- 1984-05-30 DK DK269284A patent/DK269284D0/da not_active Application Discontinuation
- 1984-06-01 RO RO114739A patent/RO91186B/ro unknown
- 1984-06-01 SU SU843750475A patent/SU1426455A3/ru active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3369144D1 (en) | Human pancreatic grf | |
ES2001274A6 (es) | Un metodo para preparar peptidos que tienen influencia sobre la funcion de la glandula pituitaria en seres humanos y otros animales | |
ES8506263A1 (es) | Un procedimiento para preparar peptidos analogos del factor de liberacion de la hormona del crecimiento de tumor pancreatico humano | |
FI893532A (fi) | Menetelmä terapeuttisesti käyttökelpoisen rengasrakenteen sisältävän GRF-analogin valmistamiseksi | |
TH1778EX (th) | สารคล้ายคลึง จี อาร์ เอฟ (grf) |