PT2207786E - 2'-fluoro-2'-desoxitetra-hidrouridinas como inibidores de citidina desaminase - Google Patents

2'-fluoro-2'-desoxitetra-hidrouridinas como inibidores de citidina desaminase Download PDF

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Publication number
PT2207786E
PT2207786E PT08840633T PT08840633T PT2207786E PT 2207786 E PT2207786 E PT 2207786E PT 08840633 T PT08840633 T PT 08840633T PT 08840633 T PT08840633 T PT 08840633T PT 2207786 E PT2207786 E PT 2207786E
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Portugal
Prior art keywords
compound
cancer
cda
substrate drug
pharmaceutically acceptable
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PT08840633T
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English (en)
Portuguese (pt)
Inventor
Gregory S Hamilton
Takashi Tsukamoto
Dana V Ferraris
Rena Lapidus
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Eisai Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40251685&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2207786(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai Inc filed Critical Eisai Inc
Publication of PT2207786E publication Critical patent/PT2207786E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT08840633T 2007-10-16 2008-10-16 2'-fluoro-2'-desoxitetra-hidrouridinas como inibidores de citidina desaminase PT2207786E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98039707P 2007-10-16 2007-10-16

Publications (1)

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PT2207786E true PT2207786E (pt) 2012-05-28

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PT08840633T PT2207786E (pt) 2007-10-16 2008-10-16 2'-fluoro-2'-desoxitetra-hidrouridinas como inibidores de citidina desaminase

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US (4) US8268800B2 (enExample)
EP (2) EP2207786B1 (enExample)
JP (2) JP5496899B2 (enExample)
KR (1) KR101543049B1 (enExample)
CN (1) CN101827856B (enExample)
AT (1) ATE548374T1 (enExample)
BR (1) BRPI0818672B8 (enExample)
CA (1) CA2702274C (enExample)
CO (1) CO6270330A2 (enExample)
CR (1) CR11427A (enExample)
CY (3) CY1112781T1 (enExample)
DK (1) DK2207786T3 (enExample)
EA (1) EA018757B1 (enExample)
EC (1) ECSP10010095A (enExample)
ES (2) ES2384011T3 (enExample)
FI (2) FIC20230039I1 (enExample)
FR (2) FR23C1051I2 (enExample)
GT (1) GT201000088A (enExample)
HR (1) HRP20120419T1 (enExample)
HU (2) HUS2300044I1 (enExample)
IL (1) IL204732A (enExample)
JO (1) JO2778B1 (enExample)
LT (2) LTC2207786I2 (enExample)
LU (2) LUC00327I2 (enExample)
ME (1) ME00997B (enExample)
MX (1) MX2010004109A (enExample)
MY (1) MY147970A (enExample)
NI (1) NI201000055A (enExample)
NL (2) NL301256I2 (enExample)
NO (2) NO2023048I1 (enExample)
NZ (1) NZ584229A (enExample)
PL (1) PL2207786T3 (enExample)
PT (1) PT2207786E (enExample)
RS (1) RS52323B (enExample)
SA (1) SA08290661B1 (enExample)
SI (1) SI2207786T1 (enExample)
TW (1) TWI445539B (enExample)
UA (1) UA99476C2 (enExample)
WO (1) WO2009052287A1 (enExample)
ZA (1) ZA201002178B (enExample)

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CN101827856A (zh) 2010-09-08
US20150210730A1 (en) 2015-07-30
AU2008312435A1 (en) 2009-04-23
EA018757B1 (ru) 2013-10-30
LUC00326I2 (enExample) 2026-02-02
PL2207786T3 (pl) 2012-09-28
RS52323B (sr) 2012-12-31
NI201000055A (es) 2010-08-13
BRPI0818672B1 (pt) 2020-10-20
EP2207786A1 (en) 2010-07-21
UA99476C2 (en) 2012-08-27
HUS2300045I1 (hu) 2024-01-28
EA201000642A1 (ru) 2010-10-29
ATE548374T1 (de) 2012-03-15
KR20100091978A (ko) 2010-08-19
JP5496899B2 (ja) 2014-05-21
CA2702274A1 (en) 2009-04-23
US8268800B2 (en) 2012-09-18
NO2023048I1 (en) 2023-12-21
IL204732A (en) 2013-07-31
ES2384011T3 (es) 2012-06-28
NL301256I2 (nl) 2024-01-11
HUS2300044I1 (hu) 2024-01-28
US20090137521A1 (en) 2009-05-28
LUC00326I9 (enExample) 2026-02-25
ZA201002178B (en) 2011-05-25
KR101543049B1 (ko) 2015-08-07
NL301256I1 (enExample) 2024-01-03
EP2447272A1 (en) 2012-05-02
CY1112781T1 (el) 2016-02-10
EP2207786B1 (en) 2012-03-07
ME00997B (me) 2012-10-20
LUC00327I2 (enExample) 2026-02-02
SA08290661B1 (ar) 2012-06-10
CN101827856B (zh) 2013-02-06
ES2616566T3 (es) 2017-06-13
MY147970A (en) 2013-02-28
HRP20120419T1 (hr) 2012-07-31
JP2014177455A (ja) 2014-09-25
BRPI0818672A2 (pt) 2015-04-14
CR11427A (es) 2010-08-16
FIC20230040I1 (fi) 2023-12-22
BRPI0818672B8 (pt) 2021-05-25
AU2008312435B2 (en) 2014-04-17
JP5859588B2 (ja) 2016-02-10
JO2778B1 (en) 2014-03-15
NO2023047I1 (no) 2023-12-21
LTPA2023538I1 (enExample) 2024-02-26
ECSP10010095A (es) 2010-07-30
GT201000088A (es) 2012-03-13
US20140186335A1 (en) 2014-07-03
JP2011500713A (ja) 2011-01-06
US20120289475A1 (en) 2012-11-15
AU2008312435A8 (en) 2014-07-24
NZ584229A (en) 2012-06-29
LTC2207786I2 (enExample) 2025-09-10
TWI445539B (zh) 2014-07-21
US8951987B2 (en) 2015-02-10
HK1146410A1 (en) 2011-06-03
DK2207786T3 (da) 2012-06-18
US9567363B2 (en) 2017-02-14
CY2023029I1 (el) 2024-02-16
FR23C1052I2 (fr) 2025-02-07
SI2207786T1 (sl) 2012-10-30
FR23C1051I2 (fr) 2025-02-07
TW200924786A (en) 2009-06-16
CA2702274C (en) 2015-12-29
MX2010004109A (es) 2010-08-10
WO2009052287A1 (en) 2009-04-23
EP2447272B1 (en) 2017-02-01
FIC20230039I1 (fi) 2023-12-22
LTPA2023539I1 (enExample) 2024-02-26
CY2023028I1 (el) 2024-02-16
NL301257I2 (nl) 2025-11-06
US8618075B2 (en) 2013-12-31
IL204732A0 (en) 2010-11-30
FR23C1052I1 (fr) 2024-01-26
FR23C1051I1 (fr) 2024-01-26
CO6270330A2 (es) 2011-04-20

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