PT3625233T - Derivados de 3-(((((2s,5r)-2-carbamoil-7-oxo-1,6-diazabiciclo[3.2.1]octan-6-il)oxi)sulfonil)oxi)-2,2-dimetilpropanoato e compostos relacionados como pró-fármacos de inibidores da beta-lactamase administrados por via oral para o tratamento de infecções bacterianas - Google Patents
Derivados de 3-(((((2s,5r)-2-carbamoil-7-oxo-1,6-diazabiciclo[3.2.1]octan-6-il)oxi)sulfonil)oxi)-2,2-dimetilpropanoato e compostos relacionados como pró-fármacos de inibidores da beta-lactamase administrados por via oral para o tratamento de infecções bacterianasInfo
- Publication number
- PT3625233T PT3625233T PT187292230T PT18729223T PT3625233T PT 3625233 T PT3625233 T PT 3625233T PT 187292230 T PT187292230 T PT 187292230T PT 18729223 T PT18729223 T PT 18729223T PT 3625233 T PT3625233 T PT 3625233T
- Authority
- PT
- Portugal
- Prior art keywords
- oxy
- profrugs
- dimethylprop
- noate
- octan
- Prior art date
Links
- -1 (2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl Chemical group 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 239000003781 beta lactamase inhibitor Substances 0.000 title 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
- Storage Device Security (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762504523P | 2017-05-10 | 2017-05-10 | |
| US201762551043P | 2017-08-28 | 2017-08-28 | |
| US15/934,497 US10085999B1 (en) | 2017-05-10 | 2018-03-23 | Beta-lactamase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3625233T true PT3625233T (pt) | 2023-09-19 |
Family
ID=63639355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT187292230T PT3625233T (pt) | 2017-05-10 | 2018-05-02 | Derivados de 3-(((((2s,5r)-2-carbamoil-7-oxo-1,6-diazabiciclo[3.2.1]octan-6-il)oxi)sulfonil)oxi)-2,2-dimetilpropanoato e compostos relacionados como pró-fármacos de inibidores da beta-lactamase administrados por via oral para o tratamento de infecções bacterianas |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US10085999B1 (enExample) |
| EP (1) | EP3625233B9 (enExample) |
| JP (2) | JP6909924B2 (enExample) |
| KR (1) | KR102411517B1 (enExample) |
| CN (1) | CN110662746B (enExample) |
| AU (2) | AU2018266566B2 (enExample) |
| CA (2) | CA3153583A1 (enExample) |
| DK (1) | DK3625233T5 (enExample) |
| ES (1) | ES2955871T3 (enExample) |
| FI (1) | FI3625233T5 (enExample) |
| HR (1) | HRP20230977T1 (enExample) |
| HU (1) | HUE062752T2 (enExample) |
| IL (2) | IL296379B2 (enExample) |
| LT (1) | LT3625233T (enExample) |
| MX (2) | MX385265B (enExample) |
| PL (1) | PL3625233T3 (enExample) |
| PT (1) | PT3625233T (enExample) |
| RS (1) | RS64547B9 (enExample) |
| RU (1) | RU2753401C2 (enExample) |
| SG (2) | SG10202102306TA (enExample) |
| SI (1) | SI3625233T1 (enExample) |
| WO (1) | WO2018208557A1 (enExample) |
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| AU2017290060B2 (en) | 2016-06-30 | 2021-07-22 | Qpex Biopharma, Inc | Boronic acid derivatives and therapeutic uses thereof |
| US10085999B1 (en) * | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| MX2020004071A (es) * | 2017-10-02 | 2020-07-28 | Arixa Pharmaceuticals Inc | Derivados de aztreonam y usos de los mismos. |
| CN112424209A (zh) | 2018-04-20 | 2021-02-26 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
| ES2991492T3 (es) | 2018-10-01 | 2024-12-03 | Arixa Pharmaceuticals Inc | Derivados de relebactam y usos de los mismos |
| US11008321B2 (en) * | 2019-03-12 | 2021-05-18 | Arixa Pharmaceuticals, Inc. | Crystalline form of an avibactam derivative |
| EP3959205B1 (en) | 2019-04-26 | 2025-11-12 | Merck Sharp & Dohme LLC | Process for the preparation of intermediates useful for making (2s,5r)-7-oxo-n-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide |
| US12636297B2 (en) | 2019-06-19 | 2026-05-26 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP4021443A1 (en) * | 2019-08-29 | 2022-07-06 | Arixa Pharmaceuticals, Inc. | Orally administered combinations of beta-lactam antibiotics and avibactam derivatives for treating bacterial infections |
| US20210186983A1 (en) * | 2019-12-20 | 2021-06-24 | Arixa Pharmaceuticals, Inc. | Orally administered combinations of amoxicillin and avibactam derivatives for treating mycobacterial infections |
| US12637481B2 (en) | 2020-03-18 | 2026-05-26 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| IL297458A (en) | 2020-05-05 | 2022-12-01 | Qpex Biopharma Inc | Boronic acid derivatives and their synthesis, polymorphic forms and medicinal uses |
| CN111943950B (zh) * | 2020-09-10 | 2022-03-29 | 山东安信制药有限公司 | 一种瑞来巴坦的制备方法 |
| EP4319760A4 (en) * | 2021-04-05 | 2025-01-08 | Qpex Biopharma, Inc. | CEFTIBUTENE DOSAGE REGIMEN |
| CN113559099A (zh) * | 2021-08-27 | 2021-10-29 | 丹诺医药(苏州）有限公司 | 包含舒巴坦和阿维巴坦的药物组合物及其应用 |
| CN115448920B (zh) * | 2022-10-14 | 2025-01-03 | 广州楷石医药有限公司 | 一种β-内酰胺酶抑制剂及其应用 |
| GB202306833D0 (en) | 2023-05-09 | 2023-06-21 | Adjutec Pharma As | Therapy |
| GB202306826D0 (en) | 2023-05-09 | 2023-06-21 | Adjutec Pharma As | Therapy |
| CN119431373B (zh) * | 2024-07-24 | 2025-08-08 | 科睿迪(南京)医药科技有限公司 | 一种β-内酰胺酶抑制剂及其用途 |
| WO2026043829A1 (en) * | 2024-08-21 | 2026-02-26 | Merck Sharp & Dohme Llc | Chromane cyclic amidine monobactam compounds for the treatment of bacterial infections |
| WO2026058228A1 (en) | 2024-09-16 | 2026-03-19 | Pfizer Inc. | Process to prepare avibactam tomilopil |
| CN122079989A (zh) * | 2024-09-30 | 2026-05-26 | 科睿迪(南京)医药科技有限公司 | 二氮杂二环类β-内酰胺酶抑制剂及其应用 |
| WO2026104587A1 (en) | 2024-11-13 | 2026-05-21 | Adjutec Pharma As | Cyclic boronic acid esters useful as adjuvants in the treatment of bacterial infections |
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