NO20051774L - Taksanderivater funksjonalisert pa den 14.posisjon og en fremgangsmate for fremstilling derav - Google Patents

Taksanderivater funksjonalisert pa den 14.posisjon og en fremgangsmate for fremstilling derav

Info

Publication number
NO20051774L
NO20051774L NO20051774A NO20051774A NO20051774L NO 20051774 L NO20051774 L NO 20051774L NO 20051774 A NO20051774 A NO 20051774A NO 20051774 A NO20051774 A NO 20051774A NO 20051774 L NO20051774 L NO 20051774L
Authority
NO
Norway
Prior art keywords
group
preparation
hydrogen
taxane derivatives
alcohol
Prior art date
Application number
NO20051774A
Other languages
English (en)
Other versions
NO332250B1 (no
Inventor
Ezio Bombardelli
Arturo Battaglia
Andrea Guerrini
Maria Luisa Gelmi
Donato Pocar
Eleonora Baldelli
Gabriele Fonatana
Giacomo Carenzi
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of NO20051774L publication Critical patent/NO20051774L/no
Publication of NO332250B1 publication Critical patent/NO332250B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

En generell fremgeuigsmåte for funksjonallsering ved 14- stlllingen 1 13-ketoba)ckatinderlvat:er med formel I for å oppnå derivater med formel II R2¿ R2. O ¿.R5 hvori substituentene er som definert 1 beskrivelsen. Omdannelsen av forbindelser med formel II til forbindelser med formel III, hvori substituentene er som definert i beskrivelsen, er også beskrevet.
NO20051774A 2002-09-10 2005-04-11 Taksanderivater funksjonalisert pa den 14.posisjon og en fremgangsmate for fremstilling derav NO332250B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001921A ITMI20021921A1 (it) 2002-09-10 2002-09-10 Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
PCT/EP2003/009866 WO2004024706A2 (en) 2002-09-10 2003-09-05 Taxane derivatives functionalized at the 14- position and a process for the preparation thereof

Publications (2)

Publication Number Publication Date
NO20051774L true NO20051774L (no) 2005-05-10
NO332250B1 NO332250B1 (no) 2012-08-06

Family

ID=31986024

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20051774A NO332250B1 (no) 2002-09-10 2005-04-11 Taksanderivater funksjonalisert pa den 14.posisjon og en fremgangsmate for fremstilling derav
NO20110782A NO332367B1 (no) 2002-09-10 2011-05-30 Taksanderivater funksjonalisert pa den 14. posisjonen
NO20110781A NO332366B1 (no) 2002-09-10 2011-05-30 Taksanderivater funksjonalisert pa den 14. posisjon og en fremgangsmate for fremstilling derav

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO20110782A NO332367B1 (no) 2002-09-10 2011-05-30 Taksanderivater funksjonalisert pa den 14. posisjonen
NO20110781A NO332366B1 (no) 2002-09-10 2011-05-30 Taksanderivater funksjonalisert pa den 14. posisjon og en fremgangsmate for fremstilling derav

Country Status (20)

Country Link
US (1) US7498452B2 (no)
EP (6) EP2298754B9 (no)
JP (2) JP4690039B2 (no)
KR (1) KR101096918B1 (no)
CN (1) CN1681799A (no)
AT (1) ATE398113T1 (no)
AU (1) AU2003267049B8 (no)
CA (1) CA2498277C (no)
DE (1) DE60321577D1 (no)
DK (4) DK2298754T3 (no)
ES (4) ES2307965T3 (no)
IL (5) IL167336A (no)
IT (1) ITMI20021921A1 (no)
NO (3) NO332250B1 (no)
PL (4) PL402323A1 (no)
PT (4) PT2298754E (no)
RU (1) RU2320652C2 (no)
SG (1) SG164282A1 (no)
SI (4) SI2264019T1 (no)
WO (1) WO2004024706A2 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
CN107056767B (zh) * 2015-12-04 2022-07-15 江苏恩华络康药物研发有限公司 用于制备水溶性紫杉烷类衍生物的方法及中间体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504222A (en) 1993-08-20 1996-04-02 The Scripps Research Institute Transformations of taxol
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IL127599A (en) 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
EP0738265A1 (en) 1994-11-04 1996-10-23 PHARMACIA S.p.A. Taxane derivatives
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
EP1557422B1 (en) * 2000-08-04 2013-12-25 Senseonics, Incorporated Detection of analytes in aqueous environments
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato

Also Published As

Publication number Publication date
RU2320652C2 (ru) 2008-03-27
EP1537093B1 (en) 2008-06-11
EP2077264A3 (en) 2009-09-16
DK2264019T3 (da) 2013-10-28
RU2005106361A (ru) 2005-10-10
AU2003267049B2 (en) 2010-02-11
EP1980557A3 (en) 2008-12-31
US20060122258A1 (en) 2006-06-08
EP2077264A2 (en) 2009-07-08
US7498452B2 (en) 2009-03-03
DK1537093T3 (da) 2008-10-27
EP2264019A1 (en) 2010-12-22
IL214432A (en) 2014-05-28
CA2498277A1 (en) 2004-03-25
ES2432024T3 (es) 2013-11-29
PT2264019E (pt) 2013-10-28
PL402323A1 (pl) 2013-04-02
WO2004024706A3 (en) 2004-07-08
AU2003267049B8 (en) 2010-03-04
EP2077264B1 (en) 2012-11-14
DE60321577D1 (de) 2008-07-24
IL214432A0 (en) 2011-09-27
EP2298754A1 (en) 2011-03-23
PL402332A1 (pl) 2013-04-02
JP2010270145A (ja) 2010-12-02
KR20050035540A (ko) 2005-04-18
NO332367B1 (no) 2012-09-03
WO2004024706A2 (en) 2004-03-25
JP2006503030A (ja) 2006-01-26
ES2398324T3 (es) 2013-03-15
SI1537093T1 (sl) 2008-10-31
AU2003267049A1 (en) 2004-04-30
DK2077264T3 (da) 2013-03-04
ITMI20021921A1 (it) 2004-03-11
IL214431A0 (en) 2011-09-27
EP1537093A2 (en) 2005-06-08
CN1681799A (zh) 2005-10-12
ATE398113T1 (de) 2008-07-15
PL402333A1 (pl) 2013-04-02
EP2264019B1 (en) 2013-07-24
IL214430A0 (en) 2011-09-27
CA2498277C (en) 2011-07-05
SG164282A1 (en) 2010-09-29
NO332250B1 (no) 2012-08-06
SI2298754T1 (sl) 2013-11-29
EP2281820A2 (en) 2011-02-09
EP1980557A2 (en) 2008-10-15
NO332366B1 (no) 2012-09-03
DK2298754T3 (da) 2013-11-04
PT2077264E (pt) 2013-01-29
NO20110781L (no) 2005-05-10
PL375625A1 (en) 2005-12-12
JP4690039B2 (ja) 2011-06-01
PT1537093E (pt) 2008-09-02
ES2433580T3 (es) 2013-12-11
KR101096918B1 (ko) 2011-12-22
NO20110782L (no) 2005-05-10
SI2264019T1 (sl) 2013-10-30
PT2298754E (pt) 2013-11-07
EP2298754B1 (en) 2013-08-07
IL167336A (en) 2009-11-18
EP2281820A3 (en) 2011-05-04
IL197815A (en) 2013-02-28
SI2077264T1 (sl) 2013-03-29
ES2307965T3 (es) 2008-12-01
EP2298754B9 (en) 2013-12-18
IL214431A (en) 2014-05-28

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