PT934308E - Compostos de eter heterociclico de 3-piridiloximetilo uteis no controlo da transmissao sinaptica quimica - Google Patents
Compostos de eter heterociclico de 3-piridiloximetilo uteis no controlo da transmissao sinaptica quimicaInfo
- Publication number
- PT934308E PT934308E PT97927830T PT97927830T PT934308E PT 934308 E PT934308 E PT 934308E PT 97927830 T PT97927830 T PT 97927830T PT 97927830 T PT97927830 T PT 97927830T PT 934308 E PT934308 E PT 934308E
- Authority
- PT
- Portugal
- Prior art keywords
- pyridyloxymethyl
- compounds
- transmission
- uteis
- synapsis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/660,044 US5629325A (en) | 1996-06-06 | 1996-06-06 | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
US08/844,540 US6127386A (en) | 1996-06-06 | 1997-04-18 | 3-Pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
Publications (1)
Publication Number | Publication Date |
---|---|
PT934308E true PT934308E (pt) | 2004-11-30 |
Family
ID=24647894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97927830T PT934308E (pt) | 1996-06-06 | 1997-06-04 | Compostos de eter heterociclico de 3-piridiloximetilo uteis no controlo da transmissao sinaptica quimica |
Country Status (10)
Country | Link |
---|---|
US (2) | US5629325A (pt) |
EP (1) | EP0934308B1 (pt) |
JP (2) | JP4486712B2 (pt) |
AT (1) | ATE273296T1 (pt) |
CA (1) | CA2256022C (pt) |
DE (1) | DE69730229T2 (pt) |
DK (1) | DK0934308T3 (pt) |
ES (1) | ES2229364T3 (pt) |
PT (1) | PT934308E (pt) |
WO (1) | WO1997046554A1 (pt) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020052497A1 (en) * | 2000-03-09 | 2002-05-02 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
US6437138B1 (en) | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
HUP0001110A3 (en) * | 1996-12-10 | 2002-04-29 | Abbott Lab | 3-pyridyl enantiomers and their use as analgesics |
US6133253A (en) * | 1996-12-10 | 2000-10-17 | Abbott Laboratories | 3-Pyridyl enantiomers and their use as analgesics |
US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
DK1034174T3 (da) * | 1997-11-05 | 2003-09-22 | Neurosearch As | Azaringetherderivater og disses anvendelse som nikotin-ACh-receptormodulatorer |
DE69822668T2 (de) * | 1997-12-19 | 2005-03-10 | Abbott Laboratories, Abbott Park | Heterozyklische ether- und thioether-verbindungen, verwendbar zur steuerung von chemischer synaptischer transmission |
JP2002510619A (ja) | 1998-04-02 | 2002-04-09 | アール・ジェイ・レイノルズ・タバコ・カンパニー | 薬剤組成物及びその使用法 |
US6723838B1 (en) | 1998-04-22 | 2004-04-20 | Johns Hopkins University | Signal transducing synaptic molecules and uses thereof |
KR20010052503A (ko) | 1998-06-03 | 2001-06-25 | 다니엘 피. 맥컬럼 | N-헤테로사이클릭 카복실산 또는 카복실산 등입체의n-결합된 설폰아미드 |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
AU4230799A (en) * | 1998-06-16 | 2000-01-05 | Targacept, Inc. | Aryl substituted olefinic amines and their use as cholinergic receptors agonists |
US20050131034A1 (en) * | 1998-06-16 | 2005-06-16 | Caldwell William S. | Compounds capable of activating cholinergic receptors |
US6232316B1 (en) | 1998-06-16 | 2001-05-15 | Targacept, Inc. | Methods for treatment of CNS disorders |
US7790757B2 (en) * | 1998-06-16 | 2010-09-07 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
AU5574799A (en) * | 1998-08-25 | 2000-03-14 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
WO2000046193A2 (en) * | 1999-02-03 | 2000-08-10 | Schering Aktiengesellschaft | Ether derivatives having neuronal activity |
US6284779B1 (en) | 1999-02-03 | 2001-09-04 | Schering Aktiiengesellschaft | Heteroaromatic compounds |
US6833370B1 (en) | 1999-05-21 | 2004-12-21 | Abbott Laboratories | Heterocycle substituted aminoazacycles useful as central nervous system agents |
US20010031771A1 (en) | 1999-05-24 | 2001-10-18 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
WO2001019817A2 (en) * | 1999-09-14 | 2001-03-22 | Abbott Laboratories | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
JP2003518122A (ja) | 1999-12-21 | 2003-06-03 | ジーピーアイ エヌアイエル ホールディングズ インコーポレーテッド | ヒダントイン誘導体化合物、医薬合成品およびこれらの使用方法 |
US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
US6448276B1 (en) | 2000-05-17 | 2002-09-10 | Inspire Pharmaceuticals, Inc. | Method for treating vaginal dryness with nicotinic acetylcholine receptor agonists |
US8124625B2 (en) * | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
AU2002353147A1 (en) * | 2001-12-13 | 2003-06-30 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
EP1492784A4 (en) * | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
US7098331B2 (en) | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
WO2005000806A2 (en) * | 2003-06-10 | 2005-01-06 | Georgetown University | Ligands for nicotinic acetylcholine receptors, and methods of making and using them |
US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
WO2005085227A1 (en) * | 2004-03-02 | 2005-09-15 | Smithkline Beecham Corporation | Inhibitors of akt activity |
CA2563023C (en) * | 2004-04-02 | 2012-01-24 | Arterial Remodelling Technologies, Inc. | Polymer-based stent assembly |
US9029557B2 (en) | 2004-12-07 | 2015-05-12 | The Regents Of The University Of California | Labeled A4B2 ligands and methods therefor |
US8378109B2 (en) * | 2004-12-07 | 2013-02-19 | The Regents Of The University Of California | Labeled ALPHA4BETA2 ligands and methods therefor |
GB0428514D0 (en) * | 2004-12-31 | 2005-02-09 | Prosidion Ltd | Compounds |
JP2008542224A (ja) * | 2005-05-25 | 2008-11-27 | ビーエーエスエフ ソシエタス・ヨーロピア | 節足動物害虫および線虫を防除するためのピリジン化合物 |
US20090215857A1 (en) * | 2005-09-13 | 2009-08-27 | Pfizer Products Inc. | Therapeutic Pyrrolidines |
US20070184490A1 (en) * | 2006-01-17 | 2007-08-09 | Marleen Verlinden | Neuronal nicotinic receptor ligands and their use |
EP2086325A1 (en) * | 2006-11-29 | 2009-08-12 | Basf Se | Pyridine compounds for combating pests |
GB2448224B (en) | 2007-04-02 | 2010-09-01 | Parkinson S Inst | Solid orally administered pharmaceutical composition for the reduction of side-effects of a dopaminergic agent |
CA2687931C (en) * | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
WO2009143507A2 (en) * | 2008-05-23 | 2009-11-26 | Georgetown University | Silent desensitizers of neuronal nachr and methods of use thereof |
AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
CN102216289A (zh) * | 2008-10-14 | 2011-10-12 | 塞扣吉尼克斯公司 | 烟碱乙酰胆碱受体配体及其用途 |
US8642583B2 (en) | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
US20100125094A1 (en) * | 2008-11-17 | 2010-05-20 | Auspex Pharmaceuticals, Inc. | Pyrrolidinyl modulators of nicotinic acetylcholine receptors |
BRPI0923051B1 (pt) | 2008-12-19 | 2022-07-19 | Centrexion Therapeutics Corporation | Pirimidin-4-carboxamidas cíclicas como antagonistas do receptor de ccr2 para o tratamento de inflamação, asma e copd, seu uso, formulação e combinação farmacêutica que os compreende |
WO2011071758A1 (en) | 2009-12-07 | 2011-06-16 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands |
KR101530234B1 (ko) | 2009-12-17 | 2015-06-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 ccr2 수용체 길항제 및 이의 용도 |
JP2013522201A (ja) * | 2010-03-11 | 2013-06-13 | ターガセプト,インコーポレイテッド | 便秘のためのアリールビニルアザシクロアルカン化合物 |
EP2569298B1 (en) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2受容体アンタゴニスト |
JP5721242B2 (ja) * | 2010-06-01 | 2015-05-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2アンタゴニスト |
US9440948B2 (en) | 2010-09-03 | 2016-09-13 | University Of Florida Research Foundation, Inc. | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use |
EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
EP2776423B1 (en) | 2011-11-11 | 2020-05-06 | Georgetown University | Phenyl-substituted nicotinic ligands, and methods of use thereof |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 薬剤送達方法及びシステム |
CN108026087B (zh) | 2015-07-02 | 2021-06-04 | 中枢疗法公司 | 氨基嘧啶甲酮衍生物的柠檬酸盐 |
EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
AU2019279884A1 (en) | 2018-05-29 | 2020-12-10 | Morningside Venture Investments Limited | Drug delivery methods and systems |
WO2024146945A1 (en) | 2023-01-07 | 2024-07-11 | Syngenta Crop Protection Ag | Novel carboxamide and sulfonamide pesticidal compounds |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4592866A (en) * | 1982-09-30 | 1986-06-03 | A. H. Robins Company, Inc. | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof |
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
US4956359A (en) * | 1985-02-28 | 1990-09-11 | A. H. Robins Company, Inc. | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics |
DE3641343A1 (de) * | 1986-12-03 | 1988-06-16 | Hoechst Ag | Carbamoylimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
EP0287908A3 (de) * | 1987-04-18 | 1989-12-27 | ASTA Medica Aktiengesellschaft | Neue stickstoffhaltige, cycloaliphatische Verbindungen mit einem Aminosäurerest sowie einem Pyridinrest |
FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
DE3835291A1 (de) * | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-disubstituierte pyrrolidine |
JPH0352887A (ja) * | 1989-07-20 | 1991-03-07 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
US5242935A (en) * | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US5248690A (en) * | 1992-07-07 | 1993-09-28 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US5278176A (en) * | 1992-08-21 | 1994-01-11 | Abbott Laboratories | Nicotine derivatives that enhance cognitive function |
IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
US5472958A (en) * | 1994-08-29 | 1995-12-05 | Abbott Laboratories | 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function |
US5703100A (en) * | 1994-11-10 | 1997-12-30 | Sibia Neurosciences, Inc. | Modulators of acetylcholine receptors |
IL118279A (en) * | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
-
1996
- 1996-06-06 US US08/660,044 patent/US5629325A/en not_active Expired - Lifetime
-
1997
- 1997-04-18 US US08/844,540 patent/US6127386A/en not_active Expired - Lifetime
- 1997-06-04 PT PT97927830T patent/PT934308E/pt unknown
- 1997-06-04 DE DE69730229T patent/DE69730229T2/de not_active Expired - Lifetime
- 1997-06-04 CA CA002256022A patent/CA2256022C/en not_active Expired - Fee Related
- 1997-06-04 DK DK97927830T patent/DK0934308T3/da active
- 1997-06-04 JP JP50068698A patent/JP4486712B2/ja not_active Expired - Fee Related
- 1997-06-04 WO PCT/US1997/009167 patent/WO1997046554A1/en active IP Right Grant
- 1997-06-04 AT AT97927830T patent/ATE273296T1/de not_active IP Right Cessation
- 1997-06-04 ES ES97927830T patent/ES2229364T3/es not_active Expired - Lifetime
- 1997-06-04 EP EP97927830A patent/EP0934308B1/en not_active Expired - Lifetime
-
2009
- 2009-06-23 JP JP2009148236A patent/JP2009256360A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
ATE273296T1 (de) | 2004-08-15 |
EP0934308B1 (en) | 2004-08-11 |
ES2229364T3 (es) | 2005-04-16 |
US6127386A (en) | 2000-10-03 |
JP2009256360A (ja) | 2009-11-05 |
WO1997046554A1 (en) | 1997-12-11 |
DE69730229D1 (de) | 2004-09-16 |
JP2002515038A (ja) | 2002-05-21 |
CA2256022A1 (en) | 1997-12-11 |
CA2256022C (en) | 2008-07-29 |
EP0934308A1 (en) | 1999-08-11 |
DK0934308T3 (da) | 2004-12-06 |
DE69730229T2 (de) | 2005-07-28 |
JP4486712B2 (ja) | 2010-06-23 |
US5629325A (en) | 1997-05-13 |
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