PT2723771T - Proteínas de ligação à albumina sérica - Google Patents
Proteínas de ligação à albumina séricaInfo
- Publication number
- PT2723771T PT2723771T PT127276582T PT12727658T PT2723771T PT 2723771 T PT2723771 T PT 2723771T PT 127276582 T PT127276582 T PT 127276582T PT 12727658 T PT12727658 T PT 12727658T PT 2723771 T PT2723771 T PT 2723771T
- Authority
- PT
- Portugal
- Prior art keywords
- serum albumin
- binding proteins
- albumin binding
- proteins
- serum
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 102000007562 Serum Albumin Human genes 0.000 title 1
- 108010071390 Serum Albumin Proteins 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500464P | 2011-06-23 | 2011-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2723771T true PT2723771T (pt) | 2019-12-11 |
Family
ID=46298413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127276582T PT2723771T (pt) | 2011-06-23 | 2012-06-14 | Proteínas de ligação à albumina sérica |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9573992B2 (enExample) |
| EP (3) | EP2723771B1 (enExample) |
| JP (3) | JP6324887B2 (enExample) |
| CN (2) | CN106046168A (enExample) |
| AU (1) | AU2012271974B2 (enExample) |
| CA (1) | CA2839779C (enExample) |
| CY (1) | CY1122691T1 (enExample) |
| DK (1) | DK2723771T3 (enExample) |
| ES (1) | ES2759936T3 (enExample) |
| HR (2) | HRP20192160T1 (enExample) |
| HU (1) | HUE047238T2 (enExample) |
| IN (1) | IN2014CN00414A (enExample) |
| LT (1) | LT2723771T (enExample) |
| PL (1) | PL2723771T3 (enExample) |
| PT (1) | PT2723771T (enExample) |
| SI (1) | SI2723771T1 (enExample) |
| WO (1) | WO2012175400A1 (enExample) |
Families Citing this family (89)
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| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2723771B1 (en) * | 2011-06-23 | 2019-09-11 | Ablynx NV | Serum albumin binding proteins |
| NZ780183A (en) * | 2011-06-23 | 2024-12-20 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2747783B1 (en) * | 2011-09-30 | 2017-06-14 | Ablynx N.V. | Biological materials related to c-met |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| EP3143403B1 (en) | 2014-05-16 | 2021-10-27 | Ablynx N.V. | Methods for detecting and/or measuring anti-drug antibodies, in particular treatment-emergent anti-drug antibodies |
| KR20250099289A (ko) | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| PT3248986T (pt) | 2014-05-16 | 2022-04-05 | Ablynx Nv | Domínios variáveis de imunoglobulina |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| JP6862343B2 (ja) | 2014-12-19 | 2021-04-21 | アブリンクス エン．ヴェー． | システイン結合ナノボディダイマー |
| SG11201705986QA (en) | 2015-01-29 | 2017-08-30 | Technophage Investigação E Desenvolvimento Em Biotecnologia Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
| CN111234027A (zh) | 2015-05-21 | 2020-06-05 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| NO2768984T3 (enExample) | 2015-11-12 | 2018-06-09 | ||
| EP3974449A1 (en) | 2015-11-13 | 2022-03-30 | Ablynx NV | Improved serum albumin-binding immunoglobulin variable domains |
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| CN120535622A (zh) * | 2015-11-18 | 2025-08-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合剂 |
| HK1254952A1 (zh) | 2015-11-18 | 2019-08-02 | Merck Sharp & Dohme Llc | Ctla4结合剂 |
| SG10201911035QA (en) | 2015-11-18 | 2020-01-30 | Merck Sharp & Dohme | Pd1 and/or lag3 binders |
| CA3006398A1 (en) * | 2015-11-27 | 2017-06-01 | Ablynx Nv | Polypeptides inhibiting cd40l |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| BR112018073739A2 (pt) * | 2016-05-20 | 2019-02-26 | Harpoon Therapeutics, Inc. | proteína de ligação de albumina sérica de domínio único |
| CA3029133C (en) | 2016-06-23 | 2024-04-30 | Ablynx N.V. | Improved pharmacokinetic assays for immunoglobulin single variable domains |
| AU2017361846B2 (en) | 2016-11-16 | 2024-08-22 | Ablynx Nv | T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta |
| CN117164710A (zh) | 2016-12-07 | 2023-12-05 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合免疫球蛋白单可变结构域 |
| CN107674122A (zh) * | 2016-12-28 | 2018-02-09 | 天津天锐生物科技有限公司 | 一种识别人血清白蛋白的单域抗体 |
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| SG10202108973SA (en) | 2017-01-17 | 2021-09-29 | Ablynx Nv | Improved serum albumin binders |
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| IL303783A (en) | 2020-12-18 | 2023-08-01 | Sanofi Sa | Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor |
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2012
- 2012-06-14 EP EP12727658.2A patent/EP2723771B1/en active Active
- 2012-06-14 EP EP18205150.8A patent/EP3466972A1/en active Pending
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- 2012-06-14 WO PCT/EP2012/061304 patent/WO2012175400A1/en not_active Ceased
- 2012-06-14 ES ES12727658T patent/ES2759936T3/es active Active
- 2012-06-14 HU HUE12727658A patent/HUE047238T2/hu unknown
- 2012-06-14 DK DK12727658T patent/DK2723771T3/da active
- 2012-06-14 CN CN201610392570.9A patent/CN106046168A/zh active Pending
- 2012-06-14 HR HRP20192160TT patent/HRP20192160T1/hr unknown
- 2012-06-14 PL PL12727658T patent/PL2723771T3/pl unknown
- 2012-06-14 AU AU2012271974A patent/AU2012271974B2/en active Active
- 2012-06-14 IN IN414CHN2014 patent/IN2014CN00414A/en unknown
- 2012-06-14 EP EP23159592.7A patent/EP4218933A1/en active Pending
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- 2012-06-14 JP JP2014516279A patent/JP6324887B2/ja active Active
- 2012-06-14 PT PT127276582T patent/PT2723771T/pt unknown
- 2012-06-14 SI SI201231696T patent/SI2723771T1/sl unknown
- 2012-06-14 CN CN201280030647.8A patent/CN103619878B/zh active Active
- 2012-06-14 CA CA2839779A patent/CA2839779C/en active Active
- 2012-06-25 HR HRP20170535TT patent/HRP20170535T4/hr unknown
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2017
- 2017-01-03 US US15/397,313 patent/US20170210789A1/en not_active Abandoned
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2018
- 2018-04-11 JP JP2018076201A patent/JP6843090B2/ja active Active
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- 2019-12-10 CY CY20191101299T patent/CY1122691T1/el unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2012271974B2 (en) | 2017-01-12 |
| JP7304375B2 (ja) | 2023-07-06 |
| HRP20170535T1 (hr) | 2017-06-16 |
| PL2723771T3 (pl) | 2020-04-30 |
| CN103619878B (zh) | 2016-10-26 |
| JP6843090B2 (ja) | 2021-03-17 |
| EP4218933A1 (en) | 2023-08-02 |
| CA2839779C (en) | 2020-10-06 |
| IN2014CN00414A (enExample) | 2015-04-03 |
| JP2018127478A (ja) | 2018-08-16 |
| JP6324887B2 (ja) | 2018-05-16 |
| US20170210789A1 (en) | 2017-07-27 |
| WO2012175400A1 (en) | 2012-12-27 |
| US9573992B2 (en) | 2017-02-21 |
| AU2012271974A1 (en) | 2013-12-12 |
| CY1122691T1 (el) | 2021-03-12 |
| CA2839779A1 (en) | 2012-12-27 |
| EP3466972A1 (en) | 2019-04-10 |
| LT2723771T (lt) | 2019-12-10 |
| EP2723771A1 (en) | 2014-04-30 |
| JP2014520129A (ja) | 2014-08-21 |
| SI2723771T1 (sl) | 2019-12-31 |
| ES2759936T3 (es) | 2020-05-12 |
| DK2723771T3 (da) | 2019-12-02 |
| HRP20192160T1 (hr) | 2020-02-21 |
| HUE047238T2 (hu) | 2020-04-28 |
| HRP20170535T4 (hr) | 2022-08-19 |
| CN103619878A (zh) | 2014-03-05 |
| CN106046168A (zh) | 2016-10-26 |
| US20140228546A1 (en) | 2014-08-14 |
| EP2723771B1 (en) | 2019-09-11 |
| JP2021088585A (ja) | 2021-06-10 |
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