DE3584460D1 - Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien. - Google Patents

Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien.

Info

Publication number
DE3584460D1
DE3584460D1 DE8585103560T DE3584460T DE3584460D1 DE 3584460 D1 DE3584460 D1 DE 3584460D1 DE 8585103560 T DE8585103560 T DE 8585103560T DE 3584460 T DE3584460 T DE 3584460T DE 3584460 D1 DE3584460 D1 DE 3584460D1
Authority
DE
Germany
Prior art keywords
yield
produced
increasing
recombinant bacteria
breeding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585103560T
Other languages
English (en)
Inventor
Arie Ben-Bassat
Glenn Dorin
Keith Alan Bauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24378143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3584460(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Corp filed Critical Cetus Corp
Application granted granted Critical
Publication of DE3584460D1 publication Critical patent/DE3584460D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
DE8585103560T 1984-03-28 1985-03-26 Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien. Expired - Lifetime DE3584460D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/594,250 US4656132A (en) 1984-03-28 1984-03-28 Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria

Publications (1)

Publication Number Publication Date
DE3584460D1 true DE3584460D1 (de) 1991-11-28

Family

ID=24378143

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198585103560T Pending DE156355T1 (de) 1984-03-28 1985-03-26 Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien.
DE8585103560T Expired - Lifetime DE3584460D1 (de) 1984-03-28 1985-03-26 Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198585103560T Pending DE156355T1 (de) 1984-03-28 1985-03-26 Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien.

Country Status (6)

Country Link
US (1) US4656132A (de)
EP (1) EP0156355B2 (de)
JP (1) JP2564506B2 (de)
AT (1) ATE68830T1 (de)
CA (1) CA1262694A (de)
DE (2) DE156355T1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894334A (en) * 1984-03-28 1990-01-16 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
JPH0634746B2 (ja) * 1985-04-30 1994-05-11 武田薬品工業株式会社 インターロイキンの増収法
EP0200417B1 (de) * 1985-04-30 1992-10-21 Takeda Chemical Industries, Ltd. Produktion eines Proteins
DE3532134A1 (de) * 1985-09-10 1987-03-12 Basf Ag Verfahren zur herstellung von proteinen bestimmter n-terminaler struktur mit hilfe von prokaryonten
EP0315950A3 (de) * 1987-11-09 1990-05-23 Otsuka Pharmaceutical Co., Ltd. Verfahren zur Züchtung von Zellen, welche rekombinantes Protein exprimieren
GB9004390D0 (en) * 1990-02-27 1990-04-25 Ici Plc Process
US5223418A (en) * 1990-09-28 1993-06-29 Smithkline Beecham Corporation Method of improving the yield of heterologous proteins produced by streptomyces lividans
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
WO1993000443A1 (en) * 1991-06-26 1993-01-07 Bio-Technology General Corp. Purification of recombinant apolipoprotein e from bacteria
US5814485A (en) * 1995-06-06 1998-09-29 Chiron Corporation Production of interferon-β (IFN-β) in E. coli
US6255099B1 (en) 2000-02-17 2001-07-03 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College High-yield dual-buffered bacterial growth medium
EP1935431A3 (de) 2000-05-15 2008-08-13 Health Research, Inc. Krebsbehandlungen unter Verwendung einer Kombination aus einem HER2-Antikörper und Interleukin-2
AU2003298816C1 (en) * 2002-12-02 2010-12-16 Amgen Fremont, Inc. Antibodies directed to Tumor Necrosis Factor and uses thereof
ATE447412T1 (de) 2003-11-04 2009-11-15 Novartis Vaccines & Diagnostic Antagonist-anti-cd40-monoklonale antikörper und anwendungsverfahren
JP2007526317A (ja) * 2004-03-01 2007-09-13 エンゾン ファーマスーティカルズ インコーポレイテッド インターフェロン−ベータ・ポリマー結合体
EP1828242B1 (de) * 2004-12-20 2011-03-09 Cadila Healthcare Limited Verfahren zur herstellung von hohen niveaus von interferon-beta
JP6093712B2 (ja) 2010-12-22 2017-03-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー インターロイキン２のスーパーアゴニストおよびアンタゴニスト
CN103732241A (zh) 2011-03-11 2014-04-16 公共事业救济局-巴黎医院 低剂量il-2用于治疗自身免疫相关病症或炎性病症的应用
WO2014206899A1 (en) 2013-06-25 2014-12-31 Icm (Institut Du Cerveau Et De La Moelle Épinière) Boosting treg cells for treating alzheimer disease and related disorders
CA2925421C (en) 2013-09-24 2023-08-29 Medicenna Therapeutics, Inc. Interleukin-2 fusion proteins and uses thereof
EP2918285A1 (de) 2014-03-11 2015-09-16 Université Pierre et Marie Curie (Paris 6) Interleukin-2 zur Behandlung einer Lebensmittelallergie
US10150802B2 (en) 2014-04-24 2018-12-11 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
EP3364944A1 (de) 2015-10-22 2018-08-29 Iltoo Pharma Pharmazeutische zusammensetzungen von il-2
EP3641814A4 (de) 2017-06-19 2021-06-23 Medicenna Therapeutics Inc. Verwendungen und verfahren für il-2-superagonisten, agonisten und fusionen davon
EP3752178A1 (de) 2018-02-16 2020-12-23 Iltoo Pharma Verwendung von interleukin 2 zur behandlung des sjögren-syndroms
WO2020007937A1 (en) 2018-07-03 2020-01-09 Iltoo Pharma Use of interleukin-2 for treating systemic sclerosis
WO2020035482A1 (en) 2018-08-13 2020-02-20 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
CA3166509A1 (en) 2020-01-14 2021-07-22 Synthekine, Inc. Biased il2 muteins methods and compositions
JP2023516774A (ja) 2020-03-06 2023-04-20 サントル、オスピタリエ、ユニヴェルシテール、ド、ニーム 筋萎縮性側索硬化症の治療のための低用量ヒトインターロイキン－２

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2674561A (en) * 1950-09-08 1954-04-06 Andrew J Moyer Production of organic acids
US3674640A (en) * 1969-01-30 1972-07-04 Asahi Chemical Ind Cultivation of hydrocarbon-consuming yeasts
JPS5495991A (en) 1977-11-22 1979-07-28 Fischer Karl Otto Paul Oil bonding agent and its manufacture
EP0014050A3 (de) * 1979-01-16 1980-10-01 Beecham Group Plc Herstellung von Interferon
JPS5646832A (en) * 1979-09-25 1981-04-28 Asahi Chem Ind Co Ltd Preparation of methacrolein
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
JPS5786299A (en) * 1980-11-19 1982-05-29 Dai Ichi Seiyaku Co Ltd Plasmid and its preparation
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions

Also Published As

Publication number Publication date
EP0156355A2 (de) 1985-10-02
DE156355T1 (de) 1986-02-27
JP2564506B2 (ja) 1996-12-18
EP0156355A3 (en) 1987-09-02
JPS60217898A (ja) 1985-10-31
EP0156355B1 (de) 1991-10-23
US4656132A (en) 1987-04-07
CA1262694A (en) 1989-11-07
EP0156355B2 (de) 1999-03-10
ATE68830T1 (de) 1991-11-15

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: CHIRON CORP. (N.D.GES.D. STAATES DELAWARE), EMERYV

8366 Restricted maintained after opposition proceedings