PT86188B - Processo para a preparacao de analogos de rebecamicina e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de analogos de rebecamicina e de composicoes farmaceuticas que os contem Download PDF

Info

Publication number
PT86188B
PT86188B PT86188A PT8618887A PT86188B PT 86188 B PT86188 B PT 86188B PT 86188 A PT86188 A PT 86188A PT 8618887 A PT8618887 A PT 8618887A PT 86188 B PT86188 B PT 86188B
Authority
PT
Portugal
Prior art keywords
group
compounds
rebecamycin
preparation
general formula
Prior art date
Application number
PT86188A
Other languages
English (en)
Portuguese (pt)
Other versions
PT86188A (en
Inventor
Takushi Kaneko
Henry S Wong
Jacob J Utzig
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT86188A publication Critical patent/PT86188A/pt
Publication of PT86188B publication Critical patent/PT86188B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
PT86188A 1986-11-21 1987-11-20 Processo para a preparacao de analogos de rebecamicina e de composicoes farmaceuticas que os contem PT86188B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/933,428 US4785085A (en) 1986-11-21 1986-11-21 Rebeccamycin analogs

Publications (2)

Publication Number Publication Date
PT86188A PT86188A (en) 1987-12-01
PT86188B true PT86188B (pt) 1990-11-07

Family

ID=25463937

Family Applications (1)

Application Number Title Priority Date Filing Date
PT86188A PT86188B (pt) 1986-11-21 1987-11-20 Processo para a preparacao de analogos de rebecamicina e de composicoes farmaceuticas que os contem

Country Status (28)

Country Link
US (1) US4785085A (2)
EP (1) EP0269025B1 (2)
JP (1) JPS63198695A (2)
KR (1) KR910000897B1 (2)
CN (1) CN1019806B (2)
AT (1) ATE84539T1 (2)
AU (1) AU614068B2 (2)
CA (1) CA1287349C (2)
CS (1) CS265248B2 (2)
CY (1) CY1701A (2)
DE (1) DE3783577T2 (2)
DK (1) DK165986C (2)
EG (1) EG18409A (2)
ES (1) ES2053510T3 (2)
FI (1) FI86189C (2)
GR (1) GR3006776T3 (2)
HK (1) HK49093A (2)
HU (1) HU201773B (2)
IE (1) IE60595B1 (2)
IL (1) IL84515A (2)
MX (1) MX9202849A (2)
MY (1) MY102722A (2)
NO (1) NO167741C (2)
NZ (1) NZ222544A (2)
PT (1) PT86188B (2)
SG (1) SG25193G (2)
YU (1) YU46087B (2)
ZA (1) ZA878714B (2)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5496809A (en) * 1989-05-10 1996-03-05 Bristol-Myers Squibb Co Stable solutions of rebeccamycin analog
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) * 1990-03-06 1995-03-22 ブリストル−マイヤーズ スクイブ カンパニー 臭化物前駆物質物質供給によるレベカマイシン類似体
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
US5344823A (en) * 1990-03-06 1994-09-06 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41219
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
EP0528030B1 (en) * 1990-05-11 1997-09-17 Banyu Pharmaceutical Co., Ltd. Antitumor be-13793c derivative
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5547976A (en) * 1992-03-20 1996-08-20 Burroughs Wellcome Co. Further indole derivatives with antiviral activity
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
PT657458E (pt) * 1993-12-07 2002-02-28 Lilly Co Eli Inibidores de proteina cinase c
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
EP0657411B1 (en) * 1993-12-07 1999-06-09 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
CA2179650C (en) * 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
DE69531686T2 (de) * 1994-06-13 2004-07-15 Banyu Pharmaceutical Co., Ltd. Glycosyltransferase kodierendes gen und seine verwendung
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
EP0695755B1 (en) * 1994-08-04 1998-10-21 F. Hoffmann-La Roche AG Pyrrolocarbazole
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
US5919946A (en) * 1996-03-20 1999-07-06 Eli Lilly And Company Synthesis of indolylmaleimides
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
RU2003131269A (ru) 2001-03-22 2005-05-10 Бристол-Маерс Сквибб Компани (Us) Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
US20070042975A1 (en) * 2003-09-16 2007-02-22 Koji Yamada Novel indolopyrrolocarbazole derivative with antitumor activity
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102125578B (zh) * 2010-11-24 2013-03-27 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102898489B (zh) * 2010-11-24 2014-04-02 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１

Also Published As

Publication number Publication date
YU208687A (en) 1988-10-31
AU8114887A (en) 1988-05-26
KR910000897B1 (ko) 1991-02-12
DK612987D0 (da) 1987-11-20
FI86189C (fi) 1992-07-27
IE873152L (en) 1988-05-21
CN87107928A (zh) 1988-08-10
ES2053510T3 (es) 1994-08-01
PT86188A (en) 1987-12-01
FI875091A7 (fi) 1988-05-22
YU46087B (sh) 1992-12-21
IL84515A (en) 1991-11-21
CA1287349C (en) 1991-08-06
IE60595B1 (en) 1994-07-27
CS265248B2 (en) 1989-10-13
CY1701A (en) 1994-01-14
SG25193G (en) 1993-05-21
NO167741B (no) 1991-08-26
NO874857L (no) 1988-05-24
EP0269025A2 (en) 1988-06-01
DE3783577D1 (de) 1993-02-25
MX9202849A (es) 1992-06-30
HUT45543A (en) 1988-07-28
JPS63198695A (ja) 1988-08-17
FI86189B (fi) 1992-04-15
NO874857D0 (no) 1987-11-20
ATE84539T1 (de) 1993-01-15
DK165986C (da) 1993-07-19
NO167741C (no) 1991-12-04
EP0269025A3 (en) 1990-08-29
ZA878714B (2) 1988-05-20
FI875091A0 (fi) 1987-11-18
KR880006246A (ko) 1988-07-22
DK612987A (da) 1988-05-22
MY102722A (en) 1992-09-30
AU614068B2 (en) 1991-08-22
HK49093A (en) 1993-05-27
US4785085A (en) 1988-11-15
EG18409A (en) 1993-02-28
DK165986B (da) 1993-02-22
GR3006776T3 (2) 1993-06-30
HU201773B (en) 1990-12-28
JPH05400B2 (2) 1993-01-05
NZ222544A (en) 1990-11-27
DE3783577T2 (de) 1993-05-19
EP0269025B1 (en) 1993-01-13
IL84515A0 (en) 1988-04-29
CN1019806B (zh) 1992-12-30
CS824987A2 (en) 1989-01-12

Similar Documents

Publication Publication Date Title
PT86188B (pt) Processo para a preparacao de analogos de rebecamicina e de composicoes farmaceuticas que os contem
US5510353A (en) Certain aminoguanidine compounds, pharmaceutical compositions containing them and their use in treating gastrointestinal motility disorders and disorders associated with cephalic pain
US5380746A (en) Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5567711A (en) Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
DE69332504T2 (de) Trifluoromethylpyrroloindolcarbonsäure und dessen esterderivat sowie ein verfahren zu seiner herstellung
EP0397060A2 (de) Maleinimid-Derivate und deren Verwendung als Arzneimittel
US4808613A (en) Rebeccamycin derivative containing pharmaceutical composition
PT88206B (pt) Processo para a preparacao de derivados de 2-{(4-piperidinil)-metil}-1,2,3,4-tetrahidro-9h-pirido{3,4-b}indol e de composicoes farmaceuticas que os contem
RU2034846C1 (ru) СПОСОБ ПОЛУЧЕНИЯ СОЕДИНЕНИЙ ГРУППЫ ИМИДАЗО (1,2-b)-ПИРИДАЗИНА ИЛИ ИХ СОЛЕЙ
KR970008106B1 (ko) 항종양제
JPH0597853A (ja) Ｄｃ−８９誘導体の臭化水素酸塩
EP0369145A2 (en) Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same
WO2022033552A1 (zh) Cdk激酶抑制剂、其制备方法、药物组合物和应用
JPH08509740A (ja) カンプトテシンの水溶性誘導体
NZ208757A (en) Rifampicin derivatives and pharmaceutical compositions
ES2232147T3 (es) Derivados de lk6-a.
US6458792B1 (en) Compounds
CA2070799C (en) Thioxanthenone antitumor agents
US3691199A (en) 2-hydroxy-indole-3-dithiocarboxylates
US3444174A (en) Substituted 4,7-dihydroindoles
CN120693323A (zh) Kif18a抑制剂
DE3942991A1 (de) Maleinimid-derivate und deren verwendung als arzneimittel
EP0601520A1 (en) Trifluorothymidine derivatives, process for producing the same and anti-cancer agent containing the same
JPS5833222B2 (ja) 新規ジペプチド類
JPH0834787A (ja) ピロロカルバゾール誘導体及びその製造方法