ES2001274A6 - Un metodo para preparar peptidos que tienen influencia sobre la funcion de la glandula pituitaria en seres humanos y otros animales - Google Patents

Un metodo para preparar peptidos que tienen influencia sobre la funcion de la glandula pituitaria en seres humanos y otros animales

Info

Publication number
ES2001274A6
ES2001274A6 ES8601432A ES8601432A ES2001274A6 ES 2001274 A6 ES2001274 A6 ES 2001274A6 ES 8601432 A ES8601432 A ES 8601432A ES 8601432 A ES8601432 A ES 8601432A ES 2001274 A6 ES2001274 A6 ES 2001274A6
Authority
ES
Spain
Prior art keywords
leu
ala
phe
ser
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601432A
Other languages
English (en)
Inventor
Emil Thomas Kaiser
Gonul Velicelebi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of ES2001274A6 publication Critical patent/ES2001274A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)

Abstract

EL METODO DESCRITO SINTETIZA EN FASE SOLIDA PEPTIDOS DE FORMULA: R1-R2-R3-ALA-R5-R6-R7-R8-R9-R10-R11-R12-R13-LEU-R15-GIN-LEU-R18-R19-R SI20-R21-LEU-LEU-GLN-GLU-R26-R27-R28-ARG-Y, DONDE R1-R3, R5-R13, R15, R18-R21 Y R26-R28 SIGNIFICAN DIVERSOS AMINOACIDOS E Y SIGNIFICA OH O NH2, A CONDICION DE QUE AL MENOS CUATRO DE LOS RESTOS R7-R13, R15, R18-R21 Y R26 DIFIEREN RESPECTO DE LA MOLECULA NATURAL, COPULANDO SUCESIVAMENTE AMINOACIDOS PROTEGIDOS EN SU GRUPO ALFA-AMINO A UN SOPORTE SOLIDO DE RESINA HASTA OBTENER UN PEPTIDO INTERMEDIO CON AL MENOS UN GRUPO PROTECTOR, ESCIDIENDO TODOS LOS GRUPOS PROTECTORES Y SEPARANDO EL PEPETIDO FINAL DEL SOPORTE DE RESINA Y, OPCIONALMENTE, CONVIRTIENDO ESTE PEPTIDO EN UNA DE SUS SALES NO TOXICAS. LOS PEPTIDOS OBTENIDOS SON UTILES PARA ESTIMULAR LA LIBERACION DE LA HORMONA DEL CRECIMIENTO POR LA PITUITARIA DE ANIMALES, INCLUIDOS SERES HUMANOS, Y PUEDEN EMPLEARSE PARA DIAGNOSTICOS.
ES8601432A 1985-08-29 1986-08-28 Un metodo para preparar peptidos que tienen influencia sobre la funcion de la glandula pituitaria en seres humanos y otros animales Expired ES2001274A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/770,683 US4689318A (en) 1985-08-29 1985-08-29 GRF analogs

Publications (1)

Publication Number Publication Date
ES2001274A6 true ES2001274A6 (es) 1988-05-01

Family

ID=25089358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601432A Expired ES2001274A6 (es) 1985-08-29 1986-08-28 Un metodo para preparar peptidos que tienen influencia sobre la funcion de la glandula pituitaria en seres humanos y otros animales

Country Status (19)

Country Link
US (1) US4689318A (es)
EP (1) EP0216517B1 (es)
JP (1) JPH0762037B2 (es)
KR (1) KR910002701B1 (es)
AT (1) ATE69821T1 (es)
AU (1) AU589674B2 (es)
CA (1) CA1299507C (es)
DE (1) DE3682641D1 (es)
DK (1) DK413986A (es)
ES (1) ES2001274A6 (es)
GR (1) GR862194B (es)
HU (1) HU206126B (es)
IL (1) IL79534A0 (es)
IN (1) IN163758B (es)
NO (1) NO863432L (es)
NZ (1) NZ217280A (es)
PH (1) PH23188A (es)
SU (1) SU1651787A3 (es)
ZA (1) ZA865886B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4828988A (en) * 1986-05-15 1989-05-09 Smith Kline - Rit Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
DE3742633A1 (de) * 1987-12-16 1989-06-29 Hoechst Ag Peptide mit beeinflussender wirkung auf die hypophyse von saeugern
US4843064A (en) * 1987-01-13 1989-06-27 The Salk Institute For Biological Studies GRF analogs V
US4784987A (en) * 1987-01-13 1988-11-15 The Salk Institute For Biological Studies GRF analogs VI
IL84758A (en) * 1987-01-13 1992-03-29 Salk Inst For Biological Studi Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
IL86102A (en) * 1987-05-11 1994-04-12 Univ Tulane Alkylated peptides that release growth hormone and their use
US5112808A (en) * 1987-05-11 1992-05-12 American Cyanamid Company Alkylated hormone-releasing peptides and method of treatig mammals therewith
US5098995A (en) * 1987-05-22 1992-03-24 The Salk Institute For Biological Studies GRF Analogs VIIA
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
EP0527914A4 (en) * 1990-05-04 1993-08-11 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
CA2085362A1 (en) * 1990-06-29 1991-12-30 Arthur M. Felix Histidine substituted growth hormone releasing factor analogs
RU2119800C1 (ru) * 1990-11-14 1998-10-10 Дзе Апджон Компани Аналог пептида фактора гормона роста (фгр), способ стимулирования секреции гормона роста и композиция для стимулирования секреции
ATE119916T1 (de) * 1990-12-10 1995-04-15 Hoffmann La Roche Verfahren zur enzymatischen herstellung von grf(1-44)nh2.
JPH05507939A (ja) * 1991-04-09 1993-11-11 エフ・ホフマン―ラ　ロシユ　アーゲー 成長ホルモン放出因子の類似体
CA2106764A1 (en) * 1991-04-24 1992-10-25 David C. Horwell Ó-substituted polypeptides having therapeutic activity
US5262519A (en) * 1991-05-15 1993-11-16 The Salk Institute For Biological Studies GRF analogs XI
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
JPH07200419A (ja) * 1993-12-28 1995-08-04 Nec Corp バスインタフェース装置
US5792747A (en) * 1995-01-24 1998-08-11 The Administrators Of The Tulane Educational Fund Highly potent agonists of growth hormone releasing hormone
JPH11503454A (ja) * 1995-04-14 1999-03-26 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド 成長ホルモン放出因子の類似体
EP1355941A2 (en) * 2001-02-02 2003-10-29 ConjuChem, Inc. Long lasting growth hormone releasing factor derivatives
NZ539218A (en) * 2002-09-18 2008-03-28 Univ Montreal Ct Hospitalier Chum Synthetic GHRH analogues of 29 amino acids or more
WO2009009727A2 (en) * 2007-07-12 2009-01-15 Akela Pharma Srl Ghrh analogs and therapeutic uses thereof
WO2009108364A2 (en) * 2008-02-27 2009-09-03 Ipsen Pharma S.A.S. Antagonistic analogues of ghrh
US8980249B2 (en) 2010-06-03 2015-03-17 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
US9079974B2 (en) 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
US9855312B2 (en) 2012-12-21 2018-01-02 University Of Miami GHRH agonists for the treatment of ischemic disorders
MX2018012716A (es) 2016-04-19 2019-02-11 Griffon Pharmaceuticals Inc Peptidos bioactivos pegilados y usos de los mismos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595676A (en) * 1983-04-26 1986-06-17 The Salk Institute For Biological Studies Rat hypothalamic GRF
US4529595A (en) * 1983-01-13 1985-07-16 The Salk Institute For Biological Studies GRF Analogs
US4500910A (en) * 1982-11-30 1985-02-19 Rca Corporation Hue control system
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4518586A (en) * 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
US4514331A (en) * 1983-06-29 1985-04-30 University Patents, Inc. Peptide hormones with calcitonin-like activity
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs

Also Published As

Publication number Publication date
HU206126B (en) 1992-08-28
AU589674B2 (en) 1989-10-19
DK413986A (da) 1987-03-01
HUT41819A (en) 1987-05-28
GR862194B (en) 1986-12-31
NO863432D0 (no) 1986-08-27
JPS6251698A (ja) 1987-03-06
KR870002163A (ko) 1987-03-30
PH23188A (en) 1989-05-29
NZ217280A (en) 1989-04-26
JPH0762037B2 (ja) 1995-07-05
EP0216517A3 (en) 1988-09-21
AU6183886A (en) 1987-03-05
IN163758B (es) 1988-11-05
KR910002701B1 (ko) 1991-05-03
SU1651787A3 (ru) 1991-05-23
ATE69821T1 (de) 1991-12-15
DK413986D0 (da) 1986-08-29
EP0216517B1 (en) 1991-11-27
CA1299507C (en) 1992-04-28
US4689318A (en) 1987-08-25
NO863432L (no) 1987-03-02
DE3682641D1 (de) 1992-01-09
ZA865886B (en) 1987-03-25
EP0216517A2 (en) 1987-04-01
IL79534A0 (en) 1986-10-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001204