ES8600217A1 - Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria - Google Patents

Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria

Info

Publication number
ES8600217A1
ES8600217A1 ES535846A ES535846A ES8600217A1 ES 8600217 A1 ES8600217 A1 ES 8600217A1 ES 535846 A ES535846 A ES 535846A ES 535846 A ES535846 A ES 535846A ES 8600217 A1 ES8600217 A1 ES 8600217A1
Authority
ES
Spain
Prior art keywords
leu
arg
ala
ser
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535846A
Other languages
English (en)
Other versions
ES535846A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of ES535846A0 publication Critical patent/ES535846A0/es
Publication of ES8600217A1 publication Critical patent/ES8600217A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PEPTIDOS QUE INFLUYEN EN LA FUNCION DE LA GLANDULA PITUITARIA, DE FORMULA (I), EN LA QUE LOS DIFERENTES RADICALES REPRESENTAN VARIOS RESTOS AMINOACIDOS.CONSISTE EN LA FORMACION DE UN COMPUESTO QUE TIENE AL MENOS UN GRUPO PROTECTOR Y LA FORMULA (II) X Y X1 C X8 SON HIDROGENO O UN GRUPO PROTECTOR Y X9 ES AMIDA, HIDROXILO O GRUPO PROTECTOR; SEGUIDA DE LA SEPARACION DEL GRUPO O GRUPOS PROTECTORES, DE MODO QUE SE FORMA EL COMPUESTO DE FORMULA (I) O UN FRAGMENTO BIOLOGICAMENTE ACTIVO DEL MISMO; Y, FINALMENTE, EVENTUAL FORMACION DE UNA SAL DE ADICION, NO TOXICA DE DICHO PEPTIDO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS Y EN VETERINARIA PARA ESTIMULAR LA LIBERACION DE LA HORMONA DEL CRECIMIENTO, ASI COMO EN LA ESTIMULACION DE PROCESOS ANABOLICOS DESPUES DE QUEMADURAS.
ES535846A 1983-09-13 1984-09-12 Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria Expired ES8600217A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53217083A 1983-09-13 1983-09-13
US06/545,094 US4518586A (en) 1983-01-13 1983-10-25 GRF Analogs III

Publications (2)

Publication Number Publication Date
ES535846A0 ES535846A0 (es) 1985-10-01
ES8600217A1 true ES8600217A1 (es) 1985-10-01

Family

ID=27063766

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535846A Expired ES8600217A1 (es) 1983-09-13 1984-09-12 Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria

Country Status (21)

Country Link
US (1) US4518586A (es)
EP (1) EP0146210B1 (es)
JP (1) JPH0689035B2 (es)
AU (1) AU577057B2 (es)
CA (1) CA1271599A (es)
DE (1) DE3462603D1 (es)
DK (1) DK165749C (es)
ES (1) ES8600217A1 (es)
FI (1) FI88402C (es)
GR (1) GR80335B (es)
HU (1) HU200192B (es)
IE (1) IE57774B1 (es)
IL (1) IL72799A (es)
IN (1) IN160247B (es)
MX (1) MX161018A (es)
NO (1) NO166944C (es)
NZ (1) NZ209515A (es)
PH (1) PH22310A (es)
PT (1) PT79189B (es)
SU (1) SU1435157A3 (es)
YU (1) YU45968B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
US4626523A (en) * 1983-09-13 1986-12-02 The Salk Institute For Biological Studies GRF analogs II
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
CA1271600A (en) * 1985-01-07 1990-07-10 David Howard Coy Growth hormone-releasing peptides and method of treating mammals therewith
EP0193910A3 (en) * 1985-03-06 1988-11-23 Sumitomo Pharmaceuticals Company, Limited Synthesis of a derivative of grf and intermediate peptides
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
ZA866026B (en) * 1985-08-12 1988-04-27 Syntex Inc Bovine growth hormone releasing factor derivative
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US4870054A (en) * 1985-09-27 1989-09-26 Recker Robert R Treatment for osteoporosis using GRF or a biologically active analog thereof
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
IL84758A (en) * 1987-01-13 1992-03-29 Salk Inst For Biological Studi Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
IL86102A (en) * 1987-05-11 1994-04-12 Univ Tulane Alkylated peptides that release growth hormone and their use
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US4801456A (en) * 1987-07-09 1989-01-31 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
USRE33699E (en) * 1987-07-09 1991-09-24 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
WO1989007110A1 (en) * 1988-01-28 1989-08-10 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5023322A (en) * 1988-08-31 1991-06-11 Mta Kutatas-Es Szervezetelemzo Intezete Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
JPH06500311A (ja) * 1990-06-29 1994-01-13 エフ・ホフマン―ラ　ロシュ　アーゲー ヒスチジン置換されたヒト成長ホルモン放出因子類縁体
ATE119916T1 (de) * 1990-12-10 1995-04-15 Hoffmann La Roche Verfahren zur enzymatischen herstellung von grf(1-44)nh2.
JPH05507939A (ja) * 1991-04-09 1993-11-11 エフ・ホフマン―ラ　ロシユ　アーゲー 成長ホルモン放出因子の類似体
US5246920A (en) * 1992-06-15 1993-09-21 University Of South Florida Treatment of hyperprolactinemia
US5811074A (en) * 1992-06-29 1998-09-22 University Of South Florida Method of diagnosing pituitary dependent growth hormone deficiency
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
AU2002233082B2 (en) * 2001-02-02 2005-11-10 Conjuchem Biotechnologies Inc. Long lasting growth hormone releasing factor derivatives
NZ539218A (en) * 2002-09-18 2008-03-28 Univ Montreal Ct Hospitalier Chum Synthetic GHRH analogues of 29 amino acids or more
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
WO2009009727A2 (en) * 2007-07-12 2009-01-15 Akela Pharma Srl Ghrh analogs and therapeutic uses thereof
CN108570097A (zh) 2010-08-13 2018-09-25 爱勒让治疗公司 拟肽大环化合物
WO2012142706A1 (en) 2011-04-21 2012-10-26 Theratechnologies Inc. Growth hormone releasing factor (grf) analogs and uses thereof
AU2012326026B2 (en) 2011-10-18 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CA2961258A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ204456A (en) * 1982-06-16 1987-05-29 Salk Inst For Biological Studi Synthetic pancreatic growth-hormone releasing factor
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
DE3482387D1 (en) * 1983-03-07 1990-07-05 Hoffmann La Roche Polypeptide.
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
PT79094B (en) * 1983-08-29 1986-08-14 Salk Inst For Biological Studi Grf analogs

Also Published As

Publication number Publication date
FI88402B (fi) 1993-01-29
DK165749B (da) 1993-01-11
FI843579L (fi) 1985-03-14
EP0146210A1 (en) 1985-06-26
PH22310A (en) 1988-07-22
AU577057B2 (en) 1988-09-15
DK433684D0 (da) 1984-09-11
IE57774B1 (en) 1993-04-07
DE3462603D1 (en) 1987-04-16
YU45968B (sh) 1992-12-21
NZ209515A (en) 1988-08-30
SU1435157A3 (ru) 1988-10-30
JPH0689035B2 (ja) 1994-11-09
DK433684A (da) 1985-03-14
ES535846A0 (es) 1985-10-01
GR80335B (en) 1985-01-11
YU157984A (en) 1988-04-30
HU200192B (en) 1990-04-28
AU3259484A (en) 1985-03-21
PT79189B (en) 1986-08-14
EP0146210B1 (en) 1987-03-11
FI88402C (fi) 1993-05-10
IL72799A (en) 1987-10-30
JPS60100596A (ja) 1985-06-04
FI843579A0 (fi) 1984-09-12
US4518586A (en) 1985-05-21
CA1271599A (en) 1990-07-10
NO843592L (no) 1985-03-14
NO166944B (no) 1991-06-10
IL72799A0 (en) 1984-11-30
DK165749C (da) 1993-06-14
IE842324L (en) 1985-03-13
HUT35696A (en) 1985-07-29
NO166944C (no) 1991-09-18
MX161018A (es) 1990-07-05
IN160247B (es) 1987-07-04
PT79189A (en) 1984-10-01

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