US5466823A
(en)
*
|
1993-11-30 |
1995-11-14 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides
|
US5486534A
(en)
*
|
1994-07-21 |
1996-01-23 |
G. D. Searle & Co. |
3,4-substituted pyrazoles for the treatment of inflammation
|
US5908852A
(en)
*
|
1994-11-14 |
1999-06-01 |
G. D. Searle & Co. |
1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
|
EP0828718A1
(de)
|
1995-06-02 |
1998-03-18 |
G.D. SEARLE & CO. |
Heterocyclo-substituierte hydroxaminsäurederivate als cyclooxygenase-2 und 5-lipoxygenase inhibitoren
|
CA2224563A1
(en)
|
1995-06-12 |
1996-12-27 |
G.D. Searle & Co. |
Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations
|
US5700816A
(en)
*
|
1995-06-12 |
1997-12-23 |
Isakson; Peter C. |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
|
US5968974A
(en)
|
1995-07-19 |
1999-10-19 |
Merck & Co., Inc. |
Method of treating colonic adenomas
|
US6593361B2
(en)
|
1995-07-19 |
2003-07-15 |
Merck & Co Inc |
Method of treating colonic adenomas
|
US5756529A
(en)
*
|
1995-09-29 |
1998-05-26 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
|
GB9520584D0
(en)
*
|
1995-10-09 |
1995-12-13 |
Fujisawa Pharmaceutical Co |
Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
|
ATE296114T1
(de)
|
1996-02-13 |
2005-06-15 |
Searle & Co |
Zubereitungen, enthaltend einen cyclooxygenase-2- inhibitor und einen leukotrien-b4-rezeptor- antagonisten
|
US5908858A
(en)
*
|
1996-04-05 |
1999-06-01 |
Sankyo Company, Limited |
1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
|
DE69739003D1
(de)
|
1996-04-12 |
2008-10-30 |
Searle Llc |
Substituierte Benzensulfonamid-Derivate als Wirkstoff-Vorläufer von COX-2 Inhibitoren
|
US5677318A
(en)
*
|
1996-07-11 |
1997-10-14 |
Merck Frosst Canada, Inc. |
Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
|
PT1479385E
(pt)
|
1996-10-15 |
2008-09-02 |
Searle Llc |
Utilização de inibidores de ciclo-oxigenase 2 no tratamento e na prevenção de neoplasias
|
NZ500141A
(en)
*
|
1997-04-18 |
2002-05-31 |
G |
Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders
|
DE19744026A1
(de)
*
|
1997-10-06 |
1999-04-08 |
Hoechst Marion Roussel De Gmbh |
Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
|
US5972986A
(en)
*
|
1997-10-14 |
1999-10-26 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
|
AUPP042397A0
(en)
*
|
1997-11-18 |
1997-12-11 |
Fujisawa Pharmaceutical Co., Ltd. |
5-arylpyrazole compounds
|
US6025353A
(en)
*
|
1997-11-19 |
2000-02-15 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
|
JP2002514640A
(ja)
*
|
1998-05-14 |
2002-05-21 |
ジー・ディー・サール・アンド・カンパニー |
p38キナーゼ阻害剤としての1,5−ジアリール置換ピラゾール類
|
US6294558B1
(en)
|
1999-05-31 |
2001-09-25 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
US6727238B2
(en)
|
1998-06-11 |
2004-04-27 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
USRE39708E1
(en)
|
1998-08-07 |
2007-06-26 |
Chiron Corporation |
Estrogen receptor modulators
|
US20030013739A1
(en)
*
|
1998-12-23 |
2003-01-16 |
Pharmacia Corporation |
Methods of using a combination of cyclooxygenase-2 selective inhibitors and thalidomide for the treatment of neoplasia
|
US6649645B1
(en)
|
1998-12-23 |
2003-11-18 |
Pharmacia Corporation |
Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
|
DE69926542T2
(de)
*
|
1998-12-25 |
2006-04-27 |
Teikoku Hormone Mfg. Co., Ltd. |
Aminopyrazolderivate
|
DE19904397A1
(de)
*
|
1999-02-04 |
2000-08-10 |
Bayer Ag |
Verwendung von Pyrazol-Carbonsäureamiden
|
US6509361B1
(en)
*
|
1999-05-12 |
2003-01-21 |
Pharmacia Corporation |
1,5-Diaryl substituted pyrazoles as p38 kinase inhibitors
|
CA2377153A1
(en)
|
1999-06-16 |
2000-12-21 |
Temple University - Of The Commonwealth System Of Higher Education |
1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines as inhibitors of cyclooxygenase-2
|
EP1099695A1
(de)
*
|
1999-11-09 |
2001-05-16 |
Laboratoire Theramex S.A. |
5-Aryl-1H-1,2,4-triazolverbindungen als Cyclooxygenase-2 Inhibitoren und diese enthaltende pharmazeutische Zusammensetzungen
|
DK1104758T3
(da)
|
1999-12-03 |
2003-10-20 |
Pfizer Prod Inc |
Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler
|
JP2003517475A
(ja)
|
1999-12-03 |
2003-05-27 |
ファイザー・プロダクツ・インク |
抗炎症/鎮痛薬としてのヘテロシクロ−アルキルスルホニルピラゾール誘導体
|
DK1104760T3
(da)
|
1999-12-03 |
2003-06-30 |
Pfizer Prod Inc |
Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
|
ATE252576T1
(de)
|
1999-12-03 |
2003-11-15 |
Pfizer Prod Inc |
Heteroarylphenylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel
|
ES2236007T3
(es)
*
|
1999-12-08 |
2005-07-16 |
Pharmacia Corporation |
Composiciones de inhibidor de ciclooxigenasa-2 ue tiene un efecto terapeutico rapido.
|
US6569885B1
(en)
*
|
1999-12-23 |
2003-05-27 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
AU2001232175B2
(en)
|
2000-03-03 |
2005-07-07 |
Pfizer Products Inc. |
Pyrazole ether derivatives as anti-inflammatory/analgesic agents
|
AU5754701A
(en)
*
|
2000-07-13 |
2002-01-30 |
Pharmacia Corp |
Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
|
PE20020146A1
(es)
*
|
2000-07-13 |
2002-03-31 |
Upjohn Co |
Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
|
HUP0302068A3
(en)
*
|
2000-07-20 |
2005-05-30 |
Lauras As |
Use of cox-2 inhibitors for treating or preventing immunodeficiency and pharmaceutical compositions containing them
|
US6716829B2
(en)
|
2000-07-27 |
2004-04-06 |
Pharmacia Corporation |
Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
|
WO2002017896A2
(en)
*
|
2000-08-29 |
2002-03-07 |
Peter Van Patten |
Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid
|
US7115565B2
(en)
*
|
2001-01-18 |
2006-10-03 |
Pharmacia & Upjohn Company |
Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
|
EP1363669A2
(de)
*
|
2001-02-02 |
2003-11-26 |
Pharmacia Corporation |
Verfahren zur verwendung von einem cyclooxygenase-2 hemmer und sexsteroiden in einer kombinationstherapie zur behandlung und vorbeugung von dysmenorrhea
|
US7695736B2
(en)
|
2001-04-03 |
2010-04-13 |
Pfizer Inc. |
Reconstitutable parenteral composition
|
US20030105144A1
(en)
|
2001-04-17 |
2003-06-05 |
Ping Gao |
Stabilized oral pharmaceutical composition
|
US6673818B2
(en)
|
2001-04-20 |
2004-01-06 |
Pharmacia Corporation |
Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
|
CA2445502A1
(en)
*
|
2001-05-04 |
2002-11-14 |
Merck & Co., Inc. |
Method and compositions for treating migraines
|
US20030153801A1
(en)
*
|
2001-05-29 |
2003-08-14 |
Pharmacia Corporation |
Compositions of cyclooxygenase-2 selective inhibitors and radiation for inhibition or prevention of cardiovascular disease
|
ES2241964T3
(es)
|
2001-07-05 |
2005-11-01 |
Pfizer Products Inc. |
Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos.
|
CA2390181A1
(en)
*
|
2001-07-05 |
2003-01-05 |
Andrei Shavnya |
Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
|
UA80682C2
(en)
*
|
2001-08-06 |
2007-10-25 |
Pharmacia Corp |
Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
|
US20030114416A1
(en)
*
|
2001-08-14 |
2003-06-19 |
Pharmacia Corporation |
Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate
|
US20050101563A1
(en)
*
|
2001-08-14 |
2005-05-12 |
Pharmacia Corporation |
Method and compositions for the treatment and prevention of pain and inflammation
|
US20030236308A1
(en)
*
|
2001-09-18 |
2003-12-25 |
Pharmacia Corporation |
Compositions of cyclooxygenase-2 selective inhibitors and acetaminophen for treatment and prevention of inflammation, inflammation-mediated disorders and pain
|
US20030114483A1
(en)
*
|
2001-09-18 |
2003-06-19 |
Pharmacia Corporation |
Compositions of chromene cyclooxygenase-2 selective inhibitors and acetaminophen for treatment and prevention of inflammation, inflammation-mediated disorders and pain
|
US6849653B2
(en)
|
2001-09-19 |
2005-02-01 |
Pharmacia Corporation |
Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation
|
WO2003024935A2
(en)
|
2001-09-19 |
2003-03-27 |
Pharmacia Corporation |
Substituted pyrazolyl compounds for the treatment of inflammation
|
GT200200183A
(es)
|
2001-09-28 |
2003-05-23 |
|
Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
|
WO2003037336A1
(en)
|
2001-11-02 |
2003-05-08 |
Pfizer Products Inc. |
1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
|
US20040082940A1
(en)
*
|
2002-10-22 |
2004-04-29 |
Michael Black |
Dermatological apparatus and method
|
US20030212138A1
(en)
*
|
2002-01-14 |
2003-11-13 |
Pharmacia Corporation |
Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
|
US20030220374A1
(en)
*
|
2002-01-14 |
2003-11-27 |
Pharmacia Corporation |
Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
|
US7329401B2
(en)
*
|
2002-04-15 |
2008-02-12 |
The Regents Of The University Of California |
Cyclooxygenase-2 selective agents useful as imaging probes and related methods
|
AU2003226379A1
(en)
*
|
2002-04-18 |
2003-11-03 |
Pharmacia Corporation |
Treatment of parkinson's disease with cyclooxygenase-2 (cox 2) inhibitor(s)
|
EP1494664A2
(de)
*
|
2002-04-18 |
2005-01-12 |
Pharmacia Corporation |
Kombinationen aus cox-2-hemmer und anderen agenten zur behandlung von morbus parkinsonian
|
EP1497280A1
(de)
*
|
2002-04-22 |
2005-01-19 |
Pfizer Products Inc. |
Indol-2-one als selektive inhibitoren von cyclooxygenase-2
|
US7273616B2
(en)
*
|
2002-05-10 |
2007-09-25 |
The Trustees Of Columbia University In The City Of New York |
Genetically engineered cell lines and systems for propagating Varicella zoster virus and methods of use thereof
|
US20030225054A1
(en)
*
|
2002-06-03 |
2003-12-04 |
Jingwu Duan |
Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents
|
EP1539679A4
(de)
|
2002-06-28 |
2007-07-04 |
Nitromed Inc |
Oxim- und/oder hydrazonhaltige, nitrosierte und/oder nitrosylierte cyclooxigenase-2-selektive inhibitoren, zusammensetzungen und anwendungsverfahren
|
US20040063697A1
(en)
*
|
2002-07-02 |
2004-04-01 |
Isakson Peter C. |
Compositions of cyclooxygenase-2 selective inhibitors and thrombolytic agents for the treatment or prevention of a vaso-occlusive event
|
EP1398029A1
(de)
*
|
2002-09-10 |
2004-03-17 |
LION Bioscience AG |
3-substituierte Pyrazol-Derivate,die an den NR3B1 Rezeptor binden
|
US20040147581A1
(en)
*
|
2002-11-18 |
2004-07-29 |
Pharmacia Corporation |
Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
|
KR100470075B1
(ko)
*
|
2002-11-21 |
2005-02-05 |
씨제이 주식회사 |
1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
|
KR100470076B1
(ko)
*
|
2002-11-27 |
2005-02-05 |
씨제이 주식회사 |
1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
|
US20040235925A1
(en)
*
|
2002-12-17 |
2004-11-25 |
Pharmacia Corporation |
Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
|
US20040204411A1
(en)
*
|
2002-12-17 |
2004-10-14 |
Pharmacia Corporation |
Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
|
AU2003297397A1
(en)
*
|
2002-12-19 |
2004-07-14 |
Pharmacia Corp |
Methods and compositions for the treatment of herpes virus infections using cyclooxygenase-2 selective inhibitors or cyclooxygenase-2 inhibitors in combination with antiviral agents
|
WO2004058354A1
(en)
*
|
2002-12-20 |
2004-07-15 |
Pharmacia Corporation |
Compositions of cyclooxygenase-2 selective inhibitors and selective serotonin reuptake inhibitors for the treatment or prevention of a vaso-occlusive event
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
US20050026902A1
(en)
*
|
2003-01-31 |
2005-02-03 |
Timothy Maziasz |
Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents
|
US20070265606A1
(en)
*
|
2003-02-14 |
2007-11-15 |
Reliant Technologies, Inc. |
Method and Apparatus for Fractional Light-based Treatment of Obstructive Sleep Apnea
|
JP4354984B2
(ja)
|
2003-05-07 |
2009-10-28 |
オステオロジックス エイ/エス |
水溶性ストロンチウム塩を用いる軟骨/骨症状の治療
|
WO2005000297A1
(en)
*
|
2003-06-24 |
2005-01-06 |
Pharmacia Corporation |
Treatment of migraine accompanied by nausea
|
WO2005018561A2
(en)
*
|
2003-08-20 |
2005-03-03 |
Nitromed, Inc. |
Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
|
JP2007504136A
(ja)
*
|
2003-08-28 |
2007-03-01 |
ニトロメッド インコーポレーティッド |
ニトロソ化およびニトロシル化利尿化合物、組成物、ならびに使用方法
|
US7067159B2
(en)
*
|
2003-12-05 |
2006-06-27 |
New Chapter, Inc. |
Methods for treating prostate cancer with herbal compositions
|
US7070816B2
(en)
*
|
2003-12-05 |
2006-07-04 |
New Chapter, Inc. |
Methods for treating prostatic intraepithelial neoplasia with herbal compositions
|
AU2005207037A1
(en)
*
|
2004-01-22 |
2005-08-04 |
Nitromed, Inc. |
Nitrosated and/or nitrosylated compounds, compositions and methods of use
|
WO2005097096A1
(en)
*
|
2004-03-31 |
2005-10-20 |
Pharmacia & Upjohn Company Llc |
A phenyl acetic acid cyclooxygenase-2 inhibitor for the treatment of ocular disorders
|
WO2005097110A1
(en)
*
|
2004-03-31 |
2005-10-20 |
Pharmacia & Upjohn Company Llc |
Monotherapy for the modulation of intraocular pressure with cyclooxygenase-2 selective inhibitors
|
US7622142B2
(en)
*
|
2004-09-14 |
2009-11-24 |
New Chapter Inc. |
Methods for treating glioblastoma with herbal compositions
|
WO2006041855A2
(en)
|
2004-10-04 |
2006-04-20 |
Nitromed, Inc. |
Compositions and methods using apocynin compounds and nitric oxide donors
|
US20080300292A1
(en)
*
|
2004-11-08 |
2008-12-04 |
Nitromed, Inc |
Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders
|
AU2005306629A1
(en)
*
|
2004-11-15 |
2006-05-26 |
Nicox S.A. |
Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use
|
WO2006078995A1
(en)
*
|
2005-01-21 |
2006-07-27 |
Nitromed, Inc. |
Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use
|
AU2006336387A1
(en)
*
|
2005-02-16 |
2007-08-02 |
Nicox S.A. |
Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use
|
US20090012057A1
(en)
*
|
2005-02-28 |
2009-01-08 |
Nitromed, Inc. |
Cardiovascular Compounds Comprising Nitric Oxide Enhancing Groups, Compositions and Methods of Use
|
AU2006223392A1
(en)
*
|
2005-03-09 |
2006-09-21 |
Nicox S.A. |
Organic nitric oxide enhancing salts of angiotensin II antagonists, compositions and methods of use
|
US20090048219A1
(en)
*
|
2005-05-23 |
2009-02-19 |
Nitromed Inc. |
Organic nitric oxide donor salts of nonsteroidal antiinflammatory compounds, compositions and methods of use
|
US20090018091A1
(en)
*
|
2005-08-02 |
2009-01-15 |
Nitromed, Inc. |
Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use
|
US20090054381A1
(en)
*
|
2005-10-04 |
2009-02-26 |
Nitromed, Inc. |
Methods for treating respiratory disorders
|
EP1954685A4
(de)
*
|
2005-11-16 |
2009-11-11 |
Nitromed Inc |
Furoxanverbindungen, zusammensetzungen und anwendungsverfahren
|
EP1968584A2
(de)
*
|
2005-12-20 |
2008-09-17 |
Nitromed, Inc. |
Stickoxid-verstärkende glutaminsäure-verbindungen, zusammensetzungen und anwendungsverfahren
|
US20080293702A1
(en)
*
|
2005-12-22 |
2008-11-27 |
Nitromed, Inc. |
Nitric Oxide Enhancing Pyruvate Compounds, Compositions and Methods of Use
|
WO2007126609A1
(en)
|
2006-03-29 |
2007-11-08 |
Nitromed, Inc. |
Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
|
WO2008052198A2
(en)
*
|
2006-10-26 |
2008-05-02 |
Reliant Technologies, Inc. |
Methods of increasing skin permeability by treatment with electromagnetic radiation
|
JP2010516679A
(ja)
*
|
2007-01-19 |
2010-05-20 |
マリンクロット インコーポレイテッド |
診断用および治療用シクロオキシゲナーゼ−2結合リガンド
|
EP2170062A4
(de)
|
2007-07-12 |
2010-12-29 |
Tragara Pharmaceuticals Inc |
Verfahren und zusammensetzungen zur behandlung von krebserkrankungen, tumoren und tumorvermittelten erkrankungen
|
WO2011038261A1
(en)
*
|
2009-09-24 |
2011-03-31 |
Selexagen Therapeutics, Inc. |
Heterocyclic kinase inhibitors
|
AR088351A1
(es)
*
|
2011-10-31 |
2014-05-28 |
Lilly Co Eli |
Analogos de pirazol sustituidos
|
JP6456909B2
(ja)
*
|
2013-03-15 |
2019-01-23 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
Lxr調節因子
|
EP3292213A1
(de)
|
2015-05-04 |
2018-03-14 |
Academisch Medisch Centrum |
Biomarker für den nachweis von aspirinunempfindlichkeit
|