ATE210993T1 - Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren - Google Patents

Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren

Info

Publication number
ATE210993T1
ATE210993T1 AT94920294T AT94920294T ATE210993T1 AT E210993 T1 ATE210993 T1 AT E210993T1 AT 94920294 T AT94920294 T AT 94920294T AT 94920294 T AT94920294 T AT 94920294T AT E210993 T1 ATE210993 T1 AT E210993T1
Authority
AT
Austria
Prior art keywords
iminodiesacetic
acid
ester bonds
compounds based
selectively cleavable
Prior art date
Application number
AT94920294T
Other languages
English (en)
Inventor
Michal Lebl
Viktor Krchnak
Petr Kocis
Kit S Lam
Original Assignee
Selectide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selectide Corp filed Critical Selectide Corp
Application granted granted Critical
Publication of ATE210993T1 publication Critical patent/ATE210993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fertilizers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT94920294T 1993-06-21 1994-06-21 Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren ATE210993T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8038893A 1993-06-21 1993-06-21
US8199793A 1993-06-23 1993-06-23
PCT/US1994/007012 WO1995000165A1 (en) 1993-06-21 1994-06-21 Selectively cleavable linkers based on iminodiacetic acid ester bonds

Publications (1)

Publication Number Publication Date
ATE210993T1 true ATE210993T1 (de) 2002-01-15

Family

ID=26763448

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01114395T ATE369376T1 (de) 1993-06-21 1994-06-21 Selektiv spaltbare linker, die auf einer methionin- und einer estergruppe basieren
AT94920294T ATE210993T1 (de) 1993-06-21 1994-06-21 Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01114395T ATE369376T1 (de) 1993-06-21 1994-06-21 Selektiv spaltbare linker, die auf einer methionin- und einer estergruppe basieren

Country Status (11)

Country Link
US (1) US5635598A (de)
EP (2) EP0751779B1 (de)
JP (2) JP3469579B2 (de)
AT (2) ATE369376T1 (de)
AU (1) AU689116B2 (de)
DE (2) DE69435011T2 (de)
DK (2) DK1156059T3 (de)
ES (2) ES2291245T3 (de)
NZ (1) NZ268292A (de)
PT (2) PT751779E (de)
WO (1) WO1995000165A1 (de)

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US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
CA2187969C (en) * 1995-10-17 2006-05-30 Dale L. Boger A template for solution phase synthesis of combinatorial libraries
US6475807B1 (en) * 1996-04-08 2002-11-05 Smithkline Beecham Corporation Mass-based encoding and qualitative analysis of combinatorial libraries
DE19626762A1 (de) * 1996-07-03 1998-01-08 Basf Ag Enzymatisch spaltbare Linker für Festphasensynthesen
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
US6571227B1 (en) * 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
WO1998020437A2 (en) 1996-11-04 1998-05-14 3-Dimensional Pharmaceuticals, Inc. System, method and computer program product for identifying chemical compounds having desired properties
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
CA2268740C (en) 1996-11-06 2010-07-20 Sequenom, Inc. High density immobilization of nucleic acids
US5958703A (en) * 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
US6168913B1 (en) * 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
WO1999025752A1 (en) * 1997-11-18 1999-05-27 Aventis Pharmaceuticals Products Inc. Functionalized resin for the synthesis of amides and peptides
CA2260472A1 (en) * 1998-02-11 1999-08-11 Xiao-Yi Xiao Safety-catch linkers
US7094943B2 (en) 1998-04-27 2006-08-22 Hubert Köster Solution phase biopolymer synthesis
GB9912911D0 (en) 1999-06-04 1999-08-04 Zeneca Ltd Chemical process
US6309889B1 (en) 1999-12-23 2001-10-30 Glaxo Wellcome Inc. Nano-grid micro reactor and methods
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
US20010031475A1 (en) * 2000-02-23 2001-10-18 Gallop Mark A. Self-encoded combinatorial synthesis of compound multiplets
AU2001241800A1 (en) 2000-02-29 2001-09-12 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
WO2001071624A1 (en) 2000-03-22 2001-09-27 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing object relationships in a multidimensional space
WO2001075790A2 (en) 2000-04-03 2001-10-11 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
CA2419600A1 (en) * 2000-08-22 2002-02-28 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
WO2002025504A2 (en) * 2000-09-20 2002-03-28 Lobanov Victor S Method, system, and computer program product for encoding and building products of a virtual combinatorial library
US7054757B2 (en) * 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
US7262269B2 (en) * 2001-10-26 2007-08-28 The Regents Of University Of California Method for screening combinational bead library; ligands for cancer cells
US6670142B2 (en) 2001-10-26 2003-12-30 The Regents Of The University Of California Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells
US7291456B2 (en) 2002-01-24 2007-11-06 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
CA2585664C (en) 2004-11-05 2014-05-20 The Children's Hospital Of Philadelphia Biodegradable linkers for molecular therapies
EP2592103A1 (de) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymeraldehydderivate
CN105254576A (zh) * 2014-02-26 2016-01-20 中国科学院长春应用化学研究所 一种谷氨酸二酮哌嗪的制备方法
WO2016126748A1 (en) * 2015-02-02 2016-08-11 Two Pore Guys, Inc. Labile linkers for biomarker detection
LT3650458T (lt) * 2015-02-24 2023-10-10 City Of Hope Chemiškai koduotos erdviniu požiūriu orientuotos bibliotekų atrankos platformos
DE102015117567B4 (de) 2015-10-15 2017-05-11 Stochastic Combinatorics GbR (vertretungsberechtigter Gesellschafter: Dr. Alexander Nesterov-Müller, 76661 Philippsburg) Ultra-hochdichte Oligomerarrays und Verfahren zu deren Herstellung
WO2018236745A1 (en) 2017-06-20 2018-12-27 Carnot, Llc COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CARDIAC METABOLISM
WO2020081361A1 (en) 2018-10-17 2020-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
US20220372175A1 (en) * 2019-11-14 2022-11-24 Bcd Bioscience, Inc. High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
WO2023102255A1 (en) * 2021-12-03 2023-06-08 Massachusetts Institute Of Technology Peptide-encoded libraries of small molecules for de novo drug discovery

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Publication number Priority date Publication date Assignee Title
US3963701A (en) * 1972-04-17 1976-06-15 Richardson-Merrell Inc. Substituted benzhydryl lactamimide derivatives
FR2595695B1 (fr) * 1986-03-12 1988-12-02 Synthelabo Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
EP0274999A3 (de) * 1986-12-24 1988-12-14 Monsanto Company Harzträger für Feststoff-Peptidsynthese
ES2061714T3 (es) * 1987-12-22 1994-12-16 Hoechst Ag Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida.
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
ES2075196T3 (es) * 1989-02-17 1995-10-01 Chiron Mimotopes Pty Ltd Metodo para el uso y la sintesis de peptidos.
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
NL9002611A (nl) * 1990-11-29 1992-06-16 Crown Gear Bv Gereedschap voor het vervaardigen van kroonwielen, alsmede werkwijze voor het vervaardigen van een dergelijk gereedschap.
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Also Published As

Publication number Publication date
DE69429542T2 (de) 2002-08-08
DK1156059T3 (da) 2007-11-12
JP2003327597A (ja) 2003-11-19
DE69435011D1 (de) 2007-09-20
ATE369376T1 (de) 2007-08-15
DK0751779T3 (da) 2002-04-15
JP3469579B2 (ja) 2003-11-25
EP1156059A1 (de) 2001-11-21
EP1156059B1 (de) 2007-08-08
PT751779E (pt) 2002-05-31
NZ268292A (en) 1997-09-22
DE69429542D1 (de) 2002-01-31
ES2165880T3 (es) 2002-04-01
ES2291245T3 (es) 2008-03-01
US5635598A (en) 1997-06-03
AU689116B2 (en) 1998-03-26
WO1995000165A1 (en) 1995-01-05
EP0751779A1 (de) 1997-01-08
JPH09500111A (ja) 1997-01-07
EP0751779B1 (de) 2001-12-19
JP3672558B2 (ja) 2005-07-20
EP0751779A4 (de) 1998-12-09
PT1156059E (pt) 2007-10-19
DE69435011T2 (de) 2008-10-23
AU7114594A (en) 1995-01-17

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Legal Events

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UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEIH Change in the person of patent owner