DE69425442T2 - 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen - Google Patents

1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen

Info

Publication number
DE69425442T2
DE69425442T2 DE69425442T DE69425442T DE69425442T2 DE 69425442 T2 DE69425442 T2 DE 69425442T2 DE 69425442 T DE69425442 T DE 69425442T DE 69425442 T DE69425442 T DE 69425442T DE 69425442 T2 DE69425442 T2 DE 69425442T2
Authority
DE
Germany
Prior art keywords
sulfamyl
acylamino
alkoxycarbonyl
halo
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69425442T
Other languages
English (en)
Other versions
DE69425442D1 (de
Inventor
J Talley
J Rogier
D Penning
S Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69425442D1 publication Critical patent/DE69425442D1/de
Publication of DE69425442T2 publication Critical patent/DE69425442T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE69425442T 1993-11-30 1994-11-14 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen Expired - Fee Related DE69425442T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/160,517 US5434178A (en) 1993-11-30 1993-11-30 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
PCT/US1994/012722 WO1995015318A1 (en) 1993-11-30 1994-11-14 1,3,5-trisubstituted pyrazole compounds for treatment of inflammation

Publications (2)

Publication Number Publication Date
DE69425442D1 DE69425442D1 (de) 2000-09-07
DE69425442T2 true DE69425442T2 (de) 2001-02-08

Family

ID=22577200

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69425442T Expired - Fee Related DE69425442T2 (de) 1993-11-30 1994-11-14 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen

Country Status (12)

Country Link
US (1) US5434178A (de)
EP (1) EP0731796B1 (de)
JP (1) JPH09505830A (de)
AT (1) ATE195118T1 (de)
AU (1) AU1171595A (de)
CA (1) CA2177574A1 (de)
DE (1) DE69425442T2 (de)
DK (1) DK0731796T3 (de)
ES (1) ES2150545T3 (de)
GR (1) GR3034515T3 (de)
PT (1) PT731796E (de)
WO (1) WO1995015318A1 (de)

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US4146721A (en) * 1969-09-12 1979-03-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrazol-4-acetic acid compounds
JPS5012603A (de) * 1973-06-06 1975-02-08
JPS5891301A (ja) * 1981-11-24 1983-05-31 Mitsubishi Heavy Ind Ltd アキシヤルピストン型流体機械
US4862789A (en) * 1988-02-01 1989-09-05 Vickers, Incorporated Positive displacement pump or motor utilizing a self-lubricated bearing
JPH0351516A (ja) * 1989-07-18 1991-03-05 Komatsu Ltd 液圧ポンプ用ラジアル軸受装置
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same

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ATE195118T1 (de) 2000-08-15
US5434178A (en) 1995-07-18
JPH09505830A (ja) 1997-06-10
WO1995015318A1 (en) 1995-06-08
ES2150545T3 (es) 2000-12-01
EP0731796B1 (de) 2000-08-02
DE69425442D1 (de) 2000-09-07
GR3034515T3 (en) 2000-12-29
EP0731796A1 (de) 1996-09-18
DK0731796T3 (da) 2000-09-04
CA2177574A1 (en) 1995-06-08
AU1171595A (en) 1995-06-19
PT731796E (pt) 2001-01-31

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