PT2264019E - Derivados de taxanos funcionalizados na posição 14 e um processo para a sua preparação - Google Patents

Derivados de taxanos funcionalizados na posição 14 e um processo para a sua preparação

Info

Publication number
PT2264019E
PT2264019E PT101773299T PT10177329T PT2264019E PT 2264019 E PT2264019 E PT 2264019E PT 101773299 T PT101773299 T PT 101773299T PT 10177329 T PT10177329 T PT 10177329T PT 2264019 E PT2264019 E PT 2264019E
Authority
PT
Portugal
Prior art keywords
group
preparation
hydrogen
intermediates
alcohol
Prior art date
Application number
PT101773299T
Other languages
English (en)
Inventor
Gabriele Fontana
Ezio Bombardelli
Eleonora Baldelli
Maria Luisa Gelmi
Andrea Guerrini
Arturo Battaglia
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of PT2264019E publication Critical patent/PT2264019E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT101773299T 2002-09-10 2003-09-05 Derivados de taxanos funcionalizados na posição 14 e um processo para a sua preparação PT2264019E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001921A ITMI20021921A1 (it) 2002-09-10 2002-09-10 Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.

Publications (1)

Publication Number Publication Date
PT2264019E true PT2264019E (pt) 2013-10-28

Family

ID=31986024

Family Applications (4)

Application Number Title Priority Date Filing Date
PT101773299T PT2264019E (pt) 2002-09-10 2003-09-05 Derivados de taxanos funcionalizados na posição 14 e um processo para a sua preparação
PT101773265T PT2298754E (pt) 2002-09-10 2003-09-05 Preparação de derivados de taxanos
PT91556738T PT2077264E (pt) 2002-09-10 2003-09-05 Derivados de taxanos e um processo para a sua preparação
PT03747971T PT1537093E (pt) 2002-09-10 2003-09-05 Derivados de taxanos funcionalizados na posição 14 e um processo para a sua preparação

Family Applications After (3)

Application Number Title Priority Date Filing Date
PT101773265T PT2298754E (pt) 2002-09-10 2003-09-05 Preparação de derivados de taxanos
PT91556738T PT2077264E (pt) 2002-09-10 2003-09-05 Derivados de taxanos e um processo para a sua preparação
PT03747971T PT1537093E (pt) 2002-09-10 2003-09-05 Derivados de taxanos funcionalizados na posição 14 e um processo para a sua preparação

Country Status (20)

Country Link
US (1) US7498452B2 (pt)
EP (6) EP2077264B1 (pt)
JP (2) JP4690039B2 (pt)
KR (1) KR101096918B1 (pt)
CN (1) CN1681799A (pt)
AT (1) ATE398113T1 (pt)
AU (1) AU2003267049B8 (pt)
CA (1) CA2498277C (pt)
DE (1) DE60321577D1 (pt)
DK (4) DK1537093T3 (pt)
ES (4) ES2307965T3 (pt)
IL (5) IL167336A (pt)
IT (1) ITMI20021921A1 (pt)
NO (3) NO332250B1 (pt)
PL (4) PL402333A1 (pt)
PT (4) PT2264019E (pt)
RU (1) RU2320652C2 (pt)
SG (1) SG164282A1 (pt)
SI (4) SI2264019T1 (pt)
WO (1) WO2004024706A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
CN107056767B (zh) * 2015-12-04 2022-07-15 江苏恩华络康药物研发有限公司 用于制备水溶性紫杉烷类衍生物的方法及中间体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504222A (en) 1993-08-20 1996-04-02 The Scripps Research Institute Transformations of taxol
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IL127597A (en) 1994-01-28 2003-07-31 Upjohn Co Iso-taxol analogs
JPH09509431A (ja) 1994-11-04 1997-09-22 フアルマシア・エツセ・ピー・アー タキサン誘導体
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
DK2292626T3 (da) * 2000-08-04 2014-06-10 Senseonics Inc Påvisning af analytter i vandige miljøer
IT1318678B1 (it) 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato

Also Published As

Publication number Publication date
JP2010270145A (ja) 2010-12-02
EP2077264A3 (en) 2009-09-16
SI2077264T1 (sl) 2013-03-29
NO332250B1 (no) 2012-08-06
ES2433580T3 (es) 2013-12-11
PT2298754E (pt) 2013-11-07
EP2298754A1 (en) 2011-03-23
NO332367B1 (no) 2012-09-03
AU2003267049A1 (en) 2004-04-30
DE60321577D1 (de) 2008-07-24
NO20110782L (no) 2005-05-10
EP1980557A3 (en) 2008-12-31
EP2264019A1 (en) 2010-12-22
RU2320652C2 (ru) 2008-03-27
DK2298754T3 (da) 2013-11-04
AU2003267049B2 (en) 2010-02-11
NO332366B1 (no) 2012-09-03
EP2281820A3 (en) 2011-05-04
EP2077264A2 (en) 2009-07-08
SG164282A1 (en) 2010-09-29
PL375625A1 (en) 2005-12-12
CA2498277C (en) 2011-07-05
DK2077264T3 (da) 2013-03-04
KR20050035540A (ko) 2005-04-18
NO20051774L (no) 2005-05-10
US20060122258A1 (en) 2006-06-08
EP2077264B1 (en) 2012-11-14
EP2298754B9 (en) 2013-12-18
JP2006503030A (ja) 2006-01-26
DK2264019T3 (da) 2013-10-28
SI2264019T1 (sl) 2013-10-30
RU2005106361A (ru) 2005-10-10
US7498452B2 (en) 2009-03-03
AU2003267049B8 (en) 2010-03-04
NO20110781L (no) 2005-05-10
IL214430A0 (en) 2011-09-27
ES2398324T3 (es) 2013-03-15
WO2004024706A3 (en) 2004-07-08
EP1980557A2 (en) 2008-10-15
WO2004024706A2 (en) 2004-03-25
IL214431A (en) 2014-05-28
CA2498277A1 (en) 2004-03-25
PL402323A1 (pl) 2013-04-02
JP4690039B2 (ja) 2011-06-01
ATE398113T1 (de) 2008-07-15
IL214432A (en) 2014-05-28
KR101096918B1 (ko) 2011-12-22
EP1537093A2 (en) 2005-06-08
PL402333A1 (pl) 2013-04-02
DK1537093T3 (da) 2008-10-27
EP1537093B1 (en) 2008-06-11
PL402332A1 (pl) 2013-04-02
IL167336A (en) 2009-11-18
ES2432024T3 (es) 2013-11-29
EP2281820A2 (en) 2011-02-09
IL214431A0 (en) 2011-09-27
PT2077264E (pt) 2013-01-29
PT1537093E (pt) 2008-09-02
ITMI20021921A1 (it) 2004-03-11
ES2307965T3 (es) 2008-12-01
EP2298754B1 (en) 2013-08-07
EP2264019B1 (en) 2013-07-24
SI1537093T1 (sl) 2008-10-31
IL197815A (en) 2013-02-28
SI2298754T1 (sl) 2013-11-29
IL214432A0 (en) 2011-09-27
CN1681799A (zh) 2005-10-12

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