PT751779E - Ligantes selectivamente clivaveis baseados em ligacoes ester de acido iminodiacetico - Google Patents
Ligantes selectivamente clivaveis baseados em ligacoes ester de acido iminodiaceticoInfo
- Publication number
- PT751779E PT751779E PT94920294T PT94920294T PT751779E PT 751779 E PT751779 E PT 751779E PT 94920294 T PT94920294 T PT 94920294T PT 94920294 T PT94920294 T PT 94920294T PT 751779 E PT751779 E PT 751779E
- Authority
- PT
- Portugal
- Prior art keywords
- ligacts
- clivate
- ligants
- selectively
- acid ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fertilizers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8038893A | 1993-06-21 | 1993-06-21 | |
US8199793A | 1993-06-23 | 1993-06-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT751779E true PT751779E (pt) | 2002-05-31 |
Family
ID=26763448
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT01114395T PT1156059E (pt) | 1993-06-21 | 1994-06-21 | Ligantes cliváveis selectivamente com base num grupo de metionina e um grupo éster |
PT94920294T PT751779E (pt) | 1993-06-21 | 1994-06-21 | Ligantes selectivamente clivaveis baseados em ligacoes ester de acido iminodiacetico |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT01114395T PT1156059E (pt) | 1993-06-21 | 1994-06-21 | Ligantes cliváveis selectivamente com base num grupo de metionina e um grupo éster |
Country Status (11)
Country | Link |
---|---|
US (1) | US5635598A (pt) |
EP (2) | EP1156059B1 (pt) |
JP (2) | JP3469579B2 (pt) |
AT (2) | ATE210993T1 (pt) |
AU (1) | AU689116B2 (pt) |
DE (2) | DE69435011T2 (pt) |
DK (2) | DK1156059T3 (pt) |
ES (2) | ES2165880T3 (pt) |
NZ (1) | NZ268292A (pt) |
PT (2) | PT1156059E (pt) |
WO (1) | WO1995000165A1 (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
US5463564A (en) * | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
DE69632989T2 (de) * | 1995-10-17 | 2005-08-25 | Combichem, Inc., San Diego | Matrize für die Synthese kombinatorischer Bibliotheken in Lösung |
US6475807B1 (en) * | 1996-04-08 | 2002-11-05 | Smithkline Beecham Corporation | Mass-based encoding and qualitative analysis of combinatorial libraries |
DE19626762A1 (de) * | 1996-07-03 | 1998-01-08 | Basf Ag | Enzymatisch spaltbare Linker für Festphasensynthesen |
US6453246B1 (en) | 1996-11-04 | 2002-09-17 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for representing proximity data in a multi-dimensional space |
AU722989B2 (en) * | 1996-11-04 | 2000-08-17 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for the visualization and interactive processing and analysis of chemical data |
US6571227B1 (en) * | 1996-11-04 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Method, system and computer program product for non-linear mapping of multi-dimensional data |
DE19782096T1 (de) | 1996-11-06 | 2000-03-23 | Sequenom Inc | Immobiliserung von Nucleinsäuren in hoher Dichte |
US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
US5958703A (en) * | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
US6168913B1 (en) * | 1997-10-14 | 2001-01-02 | Abbott Laboratories | Coding combinatorial libraries with fluorine tags |
WO1999025752A1 (en) * | 1997-11-18 | 1999-05-27 | Aventis Pharmaceuticals Products Inc. | Functionalized resin for the synthesis of amides and peptides |
CA2260472A1 (en) * | 1998-02-11 | 1999-08-11 | Xiao-Yi Xiao | Safety-catch linkers |
US7094943B2 (en) | 1998-04-27 | 2006-08-22 | Hubert Köster | Solution phase biopolymer synthesis |
GB9912911D0 (en) * | 1999-06-04 | 1999-08-04 | Zeneca Ltd | Chemical process |
US6309889B1 (en) | 1999-12-23 | 2001-10-30 | Glaxo Wellcome Inc. | Nano-grid micro reactor and methods |
US7416524B1 (en) | 2000-02-18 | 2008-08-26 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | System, method and computer program product for fast and efficient searching of large chemical libraries |
EP1259823A2 (en) * | 2000-02-23 | 2002-11-27 | Xenoport, Inc. | Self-encoded combinatorial synthesis of compound multiplets |
AU2001241800A1 (en) | 2000-02-29 | 2001-09-12 | 3-Dimensional Pharmaceuticals, Inc. | Method and computer program product for designing combinatorial arrays |
AU2001247627A1 (en) | 2000-03-22 | 2001-10-03 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for representing object relationships in a multidimensional space |
WO2001075790A2 (en) | 2000-04-03 | 2001-10-11 | 3-Dimensional Pharmaceuticals, Inc. | Method, system, and computer program product for representing object relationships in a multidimensional space |
EP1350193A2 (en) * | 2000-08-22 | 2003-10-08 | 3-Dimensional Pharmaceuticals, Inc. | Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks |
US6678619B2 (en) * | 2000-09-20 | 2004-01-13 | Victor S. Lobanov | Method, system, and computer program product for encoding and building products of a virtual combinatorial library |
US7054757B2 (en) * | 2001-01-29 | 2006-05-30 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Method, system, and computer program product for analyzing combinatorial libraries |
US7262269B2 (en) * | 2001-10-26 | 2007-08-28 | The Regents Of University Of California | Method for screening combinational bead library; ligands for cancer cells |
US6670142B2 (en) | 2001-10-26 | 2003-12-30 | The Regents Of The University Of California | Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells |
US7291456B2 (en) | 2002-01-24 | 2007-11-06 | The Regents Of The University Of California | Method for determining differences in molecular interactions and for screening a combinatorial library |
US20040185499A1 (en) * | 2003-03-20 | 2004-09-23 | Jolley Michael E. | Method of epitope scanning using fluorescence polarization |
EP1807092B1 (en) | 2004-11-05 | 2016-09-07 | The Children's Hospital of Philadelphia | Biodegradable linkers for molecular therapies |
EP2592103A1 (en) | 2011-11-08 | 2013-05-15 | Adriacell S.p.A. | Polymer aldehyde derivatives |
CN105254576A (zh) * | 2014-02-26 | 2016-01-20 | 中国科学院长春应用化学研究所 | 一种谷氨酸二酮哌嗪的制备方法 |
KR20170109046A (ko) * | 2015-02-02 | 2017-09-27 | 투 포어 가이즈, 인코포레이티드 | 바이오마커 검출용 불안정성 링커 |
DK3650458T3 (da) * | 2015-02-24 | 2023-09-04 | Hope City | Platforme til screening af kemisk kodede, rumligt adresserede biblioteker |
DE102015117567B4 (de) | 2015-10-15 | 2017-05-11 | Stochastic Combinatorics GbR (vertretungsberechtigter Gesellschafter: Dr. Alexander Nesterov-Müller, 76661 Philippsburg) | Ultra-hochdichte Oligomerarrays und Verfahren zu deren Herstellung |
CA3068254A1 (en) | 2017-06-20 | 2018-12-27 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
EP3866794A4 (en) | 2018-10-17 | 2022-07-20 | Imbria Pharmaceuticals, Inc. | METHODS OF TREATING RHEUMATIC DISEASES USING TRIMETAZIDINE COMPOUNDS |
CA3158746A1 (en) * | 2019-11-14 | 2021-05-20 | Bcd Bioscience, Inc. | High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
WO2023102255A1 (en) * | 2021-12-03 | 2023-06-08 | Massachusetts Institute Of Technology | Peptide-encoded libraries of small molecules for de novo drug discovery |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3963701A (en) * | 1972-04-17 | 1976-06-15 | Richardson-Merrell Inc. | Substituted benzhydryl lactamimide derivatives |
FR2595695B1 (fr) * | 1986-03-12 | 1988-12-02 | Synthelabo | Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique |
EP0273895A3 (en) * | 1986-12-24 | 1988-12-21 | Monsanto Company | Solid phase peptide synthesis |
EP0322348B1 (de) * | 1987-12-22 | 1994-02-02 | Hoechst Aktiengesellschaft | Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode |
JP2815362B2 (ja) * | 1988-02-29 | 1998-10-27 | 中外製薬株式会社 | ベンズヒドリルアミン誘導体及びその製法 |
US5066716A (en) * | 1988-12-13 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
DE69020143T2 (de) * | 1989-02-17 | 1996-01-25 | Chiron Mimotopes Pty Ltd | Verfahren zur verwendung und herstellung von peptiden. |
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
NL9002611A (nl) * | 1990-11-29 | 1992-06-16 | Crown Gear Bv | Gereedschap voor het vervaardigen van kroonwielen, alsmede werkwijze voor het vervaardigen van een dergelijk gereedschap. |
CS103091A3 (en) * | 1991-04-12 | 1992-10-14 | Ustav Organicke Chemie A Bioch | Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use |
-
1994
- 1994-06-21 NZ NZ268292A patent/NZ268292A/en not_active IP Right Cessation
- 1994-06-21 EP EP01114395A patent/EP1156059B1/en not_active Expired - Lifetime
- 1994-06-21 AT AT94920294T patent/ATE210993T1/de active
- 1994-06-21 JP JP50304795A patent/JP3469579B2/ja not_active Expired - Fee Related
- 1994-06-21 ES ES94920294T patent/ES2165880T3/es not_active Expired - Lifetime
- 1994-06-21 PT PT01114395T patent/PT1156059E/pt unknown
- 1994-06-21 ES ES01114395T patent/ES2291245T3/es not_active Expired - Lifetime
- 1994-06-21 PT PT94920294T patent/PT751779E/pt unknown
- 1994-06-21 AU AU71145/94A patent/AU689116B2/en not_active Ceased
- 1994-06-21 DK DK01114395T patent/DK1156059T3/da active
- 1994-06-21 AT AT01114395T patent/ATE369376T1/de active
- 1994-06-21 WO PCT/US1994/007012 patent/WO1995000165A1/en active IP Right Grant
- 1994-06-21 DK DK94920294T patent/DK0751779T3/da active
- 1994-06-21 DE DE69435011T patent/DE69435011T2/de not_active Expired - Lifetime
- 1994-06-21 DE DE69429542T patent/DE69429542T2/de not_active Expired - Lifetime
- 1994-06-21 US US08/263,289 patent/US5635598A/en not_active Expired - Lifetime
- 1994-06-21 EP EP94920294A patent/EP0751779B1/en not_active Expired - Lifetime
-
2003
- 2003-06-04 JP JP2003159838A patent/JP3672558B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2165880T3 (es) | 2002-04-01 |
EP1156059B1 (en) | 2007-08-08 |
JP3469579B2 (ja) | 2003-11-25 |
PT1156059E (pt) | 2007-10-19 |
NZ268292A (en) | 1997-09-22 |
DE69429542D1 (de) | 2002-01-31 |
ES2291245T3 (es) | 2008-03-01 |
EP0751779A1 (en) | 1997-01-08 |
JP3672558B2 (ja) | 2005-07-20 |
AU7114594A (en) | 1995-01-17 |
JPH09500111A (ja) | 1997-01-07 |
ATE210993T1 (de) | 2002-01-15 |
AU689116B2 (en) | 1998-03-26 |
US5635598A (en) | 1997-06-03 |
WO1995000165A1 (en) | 1995-01-05 |
DE69435011D1 (de) | 2007-09-20 |
JP2003327597A (ja) | 2003-11-19 |
EP1156059A1 (en) | 2001-11-21 |
DK1156059T3 (da) | 2007-11-12 |
EP0751779B1 (en) | 2001-12-19 |
EP0751779A4 (en) | 1998-12-09 |
DE69429542T2 (de) | 2002-08-08 |
DK0751779T3 (da) | 2002-04-15 |
ATE369376T1 (de) | 2007-08-15 |
DE69435011T2 (de) | 2008-10-23 |
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