DE3787551T2 - Proteinproduktion mittels Zellkultur. - Google Patents

Proteinproduktion mittels Zellkultur.

Info

Publication number
DE3787551T2
DE3787551T2 DE87302156T DE3787551T DE3787551T2 DE 3787551 T2 DE3787551 T2 DE 3787551T2 DE 87302156 T DE87302156 T DE 87302156T DE 3787551 T DE3787551 T DE 3787551T DE 3787551 T2 DE3787551 T2 DE 3787551T2
Authority
DE
Germany
Prior art keywords
proteins
agents
cell culture
protein production
enhance production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE87302156T
Other languages
English (en)
Other versions
DE3787551D1 (de
Inventor
Raymond Paul Field
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcan Holdings Switzerland AG
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10594635&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3787551(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Application granted granted Critical
Publication of DE3787551D1 publication Critical patent/DE3787551D1/de
Publication of DE3787551T2 publication Critical patent/DE3787551T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
DE87302156T 1986-03-14 1987-03-13 Proteinproduktion mittels Zellkultur. Revoked DE3787551T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868606386A GB8606386D0 (en) 1986-03-14 1986-03-14 Production of protein

Publications (2)

Publication Number Publication Date
DE3787551D1 DE3787551D1 (de) 1993-11-04
DE3787551T2 true DE3787551T2 (de) 1994-02-17

Family

ID=10594635

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87302156T Revoked DE3787551T2 (de) 1986-03-14 1987-03-13 Proteinproduktion mittels Zellkultur.

Country Status (9)

Country Link
EP (1) EP0239292B1 (de)
JP (1) JP2525436B2 (de)
AT (1) ATE95231T1 (de)
AU (1) AU7126487A (de)
CA (1) CA1341367C (de)
DE (1) DE3787551T2 (de)
ES (1) ES2059367T3 (de)
GB (2) GB8606386D0 (de)
WO (1) WO1987005626A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619226B2 (en) * 1987-09-28 1992-01-23 Children's Hospital Medical Center Human cell lines of epithelial lung adenocarcinoma origin, human proteins and methods
DE3851685D1 (de) * 1987-10-13 1994-11-03 Thomae Gmbh Dr K Verfahren zur Herstellung von Proteinen.
AU2943389A (en) * 1988-01-13 1989-08-11 Upjohn Company, The Enhanced production of cellular proteins using butyrate
FR2635008B1 (fr) * 1988-08-05 1990-11-16 Sanofi Sa Agent activateur de la productivite specifique des cellules animales recombinantes a base de polyvinylpyrrolidone et milieu de culture defini le contenant
US5378612A (en) * 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
FR2674053A1 (fr) * 1991-03-12 1992-09-18 Dassault Electronique Installation pour la securisation de titres de transport, en particulier a piste magnetique.
IL102189A (en) * 1992-06-12 1995-07-31 Univ Ben Gurion Device for growing microorganisms
US5721121A (en) * 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US5705364A (en) 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
KR100447422B1 (ko) * 1996-11-28 2004-10-28 씨제이 주식회사 포유동물세포유래성당단백질의당쇄화및생산성향상성을위한새로운세포배양배지
GB9828624D0 (en) * 1998-12-23 1999-02-17 Glaxo Group Ltd Production of proteins
KR100397791B1 (ko) * 2000-08-30 2003-09-13 한국과학기술원 ＣＨＯ세포에서 ｂｃｌ-2 유전자 과발현 및 배지내 소디움부티레이트 첨가에 의한 인간화된 항체의 생산성을증가시키는 방법
KR101007171B1 (ko) * 2002-04-08 2011-01-12 론자 바이올로직스 피엘씨 세포 배양 배지
GB0208041D0 (en) 2002-04-08 2002-05-22 Lonza Biologics Plc Method of culturing animal cells
EP1551988B1 (de) * 2002-07-19 2010-11-24 Morphotek, Inc. VERFAHREN ZUR ERZEUGUNG VERBESSERTER ANTIKöRPER PRODUZIERENDER ZELLINIEN MIT VERBESSERTEN WACHSTUMSEIGENSCHAFTEN
AU2004234377A1 (en) * 2003-04-25 2004-11-11 Immunex Corporation Inducers of recombinant protein expression
EP1709185A1 (de) * 2003-12-31 2006-10-11 Samyang Genex Corporation Verfahren zur massenherstellung sekundärer metaboliten in pflanzenzellkulturen durch behandlung einer alkansäure oder eines salzes davon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5774093A (en) * 1980-10-27 1982-05-10 Ajinomoto Co Inc Method of increasing interferon production

Also Published As

Publication number Publication date
WO1987005626A1 (en) 1987-09-24
GB8606386D0 (en) 1986-04-23
CA1341367C (en) 2002-06-11
ES2059367T3 (es) 1994-11-16
EP0239292A1 (de) 1987-09-30
EP0239292B1 (de) 1993-09-29
GB2196636A (de) 1988-05-05
JP2525436B2 (ja) 1996-08-21
GB2196636B (en) 1990-09-19
AU7126487A (en) 1987-10-09
JPS63503273A (ja) 1988-12-02
DE3787551D1 (de) 1993-11-04
GB8726077D0 (en) 1987-12-09
ATE95231T1 (de) 1993-10-15

Similar Documents

Publication Publication Date Title
DE3787551T2 (de) Proteinproduktion mittels Zellkultur.
DK15182A (da) Fremgangsmaade til fremstilling af recombinant-dna
KR880700062A (ko) 동물세포의 배양
DE3584460D1 (de) Verfahren zur erhoehung der ausbeute von heterologen proteinen, produziert durch zuechtung von rekombinanten bakterien.
HUP0101136A2 (hu) Fehérjeexpresszió baculovírus-vektort alkalmazó expressziós rendszerben
DE69939330D1 (de) Wachstumsfaktor-homologe zvegf-3
DK1200561T3 (da) Rekombinant stabil celleklon, dens fremstilling og anvendelse
JPS55131399A (en) Cultivation of namalva cell and replacing animal serum protein by human albumine for producing interferon by said cell
DK619284A (da) Udtrykkelsesplasmid til forbedret produktion af heterologt protein ibakterier og fremgangsmaade til fremstilling af dette protein samtfremgangsmaade til fremstilling af plasmidet
JPS6490199A (en) T cell growth factor derived from thymic interstitial cell and production thereof
ATE112308T1 (de) Verfahren zur herstellung von proteinen.
DE69923595D1 (de) Herstellung von proteinen
JPS60110287A (ja) 電気刺激による細胞培養方法およびその装置
ATE43359T1 (de) Verfahren zur herstellung in vitro von serumfreiem und mitogenfreiem interleukin-2.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: ALUSUISSE HOLDINGS A.G., NEUHAUSEN AM RHEINFALL, C

8331 Complete revocation