PT73161B - Procede pour la preparation de derives de n-(vynblastinoyl-23) aux amino-acides et peptides et son application terapeutique - Google Patents
Procede pour la preparation de derives de n-(vynblastinoyl-23) aux amino-acides et peptides et son application terapeutiqueInfo
- Publication number
- PT73161B PT73161B PT73161A PT7316181A PT73161B PT 73161 B PT73161 B PT 73161B PT 73161 A PT73161 A PT 73161A PT 7316181 A PT7316181 A PT 7316181A PT 73161 B PT73161 B PT 73161B
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- preparation
- amino acid
- vynblastinoyl
- terapeutic
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 title 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- -1 peptide derivatives Natural products 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003048 vinblastine Drugs 0.000 abstract 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical class C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU82514A LU82514A1 (fr) | 1980-06-10 | 1980-06-10 | Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique |
| LU83034A LU83034A1 (fr) | 1980-12-23 | 1980-12-23 | Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT73161A PT73161A (fr) | 1981-07-01 |
| PT73161B true PT73161B (fr) | 1982-07-16 |
Family
ID=26640267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT73161A PT73161B (fr) | 1980-06-10 | 1981-06-09 | Procede pour la preparation de derives de n-(vynblastinoyl-23) aux amino-acides et peptides et son application terapeutique |
Country Status (21)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU83822A1 (fr) * | 1981-12-08 | 1983-09-01 | Omnichem Sa | Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique |
| US4639456A (en) * | 1980-06-10 | 1987-01-27 | Omnichem S.A. | Vinblastin-23-oyl amino acid derivatives |
| IT1170152B (it) * | 1982-07-19 | 1987-06-03 | Lilly Co Eli | Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi |
| EP0123441B1 (en) * | 1983-03-30 | 1990-10-03 | Lilly Industries Limited | Vincaleukoblastine derivatives |
| ATE64396T1 (de) * | 1983-04-29 | 1991-06-15 | Omnichem Sa | Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
| US4667030A (en) * | 1985-06-17 | 1987-05-19 | Eli Lilly And Company | Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids |
| US4675400A (en) * | 1985-06-17 | 1987-06-23 | Eli Lilly And Company | Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids |
| FI860456A7 (fi) * | 1985-07-16 | 1987-01-17 | Huhtamaeki Oy Laeaeketehdas Le | Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning. |
| EP0232693A3 (fr) * | 1985-12-16 | 1988-04-06 | La Region Wallonne | Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant |
| JPH075608B2 (ja) * | 1986-01-13 | 1995-01-25 | イ−ル−セルタ−ク ソシエテ アノニム | ビンブラスチン誘導体 |
| ES2045092T3 (es) * | 1987-11-11 | 1994-01-16 | Akzo Nv | Un procedimiento de manufactura de un producto farmaceutico para tratamiento de cancer. |
| FR2623504B1 (fr) * | 1987-11-25 | 1990-03-09 | Adir | Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2626882B1 (fr) * | 1988-02-08 | 1991-11-08 | Ire Celltarg Sa | Conjugues de derives de vinca comportant une chaine detergente en position c-3 |
| US4980343A (en) * | 1988-10-27 | 1990-12-25 | Bayer Aktiengesellschaft | Aminooxodihydroisoindoloquinazoline carcinostatic agents |
| US5043336A (en) * | 1990-04-03 | 1991-08-27 | Eli Lilly And Company | Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide |
| US5043340A (en) * | 1990-04-03 | 1991-08-27 | Eli Lilly And Company | Derivatives of 4-desacetyl VLB C-3 carboxhydrazide |
| US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| US6143864A (en) * | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
| US5599686A (en) * | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
| BE1008581A3 (fr) * | 1994-08-19 | 1996-06-04 | Wallone Region | Prodrogues, composition pharmaceutique les comprenant et leur utilisation. |
| ES2297832T3 (es) * | 1994-08-19 | 2008-05-01 | La Region Wallonne | Conjugados que comprenden un agente antitumoral y su utilizacion. |
| US5998362A (en) * | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6127333A (en) * | 1997-07-10 | 2000-10-03 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6391305B1 (en) | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| WO2000006582A1 (en) * | 1998-07-31 | 2000-02-10 | Goldsmith Seeds, Inc. | Trimeric and polymeric alkaloids |
| DE19842416A1 (de) * | 1998-09-16 | 2000-04-13 | Max Planck Gesellschaft | Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden |
| US7425541B2 (en) * | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| AU2001266853B2 (en) | 2000-06-14 | 2005-02-17 | Medarex, Inc. | Prodrug compounds with an oligopeptide having an isoleucine residue |
| US20030232760A1 (en) * | 2001-09-21 | 2003-12-18 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US7235564B2 (en) * | 2003-12-04 | 2007-06-26 | Amr Technology, Inc. | Vinorelbine derivatives |
| US7238704B2 (en) * | 2003-12-04 | 2007-07-03 | Amr Technology, Inc. | Vinca derivatives |
| WO2008033935A2 (en) * | 2006-09-12 | 2008-03-20 | Amr Technology, Inc. | Vinorelbine derivatives |
| WO2008033930A2 (en) * | 2006-09-12 | 2008-03-20 | Amr Technology, Inc. | Vinca derivatives |
| CA3183740A1 (en) | 2020-06-10 | 2021-12-16 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
| EP4366831A4 (en) | 2021-07-09 | 2025-06-11 | Aligos Therapeutics, Inc. | ANTI-VIRAL COMPOUNDS |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3387001A (en) * | 1964-10-19 | 1968-06-04 | Lilly Co Eli | Novel aminoacyl esters of desacetyl vincaleukoblastine |
| AR204004A1 (es) * | 1973-04-02 | 1975-11-12 | Lilly Co Eli | Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina |
| GR69783B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1976-09-08 | 1982-07-07 | Lilly Co Eli | |
| US4203898A (en) * | 1977-08-29 | 1980-05-20 | Eli Lilly And Company | Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids |
-
1979
- 1979-12-13 OA OA56972A patent/OA06421A/xx unknown
-
1981
- 1981-05-30 ES ES502644A patent/ES502644A0/es active Granted
- 1981-06-02 GR GR65133A patent/GR74565B/el unknown
- 1981-06-02 AU AU71262/81A patent/AU541747B2/en not_active Ceased
- 1981-06-03 US US06/269,876 patent/US4388305A/en not_active Expired - Fee Related
- 1981-06-03 NZ NZ197299A patent/NZ197299A/en unknown
- 1981-06-04 CA CA000379041A patent/CA1196326A/en not_active Expired
- 1981-06-04 IE IE1275/81A patent/IE51403B1/en not_active IP Right Cessation
- 1981-06-04 IL IL63038A patent/IL63038A0/xx not_active IP Right Cessation
- 1981-06-05 DE DE19813122479 patent/DE3122479A1/de not_active Withdrawn
- 1981-06-05 AT AT0253881A patent/AT390793B/de not_active IP Right Cessation
- 1981-06-08 IT IT67782/81A patent/IT1144601B/it active
- 1981-06-08 GB GB8117454A patent/GB2078730A/en not_active Withdrawn
- 1981-06-09 FR FR8111330A patent/FR2483926A1/fr active Granted
- 1981-06-09 EP EP81870028A patent/EP0041935B1/fr not_active Expired
- 1981-06-09 SE SE8103594A patent/SE8103594L/xx not_active Application Discontinuation
- 1981-06-09 DK DK250181A patent/DK160614C/da not_active IP Right Cessation
- 1981-06-09 PT PT73161A patent/PT73161B/pt unknown
- 1981-06-09 DD DD81230660A patent/DD160417A5/de not_active IP Right Cessation
- 1981-06-09 DE DE8181870028T patent/DE3166150D1/de not_active Expired
- 1981-06-09 AT AT81870028T patent/ATE9475T1/de active
- 1981-06-10 NL NL8102802A patent/NL8102802A/nl not_active Application Discontinuation
- 1981-06-10 HU HU811725A patent/HU185261B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2078730A (en) | 1982-01-13 |
| EP0041935B1 (fr) | 1984-09-19 |
| ES8203385A1 (es) | 1982-04-01 |
| IT1144601B (it) | 1986-10-29 |
| DD160417A5 (de) | 1983-07-27 |
| DK250181A (da) | 1981-12-11 |
| ATA253881A (de) | 1989-12-15 |
| AU7126281A (en) | 1981-12-17 |
| AT390793B (de) | 1990-06-25 |
| AU541747B2 (en) | 1985-01-17 |
| OA06421A (fr) | 1981-09-30 |
| DE3122479A1 (de) | 1982-06-16 |
| US4388305A (en) | 1983-06-14 |
| IE51403B1 (en) | 1986-12-24 |
| ATE9475T1 (de) | 1984-10-15 |
| GR74565B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-06-29 |
| NL8102802A (nl) | 1982-01-04 |
| IL63038A0 (en) | 1981-09-13 |
| PT73161A (fr) | 1981-07-01 |
| DK160614C (da) | 1991-09-23 |
| DK160614B (da) | 1991-04-02 |
| IT8167782A0 (it) | 1981-06-08 |
| NZ197299A (en) | 1985-10-11 |
| SE8103594L (sv) | 1981-12-11 |
| DE3166150D1 (en) | 1984-10-25 |
| HU185261B (en) | 1984-12-28 |
| CA1196326A (en) | 1985-11-05 |
| FR2483926A1 (fr) | 1981-12-11 |
| EP0041935A1 (fr) | 1981-12-16 |
| IE811275L (en) | 1981-12-10 |
| ES502644A0 (es) | 1982-04-01 |
| FR2483926B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT73161B (fr) | Procede pour la preparation de derives de n-(vynblastinoyl-23) aux amino-acides et peptides et son application terapeutique | |
| DE3366494D1 (de) | New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives | |
| DE69027865D1 (de) | ZUSAMMENSETZUNGEN enthaltend omega Conotoxin Peptide Derivate und deren Verwendung ZUR BEHANDLUNG VON ISCHÄMIE-ARTIGEN NEURONALEN SCHÄDIGUNGEN | |
| ES530046A0 (es) | Procedimiento para la obtencion de acidos quinoloncarboxilicos | |
| MA19753A1 (fr) | Procede de preparation de nouveaux derives d'acides amines bicycliques. | |
| GR80840B (en) | Novel polypeptide with a - amylase inhibiting effect, method for the preparation thereof, use and pharmaceutical preparations thereof | |
| ES8601108A1 (es) | Procedimiento para la obtencion de eglinas b o c modificadas | |
| DK346783D0 (da) | Triphenylimidazolyloxyalkansyrer og derivater deraf, fremgangsmade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser | |
| DK403384A (da) | Enteralt effektivt, biologisk aktivt peptid- eller proteinmiddel ogfremgangsmaader til fremstilling deraf | |
| DE3568048D1 (en) | Process for the synthesis of peptides | |
| IT1171092B (it) | Tripeptide e tetrapeptide alchilamidi biologicamente attive,processi per la loro preparazione e composizioni farmaceutiche che le contengono | |
| DE2961609D1 (en) | Sila-substituted 1,4-dihydropyridine derivatives, processes for their preparation, pharmaceutical compositions and process for their preparation | |
| DE3160757D1 (en) | Amino acid and peptide esters of leuco-indo anilines, process for their preparation and agents containing these compounds for the detection of proteolytic enzymes | |
| DK161384C (da) | Pyrazolooe3,4,5-klaaacridinforbindelser og farmaceutiske praeparater indeholdende saadanne forbindelser | |
| BG43187A3 (bg) | Метод за получаване на ауронови производни | |
| DK229984D0 (da) | 4-oxothiazolidin-2-yliden-acetamid-derivater | |
| DE59107762D1 (de) | Komplexe, enthaltend S(+)-Phenyl-alkansäuren und alpha-Hydroxy-alkansäuren | |
| SE8202962D0 (sv) | 2-metoxifenylestrar av n-substiterade aminosyror, forfarande for deras framstellning och farmaceutiska beredningar innehallande desamma | |
| FR2559157B1 (fr) | Nouvel hexapeptide, son procede d'obtention et les compositions pharmaceutiques qui le contiennent | |
| IT1194346B (it) | Amino derivati di benziliden-pirrolo (2,1-b) chinazoline e benziliden-pirido (2,1-b) chinazoline e procedimento per la loro preparazione | |
| ATE10934T1 (de) | Peptid, verfahren zu dessen herstellung und dessen verwendung. | |
| JPS51136602A (en) | Process for preparation of amino acid or peptide | |
| FI810866A7 (fi) | Substituoituja alkyylitioasyyliaminohappoja, niiden valmistusmenetelmiä ja farmaseuttfarmaseuttisia seoksia. | |
| IT8223417A0 (it) | Derivati di amminoacidi malonil- e malonil-2-sostituiti e metodi per la loro preparazione. |