PT2269602E - Composições de antibiótico para o tratamento do ouvido - Google Patents

Composições de antibiótico para o tratamento do ouvido Download PDF

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Publication number
PT2269602E
PT2269602E PT101764124T PT10176412T PT2269602E PT 2269602 E PT2269602 E PT 2269602E PT 101764124 T PT101764124 T PT 101764124T PT 10176412 T PT10176412 T PT 10176412T PT 2269602 E PT2269602 E PT 2269602E
Authority
PT
Portugal
Prior art keywords
composition
influenzae
use according
ear
compositions
Prior art date
Application number
PT101764124T
Other languages
English (en)
Portuguese (pt)
Inventor
John M Yanni
Gerald Cagle
Robert L Abshire
David W Stroman
Original Assignee
Alcon Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26799441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2269602(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Pharmaceuticals Ltd filed Critical Alcon Pharmaceuticals Ltd
Publication of PT2269602E publication Critical patent/PT2269602E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT101764124T 1998-09-30 1999-09-29 Composições de antibiótico para o tratamento do ouvido PT2269602E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10250498P 1998-09-30 1998-09-30
US10250698P 1998-09-30 1998-09-30

Publications (1)

Publication Number Publication Date
PT2269602E true PT2269602E (pt) 2014-12-29

Family

ID=26799441

Family Applications (5)

Application Number Title Priority Date Filing Date
PT101764124T PT2269602E (pt) 1998-09-30 1999-09-29 Composições de antibiótico para o tratamento do ouvido
PT141763664T PT2796138T (pt) 1998-09-30 1999-09-29 Composições antibióticas para tratamento da conjuntivite
PT03020587T PT1384478E (pt) 1998-09-30 1999-09-29 Composi??es de antibi?tico que cont?m moxifloxacina para o tratamento dos olhos
PT101786572T PT2301541E (pt) 1998-09-30 1999-09-29 Composições de antibiótico para o tratamento dos olhos
PT99956504T PT1117401E (pt) 1998-09-30 1999-09-29 Composicoes antibioticas para o tratamento do olho

Family Applications After (4)

Application Number Title Priority Date Filing Date
PT141763664T PT2796138T (pt) 1998-09-30 1999-09-29 Composições antibióticas para tratamento da conjuntivite
PT03020587T PT1384478E (pt) 1998-09-30 1999-09-29 Composi??es de antibi?tico que cont?m moxifloxacina para o tratamento dos olhos
PT101786572T PT2301541E (pt) 1998-09-30 1999-09-29 Composições de antibiótico para o tratamento dos olhos
PT99956504T PT1117401E (pt) 1998-09-30 1999-09-29 Composicoes antibioticas para o tratamento do olho

Country Status (18)

Country Link
EP (5) EP2269602B1 (OSRAM)
JP (5) JP2002525317A (OSRAM)
KR (1) KR101463243B1 (OSRAM)
CN (2) CN100374114C (OSRAM)
AR (2) AR020661A1 (OSRAM)
AT (2) ATE254458T1 (OSRAM)
AU (1) AU762827B2 (OSRAM)
BR (1) BRPI9914151B1 (OSRAM)
CA (3) CA2774207A1 (OSRAM)
CY (3) CY1111404T1 (OSRAM)
DE (2) DE69912972T2 (OSRAM)
DK (5) DK2301541T3 (OSRAM)
ES (4) ES2602956T3 (OSRAM)
HK (1) HK1038691B (OSRAM)
PT (5) PT2269602E (OSRAM)
TR (2) TR200704370T2 (OSRAM)
TW (1) TWI222361B (OSRAM)
WO (1) WO2000018386A2 (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6509327B1 (en) * 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
AR020661A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
DE19937115A1 (de) 1999-08-06 2001-02-08 Bayer Ag Wäßrige Arzneimittelformulierung von Moxifloxacin oder Salzen davon
DE19937116A1 (de) 1999-08-06 2001-02-08 Bayer Ag Moxifloxacin Kochsalzformulierung
MXPA02003130A (es) 1999-09-24 2004-04-21 Alcon Inc Formulaciones topicas en suspension que contienen ciprofloxacino y dexametasona.
DE19962470A1 (de) 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
WO2001089495A2 (en) * 2000-05-19 2001-11-29 Alcon Laboratories, Inc. Antibiotic compositions containing quinolone derivatives for treatment of the eye, ear and nose
CA2412575C (en) 2000-07-26 2009-12-29 Onkar N. Singh Improved process for manufacturing compositions containing ciprofloxacin and hydrocortisone
AU2002214308A1 (en) * 2000-11-16 2002-05-27 Wakamoto Pharmaceutical Co., Ltd. Antibacterial gel eye drops
AU2002228660A1 (en) 2000-12-20 2002-07-01 Alcon, Inc Use of amidoamines to treat or prevent acanthamoeba and fungal infections
AU2002226926A1 (en) * 2000-12-20 2002-07-01 Alcon, Inc. Antifungal compositions containing an antibiotic and one or more amidoamines
WO2003026671A1 (en) 2001-09-21 2003-04-03 Alcon, Inc. Method of treating middle ear infections
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
AU2004272414B2 (en) 2003-09-10 2009-05-28 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) quinolonecarboxylic acid derivative
WO2006015545A1 (fr) * 2004-08-11 2006-02-16 Shenzhen Tys R & D Co., Ltd. Capsule de gelatine de moxifloxacin et procede pour sa preparation
MX2007002462A (es) * 2004-09-03 2007-10-10 Piedmont Pharmaceuticals Llc Metodo para el tratamiento de transmembrana y prevencion de la otitis media.
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
BRPI0518891A2 (pt) * 2004-12-10 2008-12-16 Alcon Inc composiÇço farmacÊutica àptica tàpica
CN101317847B (zh) * 2007-06-06 2010-10-13 深圳市瑞谷医药技术有限公司 一种眼用或耳鼻用药物组合物及其用途
TWI544934B (zh) 2008-06-09 2016-08-11 愛爾康研究有限公司 含有氟喹諾酮抗生素藥物之經改良藥學組成物
MX2012000136A (es) * 2009-07-02 2012-02-08 Alcon Res Ltd Composiciones que comprenden finafloxacina y metodos para tratar infecciones oftalmicas, oticas, o nasales.
AU2011204275B2 (en) * 2010-01-07 2015-04-02 Novartis Ag Methods and compositions for applying moxifloxacin to the ear
RU2014127492A (ru) 2011-12-06 2016-02-10 Алькон Рисерч, Лтд. Композиции целлюлозного геля с улучшенной стабильностью вязкости
RU2472507C1 (ru) * 2012-02-01 2013-01-20 Закрытое акционерное общество "Брынцалов-А" Водный состав на основе моксифлоксацина для парентерального введения
US9504691B2 (en) 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
US20160279055A1 (en) 2013-07-22 2016-09-29 Imprimis Pharmaceuticals, Inc. Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof
US20150164882A1 (en) 2013-07-22 2015-06-18 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
CN104224802B (zh) * 2014-09-19 2017-12-12 南京优科生物医药研究有限公司 一种盐酸莫西沙星滴耳剂及其制备方法
RU2595837C2 (ru) * 2014-09-29 2016-08-27 Открытое Акционерное Общество "Татхимфармпрепараты" Состав и способ получения глазных капель
WO2017073708A1 (ja) * 2015-10-29 2017-05-04 テイカ製薬株式会社 外用剤
WO2019193513A1 (en) * 2018-04-03 2019-10-10 Hyderabad Eye Research Foundation Mucoadhesive drug delivery system for ocular administration of fluoroquinolone antibiotics
IT201900005280A1 (it) * 2019-04-05 2020-10-05 Ntc S R L Composizione otologica
CA3182196A1 (en) * 2020-06-10 2021-12-16 Anthony Sampietro Compositions and uses in method for post-operative ocular care
CN116270662A (zh) * 2021-12-03 2023-06-23 苏州欧康维视生物科技有限公司 盐酸莫西沙星地塞米松磷酸钠滴眼液
KR102656260B1 (ko) 2022-10-14 2024-04-09 주식회사태준제약 목시플록사신을 포함하는 안과용 조성물

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Publication number Priority date Publication date Assignee Title
US5223493A (en) 1984-12-28 1993-06-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
US4910225A (en) * 1988-01-27 1990-03-20 Senju Pharmaceutical Co., Ltd. Locally administrable therapeutic composition for inflammatory disease
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
WO1990001933A1 (en) 1988-08-26 1990-03-08 Alcon Laboratories, Inc. Combination of quinolone antibiotics and steroids for topical ophthalmic use
JPH03109236A (ja) * 1989-09-22 1991-05-09 Hoya Corp 半導体超微粒子分散ガラスの製造方法
JPH085779B2 (ja) * 1989-09-22 1996-01-24 杏林製薬株式会社 フレロキサシン点眼液
TW209865B (OSRAM) * 1992-01-10 1993-07-21 Bayer Ag
AU674852B2 (en) 1992-05-06 1997-01-16 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
DE4424369A1 (de) * 1994-07-11 1996-01-18 Bayer Ag Pyrido[3,2,1.i,j][3,1]benzoxazinderivate
JPH0892241A (ja) * 1994-09-22 1996-04-09 Ss Pharmaceut Co Ltd ５−ヒドラジノキノロンカルボン酸誘導体及びこれを有効成分とする抗菌剤
US5631287A (en) 1994-12-22 1997-05-20 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
NZ309624A (en) * 1995-06-06 1999-04-29 Bayer Ag Non-irritating, non-sensitizing, non-ototoxic (harmful to the ears) antibacterial compositions
JP3290914B2 (ja) * 1997-03-17 2002-06-10 参天製薬株式会社 眼組織におけるキノロン系抗菌剤の定量装置
PL192273B1 (pl) * 1997-09-25 2006-09-29 Bayer Ag Preparat środka leczniczego w postaci pastylki o kontrolowanej dyfuzji lub w postaci układu matrycowego, o kontrolowanym uwalnianiu substancji czynnej
EP1115373B1 (en) 1998-09-23 2004-12-22 Unilever N.V. Oral composition with an improved teeth whitening effect
AR020661A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
KR20010107754A (ko) * 2000-05-26 2001-12-07 민경윤 경구투여용 속용정의 제조 방법

Also Published As

Publication number Publication date
CA2774207A1 (en) 2000-04-06
ATE254458T1 (de) 2003-12-15
PT1384478E (pt) 2011-05-12
BRPI9914151B1 (pt) 2017-10-03
PT2796138T (pt) 2016-09-22
EP2269602A1 (en) 2011-01-05
AU1310100A (en) 2000-04-17
CY1111404T1 (el) 2015-08-05
JP2009007375A (ja) 2009-01-15
TR200704370T2 (tr) 2007-11-21
DK2796138T3 (en) 2016-12-05
EP2301541A1 (en) 2011-03-30
CY1115916T1 (el) 2017-01-25
WO2000018386A2 (en) 2000-04-06
ES2526521T3 (es) 2015-01-13
EP1117401B1 (en) 2003-11-19
DK2269602T3 (en) 2014-12-15
JP5563041B2 (ja) 2014-07-30
JP2013018799A (ja) 2013-01-31
CN1184968C (zh) 2005-01-19
PT1117401E (pt) 2004-03-31
DK2301541T3 (da) 2014-09-01
EP1384478B1 (en) 2011-03-16
JP2012067141A (ja) 2012-04-05
TR200100883T2 (tr) 2001-10-22
DK1117401T3 (da) 2004-02-23
HK1150769A1 (en) 2012-01-13
HK1038691B (en) 2004-04-23
EP2269602B1 (en) 2014-11-19
DE69912972T2 (de) 2004-04-22
EP2301541B1 (en) 2014-08-20
DK1384478T3 (da) 2011-05-23
EP2796138A1 (en) 2014-10-29
BRPI9914151B8 (OSRAM) 2021-05-25
CA2342211A1 (en) 2000-04-06
ES2602956T3 (es) 2017-02-23
PT2301541E (pt) 2014-10-29
DE69943287D1 (de) 2011-04-28
DE69912972D1 (de) 2003-12-24
AR020661A1 (es) 2002-05-22
EP2796138B1 (en) 2016-08-17
AR081393A2 (es) 2012-08-29
KR20010075138A (ko) 2001-08-09
CN100374114C (zh) 2008-03-12
ES2519190T3 (es) 2014-11-06
JP2014144982A (ja) 2014-08-14
ATE501732T1 (de) 2011-04-15
AU762827B2 (en) 2003-07-03
EP1384478A1 (en) 2004-01-28
BR9914151A (pt) 2001-06-26
TWI222361B (en) 2004-10-21
CA2659064A1 (en) 2000-04-06
CN1650863A (zh) 2005-08-10
ES2207307T3 (es) 2004-05-16
JP2002525317A (ja) 2002-08-13
HK1150756A1 (en) 2012-01-13
CN1320035A (zh) 2001-10-31
WO2000018386A3 (en) 2000-06-08
CY1115759T1 (el) 2017-01-25
EP1117401A2 (en) 2001-07-25
KR101463243B1 (ko) 2014-12-17
HK1059572A1 (en) 2004-07-09
HK1038691A1 (en) 2002-03-28
CA2342211C (en) 2009-05-26

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