IL69897A - Human pancreatic grf analogs,compositions comprising them and use thereof - Google Patents
Human pancreatic grf analogs,compositions comprising them and use thereofInfo
- Publication number
- IL69897A IL69897A IL69897A IL6989783A IL69897A IL 69897 A IL69897 A IL 69897A IL 69897 A IL69897 A IL 69897A IL 6989783 A IL6989783 A IL 6989783A IL 69897 A IL69897 A IL 69897A
- Authority
- IL
- Israel
- Prior art keywords
- ala
- gln
- leu
- ser
- gly
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical group C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/845—Pancreas
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Prostheses (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Machine Tool Sensing Apparatuses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/432,663 US4563352A (en) | 1982-10-04 | 1982-10-04 | Human pancreatic GRF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL69897A0 IL69897A0 (en) | 1984-01-31 |
| IL69897A true IL69897A (en) | 1986-12-31 |
Family
ID=23717095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL69897A IL69897A (en) | 1982-10-04 | 1983-10-04 | Human pancreatic grf analogs,compositions comprising them and use thereof |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4563352A (xx) |
| EP (1) | EP0105759B1 (xx) |
| JP (1) | JPS59501951A (xx) |
| KR (1) | KR900006712B1 (xx) |
| AT (1) | ATE24919T1 (xx) |
| AU (1) | AU566180B2 (xx) |
| CA (1) | CA1243016A (xx) |
| DE (1) | DE3369144D1 (xx) |
| DK (1) | DK269284D0 (xx) |
| ES (1) | ES8606399A1 (xx) |
| FI (1) | FI83660C (xx) |
| GR (1) | GR79698B (xx) |
| HU (1) | HU191263B (xx) |
| IE (1) | IE56175B1 (xx) |
| IL (1) | IL69897A (xx) |
| MX (1) | MX7701E (xx) |
| NO (1) | NO167866C (xx) |
| NZ (1) | NZ205745A (xx) |
| PH (1) | PH20333A (xx) |
| PT (1) | PT77453B (xx) |
| RO (1) | RO91186B (xx) |
| SU (1) | SU1426455A3 (xx) |
| WO (1) | WO1984001379A1 (xx) |
| YU (1) | YU45575B (xx) |
| ZA (1) | ZA837208B (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703035A (en) * | 1982-10-04 | 1987-10-27 | The Salk Institute For Biological Studies | Human pancreatic GRF amidated fragments |
| US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
| US4581168A (en) * | 1983-02-21 | 1986-04-08 | Sanofi | Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides |
| ZA844380B (en) * | 1983-07-05 | 1985-01-30 | Salk Inst For Biological Studi | Dna encoding a grf precursor |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| FR2567524B1 (fr) * | 1984-07-10 | 1987-11-27 | Sanofi Sa | Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| DE3579911D1 (de) * | 1984-12-24 | 1990-10-31 | Sumitomo Pharma | Stabiles grf-praeparat. |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
| FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
| IL84758A (en) * | 1987-01-13 | 1992-03-29 | Salk Inst For Biological Studi | Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them |
| US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US4801456A (en) * | 1987-07-09 | 1989-01-31 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4880777A (en) * | 1987-09-01 | 1989-11-14 | Eastman Kodak Company | Synthetic peptides having growth hormone releasing activity |
| ATE122357T1 (de) * | 1988-01-28 | 1995-05-15 | Polygen Holding Corp | Polypeptide mit hormonwachstumsbefreiender wirkung. |
| US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
| US5153175A (en) * | 1989-05-25 | 1992-10-06 | University Of Tennesee Research Corporation | Method of inducing sleep with GHRH complementary peptide compositions |
| US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
| IL98638A (en) * | 1990-06-29 | 1995-07-31 | Hoffmann La Roche | Analogs of the factor that releases human growth hormone, their preparation and pharmaceutical preparations that contain them |
| DE69108192T2 (de) * | 1990-12-10 | 1995-07-20 | Hoffmann La Roche | Verfahren zur enzymatischen Herstellung von GRF(1-44)NH2. |
| WO1992018531A1 (en) * | 1991-04-09 | 1992-10-29 | F. Hoffmann-La Roche Ag | Growth hormone releasing factor analogs |
| US5246920A (en) * | 1992-06-15 | 1993-09-21 | University Of South Florida | Treatment of hyperprolactinemia |
| US5811074A (en) * | 1992-06-29 | 1998-09-22 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
| US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| EP0880969A1 (en) * | 1997-05-28 | 1998-12-02 | Applied Research Systems ARS Holdings N.V. | Pharmaceutical compositions of peptides having low solubility in physiological medium |
| EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
| AU2002233082B2 (en) * | 2001-02-02 | 2005-11-10 | Conjuchem Biotechnologies Inc. | Long lasting growth hormone releasing factor derivatives |
| RU2005111253A (ru) * | 2002-09-18 | 2005-11-20 | Сантр Оспиталье Де Л` Юниверсите Де Монреаль (Схюм) (Ca) | Аналоги ghrh |
| US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
| CN107936090B (zh) * | 2017-12-08 | 2021-09-24 | 陕西慧康生物科技有限责任公司 | 一种低成本合成ARK-Cu的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3664925A (en) * | 1970-02-20 | 1972-05-23 | Martin Sonenberg | Clinically active bovine growth hormone fraction |
| US3904753A (en) * | 1970-02-20 | 1975-09-09 | Research Corp | Clinically active bovine growth hormone fraction |
| US3853833A (en) * | 1971-04-27 | 1974-12-10 | Hormone Res Foundation | Synthetic human growth-promoting and lactogenic hormones and method of producing same |
| US4056520A (en) * | 1972-03-31 | 1977-11-01 | Research Corporation | Clinically active bovine growth hormone fraction |
| PH14681A (en) * | 1977-11-30 | 1981-11-10 | Pfizer | Phenylglycinamides useful in the treatment of ischaemic heart disease |
-
1982
- 1982-10-04 US US06/432,663 patent/US4563352A/en not_active Expired - Lifetime
-
1983
- 1983-09-26 NZ NZ205745A patent/NZ205745A/en unknown
- 1983-09-27 ZA ZA837208A patent/ZA837208B/xx unknown
- 1983-10-03 JP JP83503459A patent/JPS59501951A/ja active Pending
- 1983-10-03 HU HU8497A patent/HU191263B/hu unknown
- 1983-10-03 ES ES526201A patent/ES8606399A1/es not_active Expired
- 1983-10-03 GR GR72605A patent/GR79698B/el unknown
- 1983-10-03 AU AU21269/83A patent/AU566180B2/en not_active Expired
- 1983-10-03 PH PH29648A patent/PH20333A/en unknown
- 1983-10-03 WO PCT/US1983/001564 patent/WO1984001379A1/en active IP Right Grant
- 1983-10-03 IE IE2333/83A patent/IE56175B1/en not_active IP Right Cessation
- 1983-10-04 CA CA000438354A patent/CA1243016A/en not_active Expired
- 1983-10-04 MX MX831019U patent/MX7701E/es unknown
- 1983-10-04 YU YU200083A patent/YU45575B/sh unknown
- 1983-10-04 AT AT83306008T patent/ATE24919T1/de not_active IP Right Cessation
- 1983-10-04 IL IL69897A patent/IL69897A/xx not_active IP Right Cessation
- 1983-10-04 EP EP83306008A patent/EP0105759B1/en not_active Expired
- 1983-10-04 PT PT77453A patent/PT77453B/pt not_active IP Right Cessation
- 1983-10-04 DE DE8383306008T patent/DE3369144D1/de not_active Expired
- 1983-10-26 KR KR1019830005067A patent/KR900006712B1/ko not_active IP Right Cessation
-
1984
- 1984-05-30 FI FI842166A patent/FI83660C/fi not_active IP Right Cessation
- 1984-05-30 DK DK269284A patent/DK269284D0/da not_active Application Discontinuation
- 1984-05-30 NO NO84842148A patent/NO167866C/no not_active IP Right Cessation
- 1984-06-01 RO RO114739A patent/RO91186B/ro unknown
- 1984-06-01 SU SU843750475A patent/SU1426455A3/ru active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL69897A (en) | Human pancreatic grf analogs,compositions comprising them and use thereof | |
| AU589674B2 (en) | GRF analogs | |
| ES8506263A1 (es) | Un procedimiento para preparar peptidos analogos del factor de liberacion de la hormona del crecimiento de tumor pancreatico humano | |
| KR910002900A (ko) | 합성 펩티드 및 이를 함유하는 제약학적 조성물 | |
| TH1778EX (th) | สารคล้ายคลึง จี อาร์ เอฟ (grf) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |