YU45575B - Sintetičkipeptid-humani pank reasni grf - Google Patents

Sintetičkipeptid-humani pank reasni grf

Info

Publication number
YU45575B
YU45575B YU200083A YU200083A YU45575B YU 45575 B YU45575 B YU 45575B YU 200083 A YU200083 A YU 200083A YU 200083 A YU200083 A YU 200083A YU 45575 B YU45575 B YU 45575B
Authority
YU
Yugoslavia
Prior art keywords
ala
gln
leu
ser
gly
Prior art date
Application number
YU200083A
Other languages
English (en)
Other versions
YU200083A (en
Inventor
J.E.F. Rivier
J. Spiess
Original Assignee
The Salk Institute For Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Salk Institute For Biological Studies filed Critical The Salk Institute For Biological Studies
Publication of YU200083A publication Critical patent/YU200083A/xx
Publication of YU45575B publication Critical patent/YU45575B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/843—Digestive system
    • Y10S530/845—Pancreas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Machine Tool Sensing Apparatuses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SINTETIČKIPEPTID-HUMANI PANK REASNI GRF, formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg -Lys-Val-Leu-la-Glin-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Glin-Asp-I-Met-Ser-Arg-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-R40-Y gde R40 je gde R40 je Ala ili des-R40 a Y označava karboksilni deo amino kiselinskog ostatka na C-terminalu takav kao -COOH ili CONH2 radikal ili njegov fragment ili njegov fragment koji ide od N-trminusa do ostataka u položaju 28-39 koji ima biološki aktivan efekt oslobadjanja GH iz hipofize, ili njegova netoksična so. Preparat za stimulisanje oslobadjanja GH u životinji koji obuhvata količinu peptida zahteva 1 ili njegove netoksične soli efikasnog za oslobadjanje GH iz hipofize, i farmaceutski prihvatljivih tečan ili čvrst nosač. Prijava sadrži još 4 patentna zahteva.
YU200083A 1982-10-04 1983-10-04 Sintetičkipeptid-humani pank reasni grf YU45575B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/432,663 US4563352A (en) 1982-10-04 1982-10-04 Human pancreatic GRF

Publications (2)

Publication Number Publication Date
YU200083A YU200083A (en) 1986-06-30
YU45575B true YU45575B (sh) 1992-07-20

Family

ID=23717095

Family Applications (1)

Application Number Title Priority Date Filing Date
YU200083A YU45575B (sh) 1982-10-04 1983-10-04 Sintetičkipeptid-humani pank reasni grf

Country Status (25)

Country Link
US (1) US4563352A (sh)
EP (1) EP0105759B1 (sh)
JP (1) JPS59501951A (sh)
KR (1) KR900006712B1 (sh)
AT (1) ATE24919T1 (sh)
AU (1) AU566180B2 (sh)
CA (1) CA1243016A (sh)
DE (1) DE3369144D1 (sh)
DK (1) DK269284D0 (sh)
ES (1) ES8606399A1 (sh)
FI (1) FI83660C (sh)
GR (1) GR79698B (sh)
HU (1) HU191263B (sh)
IE (1) IE56175B1 (sh)
IL (1) IL69897A (sh)
MX (1) MX7701E (sh)
NO (1) NO167866C (sh)
NZ (1) NZ205745A (sh)
PH (1) PH20333A (sh)
PT (1) PT77453B (sh)
RO (1) RO91186B (sh)
SU (1) SU1426455A3 (sh)
WO (1) WO1984001379A1 (sh)
YU (1) YU45575B (sh)
ZA (1) ZA837208B (sh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
US4703035A (en) * 1982-10-04 1987-10-27 The Salk Institute For Biological Studies Human pancreatic GRF amidated fragments
US4581168A (en) * 1983-02-21 1986-04-08 Sanofi Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
ZA844380B (en) * 1983-07-05 1985-01-30 Salk Inst For Biological Studi Dna encoding a grf precursor
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
EP0189673B1 (en) * 1984-12-24 1990-09-26 Sumitomo Pharmaceuticals Company, Limited Stable growth hormone releasing factor preparation
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
FR2599038B1 (fr) * 1986-05-26 1990-06-29 Sanofi Sa Procede de preparation de nonacosapeptides et peptides intermediaires
IL84758A (en) * 1987-01-13 1992-03-29 Salk Inst For Biological Studi Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US4801456A (en) * 1987-07-09 1989-01-31 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
USRE33699E (en) * 1987-07-09 1991-09-24 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
AU637316B2 (en) * 1988-01-28 1993-05-27 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5153175A (en) * 1989-05-25 1992-10-06 University Of Tennesee Research Corporation Method of inducing sleep with GHRH complementary peptide compositions
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
CA2085362A1 (en) * 1990-06-29 1991-12-30 Arthur M. Felix Histidine substituted growth hormone releasing factor analogs
DK0490249T3 (da) * 1990-12-10 1995-05-29 Hoffmann La Roche Fremgangsmåde til enzymatisk fremstilling af GRF(1-44)-NH2
CA2084061A1 (en) * 1991-04-09 1992-10-10 Arthur M. Felix Growth hormone releasing factor analogs
US5246920A (en) * 1992-06-15 1993-09-21 University Of South Florida Treatment of hyperprolactinemia
US5811074A (en) * 1992-06-29 1998-09-22 University Of South Florida Method of diagnosing pituitary dependent growth hormone deficiency
US5631225A (en) * 1994-10-13 1997-05-20 Novo Nordisk A/S Pharmaceutical formulation
EP0880969A1 (en) * 1997-05-28 1998-12-02 Applied Research Systems ARS Holdings N.V. Pharmaceutical compositions of peptides having low solubility in physiological medium
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
EP1355941A2 (en) * 2001-02-02 2003-10-29 ConjuChem, Inc. Long lasting growth hormone releasing factor derivatives
JP2006504694A (ja) * 2002-09-18 2006-02-09 サントル・オスピタリエ・ドゥ・リュニヴェルシテ・ドゥ・モントリオール・（シー・エイチ・ユー・エム） Ｇｈｒｈ類似体
US20090088380A1 (en) * 2007-07-12 2009-04-02 Pierrette Gaudreau Ghrh analogs and therapeutic uses thereof
CN107936090B (zh) * 2017-12-08 2021-09-24 陕西慧康生物科技有限责任公司 一种低成本合成ARK-Cu的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904753A (en) * 1970-02-20 1975-09-09 Research Corp Clinically active bovine growth hormone fraction
US3664925A (en) * 1970-02-20 1972-05-23 Martin Sonenberg Clinically active bovine growth hormone fraction
US3853833A (en) * 1971-04-27 1974-12-10 Hormone Res Foundation Synthetic human growth-promoting and lactogenic hormones and method of producing same
US4056520A (en) * 1972-03-31 1977-11-01 Research Corporation Clinically active bovine growth hormone fraction
PH14681A (en) * 1977-11-30 1981-11-10 Pfizer Phenylglycinamides useful in the treatment of ischaemic heart disease

Also Published As

Publication number Publication date
ES526201A0 (es) 1986-04-16
IE56175B1 (en) 1991-05-08
RO91186B (ro) 1987-07-31
HU191263B (en) 1987-01-28
FI83660B (fi) 1991-04-30
DE3369144D1 (en) 1987-02-19
IL69897A (en) 1986-12-31
AU566180B2 (en) 1987-10-08
GR79698B (sh) 1984-10-31
NO167866B (no) 1991-09-09
FI842166A0 (fi) 1984-05-30
ES8606399A1 (es) 1986-04-16
EP0105759B1 (en) 1987-01-14
PT77453A (en) 1983-11-01
ATE24919T1 (de) 1987-01-15
DK269284A (da) 1984-05-30
NO167866C (no) 1991-12-18
NZ205745A (en) 1987-07-31
EP0105759A3 (en) 1985-05-08
DK269284D0 (da) 1984-05-30
PT77453B (en) 1986-02-26
WO1984001379A1 (en) 1984-04-12
YU200083A (en) 1986-06-30
IL69897A0 (en) 1984-01-31
US4563352A (en) 1986-01-07
SU1426455A3 (ru) 1988-09-23
KR850003417A (ko) 1985-06-17
NO842148L (no) 1984-05-30
CA1243016A (en) 1988-10-11
IE832333L (en) 1984-04-04
ZA837208B (en) 1984-05-30
MX7701E (es) 1990-09-20
KR900006712B1 (ko) 1990-09-17
PH20333A (en) 1986-12-02
FI83660C (fi) 1991-08-12
RO91186A (ro) 1987-07-30
FI842166A (fi) 1984-05-30
AU2126983A (en) 1984-04-24
JPS59501951A (ja) 1984-11-22
EP0105759A2 (en) 1984-04-18

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