ES2145996T3 - Piridinas sustituidas con 3,4-diarilo para el tratamiento de la inflamacion. - Google Patents

Piridinas sustituidas con 3,4-diarilo para el tratamiento de la inflamacion.

Info

Publication number
ES2145996T3
ES2145996T3 ES96903715T ES96903715T ES2145996T3 ES 2145996 T3 ES2145996 T3 ES 2145996T3 ES 96903715 T ES96903715 T ES 96903715T ES 96903715 T ES96903715 T ES 96903715T ES 2145996 T3 ES2145996 T3 ES 2145996T3
Authority
ES
Spain
Prior art keywords
inflammation
substituted
piridines
diaryl
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96903715T
Other languages
English (en)
Inventor
Len F Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23527293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2145996(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2145996T3 publication Critical patent/ES2145996T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Abstract

SE DESCRIBE UNA CLASE DE COMPUESTOS PIRIDIL SUSTITUIDOS PARA EL TRATAMIENTO DE LA INFLAMACION Y DE LOS TRASTORNOS RELACIONADOS CON LA INFLAMACION. LOS COMPUESTOS DE PARTICULAR INTERES SE DEFINEN POR LA FORMULA (I), DONDE R{SUP,1} ES HALOALQUILO; DONDE R{SUP,2} ES ARILO OPCIONALMENTE SUSTITUIDO EN UNA POSICION SUSTITUIBLE CON UNO O MAS RADICALES INDEPENDIENTEMENTE SELECCIONADOS A PARTIR DE ALQUIL ARBOXILO, ALCOXICARBONILO, HALOALQUILO, HIDROXILO, HIDROXIALQUILO, HALOALCOXI, AMINO, ALQUILAMINO, ARILAMINO, NITRO, HALO, ALCOXI Y ALQUILTIO; DONDE R{SUP,3} ES ARIL SUSTITUIDO EN UNA POSICION SUSTITUIBLE CON UN RADICAL SELECCIONADO A PARTIR DE ALQUILSULFONILO Y SULFAMILO; Y DONDE R{SUP,4} SE SELECCIONA DE ENTRE HALO, ALCOXI Y ALQUINILOXI; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS.
ES96903715T 1995-02-10 1996-02-08 Piridinas sustituidas con 3,4-diarilo para el tratamiento de la inflamacion. Expired - Lifetime ES2145996T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/386,843 US5596008A (en) 1995-02-10 1995-02-10 3,4-Diaryl substituted pyridines for the treatment of inflammation

Publications (1)

Publication Number Publication Date
ES2145996T3 true ES2145996T3 (es) 2000-07-16

Family

ID=23527293

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96903715T Expired - Lifetime ES2145996T3 (es) 1995-02-10 1996-02-08 Piridinas sustituidas con 3,4-diarilo para el tratamiento de la inflamacion.

Country Status (10)

Country Link
US (1) US5596008A (es)
EP (1) EP0808305B1 (es)
AT (1) ATE192436T1 (es)
AU (1) AU4770796A (es)
DE (1) DE69608096T2 (es)
DK (1) DK0808305T3 (es)
ES (1) ES2145996T3 (es)
GR (1) GR3033428T3 (es)
PT (1) PT808305E (es)
WO (1) WO1996024585A1 (es)

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IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
PT1479385E (pt) 1996-10-15 2008-09-02 Searle Llc Utilização de inibidores de ciclo-oxigenase 2 no tratamento e na prevenção de neoplasias
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US7041694B1 (en) 1997-12-17 2006-05-09 Cornell Research Foundation, Inc. Cyclooxygenase-2 inhibition
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
EP1394149B1 (de) * 1999-01-14 2005-01-19 Lonza AG Verfahren zur Herstellung von 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)-phenyl]ethanon
KR100446324B1 (ko) 1999-01-14 2004-08-30 론자 아게 1-(6-메틸피리딘-3-일)-2-[4-(메틸술포닐)페닐]에타논 및이의 제조 방법
ES2236007T3 (es) * 1999-12-08 2005-07-16 Pharmacia Corporation Composiciones de inhibidor de ciclooxigenasa-2 ue tiene un efecto terapeutico rapido.
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
AU5754701A (en) * 2000-07-13 2002-01-30 Pharmacia Corp Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US7695736B2 (en) 2001-04-03 2010-04-13 Pfizer Inc. Reconstitutable parenteral composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
GB0119477D0 (en) 2001-08-09 2001-10-03 Glaxo Group Ltd Pyrimidine derivatives
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US7329401B2 (en) 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
DE60305053T2 (de) 2002-08-19 2006-08-31 Glaxo Group Ltd., Greenford Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
ES2341240T3 (es) 2002-12-13 2010-06-17 Warner-Lambert Company Llc Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
JP4354984B2 (ja) 2003-05-07 2009-10-28 オステオロジックス エイ／エス 水溶性ストロンチウム塩を用いる軟骨／骨症状の治療
WO2005044227A1 (en) * 2003-11-05 2005-05-19 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions
US20050100594A1 (en) * 2003-11-12 2005-05-12 Nilendu Sen Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
EP1708718A1 (en) 2004-01-22 2006-10-11 Pfizer Limited Triazole derivatives which inhibit vasopressin antagonistic activity
US7429667B2 (en) 2005-01-20 2008-09-30 Ardea Biosciences, Inc. Phenylamino isothiazole carboxamidines as MEK inhibitors
WO2006113704A2 (en) * 2005-04-18 2006-10-26 Neurogen Corporation Subtituted heteroaryl cb1 antagonists
EP1767161A1 (en) * 2005-09-22 2007-03-28 Zimmer Spine, Inc. Spinal fixation rod contouring system
ES2600804T3 (es) * 2006-01-19 2017-02-10 Orchid Pharma Limited Nuevos heterociclos
WO2007121269A2 (en) 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors
CN101454004B (zh) * 2006-04-18 2013-12-04 阿迪亚生命科学公司 作为mek抑制剂的吡啶酮磺酰胺类和吡啶酮硫酰胺类
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
CN101600458A (zh) 2006-12-22 2009-12-09 瑞蔻达蒂爱尔兰有限公司 采用α2δ配体和NSAID的下泌尿道疾病的联合治疗
JP2010516679A (ja) * 2007-01-19 2010-05-20 マリンクロット インコーポレイテッド 診断用および治療用シクロオキシゲナーゼ−２結合リガンド
US8509487B2 (en) * 2007-04-19 2013-08-13 Avago Technologies General Ip (Singapore) Pte. Ltd. System and method for optically measuring a parameter of an object
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US5593994A (en) * 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors

Also Published As

Publication number Publication date
EP0808305B1 (en) 2000-05-03
ATE192436T1 (de) 2000-05-15
WO1996024585A1 (en) 1996-08-15
DK0808305T3 (da) 2000-08-28
EP0808305A1 (en) 1997-11-26
DE69608096T2 (de) 2000-11-02
DE69608096D1 (de) 2000-06-08
US5596008A (en) 1997-01-21
PT808305E (pt) 2000-10-31
GR3033428T3 (en) 2000-09-29
AU4770796A (en) 1996-08-27

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