ES8601108A1 - Procedimiento para la obtencion de eglinas b o c modificadas - Google Patents

Procedimiento para la obtencion de eglinas b o c modificadas

Info

Publication number
ES8601108A1
ES8601108A1 ES534098A ES534098A ES8601108A1 ES 8601108 A1 ES8601108 A1 ES 8601108A1 ES 534098 A ES534098 A ES 534098A ES 534098 A ES534098 A ES 534098A ES 8601108 A1 ES8601108 A1 ES 8601108A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
proteinase inhibitors
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534098A
Other languages
English (en)
Other versions
ES534098A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8601108A1 publication Critical patent/ES8601108A1/es
Publication of ES534098A0 publication Critical patent/ES534098A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE EGLINAS B O C MODIFICADAS POR ACORTAMIENTO DE LA ESTRUCTURA PRIMARIA DE LA EGLINA B O C EN 2-10 ELEMENTOS AMINOACIDO AL PRINCIPIO DE LA MOLECULA Y 2-6 ELEMENTOS AMINOACIDO AL FINAL DE LA MISMA. CONSISTE EN SOMETER EGLINA B O C A UNA PROTEOLISIS LIMITADA MEDIANTE UN PROCESO ENZIMATICO CON UNA PEPTIDASA DISUELTA EN SISTEMA TAMPONADO QUE CONTIENE 05% DE LAURILSULFATO SODICO DURANTE 2-72 HORAS A UNA TEMPERATURA ENTRE 10JC Y 40JC. TAMBIEN SE PUEDE PROCEDER POR DISOCIACION DE LOS GRUPOS PROTECTORES EXISTENTES EN UN COMPUESTO CORRESPONDIENTE A UNA EGLINA MODIFICADA B O C EN EL QUE COMO MINIMO UNO DE LOS GRUPOS AMINO HIDROXI O CARBOSI TIENE GRUPO PROTECTOR. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES INHIBIDORES DE LA PROTEASA.
ES534098A 1983-07-07 1984-07-06 Procedimiento para la obtencion de eglinas b o c modificadas Granted ES534098A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3324534A DE3324534A1 (de) 1983-07-07 1983-07-07 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel

Publications (2)

Publication Number Publication Date
ES8601108A1 true ES8601108A1 (es) 1985-10-16
ES534098A0 ES534098A0 (es) 1985-10-16

Family

ID=6203414

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534098A Granted ES534098A0 (es) 1983-07-07 1984-07-06 Procedimiento para la obtencion de eglinas b o c modificadas

Country Status (10)

Country Link
US (1) US4636489A (es)
EP (1) EP0134479B1 (es)
JP (1) JPH0670077B2 (es)
AT (1) ATE32728T1 (es)
CA (1) CA1230069A (es)
DE (2) DE3324534A1 (es)
DK (1) DK165988C (es)
ES (1) ES534098A0 (es)
GR (1) GR82243B (es)
IE (1) IE57698B1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342373B1 (en) * 1983-11-21 2002-01-29 Ucp Gen-Pharma Ag Process for preparing recombinant eglin, protease inhibitor
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US5166134A (en) * 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
EP0332576B1 (de) * 1988-03-07 1994-04-06 Ciba-Geigy Ag Modifizierte Proteine
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
IL90356A0 (en) * 1988-05-27 1989-12-15 Magainin Sciences Inc Amphiphilic peptides and pharmaceutical compositions containing them
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
EP0514464A4 (en) * 1990-02-08 1993-04-28 Magainin Sciences, Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
JPH05507273A (ja) * 1990-05-14 1993-10-21 マゲイニン　サイエンセズ　インコーポレーテッド Ｄアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
WO1992000090A1 (en) * 1990-06-27 1992-01-09 Magainin Pharmaceuticals Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
HU217612B (hu) * 1991-05-23 2000-03-28 Merrel Dow Pharmaceuticals Inc. Eljárás elasztáz és katepszin G inhibitor hatású peptidek előállítására
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
WO1993007892A1 (en) * 1991-10-16 1993-04-29 The Children's Hospital Of Philadelphia Composition and treatment with biologically active peptides and antibiotic
KR100367389B1 (ko) * 1994-06-02 2003-07-18 메렐 파마슈티칼스 인크. 엘라스타제억제제의프로드러그로서아실화에놀유도체
US6008196A (en) * 1994-06-02 1999-12-28 Hoechst Marion Roussel, Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
JP2000506394A (ja) 1996-09-24 2000-05-30 ザ、プロクター、エンド、ギャンブル、カンパニー 安定化されたタンパク質性プロテアーゼインヒビターおよびその変種
US7001884B2 (en) * 2001-06-18 2006-02-21 Regents Of The University Of Michigan Eglin c based drugs for treatment of disease
DE102005007313A1 (de) * 2005-02-17 2006-08-24 Wacker Chemie Ag Verfahren zur Herstellung von Entschäumerformulierungen
KR101237116B1 (ko) * 2010-11-12 2013-02-25 대한유화공업 주식회사 내충격성 및 내압특성이 우수한 폴리프로필렌 조성물
CN110551707A (zh) * 2019-10-17 2019-12-10 山西大学 一种纯化中性或碱性蛋白酶的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808396C2 (de) * 1978-02-27 1984-04-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Protease-Inhibitoren
US4250086A (en) * 1979-11-19 1981-02-10 Ortho Pharmaceutical Corporation Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2

Also Published As

Publication number Publication date
EP0134479B1 (de) 1988-03-02
EP0134479A1 (de) 1985-03-20
ATE32728T1 (de) 1988-03-15
DK165988C (da) 1993-07-26
DK332684A (da) 1985-01-08
DE3324534A1 (de) 1985-01-17
JPS60105699A (ja) 1985-06-11
IE57698B1 (en) 1993-03-10
DK332684D0 (da) 1984-07-06
DK165988B (da) 1993-02-22
CA1230069A (en) 1987-12-08
ES534098A0 (es) 1985-10-16
IE841734L (en) 1985-01-07
DE3469534D1 (en) 1988-04-07
JPH0670077B2 (ja) 1994-09-07
GR82243B (es) 1984-12-13
US4636489A (en) 1987-01-13

Similar Documents

Publication Publication Date Title
ES8601108A1 (es) Procedimiento para la obtencion de eglinas b o c modificadas
DK250181A (da) Fremgangsmaade til fremstilling af vinblastinderivater
IL75637A0 (en) Thymopentin analogs and pharmaceutical compositions containing them
DK304682A (da) Vandholdigt topisk praeparat og fremgangsmaade til formindskelse af vandtab fra saadanne praeparater
PT73291A (en) Process for the preparation of novel peptides
IL70728A0 (en) Amino acid derivatives,their production and pharmaceutical compositions containing them
DK482185D0 (da) Peptider, deres fremstilling og anvendelse som laegemidler
ES8704511A1 (es) Procedimiento para sintetizar peptidos a partir de aminoaci-dos
NZ210267A (en) Expression vectors for eglin b or c (protease inhibitors), transformed host, preparation, modified eglins and compositions
DE3160757D1 (en) Amino acid and peptide esters of leuco-indo anilines, process for their preparation and agents containing these compounds for the detection of proteolytic enzymes
DE3371076D1 (en) Substituted tert. butanol derivatives, method for their preparation and antimycotic agents containing them
FI891020A0 (fi) Menetelmä proteaasi-inhibiittoriaktiivisuutta omaavien egliinimutanttien valmistamiseksi
DE3162674D1 (en) A purified polypeptide, a process for its preparation, its use and pharmaceutical compositions containing it
ES8705847A1 (es) Procedimiento para preparar nuevos derivados de n-(2-hidro- xialquil)-aminoacidos
EP0038153A3 (en) Modified allergens
IT1170975B (it) Esteri del guaiacolo con amminoacidi n-sostituiti procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
SE8304972L (sv) Piperidinylcyklopentanolheptensyrasalt
MX167915B (es) Procedimiento para preprar una composicion farmaceutica para el tratamiento de excitacion psicomotriz
NO156654C (no) Fremgangsmaate for enzymatisk erstatning av b-30-aminosyren i insuliner.
IT8323052A0 (it) N-(2-mercaptopropionil)glicina, derivati della procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
JPS51136602A (en) Process for preparation of amino acid or peptide

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401