RS64547B9 - Derivati 3-(((((2s,5r)-2-karbamoil-7-okso-1,6-diazabiciklo[3.2.1] oktan-6-il)oksi)sulfonil)oksi)-2,2-dimetilpropanoata i srodna jedinjenja kao peroralno primenjeni prolekovi inhibitora betalaktamaze za lečenje bakterijskih infekcija - Google Patents

Derivati 3-(((((2s,5r)-2-karbamoil-7-okso-1,6-diazabiciklo[3.2.1] oktan-6-il)oksi)sulfonil)oksi)-2,2-dimetilpropanoata i srodna jedinjenja kao peroralno primenjeni prolekovi inhibitora betalaktamaze za lečenje bakterijskih infekcija

Info

Publication number
RS64547B9
RS64547B9 RS20230696A RSP20230696A RS64547B9 RS 64547 B9 RS64547 B9 RS 64547B9 RS 20230696 A RS20230696 A RS 20230696A RS P20230696 A RSP20230696 A RS P20230696A RS 64547 B9 RS64547 B9 RS 64547B9
Authority
RS
Serbia
Prior art keywords
oxy
profrugs
dimethylpropanoate
octan
diazabicyclo
Prior art date
Application number
RS20230696A
Other languages
English (en)
Inventor
Eric M Gordon
John Freund
Mark A Gallop
Matthew Alexander James Duncton
Original Assignee
Arixa Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arixa Pharmaceuticals Inc filed Critical Arixa Pharmaceuticals Inc
Publication of RS64547B1 publication Critical patent/RS64547B1/sr
Publication of RS64547B9 publication Critical patent/RS64547B9/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Storage Device Security (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
RS20230696A 2017-05-10 2018-05-02 Derivati 3-(((((2s,5r)-2-karbamoil-7-okso-1,6-diazabiciklo[3.2.1] oktan-6-il)oksi)sulfonil)oksi)-2,2-dimetilpropanoata i srodna jedinjenja kao peroralno primenjeni prolekovi inhibitora betalaktamaze za lečenje bakterijskih infekcija RS64547B9 (sr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762504523P 2017-05-10 2017-05-10
US201762551043P 2017-08-28 2017-08-28
US15/934,497 US10085999B1 (en) 2017-05-10 2018-03-23 Beta-lactamase inhibitors and uses thereof
PCT/US2018/030652 WO2018208557A1 (en) 2017-05-10 2018-05-02 3-(((((2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl)oxy)sulfonyl)oxy)-2,2-dimethylprop noate derivatives and related compounds as perorally administered profrugs of beta-lactamase inhibitors for treating bacterial infections
EP18729223.0A EP3625233B9 (en) 2017-05-10 2018-05-02 3-(((((2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl)oxy)sulfonyl)oxy)-2,2-dimethylpropanoate derivatives and related compounds as perorally administered profrugs of beta-lactamase inhibitors for treating bacterial infections

Publications (2)

Publication Number Publication Date
RS64547B1 RS64547B1 (sr) 2023-09-29
RS64547B9 true RS64547B9 (sr) 2024-02-29

Family

ID=63639355

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20230696A RS64547B9 (sr) 2017-05-10 2018-05-02 Derivati 3-(((((2s,5r)-2-karbamoil-7-okso-1,6-diazabiciklo[3.2.1] oktan-6-il)oksi)sulfonil)oksi)-2,2-dimetilpropanoata i srodna jedinjenja kao peroralno primenjeni prolekovi inhibitora betalaktamaze za lečenje bakterijskih infekcija

Country Status (23)

Country Link
US (5) US10085999B1 (sr)
EP (1) EP3625233B9 (sr)
JP (2) JP6909924B2 (sr)
KR (1) KR102411517B1 (sr)
CN (1) CN110662746B (sr)
AU (2) AU2018266566B2 (sr)
BR (1) BR112019023598A2 (sr)
CA (2) CA3153583A1 (sr)
DK (1) DK3625233T5 (sr)
ES (1) ES2955871T3 (sr)
FI (1) FI3625233T5 (sr)
HR (1) HRP20230977T1 (sr)
HU (1) HUE062752T2 (sr)
IL (2) IL296379B1 (sr)
LT (1) LT3625233T (sr)
MX (2) MX2019013260A (sr)
PL (1) PL3625233T3 (sr)
PT (1) PT3625233T (sr)
RS (1) RS64547B9 (sr)
RU (1) RU2753401C2 (sr)
SG (2) SG11201909429VA (sr)
SI (1) SI3625233T1 (sr)
WO (1) WO2018208557A1 (sr)

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WO2018005662A1 (en) 2016-06-30 2018-01-04 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10085999B1 (en) * 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
US10280161B2 (en) * 2017-10-02 2019-05-07 Arixa Pharmaceuticals, Inc. Aztreonam derivatives and uses thereof
CA3114618C (en) 2018-10-01 2023-09-05 Arixa Pharmaceuticals, Inc. Derivatives of relebactam and uses thereof
JP2022524118A (ja) * 2019-03-12 2022-04-27 アリクサ ファーマシューティカルズ、インコーポレイテッド アビバクタム誘導体の結晶形
US20220194941A1 (en) * 2019-04-26 2022-06-23 Merck Sharp & Dohme Corp. PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR MAKING (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-l,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE
CA3152300C (en) 2019-08-29 2024-04-30 Arixa Pharmaceuticals, Inc. Orally administered combinations of beta lactam antibiotics and avibactam derivatives for treating bacterial infections
US20210186983A1 (en) * 2019-12-20 2021-06-24 Arixa Pharmaceuticals, Inc. Orally administered combinations of amoxicillin and avibactam derivatives for treating mycobacterial infections
CN111943950B (zh) * 2020-09-10 2022-03-29 山东安信制药有限公司 一种瑞来巴坦的制备方法
KR20230167077A (ko) * 2021-04-05 2023-12-07 큐펙스 바이오파마 인코포레이티드 세프티부텐 투여 요법
CN115448920A (zh) * 2022-10-14 2022-12-09 广州楷石医药有限公司 一种β-内酰胺酶抑制剂及其应用

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