DE69435011D1 - Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren - Google Patents

Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren

Info

Publication number
DE69435011D1
DE69435011D1 DE69435011T DE69435011T DE69435011D1 DE 69435011 D1 DE69435011 D1 DE 69435011D1 DE 69435011 T DE69435011 T DE 69435011T DE 69435011 T DE69435011 T DE 69435011T DE 69435011 D1 DE69435011 D1 DE 69435011D1
Authority
DE
Germany
Prior art keywords
methionine
ester group
cleavable linkers
selectively cleavable
linkers based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69435011T
Other languages
English (en)
Other versions
DE69435011T2 (de
Inventor
Michal Lebl
Viktor Krchnak
Petr Kocis
Kit S Lam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of DE69435011D1 publication Critical patent/DE69435011D1/de
Application granted granted Critical
Publication of DE69435011T2 publication Critical patent/DE69435011T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fertilizers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE69435011T 1993-06-21 1994-06-21 Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren Expired - Lifetime DE69435011T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8038893A 1993-06-21 1993-06-21
US80388 1993-06-21
US8199793A 1993-06-23 1993-06-23
US81997 1993-06-23

Publications (2)

Publication Number Publication Date
DE69435011D1 true DE69435011D1 (de) 2007-09-20
DE69435011T2 DE69435011T2 (de) 2008-10-23

Family

ID=26763448

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69435011T Expired - Lifetime DE69435011T2 (de) 1993-06-21 1994-06-21 Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren
DE69429542T Expired - Lifetime DE69429542T2 (de) 1993-06-21 1994-06-21 Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69429542T Expired - Lifetime DE69429542T2 (de) 1993-06-21 1994-06-21 Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren

Country Status (11)

Country Link
US (1) US5635598A (de)
EP (2) EP1156059B1 (de)
JP (2) JP3469579B2 (de)
AT (2) ATE210993T1 (de)
AU (1) AU689116B2 (de)
DE (2) DE69435011T2 (de)
DK (2) DK1156059T3 (de)
ES (2) ES2165880T3 (de)
NZ (1) NZ268292A (de)
PT (2) PT1156059E (de)
WO (1) WO1995000165A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
ATE272058T1 (de) * 1995-10-17 2004-08-15 Combichem Inc Matrize für die synthese kombinatorischer bibliotheken in lösung
WO1997037953A1 (en) * 1996-04-08 1997-10-16 Glaxo Group Ltd. Mass-based encoding and qualitative analysis of combinatorial libraries
DE19626762A1 (de) * 1996-07-03 1998-01-08 Basf Ag Enzymatisch spaltbare Linker für Festphasensynthesen
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
IL129728A0 (en) * 1996-11-04 2000-02-29 Dimensional Pharm Inc System method and computer program product for the visualization and interactive processing and analysis of chemical data
US6571227B1 (en) * 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
DK0937096T3 (da) 1996-11-06 2004-06-14 Sequenom Inc Fremgangsmåde til massespektrometri-analyse
US6133436A (en) * 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5958703A (en) * 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
US6168913B1 (en) * 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
WO1999025752A1 (en) * 1997-11-18 1999-05-27 Aventis Pharmaceuticals Products Inc. Functionalized resin for the synthesis of amides and peptides
CA2260472A1 (en) * 1998-02-11 1999-08-11 Xiao-Yi Xiao Safety-catch linkers
US7094943B2 (en) 1998-04-27 2006-08-22 Hubert Köster Solution phase biopolymer synthesis
GB9912911D0 (en) * 1999-06-04 1999-08-04 Zeneca Ltd Chemical process
US6309889B1 (en) 1999-12-23 2001-10-30 Glaxo Wellcome Inc. Nano-grid micro reactor and methods
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
EP1259823A2 (de) * 2000-02-23 2002-11-27 Xenoport, Inc. Selbstkodierte kombinatorische herstellung von zusammenfassung-mehrerelementen
US6671627B2 (en) 2000-02-29 2003-12-30 3-D Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
US7039621B2 (en) 2000-03-22 2006-05-02 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method, and computer program product for representing object relationships in a multidimensional space
AU2001249805A1 (en) 2000-04-03 2001-10-15 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
CA2419600A1 (en) * 2000-08-22 2002-02-28 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
AU2001292740A1 (en) * 2000-09-20 2002-04-02 Dimitris K. Agrafiotis Method, system, and computer program product for encoding and building products of a virtual combinatorial library
WO2002061419A1 (en) * 2001-01-29 2002-08-08 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for analyzing combinatorial libraries
US7262269B2 (en) * 2001-10-26 2007-08-28 The Regents Of University Of California Method for screening combinational bead library; ligands for cancer cells
US6670142B2 (en) 2001-10-26 2003-12-30 The Regents Of The University Of California Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells
US7291456B2 (en) 2002-01-24 2007-11-06 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
EP1807092B1 (de) 2004-11-05 2016-09-07 The Children's Hospital of Philadelphia Biologisch abbaubare verbindungsglieder für molekulare therapien
EP2592103A1 (de) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymeraldehydderivate
CN103788367B (zh) * 2014-02-26 2017-01-11 中国科学院长春应用化学研究所 一种聚酯酰胺及其制备方法
MX2017009768A (es) * 2015-02-02 2017-12-11 Two Pore Guys Inc Ligadores lábiles para detección de biomarcadores.
PL3650458T3 (pl) * 2015-02-24 2023-11-06 City Of Hope Platformy do analiz przesiewowych bibliotek kodowanych chemicznie i adresowanych przestrzennie
DE102015117567B4 (de) 2015-10-15 2017-05-11 Stochastic Combinatorics GbR (vertretungsberechtigter Gesellschafter: Dr. Alexander Nesterov-Müller, 76661 Philippsburg) Ultra-hochdichte Oligomerarrays und Verfahren zu deren Herstellung
JP2020527133A (ja) 2017-06-20 2020-09-03 インブリア ファーマシューティカルズ， インコーポレイテッド 心臓代謝の効率を高めるための組成物および方法
EP3866794A4 (de) 2018-10-17 2022-07-20 Imbria Pharmaceuticals, Inc. Verfahren zur behandlung von rheumatischen erkrankungen unter verwendung von trimetazidinbasierten verbindungen
US20220372175A1 (en) * 2019-11-14 2022-11-24 Bcd Bioscience, Inc. High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
WO2023102255A1 (en) * 2021-12-03 2023-06-08 Massachusetts Institute Of Technology Peptide-encoded libraries of small molecules for de novo drug discovery

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963701A (en) * 1972-04-17 1976-06-15 Richardson-Merrell Inc. Substituted benzhydryl lactamimide derivatives
FR2595695B1 (fr) * 1986-03-12 1988-12-02 Synthelabo Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
ES2003862A4 (es) * 1986-12-24 1988-12-01 Monsanto Co Resina soporte para la sintesis de peptidos en fase solida.
DE3887670D1 (de) * 1987-12-22 1994-03-17 Hoechst Ag Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode.
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
EP0628570A1 (de) * 1989-02-17 1994-12-14 Chiron Mimotopes Pty. Ltd. Verfahren zur Verwendung und Herstellung von Peptiden
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
NL9002611A (nl) * 1990-11-29 1992-06-16 Crown Gear Bv Gereedschap voor het vervaardigen van kroonwielen, alsmede werkwijze voor het vervaardigen van een dergelijk gereedschap.
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Also Published As

Publication number Publication date
PT1156059E (pt) 2007-10-19
DK1156059T3 (da) 2007-11-12
AU7114594A (en) 1995-01-17
ATE210993T1 (de) 2002-01-15
DK0751779T3 (da) 2002-04-15
JP3672558B2 (ja) 2005-07-20
DE69435011T2 (de) 2008-10-23
PT751779E (pt) 2002-05-31
ES2165880T3 (es) 2002-04-01
NZ268292A (en) 1997-09-22
JP3469579B2 (ja) 2003-11-25
JPH09500111A (ja) 1997-01-07
EP0751779B1 (de) 2001-12-19
US5635598A (en) 1997-06-03
ES2291245T3 (es) 2008-03-01
WO1995000165A1 (en) 1995-01-05
EP0751779A4 (de) 1998-12-09
ATE369376T1 (de) 2007-08-15
DE69429542D1 (de) 2002-01-31
EP1156059B1 (de) 2007-08-08
JP2003327597A (ja) 2003-11-19
EP1156059A1 (de) 2001-11-21
AU689116B2 (en) 1998-03-26
DE69429542T2 (de) 2002-08-08
EP0751779A1 (de) 1997-01-08

Similar Documents

Publication Publication Date Title
DE69435011D1 (de) Selektiv spaltbare Linker, die auf einer Methionin- und einer Estergruppe basieren
HN1998000011A (es) Derivados de acidos arilsulfonilaminohidroxamicos
PT788360E (pt) Compostos de acido e ester boronico, sinteses e utilizacoes.
DE69607536T2 (de) Estersynthese
DE69413052D1 (de) Sprachsynthese
AU3990697A (en) Intermediate of condensed benzazepine derivative
WO1992022523A3 (en) Peptide derivatives of collagenase inhibitor
AR038427A2 (es) Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
DE69735871D1 (de) Synthese von 9-Deoxo-9a-Aza 11,12-Deoxy-9a-Methyl-9a-Homoerythromycin A 11,12-hydrogenorthoborat-dihydrat
DK0843672T3 (da) Enkeltreaktorsyntese af 2-oxazolidinonderivater
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
ES2134910T3 (es) Sintesis de bisindolilmaleimidas.
ES2140422T3 (es) Composiciones transdermicas.
NO940018D0 (no) Fremgangsmaate for fremstilling av svovelholdige imidazolderivater
AU5135796A (en) Novel intermediates for the synthesis of trifluoromethylated organic compounds
FR2767824B1 (fr) Synthese d'acides carboxyalkylthiosucciniques
ES2189169T3 (es) Procedimiento de reduccion de alfa-amino cetonas.
FI93443B (fi) Menetelmä välituotteiden valmistamiseksi ja N-(2-hydroksietyyli)-2-hydroksimetyyli-3,4,5-trihydroksipiperidiinien syntetisoimiseksi
TR199600434A1 (tr) Ikame edilmis 8-klorokinolin'lerin ikame edilmis 8-hidrosikinolin'lere cevrilmesi.
FR2742826B1 (fr) Module d'embrayage dont le couvercle est fixe sur un flasque de support par des pattes axiales
ES8608534A1 (es) Procedimiento para la fabricacion de etoposido.
BR7500931U (pt) Disposição construtiva proporcionada a obra de arte

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS HOLDINGS INC., GREENVILLE, DEL., US

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US