DK0751779T3 - Selektivt kløvbare linkere som er baseret på iminodieddikesyreester-bindinger - Google Patents

Selektivt kløvbare linkere som er baseret på iminodieddikesyreester-bindinger

Info

Publication number
DK0751779T3
DK0751779T3 DK94920294T DK94920294T DK0751779T3 DK 0751779 T3 DK0751779 T3 DK 0751779T3 DK 94920294 T DK94920294 T DK 94920294T DK 94920294 T DK94920294 T DK 94920294T DK 0751779 T3 DK0751779 T3 DK 0751779T3
Authority
DK
Denmark
Prior art keywords
acid ester
iminodiacetic acid
ester linkages
cleavable linkers
selectively cleavable
Prior art date
Application number
DK94920294T
Other languages
English (en)
Inventor
Michal Lebl
Viktor Krchnak
Petr Kocis
Kit S Lam
Original Assignee
Selectide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selectide Corp filed Critical Selectide Corp
Application granted granted Critical
Publication of DK0751779T3 publication Critical patent/DK0751779T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
DK94920294T 1993-06-21 1994-06-21 Selektivt kløvbare linkere som er baseret på iminodieddikesyreester-bindinger DK0751779T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8038893A 1993-06-21 1993-06-21
US8199793A 1993-06-23 1993-06-23
PCT/US1994/007012 WO1995000165A1 (en) 1993-06-21 1994-06-21 Selectively cleavable linkers based on iminodiacetic acid ester bonds

Publications (1)

Publication Number Publication Date
DK0751779T3 true DK0751779T3 (da) 2002-04-15

Family

ID=26763448

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94920294T DK0751779T3 (da) 1993-06-21 1994-06-21 Selektivt kløvbare linkere som er baseret på iminodieddikesyreester-bindinger
DK01114395T DK1156059T3 (da) 1993-06-21 1994-06-21 Selektivt spaltelige linkere baseret på en methioningruppe og en estergruppe

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01114395T DK1156059T3 (da) 1993-06-21 1994-06-21 Selektivt spaltelige linkere baseret på en methioningruppe og en estergruppe

Country Status (11)

Country Link
US (1) US5635598A (da)
EP (2) EP0751779B1 (da)
JP (2) JP3469579B2 (da)
AT (2) ATE369376T1 (da)
AU (1) AU689116B2 (da)
DE (2) DE69429542T2 (da)
DK (2) DK0751779T3 (da)
ES (2) ES2291245T3 (da)
NZ (1) NZ268292A (da)
PT (2) PT1156059E (da)
WO (1) WO1995000165A1 (da)

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US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
ATE272058T1 (de) * 1995-10-17 2004-08-15 Combichem Inc Matrize für die synthese kombinatorischer bibliotheken in lösung
EP0863858B1 (en) * 1996-04-08 2004-02-04 Glaxo Group Limited Mass-based encoding and qualitative analysis of combinatorial libraries
DE19626762A1 (de) * 1996-07-03 1998-01-08 Basf Ag Enzymatisch spaltbare Linker für Festphasensynthesen
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
US6571227B1 (en) 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
US6421612B1 (en) 1996-11-04 2002-07-16 3-Dimensional Pharmaceuticals Inc. System, method and computer program product for identifying chemical compounds having desired properties
DK0937096T3 (da) 1996-11-06 2004-06-14 Sequenom Inc Fremgangsmåde til massespektrometri-analyse
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5958703A (en) * 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
US6168913B1 (en) * 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
AU1589099A (en) * 1997-11-18 1999-06-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Functionalized resin for the synthesis of amides and peptides
CA2260472A1 (en) * 1998-02-11 1999-08-11 Xiao-Yi Xiao Safety-catch linkers
US7094943B2 (en) 1998-04-27 2006-08-22 Hubert Köster Solution phase biopolymer synthesis
GB9912911D0 (en) 1999-06-04 1999-08-04 Zeneca Ltd Chemical process
US6309889B1 (en) 1999-12-23 2001-10-30 Glaxo Wellcome Inc. Nano-grid micro reactor and methods
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
AU2001241668A1 (en) * 2000-02-23 2001-09-03 Xenoport, Inc. Self-encoded combinatorial synthesis of compound multiplets
WO2001065462A2 (en) 2000-02-29 2001-09-07 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
AU2001247627A1 (en) 2000-03-22 2001-10-03 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing object relationships in a multidimensional space
US7139739B2 (en) 2000-04-03 2006-11-21 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for representing object relationships in a multidimensional space
CA2419600A1 (en) * 2000-08-22 2002-02-28 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
AU2001292740A1 (en) * 2000-09-20 2002-04-02 Dimitris K. Agrafiotis Method, system, and computer program product for encoding and building products of a virtual combinatorial library
US7054757B2 (en) * 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
US7262269B2 (en) * 2001-10-26 2007-08-28 The Regents Of University Of California Method for screening combinational bead library; ligands for cancer cells
US6670142B2 (en) 2001-10-26 2003-12-30 The Regents Of The University Of California Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells
US7291456B2 (en) 2002-01-24 2007-11-06 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
EP1807092B1 (en) 2004-11-05 2016-09-07 The Children's Hospital of Philadelphia Biodegradable linkers for molecular therapies
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
CN103788367B (zh) * 2014-02-26 2017-01-11 中国科学院长春应用化学研究所 一种聚酯酰胺及其制备方法
WO2016126748A1 (en) * 2015-02-02 2016-08-11 Two Pore Guys, Inc. Labile linkers for biomarker detection
DE102015117567B4 (de) 2015-10-15 2017-05-11 Stochastic Combinatorics GbR (vertretungsberechtigter Gesellschafter: Dr. Alexander Nesterov-Müller, 76661 Philippsburg) Ultra-hochdichte Oligomerarrays und Verfahren zu deren Herstellung
PL3641769T3 (pl) 2017-06-20 2022-09-26 Imbria Pharmaceuticals, Inc. Pochodna 1-[(2,3,4-trimetoksyfenylo)metylo]piperazyny, jej kompozycje oraz sposoby zwiększania wydajności metabolizmu serca
EP3866794A4 (en) 2018-10-17 2022-07-20 Imbria Pharmaceuticals, Inc. METHODS OF TREATING RHEUMATIC DISEASES USING TRIMETAZIDINE COMPOUNDS
EP4057830A4 (en) * 2019-11-14 2023-09-13 BCD Bioscience, Inc. HIGH YIELD PEROXIDE QUENCH CONTROLLED POLYSACCHARIDE DEPOLYMERIZATION AND COMPOSITIONS THEREOF
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
WO2023102255A1 (en) * 2021-12-03 2023-06-08 Massachusetts Institute Of Technology Peptide-encoded libraries of small molecules for de novo drug discovery

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US3963701A (en) * 1972-04-17 1976-06-15 Richardson-Merrell Inc. Substituted benzhydryl lactamimide derivatives
FR2595695B1 (fr) * 1986-03-12 1988-12-02 Synthelabo Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
EP0274999A3 (en) * 1986-12-24 1988-12-14 Monsanto Company Resin support for solid phase peptide synthesis
EP0322348B1 (de) * 1987-12-22 1994-02-02 Hoechst Aktiengesellschaft Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
DK0458841T3 (da) * 1989-02-17 1995-11-20 Chiron Mimotopes Pty Ltd Fremgangsmåde til anvendelse og fremstilling af peptider
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
NL9002611A (nl) * 1990-11-29 1992-06-16 Crown Gear Bv Gereedschap voor het vervaardigen van kroonwielen, alsmede werkwijze voor het vervaardigen van een dergelijk gereedschap.
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Also Published As

Publication number Publication date
JP3672558B2 (ja) 2005-07-20
AU689116B2 (en) 1998-03-26
NZ268292A (en) 1997-09-22
ATE210993T1 (de) 2002-01-15
JP2003327597A (ja) 2003-11-19
DE69429542D1 (de) 2002-01-31
JPH09500111A (ja) 1997-01-07
EP1156059B1 (en) 2007-08-08
DE69435011D1 (de) 2007-09-20
EP1156059A1 (en) 2001-11-21
ES2165880T3 (es) 2002-04-01
EP0751779A1 (en) 1997-01-08
WO1995000165A1 (en) 1995-01-05
ES2291245T3 (es) 2008-03-01
PT751779E (pt) 2002-05-31
AU7114594A (en) 1995-01-17
DE69435011T2 (de) 2008-10-23
JP3469579B2 (ja) 2003-11-25
PT1156059E (pt) 2007-10-19
DE69429542T2 (de) 2002-08-08
EP0751779A4 (en) 1998-12-09
DK1156059T3 (da) 2007-11-12
EP0751779B1 (en) 2001-12-19
US5635598A (en) 1997-06-03
ATE369376T1 (de) 2007-08-15

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