DE69730229D1 - 3-pyridyloxymethyl heterocyclische ether verbindungen für die kontrolle chemischer synaptischer übertragung - Google Patents

3-pyridyloxymethyl heterocyclische ether verbindungen für die kontrolle chemischer synaptischer übertragung

Info

Publication number
DE69730229D1
DE69730229D1 DE69730229T DE69730229T DE69730229D1 DE 69730229 D1 DE69730229 D1 DE 69730229D1 DE 69730229 T DE69730229 T DE 69730229T DE 69730229 T DE69730229 T DE 69730229T DE 69730229 D1 DE69730229 D1 DE 69730229D1
Authority
DE
Germany
Prior art keywords
ether compounds
synaptic transmission
heterocyclic ether
controlling chemical
chemical synaptic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69730229T
Other languages
English (en)
Other versions
DE69730229T2 (de
Inventor
Nan-Horng Lin
Yun He
W Holladay
Keith Ryther
Yihong Li
Hao Bai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69730229D1 publication Critical patent/DE69730229D1/de
Application granted granted Critical
Publication of DE69730229T2 publication Critical patent/DE69730229T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69730229T 1996-06-06 1997-06-04 3-pyridyloxymethyl heterocyclische ether verbindungen für die kontrolle chemischer synaptischer übertragung Expired - Lifetime DE69730229T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/660,044 US5629325A (en) 1996-06-06 1996-06-06 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US660044 1996-06-06
US08/844,540 US6127386A (en) 1996-06-06 1997-04-18 3-Pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US844540 1997-04-18
PCT/US1997/009167 WO1997046554A1 (en) 1996-06-06 1997-06-04 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Publications (2)

Publication Number Publication Date
DE69730229D1 true DE69730229D1 (de) 2004-09-16
DE69730229T2 DE69730229T2 (de) 2005-07-28

Family

ID=24647894

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69730229T Expired - Lifetime DE69730229T2 (de) 1996-06-06 1997-06-04 3-pyridyloxymethyl heterocyclische ether verbindungen für die kontrolle chemischer synaptischer übertragung

Country Status (10)

Country Link
US (2) US5629325A (de)
EP (1) EP0934308B1 (de)
JP (2) JP4486712B2 (de)
AT (1) ATE273296T1 (de)
CA (1) CA2256022C (de)
DE (1) DE69730229T2 (de)
DK (1) DK0934308T3 (de)
ES (1) ES2229364T3 (de)
PT (1) PT934308E (de)
WO (1) WO1997046554A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6979695B2 (en) * 1996-04-23 2005-12-27 Targacept, Inc. Compounds capable of activating cholinergic receptors
US20020052497A1 (en) * 2000-03-09 2002-05-02 Targacept, Inc. Compounds capable of activating cholinergic receptors
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US6437138B1 (en) 1996-06-06 2002-08-20 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US6133253A (en) * 1996-12-10 2000-10-17 Abbott Laboratories 3-Pyridyl enantiomers and their use as analgesics
DE69717148T2 (de) * 1996-12-10 2003-10-02 Abbott Laboratories, Abbott Park 3-pyridylenantiomere und ihre verwendung als analgetika
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
WO1999024422A1 (en) * 1997-11-05 1999-05-20 Neurosearch A/S Azaring-ether derivatives and their use as nicotinic ach receptor modulators
DE69822668T2 (de) * 1997-12-19 2005-03-10 Abbott Laboratories, Abbott Park Heterozyklische ether- und thioether-verbindungen, verwendbar zur steuerung von chemischer synaptischer transmission
EP1068186A2 (de) 1998-04-02 2001-01-17 Targacept, Inc. 3-pyridylalkoxyamine oder aryloxyalkylamine derivate als cholinergische agonisten
US6723838B1 (en) 1998-04-22 2004-04-20 Johns Hopkins University Signal transducing synaptic molecules and uses thereof
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
CA2334002A1 (en) 1998-06-03 1999-12-09 Mark H. Norman N-linked sulphonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
US6232316B1 (en) 1998-06-16 2001-05-15 Targacept, Inc. Methods for treatment of CNS disorders
US20050131034A1 (en) * 1998-06-16 2005-06-16 Caldwell William S. Compounds capable of activating cholinergic receptors
WO1999065876A1 (en) * 1998-06-16 1999-12-23 R.J. Reynolds Tobacco Company Aryl substituted olefinic amines and their use as cholinergic receptors agonists
US7790757B2 (en) * 1998-06-16 2010-09-07 Targacept, Inc. Compounds capable of activating cholinergic receptors
DK1107965T3 (da) * 1998-08-25 2004-11-29 Ortho Mcneil Pharm Inc Pyridylethere og -thioethere som nikotin-acetylcholinreceptorligander og deres terapeutiske anvendelse
AU3587300A (en) * 1999-02-03 2000-08-25 Schering Aktiengesellschaft Ether derivatives
US6284779B1 (en) 1999-02-03 2001-09-04 Schering Aktiiengesellschaft Heteroaromatic compounds
US6833370B1 (en) * 1999-05-21 2004-12-21 Abbott Laboratories Heterocycle substituted aminoazacycles useful as central nervous system agents
US20010031771A1 (en) 1999-05-24 2001-10-18 Gary Maurice Dull Pharmaceutical compositions and methods for use
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
MXPA02002115A (es) * 1999-09-14 2002-10-31 Abbott Lab Compuestos de eter 3-pirrolidiniloxi-3'-piridilico, utiles para controlar la transmision sinaptica quimica. .
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
MXPA02006134A (es) 1999-12-21 2002-12-13 Guilford Pharm Inc Compuestos derivados de hidantoina, composiciones farmaceuticas y metodos de uso de los mismos.
US6277855B1 (en) 2000-04-21 2001-08-21 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with nicotinic acetylcholine receptor agonists
US6448276B1 (en) 2000-05-17 2002-09-10 Inspire Pharmaceuticals, Inc. Method for treating vaginal dryness with nicotinic acetylcholine receptor agonists
US8124625B2 (en) * 2001-09-14 2012-02-28 Shionogi & Co., Ltd. Method of enhancing the expression of apolipoprotein AI using olefin derivatives
AU2002353147A1 (en) * 2001-12-13 2003-06-30 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
US20030187026A1 (en) * 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
WO2003082191A2 (en) * 2002-03-28 2003-10-09 Merck & Co., Inc. Substituted 2,3-diphenyl pyridines
US7098331B2 (en) 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
US8030300B2 (en) * 2003-06-10 2011-10-04 Georgetown University Ligands for nicotinic acetylcholine receptors, and methods of making and using them
WO2005085227A1 (en) * 2004-03-02 2005-09-15 Smithkline Beecham Corporation Inhibitors of akt activity
CA2563023C (en) * 2004-04-02 2012-01-24 Arterial Remodelling Technologies, Inc. Polymer-based stent assembly
JP5254616B2 (ja) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達
US9029557B2 (en) 2004-12-07 2015-05-12 The Regents Of The University Of California Labeled A4B2 ligands and methods therefor
US8378109B2 (en) * 2004-12-07 2013-02-19 The Regents Of The University Of California Labeled ALPHA4BETA2 ligands and methods therefor
GB0428514D0 (en) * 2004-12-31 2005-02-09 Prosidion Ltd Compounds
WO2006125641A2 (en) * 2005-05-25 2006-11-30 Basf Aktiengesellschaft Pyridine compounds for combating arthropod pests and nematodes
US20090215857A1 (en) * 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
US20070184490A1 (en) * 2006-01-17 2007-08-09 Marleen Verlinden Neuronal nicotinic receptor ligands and their use
WO2008065145A1 (en) * 2006-11-29 2008-06-05 Basf Se Pyridine compounds for combating pests
WO2008122049A2 (en) 2007-04-02 2008-10-09 Parkinson's Institute Methods and compositions for reduction of side effects of therapeutic treatments
US8653262B2 (en) * 2007-05-31 2014-02-18 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists and uses thereof
CN102112469B (zh) * 2008-05-23 2014-09-10 乔治敦大学 神经元nAChR的安静减敏剂及其使用方法
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
KR20110091501A (ko) * 2008-10-14 2011-08-11 싸이코제닉스 아이엔씨. 니코틴성 아세틸콜린 수용체 리간드 및 이들의 용도
WO2010059393A1 (en) * 2008-10-30 2010-05-27 Janssen Pharmaceutica Nv Serotonin receptor modulators
US20100125094A1 (en) * 2008-11-17 2010-05-20 Auspex Pharmaceuticals, Inc. Pyrrolidinyl modulators of nicotinic acetylcholine receptors
PL2379525T3 (pl) 2008-12-19 2016-01-29 Centrexion Therapeutics Corp Cykliczne pirymidyno-4-karboksamidy jako antagoniści receptora CCR2 do leczenia stanów zapalnych, astmy oraz COPD
MX2012006484A (es) 2009-12-07 2012-08-01 Targacept Inc 3,6-diazabiciclo [3.1.1] heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina.
JP5632014B2 (ja) 2009-12-17 2014-11-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト及びこれらの使用
CA2792157A1 (en) * 2010-03-11 2011-09-15 Targacept, Inc. Arylvinylazacycloalkane compounds for constipation
EP2569298B1 (de) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Neuartige ccr2-rezeptorantagnonisten, herstellungsverfahren dafür und verwendung davon als medikamente
EP2569295B1 (de) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH Neue ccr2-rezeptorantagnonisten, herstellungsverfahren dafür und verwendung davon als medikamente
JP5647339B2 (ja) 2010-05-17 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２アンタゴニスト及びこれらの使用
EP2576542B1 (de) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Zur Behandlung von Atemwegs-, Schmerz,- Immun- und cardoivaskulären Erkrankungen geeignete cyclische Amidderivate von Pyridazin-3-carbonsäuren
US8962656B2 (en) * 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
EP2611788B1 (de) * 2010-09-03 2017-04-12 University of Florida Research Foundation, Incorporated Nikotinverbindungen und analoga davon, syntheseverfahren zur herstellung von verbindungen und verfahren zu ihrer verwendung
EP2731941B1 (de) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Neuartige und selektive ccr2-antagonisten
EP2776423B1 (de) * 2011-11-11 2020-05-06 Georgetown University Phenylsubstituierte nikotinische liganden und verwendungsverfahren dafür
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP3250258A4 (de) 2015-01-28 2018-09-05 Chrono Therapeutics, Inc. Verfahren und systeme zur wirkstofffreisetzung
WO2017004537A1 (en) 2015-07-02 2017-01-05 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
JP2020503950A (ja) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 経皮薬剤送達の装置及び方法
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems
WO2024146945A1 (en) 2023-01-07 2024-07-11 Syngenta Crop Protection Ag Novel carboxamide and sulfonamide pesticidal compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4592866A (en) * 1982-09-30 1986-06-03 A. H. Robins Company, Inc. Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
ZA848275B (en) * 1983-12-28 1985-08-28 Degussa New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US4956359A (en) * 1985-02-28 1990-09-11 A. H. Robins Company, Inc. 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics
DE3641343A1 (de) * 1986-12-03 1988-06-16 Hoechst Ag Carbamoylimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
EP0287908A3 (de) * 1987-04-18 1989-12-27 ASTA Medica Aktiengesellschaft Neue stickstoffhaltige, cycloaliphatische Verbindungen mit einem Aminosäurerest sowie einem Pyridinrest
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
JPH0352887A (ja) * 1989-07-20 1991-03-07 Yoshitomi Pharmaceut Ind Ltd ピリジン化合物
US5242935A (en) * 1992-03-06 1993-09-07 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US5248690A (en) * 1992-07-07 1993-09-28 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US5278176A (en) * 1992-08-21 1994-01-11 Abbott Laboratories Nicotine derivatives that enhance cognitive function
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5472958A (en) * 1994-08-29 1995-12-05 Abbott Laboratories 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function
US5703100A (en) * 1994-11-10 1997-12-30 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
IL118279A (en) * 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Also Published As

Publication number Publication date
WO1997046554A1 (en) 1997-12-11
PT934308E (pt) 2004-11-30
JP2009256360A (ja) 2009-11-05
CA2256022C (en) 2008-07-29
JP4486712B2 (ja) 2010-06-23
ATE273296T1 (de) 2004-08-15
EP0934308B1 (de) 2004-08-11
EP0934308A1 (de) 1999-08-11
DK0934308T3 (da) 2004-12-06
DE69730229T2 (de) 2005-07-28
US6127386A (en) 2000-10-03
ES2229364T3 (es) 2005-04-16
JP2002515038A (ja) 2002-05-21
US5629325A (en) 1997-05-13
CA2256022A1 (en) 1997-12-11

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