PT95515A - Processo para a preparacao de derivados da quinolina e de composicoes farmaceuticas qoe os contem - Google Patents
Processo para a preparacao de derivados da quinolina e de composicoes farmaceuticas qoe os contem Download PDFInfo
- Publication number
- PT95515A PT95515A PT95515A PT9551590A PT95515A PT 95515 A PT95515 A PT 95515A PT 95515 A PT95515 A PT 95515A PT 9551590 A PT9551590 A PT 9551590A PT 95515 A PT95515 A PT 95515A
- Authority
- PT
- Portugal
- Prior art keywords
- methyl
- dihydro
- compound
- formula
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Measurement Of Radiation (AREA)
- Holo Graphy (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26278289 | 1989-10-06 | ||
| JP32229089 | 1989-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT95515A true PT95515A (pt) | 1991-08-14 |
Family
ID=26545706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95515A PT95515A (pt) | 1989-10-06 | 1990-10-04 | Processo para a preparacao de derivados da quinolina e de composicoes farmaceuticas qoe os contem |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5223513A (member.php) |
| EP (1) | EP0421456B1 (member.php) |
| KR (1) | KR910007883A (member.php) |
| CN (1) | CN1050715A (member.php) |
| AT (1) | ATE116301T1 (member.php) |
| AU (1) | AU629048B2 (member.php) |
| CA (1) | CA2026890C (member.php) |
| DE (1) | DE69015541T2 (member.php) |
| FI (1) | FI904915A7 (member.php) |
| HU (1) | HUT55364A (member.php) |
| IE (1) | IE903454A1 (member.php) |
| IL (1) | IL95839A (member.php) |
| NO (1) | NO904300L (member.php) |
| NZ (1) | NZ235582A (member.php) |
| PT (1) | PT95515A (member.php) |
| RU (1) | RU2001910C1 (member.php) |
| TW (1) | TW205037B (member.php) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| JPH0776215B2 (ja) * | 1991-04-26 | 1995-08-16 | フアイザー・インコーポレイテツド | ４−アリール−３−（ヘテロアリールウレイド）キノリン誘導体 |
| ATE175196T1 (de) * | 1992-01-23 | 1999-01-15 | Pfizer | 4-phenyl-3-(heteroarylureido)-1,2-dihydro-2- oxochinolin derivate, als antihypercholesterolemische und antiatherosklerotische mittel |
| TW241258B (member.php) * | 1992-04-15 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| CA2134359C (en) * | 1992-05-28 | 1997-07-01 | Ernest S. Hamanaka | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| DE69315920T2 (de) * | 1992-09-04 | 1998-06-10 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| TW263498B (member.php) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| US5843957A (en) * | 1995-05-19 | 1998-12-01 | Sumitomo Pharmaceuticals Company, Ltd. | Naphthyridine derivatives |
| WO1999009983A1 (en) * | 1997-08-28 | 1999-03-04 | Bristol-Myers Squibb Company | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| AU2547399A (en) | 1998-02-25 | 1999-09-15 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for producing the same |
| CZ20011965A3 (cs) * | 1998-12-04 | 2001-09-12 | Bristol-Myers Squibb Company | Derivát v poloze 3 substituovaného 4-arylchinolin-2-onu jako modulátor draslíkového kanálku |
| SK10972002A3 (sk) | 2000-02-02 | 2003-07-01 | Warner-Lambert Company | Duálne inhibítory cholesterylesteru a syntéza voskového esteru na liečenie ochorení tukových žliaz |
| JP4300457B2 (ja) * | 2001-03-02 | 2009-07-22 | 住友化学株式会社 | キノリン−３−カルボン酸化合物の製造方法 |
| CA2445693A1 (en) * | 2001-04-30 | 2002-11-07 | Pfizer Products Inc. | Compounds useful as intermediates for 4-aminoquinoline derivatives |
| JP4794445B2 (ja) | 2003-09-23 | 2011-10-19 | メルク・シャープ・エンド・ドーム・コーポレイション | キノリンカリウムチャネル阻害剤 |
| EP2773619B1 (en) | 2011-11-04 | 2016-11-16 | F.Hoffmann-La Roche Ag | New aryl-quinoline derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1216878B (de) * | 1963-04-02 | 1966-05-18 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins |
| NO133758C (member.php) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
| JPS555502B1 (member.php) * | 1971-07-31 | 1980-02-07 | ||
| US4530931A (en) * | 1983-01-03 | 1985-07-23 | Usv Pharmaceutical Corp. | 8-Quinoline carbanilates for the inhibition of lipolysis |
| DE3586445T2 (de) * | 1984-06-26 | 1993-01-14 | Merck & Co Inc | Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen. |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
-
1990
- 1990-09-20 TW TW079107912A patent/TW205037B/zh active
- 1990-09-25 US US07/587,795 patent/US5223513A/en not_active Expired - Fee Related
- 1990-09-25 IE IE345490A patent/IE903454A1/en unknown
- 1990-09-28 IL IL9583990A patent/IL95839A/en not_active IP Right Cessation
- 1990-09-28 AU AU63707/90A patent/AU629048B2/en not_active Ceased
- 1990-10-03 NO NO90904300A patent/NO904300L/no unknown
- 1990-10-04 PT PT95515A patent/PT95515A/pt not_active Application Discontinuation
- 1990-10-04 CA CA002026890A patent/CA2026890C/en not_active Expired - Fee Related
- 1990-10-05 CN CN90108222A patent/CN1050715A/zh active Pending
- 1990-10-05 FI FI904915A patent/FI904915A7/fi not_active Application Discontinuation
- 1990-10-05 RU SU904831426A patent/RU2001910C1/ru active
- 1990-10-05 EP EP90119128A patent/EP0421456B1/en not_active Expired - Lifetime
- 1990-10-05 NZ NZ235582A patent/NZ235582A/en unknown
- 1990-10-05 DE DE69015541T patent/DE69015541T2/de not_active Expired - Fee Related
- 1990-10-05 AT AT90119128T patent/ATE116301T1/de not_active IP Right Cessation
- 1990-10-05 HU HU906360A patent/HUT55364A/hu unknown
- 1990-10-06 KR KR1019900015908A patent/KR910007883A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0421456A2 (en) | 1991-04-10 |
| HUT55364A (en) | 1991-05-28 |
| KR910007883A (ko) | 1991-05-30 |
| CA2026890C (en) | 2001-09-18 |
| IL95839A (en) | 1995-03-15 |
| AU6370790A (en) | 1991-04-11 |
| DE69015541T2 (de) | 1995-06-01 |
| DE69015541D1 (de) | 1995-02-09 |
| EP0421456B1 (en) | 1994-12-28 |
| EP0421456A3 (en) | 1991-05-29 |
| IE903454A1 (en) | 1991-04-10 |
| IL95839A0 (en) | 1991-06-30 |
| US5223513A (en) | 1993-06-29 |
| NO904300L (no) | 1991-04-08 |
| ATE116301T1 (de) | 1995-01-15 |
| CA2026890A1 (en) | 1991-04-07 |
| TW205037B (member.php) | 1993-05-01 |
| FI904915A7 (fi) | 1991-04-07 |
| NO904300D0 (no) | 1990-10-03 |
| RU2001910C1 (ru) | 1993-10-30 |
| CN1050715A (zh) | 1991-04-17 |
| FI904915A0 (fi) | 1990-10-05 |
| AU629048B2 (en) | 1992-09-24 |
| HU906360D0 (en) | 1991-04-29 |
| NZ235582A (en) | 1992-03-26 |
| JPH03223254A (ja) | 1991-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910306 |
|
| FC3A | Refusal |
Effective date: 19961010 |