ATE119916T1 - Verfahren zur enzymatischen herstellung von grf(1-44)nh2. - Google Patents
Verfahren zur enzymatischen herstellung von grf(1-44)nh2.Info
- Publication number
- ATE119916T1 ATE119916T1 AT91120820T AT91120820T ATE119916T1 AT E119916 T1 ATE119916 T1 AT E119916T1 AT 91120820 T AT91120820 T AT 91120820T AT 91120820 T AT91120820 T AT 91120820T AT E119916 T1 ATE119916 T1 AT E119916T1
- Authority
- AT
- Austria
- Prior art keywords
- grf
- enzymatic production
- leu
- prepared
- recombinant dna
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- FORGMRSGVSYZQR-YFKPBYRVSA-N L-leucinamide Chemical compound CC(C)C[C@H](N)C(N)=O FORGMRSGVSYZQR-YFKPBYRVSA-N 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 108010078767 somatotropin releasing hormone (1-43) Proteins 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62444590A | 1990-12-10 | 1990-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE119916T1 true ATE119916T1 (de) | 1995-04-15 |
Family
ID=24502049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91120820T ATE119916T1 (de) | 1990-12-10 | 1991-12-04 | Verfahren zur enzymatischen herstellung von grf(1-44)nh2. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5563044A (de) |
| EP (1) | EP0490249B1 (de) |
| JP (1) | JPH05178893A (de) |
| AT (1) | ATE119916T1 (de) |
| AU (1) | AU644032B2 (de) |
| CA (1) | CA2057269A1 (de) |
| DE (1) | DE69108192T2 (de) |
| DK (1) | DK0490249T3 (de) |
| IE (1) | IE67052B1 (de) |
| IL (1) | IL100261A (de) |
| NZ (1) | NZ240895A (de) |
| PH (1) | PH30442A (de) |
| ZA (1) | ZA919655B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512459A (en) * | 1993-07-20 | 1996-04-30 | Bionebraska, Inc. | Enzymatic method for modification or recombinant polypeptides |
| WO1995003321A1 (en) * | 1993-07-20 | 1995-02-02 | Bionebraska, Inc. | Method for endomodification of proteins |
| DE102005046113A1 (de) | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
| NZ570886A (en) | 2008-08-29 | 2011-05-27 | Nz Inst Plant & Food Res Ltd | Method and compositions to reduce polygalacturonase expression in plants for increasing storage-life of fruit |
| US9587006B2 (en) | 2010-02-11 | 2017-03-07 | Hoffmann-La Roche Inc. | IGF-I poly (ethylene glycol) conjugates |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2838659C2 (de) * | 1978-09-05 | 1981-07-16 | Bio-Melktechnik Swiss Hoefelmayer & Co, Niederteufen, Aargau | Schlauchanordnung für eine Viertelgemelksmaschine |
| US4618598A (en) * | 1982-04-12 | 1986-10-21 | Duke University | Method of regulating hormone function or release |
| US4517181A (en) * | 1982-09-15 | 1985-05-14 | The Salk Institute For Biological Studies | Mammalian PGRF |
| US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
| US4529595A (en) * | 1983-01-13 | 1985-07-16 | The Salk Institute For Biological Studies | GRF Analogs |
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4703035A (en) * | 1982-10-04 | 1987-10-27 | The Salk Institute For Biological Studies | Human pancreatic GRF amidated fragments |
| US4595676A (en) * | 1983-04-26 | 1986-06-17 | The Salk Institute For Biological Studies | Rat hypothalamic GRF |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| US4581168A (en) * | 1983-02-21 | 1986-04-08 | Sanofi | Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides |
| US4704450A (en) * | 1983-02-21 | 1987-11-03 | Sanofi | Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides |
| ATE53220T1 (de) * | 1983-03-07 | 1990-06-15 | Hoffmann La Roche | Polypeptide. |
| US4732972A (en) * | 1983-03-07 | 1988-03-22 | Hoffmann-La Roche Inc. | Polypeptides having growth hormone releasing activity |
| US4628043A (en) * | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
| DE3327007A1 (de) * | 1983-07-27 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Herstellung von polypeptiden mit einem saeureamid-carboxyterminus |
| US4585756A (en) * | 1983-10-12 | 1986-04-29 | The Salk Institute For Biological Studies | Bovine GRF |
| US4610976A (en) * | 1983-08-29 | 1986-09-09 | The Salk Institute For Biological Studies | Porcine GRF |
| US4605643A (en) * | 1984-03-02 | 1986-08-12 | The Salk Institute For Biological Studies | Ovine GRF |
| US4626523A (en) * | 1983-09-13 | 1986-12-02 | The Salk Institute For Biological Studies | GRF analogs II |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| US4562175A (en) * | 1984-02-03 | 1985-12-31 | Ding Chang | Synthetic peptides |
| US4649039A (en) * | 1984-07-03 | 1987-03-10 | E. I. Du Pont De Nemours And Company | Radiolabeling of methionine-containing proteins and peptides |
| US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US4783524A (en) * | 1985-09-17 | 1988-11-08 | Monsanto Company | Growth factors |
| US4784987A (en) * | 1987-01-13 | 1988-11-15 | The Salk Institute For Biological Studies | GRF analogs VI |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
| GB8829432D0 (en) * | 1988-12-15 | 1989-02-01 | Celltech Ltd | Enzymatic process |
-
1991
- 1991-12-04 AT AT91120820T patent/ATE119916T1/de not_active IP Right Cessation
- 1991-12-04 DE DE69108192T patent/DE69108192T2/de not_active Expired - Fee Related
- 1991-12-04 EP EP91120820A patent/EP0490249B1/de not_active Expired - Lifetime
- 1991-12-04 DK DK91120820.5T patent/DK0490249T3/da active
- 1991-12-06 IL IL10026191A patent/IL100261A/en not_active IP Right Cessation
- 1991-12-06 ZA ZA919655A patent/ZA919655B/xx unknown
- 1991-12-06 NZ NZ240895A patent/NZ240895A/xx unknown
- 1991-12-06 JP JP3348582A patent/JPH05178893A/ja active Pending
- 1991-12-09 PH PH43607A patent/PH30442A/en unknown
- 1991-12-09 IE IE427691A patent/IE67052B1/en not_active IP Right Cessation
- 1991-12-09 AU AU88964/91A patent/AU644032B2/en not_active Ceased
- 1991-12-09 CA CA002057269A patent/CA2057269A1/en not_active Abandoned
-
1995
- 1995-06-05 US US08/462,453 patent/US5563044A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69108192T2 (de) | 1995-07-20 |
| IE914276A1 (en) | 1992-06-17 |
| US5563044A (en) | 1996-10-08 |
| AU8896491A (en) | 1992-06-11 |
| ZA919655B (en) | 1992-08-26 |
| PH30442A (en) | 1997-05-09 |
| EP0490249B1 (de) | 1995-03-15 |
| DK0490249T3 (da) | 1995-05-29 |
| IE67052B1 (en) | 1996-02-21 |
| DE69108192D1 (de) | 1995-04-20 |
| EP0490249A1 (de) | 1992-06-17 |
| JPH05178893A (ja) | 1993-07-20 |
| NZ240895A (en) | 1993-08-26 |
| IL100261A0 (en) | 1992-09-06 |
| CA2057269A1 (en) | 1992-06-11 |
| AU644032B2 (en) | 1993-12-02 |
| IL100261A (en) | 1996-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69020794D1 (de) | Enzymatische Entfernung einer aminoterminalen Proteinsequenz. | |
| DE69717356D1 (de) | Verfahren zur Herstellung von Heteroübergang-Bipolartransistoren mit hoher Verstärkung | |
| DE69428165D1 (de) | Teilhydrolysat aus Milcheiweiss und Verfahren zu dessen Herstellung | |
| DE3584460D1 (de) | Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien. | |
| ATE131876T1 (de) | Verfahren zur herstellung von proteinen durch verwendung von cks-fusionsproteinen | |
| DE69011880D1 (de) | Verfahren zur Herstellung von L-Aminosäuren durch Fermentation. | |
| ATE119916T1 (de) | Verfahren zur enzymatischen herstellung von grf(1-44)nh2. | |
| ATE227307T1 (de) | Verfahren zur herstellung modifizierten proteine | |
| DE59106876D1 (de) | Verfahren zur enzymatischen Herstellung optisch aktiver Cyanhydrine. | |
| DE69416018T2 (de) | Verfahren zur Herstellung von Alkoxyiminoacetamid-Verbindungen | |
| ATE118008T1 (de) | Verfahren zur herstellung von aminomethanphosphonsäure und aminomethyl- phosphinsäuren. | |
| DE69109510D1 (de) | Verfahren zur Herstellung von Glycin. | |
| DE60015931D1 (de) | Verfahren zur herstellung eines chiralen-beta-aminosäureesters | |
| ATE30155T1 (de) | Verfahren zur herstellung von azetidinsulfonsaeuren. | |
| DE69024999D1 (de) | Verfahren zur Herstellung von 2-Oxindol-1-carboxamiden | |
| DE59803194D1 (de) | Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen | |
| ATE117676T1 (de) | Verfahren zur herstellung von molluskiziden 2,4,5-tribrompyrrol-3-carbonitrilen. | |
| ATE200776T1 (de) | Verfahren zur herstellung von 2,4,5-tribrompyrrol-3-carbonitril | |
| ATE124053T1 (de) | Verfahren zur herstellung von tripeptiden. | |
| AU643773B2 (en) | Growth hormone releasing factor analogs | |
| ATE47427T1 (de) | Verfahren zur herstellung von arphamenin mit hoher ausbeute. | |
| DE59501436D1 (de) | Verfahren zur Herstellung von 2-Cyaniminothiazolidin | |
| ATE198737T1 (de) | Verfahren zur herstellung von n-(2-carboxy-5- chlor-phenyl)glycin | |
| DE69126213D1 (de) | Verfahren zur Herstellung von L-Alanin durch Fermentation | |
| DE59506734D1 (de) | Verfahren zur herstellung n-z-geschützter n-alkylierter aminosäuren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |