ATE192436T1 - 3,4-diarryl substituierte pyridine zur behandlung von entzündungen - Google Patents

3,4-diarryl substituierte pyridine zur behandlung von entzündungen

Info

Publication number
ATE192436T1
ATE192436T1 AT96903715T AT96903715T ATE192436T1 AT E192436 T1 ATE192436 T1 AT E192436T1 AT 96903715 T AT96903715 T AT 96903715T AT 96903715 T AT96903715 T AT 96903715T AT E192436 T1 ATE192436 T1 AT E192436T1
Authority
AT
Austria
Prior art keywords
inflammation
diarryl
treatment
haloalkyl
halo
Prior art date
Application number
AT96903715T
Other languages
English (en)
Inventor
Len F Lee
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23527293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE192436(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE192436T1 publication Critical patent/ATE192436T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
AT96903715T 1995-02-10 1996-02-08 3,4-diarryl substituierte pyridine zur behandlung von entzündungen ATE192436T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/386,843 US5596008A (en) 1995-02-10 1995-02-10 3,4-Diaryl substituted pyridines for the treatment of inflammation
PCT/US1996/001110 WO1996024585A1 (en) 1995-02-10 1996-02-08 3,4-diaryl substituted pyridines for the treatment of inflammation

Publications (1)

Publication Number Publication Date
ATE192436T1 true ATE192436T1 (de) 2000-05-15

Family

ID=23527293

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96903715T ATE192436T1 (de) 1995-02-10 1996-02-08 3,4-diarryl substituierte pyridine zur behandlung von entzündungen

Country Status (10)

Country Link
US (1) US5596008A (de)
EP (1) EP0808305B1 (de)
AT (1) ATE192436T1 (de)
AU (1) AU4770796A (de)
DE (1) DE69608096T2 (de)
DK (1) DK0808305T3 (de)
ES (1) ES2145996T3 (de)
GR (1) GR3033428T3 (de)
PT (1) PT808305E (de)
WO (1) WO1996024585A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
PT1479385E (pt) 1996-10-15 2008-09-02 Searle Llc Utilização de inibidores de ciclo-oxigenase 2 no tratamento e na prevenção de neoplasias
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US7041694B1 (en) 1997-12-17 2006-05-09 Cornell Research Foundation, Inc. Cyclooxygenase-2 inhibition
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
EP1394149B1 (de) * 1999-01-14 2005-01-19 Lonza AG Verfahren zur Herstellung von 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)-phenyl]ethanon
KR100446324B1 (ko) 1999-01-14 2004-08-30 론자 아게 1-(6-메틸피리딘-3-일)-2-[4-(메틸술포닐)페닐]에타논 및이의 제조 방법
ES2236007T3 (es) * 1999-12-08 2005-07-16 Pharmacia Corporation Composiciones de inhibidor de ciclooxigenasa-2 ue tiene un efecto terapeutico rapido.
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
AU5754701A (en) * 2000-07-13 2002-01-30 Pharmacia Corp Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US7695736B2 (en) 2001-04-03 2010-04-13 Pfizer Inc. Reconstitutable parenteral composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
GB0119477D0 (en) 2001-08-09 2001-10-03 Glaxo Group Ltd Pyrimidine derivatives
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US7329401B2 (en) 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
DE60305053T2 (de) 2002-08-19 2006-08-31 Glaxo Group Ltd., Greenford Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
ES2341240T3 (es) 2002-12-13 2010-06-17 Warner-Lambert Company Llc Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
JP4354984B2 (ja) 2003-05-07 2009-10-28 オステオロジックス エイ／エス 水溶性ストロンチウム塩を用いる軟骨／骨症状の治療
WO2005044227A1 (en) * 2003-11-05 2005-05-19 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions
US20050100594A1 (en) * 2003-11-12 2005-05-12 Nilendu Sen Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
EP1708718A1 (de) 2004-01-22 2006-10-11 Pfizer Limited Triazol-derivate zur hemmung der vasopressing-antagonistischen aktivität
US7429667B2 (en) 2005-01-20 2008-09-30 Ardea Biosciences, Inc. Phenylamino isothiazole carboxamidines as MEK inhibitors
WO2006113704A2 (en) * 2005-04-18 2006-10-26 Neurogen Corporation Subtituted heteroaryl cb1 antagonists
EP1767161A1 (de) * 2005-09-22 2007-03-28 Zimmer Spine, Inc. Vorrichtung zum Modellieren eines spinalen Fixierungsstabes
ES2600804T3 (es) * 2006-01-19 2017-02-10 Orchid Pharma Limited Nuevos heterociclos
WO2007121269A2 (en) 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors
CN101454004B (zh) * 2006-04-18 2013-12-04 阿迪亚生命科学公司 作为mek抑制剂的吡啶酮磺酰胺类和吡啶酮硫酰胺类
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
CN101600458A (zh) 2006-12-22 2009-12-09 瑞蔻达蒂爱尔兰有限公司 采用α2δ配体和NSAID的下泌尿道疾病的联合治疗
JP2010516679A (ja) * 2007-01-19 2010-05-20 マリンクロット インコーポレイテッド 診断用および治療用シクロオキシゲナーゼ−２結合リガンド
US8509487B2 (en) * 2007-04-19 2013-08-13 Avago Technologies General Ip (Singapore) Pte. Ltd. System and method for optically measuring a parameter of an object
WO2008141013A1 (en) * 2007-05-08 2008-11-20 Allergan, Inc. S1p3 receptor inhibitors for treating pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6816241A (de) * 1967-12-01 1969-06-03
US3655679A (en) * 1969-06-25 1972-04-11 Merck & Co Inc Certain aryl pyridine carboxylic acid derivatives
FR2248027B2 (de) * 1973-10-18 1977-09-09 Serdex
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
US5004743A (en) * 1987-11-25 1991-04-02 Merck Frosst Canada, Inc. Pyridyl styrene dialkanoic acids as anti-leukotriene agents
US5593994A (en) * 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors

Also Published As

Publication number Publication date
EP0808305B1 (de) 2000-05-03
ES2145996T3 (es) 2000-07-16
WO1996024585A1 (en) 1996-08-15
DK0808305T3 (da) 2000-08-28
EP0808305A1 (de) 1997-11-26
DE69608096T2 (de) 2000-11-02
DE69608096D1 (de) 2000-06-08
US5596008A (en) 1997-01-21
PT808305E (pt) 2000-10-31
GR3033428T3 (en) 2000-09-29
AU4770796A (en) 1996-08-27

Similar Documents

Publication Publication Date Title
ATE192436T1 (de) 3,4-diarryl substituierte pyridine zur behandlung von entzündungen
DE69425442T2 (de) 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen
DE69611354D1 (de) 2,3-substituierte pyridine zur behandlung von entzündung
ATE224375T1 (de) 4,5-substituierte imidazolylverbindungen zur behandlung von entzundungen
TR200000059T2 (tr) Piridin türevleri
BG101934A (en) Imidazo(1,2-a)pyridine derivatives
ES2128092T3 (es) Derivados de anilina.
ATE230757T1 (de) Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten
NL300128I2 (nl) Gesubstitueerde isoxazolen voor de behandeling vanontsteking.
DK0589924T3 (da) Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser
ATE210648T1 (de) 3,4-substituierte pyrazole zur behandlung von entzündungen
DK0934308T3 (da) 3-pyridyloxymethylheterocykliske etherforbindelser anvendelige til kontrollering af kemisk synaptisk transmission
ES2193362T3 (es) Derivados de 2-pirimidinamina y su procedimiento de preparacion de los mismos.
TR199902060T2 (xx) Gastrik asit salg�lanmas�n�n inhibisyonu i�in bile�ikler.
DK1039912T3 (da) Angiostatiske midler og præparater til behandling af GLC1A-glaukom
DK142084A (da) N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf
DE69623899D1 (de) Behandlung von Tinnitus mit neuroprotektiven Wirkstoffen
ATE110718T1 (de) Halogenierte pyrimidin-3-oxid-derivate, deren verwendung für die behandlung und die verhütung von haarausfall und für die wachstumsförderung von haaren.
NO20003398D0 (no) Substituerte 2-benzylamino-2-fenyl-acetamid-forbindelser
DK0743938T3 (da) Substituerede spiroforbindelser til behandling af inflammation
ATE169917T1 (de) Imidazo (4,5-c)pyridinderivate als paf antagonisten
TR200003877T2 (tr) İnsan CD23 üretiminin ve TNF salınmasının ihhibitörleri olan hiydroxamic acid türevleri
DE69619088T2 (de) Quinoxalin-Derivate zur Behandlung von Tinnitus
DE69403896D1 (de) 4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee