ATE273296T1 - 3-pyridyloxymethyl heterocyclische ether verbindungen für die kontrolle chemischer synaptischer übertragung - Google Patents
3-pyridyloxymethyl heterocyclische ether verbindungen für die kontrolle chemischer synaptischer übertragungInfo
- Publication number
- ATE273296T1 ATE273296T1 AT97927830T AT97927830T ATE273296T1 AT E273296 T1 ATE273296 T1 AT E273296T1 AT 97927830 T AT97927830 T AT 97927830T AT 97927830 T AT97927830 T AT 97927830T AT E273296 T1 ATE273296 T1 AT E273296T1
- Authority
- AT
- Austria
- Prior art keywords
- ether compounds
- synaptic transmission
- heterocyclic ether
- controlling chemical
- chemical synaptic
- Prior art date
Links
- -1 3-PYRIDYLOXYMETHYL Chemical class 0.000 title abstract 2
- 230000005062 synaptic transmission Effects 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 108091006146 Channels Proteins 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/660,044 US5629325A (en) | 1996-06-06 | 1996-06-06 | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| US08/844,540 US6127386A (en) | 1996-06-06 | 1997-04-18 | 3-Pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| PCT/US1997/009167 WO1997046554A1 (en) | 1996-06-06 | 1997-06-04 | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273296T1 true ATE273296T1 (de) | 2004-08-15 |
Family
ID=24647894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97927830T ATE273296T1 (de) | 1996-06-06 | 1997-06-04 | 3-pyridyloxymethyl heterocyclische ether verbindungen für die kontrolle chemischer synaptischer übertragung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5629325A (de) |
| EP (1) | EP0934308B1 (de) |
| JP (2) | JP4486712B2 (de) |
| AT (1) | ATE273296T1 (de) |
| CA (1) | CA2256022C (de) |
| DE (1) | DE69730229T2 (de) |
| DK (1) | DK0934308T3 (de) |
| ES (1) | ES2229364T3 (de) |
| PT (1) | PT934308E (de) |
| WO (1) | WO1997046554A1 (de) |
Families Citing this family (78)
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| US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| US20020052497A1 (en) * | 2000-03-09 | 2002-05-02 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| US6437138B1 (en) | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| US6133253A (en) * | 1996-12-10 | 2000-10-17 | Abbott Laboratories | 3-Pyridyl enantiomers and their use as analgesics |
| IL130083A0 (en) * | 1996-12-10 | 2000-02-29 | Abbott Lab | 3-Pyridyl enantiomers and their use as analgesics |
| US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
| ATE247104T1 (de) * | 1997-11-05 | 2003-08-15 | Neurosearch As | Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren |
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| US6723838B1 (en) | 1998-04-22 | 2004-04-20 | Johns Hopkins University | Signal transducing synaptic molecules and uses thereof |
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| PL2379525T3 (pl) | 2008-12-19 | 2016-01-29 | Centrexion Therapeutics Corp | Cykliczne pirymidyno-4-karboksamidy jako antagoniści receptora CCR2 do leczenia stanów zapalnych, astmy oraz COPD |
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| JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
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| EP2571870B1 (de) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Ccr2-antagonisten und verwendungen dafür |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
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| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| US9346784B2 (en) | 2011-11-11 | 2016-05-24 | Georgetown University | Phenyl-substituted nicotinic ligands, and methods of use thereof |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2970177A1 (de) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indolverbindungen zur ampk-aktivierung |
| JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 薬剤送達方法及びシステム |
| CA2990460C (en) | 2015-07-02 | 2023-10-17 | Centrexion Therapeutics Corporation | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate |
| WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| EP3801732A4 (de) | 2018-05-29 | 2022-04-27 | Morningside Venture Investments Limited | Verfahren und systeme zur wirkstofffreisetzung |
| JP2022507660A (ja) | 2018-11-16 | 2022-01-18 | モーニングサイド ベンチャー インベストメンツ リミテッド | 温度によって調節される経皮薬剤送達システム |
| AR131541A1 (es) | 2023-01-07 | 2025-04-09 | Syngenta Crop Protection Ag | Compuestos de carboxamida novedosos |
| WO2025109114A1 (en) | 2023-11-24 | 2025-05-30 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| WO2025149637A1 (en) | 2024-01-12 | 2025-07-17 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| PY2501648A (es) | 2024-01-12 | 2025-10-31 | Syngenta Crop Prot Ag | Nuevos compuestos de carboxamida |
| WO2026008750A1 (en) | 2024-07-05 | 2026-01-08 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
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| US4592866A (en) * | 1982-09-30 | 1986-06-03 | A. H. Robins Company, Inc. | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof |
| ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
| US4956359A (en) * | 1985-02-28 | 1990-09-11 | A. H. Robins Company, Inc. | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics |
| DE3641343A1 (de) * | 1986-12-03 | 1988-06-16 | Hoechst Ag | Carbamoylimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| EP0287908A3 (de) * | 1987-04-18 | 1989-12-27 | ASTA Medica Aktiengesellschaft | Neue stickstoffhaltige, cycloaliphatische Verbindungen mit einem Aminosäurerest sowie einem Pyridinrest |
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| DE3835291A1 (de) * | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-disubstituierte pyrrolidine |
| JPH0352887A (ja) * | 1989-07-20 | 1991-03-07 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
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| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
-
1996
- 1996-06-06 US US08/660,044 patent/US5629325A/en not_active Expired - Lifetime
-
1997
- 1997-04-18 US US08/844,540 patent/US6127386A/en not_active Expired - Lifetime
- 1997-06-04 PT PT97927830T patent/PT934308E/pt unknown
- 1997-06-04 JP JP50068698A patent/JP4486712B2/ja not_active Expired - Fee Related
- 1997-06-04 AT AT97927830T patent/ATE273296T1/de not_active IP Right Cessation
- 1997-06-04 WO PCT/US1997/009167 patent/WO1997046554A1/en not_active Ceased
- 1997-06-04 DE DE69730229T patent/DE69730229T2/de not_active Expired - Lifetime
- 1997-06-04 DK DK97927830T patent/DK0934308T3/da active
- 1997-06-04 ES ES97927830T patent/ES2229364T3/es not_active Expired - Lifetime
- 1997-06-04 CA CA002256022A patent/CA2256022C/en not_active Expired - Fee Related
- 1997-06-04 EP EP97927830A patent/EP0934308B1/de not_active Expired - Lifetime
-
2009
- 2009-06-23 JP JP2009148236A patent/JP2009256360A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US5629325A (en) | 1997-05-13 |
| EP0934308B1 (de) | 2004-08-11 |
| DK0934308T3 (da) | 2004-12-06 |
| JP2009256360A (ja) | 2009-11-05 |
| CA2256022C (en) | 2008-07-29 |
| ES2229364T3 (es) | 2005-04-16 |
| EP0934308A1 (de) | 1999-08-11 |
| DE69730229D1 (de) | 2004-09-16 |
| PT934308E (pt) | 2004-11-30 |
| JP2002515038A (ja) | 2002-05-21 |
| CA2256022A1 (en) | 1997-12-11 |
| WO1997046554A1 (en) | 1997-12-11 |
| JP4486712B2 (ja) | 2010-06-23 |
| DE69730229T2 (de) | 2005-07-28 |
| US6127386A (en) | 2000-10-03 |
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