ATE68830T1 - Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien. - Google Patents

Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien.

Info

Publication number
ATE68830T1
ATE68830T1 AT85103560T AT85103560T ATE68830T1 AT E68830 T1 ATE68830 T1 AT E68830T1 AT 85103560 T AT85103560 T AT 85103560T AT 85103560 T AT85103560 T AT 85103560T AT E68830 T1 ATE68830 T1 AT E68830T1
Authority
AT
Austria
Prior art keywords
cultivation
yield
increasing
recombinant bacteria
heterologous proteins
Prior art date
Application number
AT85103560T
Other languages
English (en)
Inventor
Arie Ben-Bassat
Glenn Dorin
Keith Alan Bauer
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24378143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE68830(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Corp filed Critical Cetus Corp
Application granted granted Critical
Publication of ATE68830T1 publication Critical patent/ATE68830T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT85103560T 1984-03-28 1985-03-26 Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien. ATE68830T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/594,250 US4656132A (en) 1984-03-28 1984-03-28 Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
EP85103560A EP0156355B2 (de) 1984-03-28 1985-03-26 Verfahren zur Erhöhung der Ausbeute von heterologen Proteinen, produziert durch Züchtung von rekombinanten Bakterien

Publications (1)

Publication Number Publication Date
ATE68830T1 true ATE68830T1 (de) 1991-11-15

Family

ID=24378143

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85103560T ATE68830T1 (de) 1984-03-28 1985-03-26 Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien.

Country Status (6)

Country Link
US (1) US4656132A (de)
EP (1) EP0156355B2 (de)
JP (1) JP2564506B2 (de)
AT (1) ATE68830T1 (de)
CA (1) CA1262694A (de)
DE (2) DE3584460D1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894334A (en) * 1984-03-28 1990-01-16 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
EP0200417B1 (de) * 1985-04-30 1992-10-21 Takeda Chemical Industries, Ltd. Produktion eines Proteins
JPH0634746B2 (ja) * 1985-04-30 1994-05-11 武田薬品工業株式会社 インターロイキンの増収法
DE3532134A1 (de) * 1985-09-10 1987-03-12 Basf Ag Verfahren zur herstellung von proteinen bestimmter n-terminaler struktur mit hilfe von prokaryonten
EP0315950A3 (de) * 1987-11-09 1990-05-23 Otsuka Pharmaceutical Co., Ltd. Verfahren zur Züchtung von Zellen, welche rekombinantes Protein exprimieren
GB9004390D0 (en) * 1990-02-27 1990-04-25 Ici Plc Process
US5223418A (en) * 1990-09-28 1993-06-29 Smithkline Beecham Corporation Method of improving the yield of heterologous proteins produced by streptomyces lividans
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
WO1993000443A1 (en) * 1991-06-26 1993-01-07 Bio-Technology General Corp. Purification of recombinant apolipoprotein e from bacteria
US5814485A (en) * 1995-06-06 1998-09-29 Chiron Corporation Production of interferon-β (IFN-β) in E. coli
US6255099B1 (en) 2000-02-17 2001-07-03 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College High-yield dual-buffered bacterial growth medium
EP1935431A3 (de) 2000-05-15 2008-08-13 Health Research, Inc. Krebsbehandlungen unter Verwendung einer Kombination aus einem HER2-Antikörper und Interleukin-2
MXPA05005921A (es) * 2002-12-02 2005-10-19 Abgenix Inc Anticuerpos dirigidos a factor de necrosis tumoral y sus usos.
KR101403910B1 (ko) 2003-11-04 2014-06-09 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 길항제 항-ｃｄ４０ 단클론성 항체 및 그것의 사용 방법
EP1734988A4 (de) * 2004-03-01 2009-08-05 Enzon Pharmaceuticals Inc Interferon-beta-polymerkonjugate
CA2591235C (en) * 2004-12-20 2014-03-11 Cadila Healthcare Limited Process for preparing high levels of interferon beta
CA2860170C (en) 2010-12-22 2022-06-14 The Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
KR102220006B1 (ko) 2011-03-11 2021-02-24 아시스땅스 퍼블리끄-오삐또 드 빠리 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 ｉｌ­２ 의 용도
EP3013355B1 (de) 2013-06-25 2019-08-07 ICM - Institut du Cerveau et da la Moelle Epinière Il-2 zur verwendung in der behandlung von alzheimer-krankheit und verwandten erkrankungen
CA2925421C (en) 2013-09-24 2023-08-29 Medicenna Therapeutics, Inc. Interleukin-2 fusion proteins and uses thereof
EP2918285A1 (de) 2014-03-11 2015-09-16 Université Pierre et Marie Curie (Paris 6) Interleukin-2 zur Behandlung einer Lebensmittelallergie
WO2015164815A1 (en) 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
CN108135841B (zh) 2015-10-22 2024-03-05 艾尔图制药公司 Il-2的药物组合物
US11542312B2 (en) 2017-06-19 2023-01-03 Medicenna Therapeutics, Inc. IL-2 superagonists in combination with anti-PD-1 antibodies
PH12020550661A1 (en) 2017-11-21 2021-04-19 Univ Leland Stanford Junior Partial agonists of interleukin-2
US11534479B2 (en) 2018-02-16 2022-12-27 Iltoo Pharma Use of interleukin 2 for treating Sjögren's syndrome
WO2020007937A1 (en) 2018-07-03 2020-01-09 Iltoo Pharma Use of interleukin-2 for treating systemic sclerosis
WO2020035482A1 (en) 2018-08-13 2020-02-20 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
JP7303391B2 (ja) 2020-01-14 2023-07-04 シンセカイン インコーポレイテッド バイアス型ｉｌ２ムテイン、方法、および組成物
EP4114440B1 (de) 2020-03-06 2025-06-25 Centre Hospitalier Universitaire de Nimes Interleukin-2 in niedriger dosis zur behandlung der amyotrophen lateralsklerose
EP4630035A1 (de) 2022-12-05 2025-10-15 Centre Hospitalier Universitaire de Nimes Niedrigdosiertes humanes interleukin-2 zur behandlung von amyotropher lateralsklerose in einer untergruppe von patienten
WO2025032158A1 (en) 2023-08-08 2025-02-13 Institut National de la Santé et de la Recherche Médicale Method to treat tauopathies

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2674561A (en) * 1950-09-08 1954-04-06 Andrew J Moyer Production of organic acids
US3674640A (en) * 1969-01-30 1972-07-04 Asahi Chemical Ind Cultivation of hydrocarbon-consuming yeasts
JPS5495991A (en) 1977-11-22 1979-07-28 Fischer Karl Otto Paul Oil bonding agent and its manufacture
EP0014050A3 (de) * 1979-01-16 1980-10-01 Beecham Group Plc Herstellung von Interferon
JPS5646832A (en) * 1979-09-25 1981-04-28 Asahi Chem Ind Co Ltd Preparation of methacrolein
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
JPS5786299A (en) * 1980-11-19 1982-05-29 Dai Ichi Seiyaku Co Ltd Plasmid and its preparation
EP0062971B1 (de) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetisch modifizierte Mikroorganismen
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions

Also Published As

Publication number Publication date
JPS60217898A (ja) 1985-10-31
EP0156355A2 (de) 1985-10-02
JP2564506B2 (ja) 1996-12-18
EP0156355B2 (de) 1999-03-10
DE156355T1 (de) 1986-02-27
EP0156355A3 (en) 1987-09-02
US4656132A (en) 1987-04-07
CA1262694A (en) 1989-11-07
EP0156355B1 (de) 1991-10-23
DE3584460D1 (de) 1991-11-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
EEIH Change in the person of patent owner
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time