RO77533A - Procede pour la preparation des derives de vinblastyne,leurosidyne etleurocrystine - Google Patents

Procede pour la preparation des derives de vinblastyne,leurosidyne etleurocrystine

Info

Publication number
RO77533A
RO77533A RO7498695A RO9869574A RO77533A RO 77533 A RO77533 A RO 77533A RO 7498695 A RO7498695 A RO 7498695A RO 9869574 A RO9869574 A RO 9869574A RO 77533 A RO77533 A RO 77533A
Authority
RO
Romania
Prior art keywords
leurozidine
leurocristina
vinblastin
derivatives
preparation
Prior art date
Application number
RO7498695A
Other languages
English (en)
Romanian (ro)
Inventor
George J Cullinan
Koert Gerzon
Original Assignee
Eli Lilly And Co,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us
Publication of RO77533A publication Critical patent/RO77533A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RO7498695A 1973-04-02 1974-04-02 Procede pour la preparation des derives de vinblastyne,leurosidyne etleurocrystine RO77533A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (1)

Publication Number Publication Date
RO77533A true RO77533A (fr) 1982-02-01

Family

ID=23363051

Family Applications (2)

Application Number Title Priority Date Filing Date
RO78274A RO73524B (ro) 1973-04-02 1974-04-02 Procedeu de preparare a unor derivati de alcaloizi
RO7498695A RO77533A (fr) 1973-04-02 1974-04-02 Procede pour la preparation des derives de vinblastyne,leurosidyne etleurocrystine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO78274A RO73524B (ro) 1973-04-02 1974-04-02 Procedeu de preparare a unor derivati de alcaloizi

Country Status (28)

Country Link
JP (2) JPS5919117B2 (fr)
AR (2) AR204004A1 (fr)
AT (1) AT340605B (fr)
BE (1) BE813168A (fr)
BG (3) BG22831A3 (fr)
CA (1) CA1042428A (fr)
CH (1) CH603669A5 (fr)
CS (1) CS185223B2 (fr)
CY (1) CY1044A (fr)
DD (1) DD113538A5 (fr)
DE (1) DE2415980A1 (fr)
DK (1) DK141511B (fr)
ES (2) ES424882A1 (fr)
FR (1) FR2223044B1 (fr)
GB (1) GB1463575A (fr)
HK (1) HK20180A (fr)
HU (1) HU171572B (fr)
IE (1) IE39071B1 (fr)
IL (1) IL44415A (fr)
KE (1) KE3028A (fr)
MY (1) MY8100025A (fr)
NL (1) NL181079C (fr)
PH (1) PH13623A (fr)
RO (2) RO73524B (fr)
SE (1) SE416206B (fr)
SU (4) SU731900A3 (fr)
YU (3) YU39719B (fr)
ZA (1) ZA741674B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (fr) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
AU2006207321B2 (en) 2005-01-21 2012-09-06 Astex Therapeutics Limited Pharmaceutical compounds
NZ587586A (en) 2005-07-18 2012-04-27 Bipar Sciences Inc Treatment of cancer
WO2008030891A2 (fr) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition de la synthèse d'acides gras au moyen d'inhibiteurs parp et méthodes de traitement associées
CN101522609A (zh) 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
WO2008044045A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
CN101917982B (zh) 2007-11-12 2013-03-20 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
DK141511C (fr) 1980-09-29
DD113538A5 (fr) 1975-06-12
SE416206B (sv) 1980-12-08
BE813168A (fr) 1974-10-02
ES424882A1 (es) 1976-12-16
ZA741674B (en) 1975-10-29
CY1044A (en) 1980-08-01
YU113980A (en) 1982-05-31
YU113880A (en) 1982-05-31
HU171572B (hu) 1978-02-28
SU784783A3 (ru) 1980-11-30
AR204004A1 (es) 1975-11-12
AU6671974A (en) 1975-09-18
YU39876B (en) 1985-04-30
DK141511B (da) 1980-04-08
YU39875B (en) 1985-04-30
RO73524B (ro) 1984-11-30
IE39071B1 (en) 1978-08-02
CA1042428A (fr) 1978-11-14
YU39719B (en) 1985-04-30
BG22831A3 (fr) 1977-04-20
PH13623A (en) 1980-08-07
NL7404423A (fr) 1974-10-04
IE39071L (en) 1974-10-02
FR2223044B1 (fr) 1978-06-30
HK20180A (en) 1980-04-25
YU81774A (en) 1982-05-31
JPS49128000A (fr) 1974-12-07
SU731900A3 (ru) 1980-04-30
AR203882A1 (es) 1975-10-31
BG21235A3 (fr) 1976-03-20
AT340605B (de) 1977-12-27
IL44415A (en) 1978-08-31
FR2223044A1 (fr) 1974-10-25
RO73524A (fr) 1984-10-31
JPS6033837B2 (ja) 1985-08-05
ATA267974A (de) 1977-04-15
NL181079B (nl) 1987-01-16
SU652896A3 (ru) 1979-03-15
DE2415980A1 (de) 1974-10-10
CS185223B2 (en) 1978-09-15
IL44415A0 (en) 1974-06-30
JPS5919117B2 (ja) 1984-05-02
BG21612A3 (fr) 1976-07-20
DE2415980C2 (fr) 1989-11-09
SU623522A3 (ru) 1978-09-05
GB1463575A (en) 1977-02-02
KE3028A (en) 1980-03-28
MY8100025A (en) 1981-12-31
CH603669A5 (fr) 1978-08-31
ES446571A1 (es) 1977-06-16
JPS59193895A (ja) 1984-11-02
NL181079C (nl) 1987-06-16

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