LTC2207786I2 - - Google Patents

Info

Publication number
LTC2207786I2
LTC2207786I2 LTPA2023538C LTPA2023538C LTC2207786I2 LT C2207786 I2 LTC2207786 I2 LT C2207786I2 LT PA2023538 C LTPA2023538 C LT PA2023538C LT PA2023538 C LTPA2023538 C LT PA2023538C LT C2207786 I2 LTC2207786 I2 LT C2207786I2
Authority
LT
Lithuania
Application number
LTPA2023538C
Other languages
Lithuanian (lt)
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40251685&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LTC2207786(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of LTPA2023538I1 publication Critical patent/LTPA2023538I1/lt
Publication of LTC2207786I2 publication Critical patent/LTC2207786I2/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTPA2023538C 2007-10-16 2023-12-29 LTC2207786I2 (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98039707P 2007-10-16 2007-10-16
PCT/US2008/080163 WO2009052287A1 (en) 2007-10-16 2008-10-16 2 ' -flu0r0-2 ' -deoxytetrahydrouridines as cytidine deaminase inhibitors

Publications (2)

Publication Number Publication Date
LTPA2023538I1 LTPA2023538I1 (enExample) 2024-02-26
LTC2207786I2 true LTC2207786I2 (enExample) 2025-09-10

Family

ID=40251685

Family Applications (2)

Application Number Title Priority Date Filing Date
LTPA2023539C LTPA2023539I1 (enExample) 2007-10-16 2023-12-29
LTPA2023538C LTC2207786I2 (enExample) 2007-10-16 2023-12-29

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTPA2023539C LTPA2023539I1 (enExample) 2007-10-16 2023-12-29

Country Status (39)

Country Link
US (4) US8268800B2 (enExample)
EP (2) EP2447272B1 (enExample)
JP (2) JP5496899B2 (enExample)
KR (1) KR101543049B1 (enExample)
CN (1) CN101827856B (enExample)
AT (1) ATE548374T1 (enExample)
BR (1) BRPI0818672B8 (enExample)
CA (1) CA2702274C (enExample)
CO (1) CO6270330A2 (enExample)
CR (1) CR11427A (enExample)
CY (3) CY1112781T1 (enExample)
DK (1) DK2207786T3 (enExample)
EA (1) EA018757B1 (enExample)
EC (1) ECSP10010095A (enExample)
ES (2) ES2384011T3 (enExample)
FI (2) FIC20230039I1 (enExample)
FR (2) FR23C1052I2 (enExample)
GT (1) GT201000088A (enExample)
HR (1) HRP20120419T1 (enExample)
HU (2) HUS2300044I1 (enExample)
IL (1) IL204732A (enExample)
JO (1) JO2778B1 (enExample)
LT (2) LTPA2023539I1 (enExample)
ME (1) ME00997B (enExample)
MX (1) MX2010004109A (enExample)
MY (1) MY147970A (enExample)
NI (1) NI201000055A (enExample)
NL (2) NL301257I2 (enExample)
NO (2) NO2023047I1 (enExample)
NZ (1) NZ584229A (enExample)
PL (1) PL2207786T3 (enExample)
PT (1) PT2207786E (enExample)
RS (1) RS52323B (enExample)
SA (1) SA08290661B1 (enExample)
SI (1) SI2207786T1 (enExample)
TW (1) TWI445539B (enExample)
UA (1) UA99476C2 (enExample)
WO (1) WO2009052287A1 (enExample)
ZA (1) ZA201002178B (enExample)

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US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
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PT3782611T (pt) 2008-05-15 2022-11-18 Celgene Corp Formulações orais de análogos da citidina e métodos de utilização dos mesmos
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US8324180B2 (en) * 2009-04-06 2012-12-04 Eisai Inc. Compositions and methods for treating cancer
US8329665B2 (en) 2009-04-06 2012-12-11 Eisai Inc. Compositions and methods for treating cancer
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US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
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US11224610B2 (en) * 2018-09-19 2022-01-18 Otsuka Pharmaceutical Co., Ltd. Low dose combination CDA substrate drug/cedazuridine with extended administration
KR102280330B1 (ko) * 2018-10-19 2021-07-21 인터올리고 주식회사 치료 효능을 개선한 핵산 변형체 및 이를 포함하는 항암용 약학 조성물
US12448624B2 (en) 2018-10-19 2025-10-21 Interoligo Corporation Modified nucleic acid having improved treatment efficacy, and anticancer pharmaceutical composition containing same
CN120040527A (zh) 2019-10-08 2025-05-27 大塚制药株式会社 包括2’-脱氧-2’,2’-二氟四氢尿苷的组合物
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US20240279266A1 (en) * 2021-05-29 2024-08-22 Msn Laboratories Private Limited, R&D Center An improved process for the preparation of (4r)-1-[(2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-4-hydroxy-1,3-diazinan-2one and its intermediate compounds
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Also Published As

Publication number Publication date
US8618075B2 (en) 2013-12-31
KR101543049B1 (ko) 2015-08-07
AU2008312435A8 (en) 2014-07-24
SA08290661B1 (ar) 2012-06-10
GT201000088A (es) 2012-03-13
US8268800B2 (en) 2012-09-18
CA2702274C (en) 2015-12-29
BRPI0818672A2 (pt) 2015-04-14
JP2014177455A (ja) 2014-09-25
ATE548374T1 (de) 2012-03-15
US20090137521A1 (en) 2009-05-28
NL301256I1 (enExample) 2024-01-03
FR23C1052I1 (fr) 2024-01-26
NZ584229A (en) 2012-06-29
EP2207786B1 (en) 2012-03-07
CO6270330A2 (es) 2011-04-20
JO2778B1 (en) 2014-03-15
ES2384011T3 (es) 2012-06-28
FR23C1051I2 (fr) 2025-02-07
EP2447272B1 (en) 2017-02-01
US20140186335A1 (en) 2014-07-03
FIC20230040I1 (fi) 2023-12-22
BRPI0818672B8 (pt) 2021-05-25
ES2616566T3 (es) 2017-06-13
BRPI0818672B1 (pt) 2020-10-20
LTPA2023539I1 (enExample) 2024-02-26
MX2010004109A (es) 2010-08-10
HRP20120419T1 (hr) 2012-07-31
JP2011500713A (ja) 2011-01-06
TW200924786A (en) 2009-06-16
NI201000055A (es) 2010-08-13
NO2023048I1 (en) 2023-12-21
IL204732A0 (en) 2010-11-30
LTPA2023538I1 (enExample) 2024-02-26
KR20100091978A (ko) 2010-08-19
NL301256I2 (nl) 2024-01-11
TWI445539B (zh) 2014-07-21
CN101827856A (zh) 2010-09-08
NL301257I2 (nl) 2025-11-06
US20120289475A1 (en) 2012-11-15
NO2023047I1 (no) 2023-12-21
AU2008312435B2 (en) 2014-04-17
CN101827856B (zh) 2013-02-06
FIC20230039I1 (fi) 2023-12-22
US8951987B2 (en) 2015-02-10
CY2023029I1 (el) 2024-02-16
FR23C1051I1 (fr) 2024-01-26
DK2207786T3 (da) 2012-06-18
EP2207786A1 (en) 2010-07-21
AU2008312435A1 (en) 2009-04-23
FR23C1052I2 (fr) 2025-02-07
RS52323B (sr) 2012-12-31
CY1112781T1 (el) 2016-02-10
ZA201002178B (en) 2011-05-25
US9567363B2 (en) 2017-02-14
CA2702274A1 (en) 2009-04-23
MY147970A (en) 2013-02-28
UA99476C2 (en) 2012-08-27
EA018757B1 (ru) 2013-10-30
US20150210730A1 (en) 2015-07-30
IL204732A (en) 2013-07-31
PT2207786E (pt) 2012-05-28
EA201000642A1 (ru) 2010-10-29
HUS2300044I1 (hu) 2024-01-28
HK1146410A1 (en) 2011-06-03
CY2023028I1 (el) 2024-02-16
JP5859588B2 (ja) 2016-02-10
ME00997B (me) 2012-10-20
PL2207786T3 (pl) 2012-09-28
WO2009052287A1 (en) 2009-04-23
ECSP10010095A (es) 2010-07-30
HUS2300045I1 (hu) 2024-01-28
SI2207786T1 (sl) 2012-10-30
EP2447272A1 (en) 2012-05-02
CR11427A (es) 2010-08-16
JP5496899B2 (ja) 2014-05-21

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