DE69429542T2 - Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren - Google Patents

Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren

Info

Publication number
DE69429542T2
DE69429542T2 DE69429542T DE69429542T DE69429542T2 DE 69429542 T2 DE69429542 T2 DE 69429542T2 DE 69429542 T DE69429542 T DE 69429542T DE 69429542 T DE69429542 T DE 69429542T DE 69429542 T2 DE69429542 T2 DE 69429542T2
Authority
DE
Germany
Prior art keywords
fissionable
selectively
acetic acid
acid ester
ester bonds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429542T
Other languages
English (en)
Other versions
DE69429542D1 (de
Inventor
Michal Lebl
Viktor Krchnak
Petr Kocis
Kit S Lam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
SELECTIDE CORP TUCSON
Selectide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SELECTIDE CORP TUCSON, Selectide Corp filed Critical SELECTIDE CORP TUCSON
Publication of DE69429542D1 publication Critical patent/DE69429542D1/de
Application granted granted Critical
Publication of DE69429542T2 publication Critical patent/DE69429542T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fertilizers (AREA)
  • Medicinal Preparation (AREA)
DE69429542T 1993-06-21 1994-06-21 Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren Expired - Lifetime DE69429542T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8038893A 1993-06-21 1993-06-21
US8199793A 1993-06-23 1993-06-23
PCT/US1994/007012 WO1995000165A1 (en) 1993-06-21 1994-06-21 Selectively cleavable linkers based on iminodiacetic acid ester bonds

Publications (2)

Publication Number Publication Date
DE69429542D1 DE69429542D1 (de) 2002-01-31
DE69429542T2 true DE69429542T2 (de) 2002-08-08

Family

ID=26763448

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69435011T Expired - Lifetime DE69435011T2 (de) 1993-06-21 1994-06-21 Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren
DE69429542T Expired - Lifetime DE69429542T2 (de) 1993-06-21 1994-06-21 Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69435011T Expired - Lifetime DE69435011T2 (de) 1993-06-21 1994-06-21 Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren

Country Status (11)

Country Link
US (1) US5635598A (de)
EP (2) EP1156059B1 (de)
JP (2) JP3469579B2 (de)
AT (2) ATE210993T1 (de)
AU (1) AU689116B2 (de)
DE (2) DE69435011T2 (de)
DK (2) DK1156059T3 (de)
ES (2) ES2165880T3 (de)
NZ (1) NZ268292A (de)
PT (2) PT1156059E (de)
WO (1) WO1995000165A1 (de)

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US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
DE69632989T2 (de) * 1995-10-17 2005-08-25 Combichem, Inc., San Diego Matrize für die Synthese kombinatorischer Bibliotheken in Lösung
US6475807B1 (en) * 1996-04-08 2002-11-05 Smithkline Beecham Corporation Mass-based encoding and qualitative analysis of combinatorial libraries
DE19626762A1 (de) * 1996-07-03 1998-01-08 Basf Ag Enzymatisch spaltbare Linker für Festphasensynthesen
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
AU722989B2 (en) * 1996-11-04 2000-08-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for the visualization and interactive processing and analysis of chemical data
US6571227B1 (en) * 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
DE19782096T1 (de) 1996-11-06 2000-03-23 Sequenom Inc Immobiliserung von Nucleinsäuren in hoher Dichte
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5958703A (en) * 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
US6168913B1 (en) * 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
WO1999025752A1 (en) * 1997-11-18 1999-05-27 Aventis Pharmaceuticals Products Inc. Functionalized resin for the synthesis of amides and peptides
CA2260472A1 (en) * 1998-02-11 1999-08-11 Xiao-Yi Xiao Safety-catch linkers
US7094943B2 (en) 1998-04-27 2006-08-22 Hubert Köster Solution phase biopolymer synthesis
GB9912911D0 (en) * 1999-06-04 1999-08-04 Zeneca Ltd Chemical process
US6309889B1 (en) 1999-12-23 2001-10-30 Glaxo Wellcome Inc. Nano-grid micro reactor and methods
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
EP1259823A2 (de) * 2000-02-23 2002-11-27 Xenoport, Inc. Selbstkodierte kombinatorische herstellung von zusammenfassung-mehrerelementen
AU2001241800A1 (en) 2000-02-29 2001-09-12 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
AU2001247627A1 (en) 2000-03-22 2001-10-03 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing object relationships in a multidimensional space
WO2001075790A2 (en) 2000-04-03 2001-10-11 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
EP1350193A2 (de) * 2000-08-22 2003-10-08 3-Dimensional Pharmaceuticals, Inc. Verfahren, system und computerprogrammprodukt zur bestimmung der eigenschaften von kombinatorischen bibliothekprodukten aus merkmalen von bausteinen der bibliothek
US6678619B2 (en) * 2000-09-20 2004-01-13 Victor S. Lobanov Method, system, and computer program product for encoding and building products of a virtual combinatorial library
US7054757B2 (en) * 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
US7262269B2 (en) * 2001-10-26 2007-08-28 The Regents Of University Of California Method for screening combinational bead library; ligands for cancer cells
US6670142B2 (en) 2001-10-26 2003-12-30 The Regents Of The University Of California Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells
US7291456B2 (en) 2002-01-24 2007-11-06 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
EP1807092B1 (de) 2004-11-05 2016-09-07 The Children's Hospital of Philadelphia Biologisch abbaubare verbindungsglieder für molekulare therapien
EP2592103A1 (de) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymeraldehydderivate
CN105254576A (zh) * 2014-02-26 2016-01-20 中国科学院长春应用化学研究所 一种谷氨酸二酮哌嗪的制备方法
KR20170109046A (ko) * 2015-02-02 2017-09-27 투 포어 가이즈, 인코포레이티드 바이오마커 검출용 불안정성 링커
DK3650458T3 (da) * 2015-02-24 2023-09-04 Hope City Platforme til screening af kemisk kodede, rumligt adresserede biblioteker
DE102015117567B4 (de) 2015-10-15 2017-05-11 Stochastic Combinatorics GbR (vertretungsberechtigter Gesellschafter: Dr. Alexander Nesterov-Müller, 76661 Philippsburg) Ultra-hochdichte Oligomerarrays und Verfahren zu deren Herstellung
CA3068254A1 (en) 2017-06-20 2018-12-27 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
EP3866794A4 (de) 2018-10-17 2022-07-20 Imbria Pharmaceuticals, Inc. Verfahren zur behandlung von rheumatischen erkrankungen unter verwendung von trimetazidinbasierten verbindungen
CA3158746A1 (en) * 2019-11-14 2021-05-20 Bcd Bioscience, Inc. High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
WO2023102255A1 (en) * 2021-12-03 2023-06-08 Massachusetts Institute Of Technology Peptide-encoded libraries of small molecules for de novo drug discovery

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963701A (en) * 1972-04-17 1976-06-15 Richardson-Merrell Inc. Substituted benzhydryl lactamimide derivatives
FR2595695B1 (fr) * 1986-03-12 1988-12-02 Synthelabo Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
EP0273895A3 (de) * 1986-12-24 1988-12-21 Monsanto Company Feststoff-Peptidsynthese
EP0322348B1 (de) * 1987-12-22 1994-02-02 Hoechst Aktiengesellschaft Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
DE69020143T2 (de) * 1989-02-17 1996-01-25 Chiron Mimotopes Pty Ltd Verfahren zur verwendung und herstellung von peptiden.
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
NL9002611A (nl) * 1990-11-29 1992-06-16 Crown Gear Bv Gereedschap voor het vervaardigen van kroonwielen, alsmede werkwijze voor het vervaardigen van een dergelijk gereedschap.
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Also Published As

Publication number Publication date
ES2165880T3 (es) 2002-04-01
EP1156059B1 (de) 2007-08-08
JP3469579B2 (ja) 2003-11-25
PT1156059E (pt) 2007-10-19
NZ268292A (en) 1997-09-22
DE69429542D1 (de) 2002-01-31
ES2291245T3 (es) 2008-03-01
EP0751779A1 (de) 1997-01-08
JP3672558B2 (ja) 2005-07-20
AU7114594A (en) 1995-01-17
JPH09500111A (ja) 1997-01-07
ATE210993T1 (de) 2002-01-15
AU689116B2 (en) 1998-03-26
US5635598A (en) 1997-06-03
WO1995000165A1 (en) 1995-01-05
DE69435011D1 (de) 2007-09-20
JP2003327597A (ja) 2003-11-19
EP1156059A1 (de) 2001-11-21
DK1156059T3 (da) 2007-11-12
EP0751779B1 (de) 2001-12-19
EP0751779A4 (de) 1998-12-09
PT751779E (pt) 2002-05-31
DK0751779T3 (da) 2002-04-15
ATE369376T1 (de) 2007-08-15
DE69435011T2 (de) 2008-10-23

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMACEUTICALS INC. (N.D.GES.D.STAATES DE

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS HOLDINGS INC., GREENVILLE, DEL., US

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US