PT566199E - 1,2,4-oxadiazolil-fenioxialquilizoxazoles e suas utilizacoes como agentes antivirais - Google Patents

1,2,4-oxadiazolil-fenioxialquilizoxazoles e suas utilizacoes como agentes antivirais Download PDF

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Publication number
PT566199E
PT566199E PT93201058T PT93201058T PT566199E PT 566199 E PT566199 E PT 566199E PT 93201058 T PT93201058 T PT 93201058T PT 93201058 T PT93201058 T PT 93201058T PT 566199 E PT566199 E PT 566199E
Authority
PT
Portugal
Prior art keywords
compound
alkoxy
formula
alkyl
mmol
Prior art date
Application number
PT93201058T
Other languages
English (en)
Portuguese (pt)
Inventor
Guy Dominic Diana
Theodore John Nitz
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of PT566199E publication Critical patent/PT566199E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT93201058T 1992-04-15 1993-04-13 1,2,4-oxadiazolil-fenioxialquilizoxazoles e suas utilizacoes como agentes antivirais PT566199E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (1)

Publication Number Publication Date
PT566199E true PT566199E (pt) 2000-09-29

Family

ID=25353269

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93201058T PT566199E (pt) 1992-04-15 1993-04-13 1,2,4-oxadiazolil-fenioxialquilizoxazoles e suas utilizacoes como agentes antivirais

Country Status (26)

Country Link
US (3) US5349068A (forum.php)
EP (1) EP0566199B1 (forum.php)
JP (1) JP3103845B2 (forum.php)
KR (1) KR100314158B1 (forum.php)
AT (1) ATE189958T1 (forum.php)
AU (1) AU666528B2 (forum.php)
CA (1) CA2094012C (forum.php)
CZ (1) CZ285845B6 (forum.php)
DE (1) DE69327913T2 (forum.php)
DK (1) DK0566199T3 (forum.php)
ES (1) ES2143487T3 (forum.php)
FI (1) FI112229B (forum.php)
GR (1) GR3033486T3 (forum.php)
HU (2) HU220606B1 (forum.php)
IL (1) IL105372A (forum.php)
MX (1) MX9302169A (forum.php)
MY (1) MY110191A (forum.php)
NO (1) NO302700B1 (forum.php)
NZ (1) NZ247411A (forum.php)
PH (1) PH30454A (forum.php)
PT (1) PT566199E (forum.php)
RU (1) RU2114112C1 (forum.php)
SG (1) SG50663A1 (forum.php)
SK (1) SK279786B6 (forum.php)
TW (1) TW239140B (forum.php)
UA (1) UA35557C2 (forum.php)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
CN1638776A (zh) * 2001-06-08 2005-07-13 西托维亚公司 取代的3－芳基－5－芳基－[1,2,4]－噁二唑和类似物
US7129359B2 (en) 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
WO2003020270A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
US7429606B2 (en) * 2001-08-29 2008-09-30 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
DK2193792T3 (da) * 2001-12-07 2012-01-02 Ana Maria Sandino Neomycin til forøgelse af overlevelsesraten for vandlevende dyr, der udsættes for IPNV
WO2003068222A1 (en) * 2002-02-14 2003-08-21 Viropharma Incorporated Methods of reducing rhinovirus contagion and related compositions
CN100364531C (zh) * 2002-12-18 2008-01-30 西托维亚公司 3,5－二取代－[1,2,4]－二唑及类似物和其用途
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
JP2008509143A (ja) * 2004-08-04 2008-03-27 シェーリング コーポレイション 気道疾患の処置のためのプレコナリルを含む薬学的処方物
CA2641604A1 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
WO2007095043A2 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
AR059357A1 (es) * 2006-02-09 2008-03-26 Schering Corp Formulaciones farmaceuticas
JP5415957B2 (ja) 2006-12-13 2014-02-12 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤としての２−（ピペリジン−４−イル）−４−フェノキシ−又はフェニルアミノ−ピリミジン誘導体
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102322B (zh) * 2011-11-14 2016-02-24 上海交通大学 噁唑类化合物及其制备方法、药物组合物及其用途
CN112752761B (zh) 2018-08-21 2024-03-29 杏林制药株式会社 双环杂芳族环衍生物
EP4025212B8 (en) * 2019-09-27 2025-04-16 Collaborations Pharmaceuticals, Inc. Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
CA1299176C (en) * 1985-07-02 1992-04-21 Guy Dominic Diana Process for preparing isoxazole and furan derivatives
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
DE69327913T2 (de) 2000-10-12
SG50663A1 (en) 1998-07-20
IL105372A0 (en) 1993-08-18
HU9301084D0 (en) 1993-06-28
NO302700B1 (no) 1998-04-14
DK0566199T3 (da) 2000-06-19
JPH0649066A (ja) 1994-02-22
AU666528B2 (en) 1996-02-15
MX9302169A (es) 1993-10-01
SK279786B6 (sk) 1999-03-12
KR100314158B1 (ko) 2002-02-19
CA2094012C (en) 2001-08-21
NZ247411A (en) 1994-06-27
CZ285845B6 (cs) 1999-11-17
IL105372A (en) 1998-12-27
JP3103845B2 (ja) 2000-10-30
EP0566199B1 (en) 2000-03-01
NO931366L (no) 1993-10-18
KR930021637A (ko) 1993-11-22
TW239140B (forum.php) 1995-01-21
GR3033486T3 (en) 2000-09-29
CA2094012A1 (en) 1993-10-16
FI931707A0 (fi) 1993-04-15
RU2114112C1 (ru) 1998-06-27
NO931366D0 (no) 1993-04-14
HU220606B1 (hu) 2002-03-28
HUT65574A (en) 1994-07-28
FI112229B (fi) 2003-11-14
ATE189958T1 (de) 2000-03-15
US5349068A (en) 1994-09-20
UA35557C2 (uk) 2001-04-16
DE69327913D1 (de) 2000-04-06
SK35393A3 (en) 1994-06-08
PH30454A (en) 1997-05-28
AU3688193A (en) 1993-10-21
US5464848A (en) 1995-11-07
EP0566199A1 (en) 1993-10-20
CZ59793A3 (en) 1994-02-16
FI931707L (fi) 1993-10-16
US5643929A (en) 1997-07-01
HU211320A9 (en) 1995-11-28
ES2143487T3 (es) 2000-05-16
MY110191A (en) 1998-02-28

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