DE69608804D1 - Di- und trivalente kleine moleküle als selektininhibitoren - Google Patents

Di- und trivalente kleine moleküle als selektininhibitoren

Info

Publication number
DE69608804D1
DE69608804D1 DE69608804T DE69608804T DE69608804D1 DE 69608804 D1 DE69608804 D1 DE 69608804D1 DE 69608804 T DE69608804 T DE 69608804T DE 69608804 T DE69608804 T DE 69608804T DE 69608804 D1 DE69608804 D1 DE 69608804D1
Authority
DE
Germany
Prior art keywords
trivalent
dial
small molecules
selective inhibitors
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69608804T
Other languages
English (en)
Other versions
DE69608804T2 (de
Inventor
P Kogan
Brian Dupre
L Scott
Huong Bui
L Wheeler
M Keller
M Kassir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Encysive Pharmaceuticals Inc
Original Assignee
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp
Application granted granted Critical
Publication of DE69608804D1 publication Critical patent/DE69608804D1/de
Publication of DE69608804T2 publication Critical patent/DE69608804T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
DE69608804T 1995-06-29 1996-06-26 Di- und trivalente kleine moleküle als selektininhibitoren Expired - Lifetime DE69608804T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53395P 1995-06-29 1995-06-29
US278495P 1995-06-29 1995-06-29
PCT/US1996/011032 WO1997001335A1 (en) 1995-06-29 1996-06-26 Di- and trivalent small molecule selectin inhibitors

Publications (2)

Publication Number Publication Date
DE69608804D1 true DE69608804D1 (de) 2000-07-13
DE69608804T2 DE69608804T2 (de) 2000-11-02

Family

ID=26667782

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69608804T Expired - Lifetime DE69608804T2 (de) 1995-06-29 1996-06-26 Di- und trivalente kleine moleküle als selektininhibitoren

Country Status (21)

Country Link
EP (1) EP0840606B1 (de)
JP (1) JP4046351B2 (de)
KR (1) KR100438136B1 (de)
CN (1) CN1149082C (de)
AT (1) ATE193647T1 (de)
AU (1) AU704596B2 (de)
BR (1) BR9608873A (de)
CA (1) CA2221991C (de)
CZ (1) CZ290072B6 (de)
DE (1) DE69608804T2 (de)
DK (1) DK0840606T3 (de)
ES (1) ES2146886T3 (de)
FI (1) FI974618A0 (de)
GR (1) GR3034289T3 (de)
HU (1) HU224590B1 (de)
NO (1) NO310623B1 (de)
PL (1) PL185372B1 (de)
PT (1) PT840606E (de)
RU (1) RU2165931C2 (de)
UA (1) UA52607C2 (de)
WO (1) WO1997001335A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031697A1 (en) * 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
AU1903699A (en) * 1997-12-08 1999-06-28 Glycomed Incorporated Disalicylate analog based sialyl lewisx mimetics
AU5625499A (en) * 1998-09-04 2000-03-27 Altana Pharma Ag Novel pyranoses
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
GB9924990D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicaments
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
EP1577289A1 (de) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen.
PL2264043T3 (pl) 2005-09-02 2018-04-30 Glycomimetics, Inc. Heterobifunkcyjne inhibitory pan-selektyny
EP1764093A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue aromatische Verbindungen und deren medizinische Verwendung
EP1764096A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität
EP1764095A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Nitrocatecholderivate mit Selectin-Ligand-Activität
KR100827674B1 (ko) * 2006-05-23 2008-05-07 (주)한빛테크 자동트립 장치와 그 제어방법
EP1897533A1 (de) * 2006-09-08 2008-03-12 Revotar Biopharmaceuticals AG Verwendung von 1,6-Bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D-mannopyranosyl-oxy)-phenyl]hexan zur Herstellung von kosmetischen Zusammensetzungen
EP1903049A1 (de) * 2006-09-08 2008-03-26 Revotar Biopharmaceuticals AG Kristalline Formen von 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane
EP1958637A1 (de) * 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Pharmazeutische Zusammensetzung zur Behandlung von IL-8-vermittelten Erkrankungen
KR20100135711A (ko) 2007-12-20 2010-12-27 엔비보 파마슈티칼즈, 인코퍼레이티드 사중치환된 벤젠
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
WO2011138365A1 (en) * 2010-05-07 2011-11-10 Revotar Biopharmaceuticals Ag Process for the preparation of bimosiamose
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
PL2794626T6 (pl) 2011-12-22 2020-11-02 Glycomimetics, Inc. Związki antagonistyczne E-selektyny
PL2928476T3 (pl) 2012-12-07 2018-07-31 Glycomimetics, Inc. Związki, kompozycje i sposoby wykorzystujące antagonistów e-selektyny do mobilizacji komórek hematopoietycznych
AU2015355136B2 (en) 2014-12-03 2020-06-25 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498604A (en) * 1992-01-31 1996-03-12 Nippon Shinyaku Company, Limited Lewis-type sugar chain derivative
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation

Also Published As

Publication number Publication date
JPH11508885A (ja) 1999-08-03
CA2221991A1 (en) 1997-01-16
AU6292396A (en) 1997-01-30
EP0840606B1 (de) 2000-06-07
ES2146886T3 (es) 2000-08-16
ATE193647T1 (de) 2000-06-15
BR9608873A (pt) 1999-07-06
NO976074D0 (no) 1997-12-23
KR100438136B1 (ko) 2004-08-25
EP0840606A4 (de) 1998-05-13
NO310623B1 (no) 2001-07-30
CN1196678A (zh) 1998-10-21
FI974618A (fi) 1997-12-23
CN1149082C (zh) 2004-05-12
WO1997001335A1 (en) 1997-01-16
HUP9802602A3 (en) 1999-08-30
DK0840606T3 (da) 2000-08-07
KR19990028441A (ko) 1999-04-15
CA2221991C (en) 2007-09-18
NO976074L (no) 1998-03-02
DE69608804T2 (de) 2000-11-02
FI974618A0 (fi) 1997-12-23
JP4046351B2 (ja) 2008-02-13
PL185372B1 (pl) 2003-04-30
GR3034289T3 (en) 2000-12-29
AU704596B2 (en) 1999-04-29
UA52607C2 (uk) 2003-01-15
PL324330A1 (en) 1998-05-25
PT840606E (pt) 2000-11-30
CZ407597A3 (cs) 1998-07-15
CZ290072B6 (cs) 2002-05-15
EP0840606A1 (de) 1998-05-13
HUP9802602A2 (hu) 1999-02-01
RU2165931C2 (ru) 2001-04-27
HU224590B1 (hu) 2005-11-28

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Legal Events

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