PT1353911E - Agentes antivirais - Google Patents
Agentes antivirais Download PDFInfo
- Publication number
- PT1353911E PT1353911E PT01271365T PT01271365T PT1353911E PT 1353911 E PT1353911 E PT 1353911E PT 01271365 T PT01271365 T PT 01271365T PT 01271365 T PT01271365 T PT 01271365T PT 1353911 E PT1353911 E PT 1353911E
- Authority
- PT
- Portugal
- Prior art keywords
- compounds
- antiviral agents
- formula
- mammals
- salts
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000005155 Picornaviridae Infections Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR2137A AUPR213700A0 (en) | 2000-12-18 | 2000-12-18 | Antiviral agents |
| PCT/AU2001/001627 WO2002050045A1 (en) | 2000-12-18 | 2001-12-18 | Antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1353911E true PT1353911E (pt) | 2011-07-06 |
Family
ID=3826171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01271365T PT1353911E (pt) | 2000-12-18 | 2001-12-18 | Agentes antivirais |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US7166604B2 (enExample) |
| EP (2) | EP1353911B1 (enExample) |
| JP (3) | JP4601901B2 (enExample) |
| AT (1) | ATE504579T1 (enExample) |
| AU (3) | AUPR213700A0 (enExample) |
| BR (1) | BRPI0116299B1 (enExample) |
| CA (1) | CA2431483C (enExample) |
| CY (1) | CY1111693T1 (enExample) |
| DE (1) | DE60144392D1 (enExample) |
| DK (2) | DK2314582T3 (enExample) |
| ES (2) | ES2363234T3 (enExample) |
| MX (1) | MXPA03005464A (enExample) |
| PT (1) | PT1353911E (enExample) |
| WO (1) | WO2002050045A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR213700A0 (en) * | 2000-12-18 | 2001-01-25 | Biota Scientific Management Pty Ltd | Antiviral agents |
| ATE430742T1 (de) | 2000-12-21 | 2009-05-15 | Smithkline Beecham Corp | Pyrimidinamine als angiogenesemodulatoren |
| WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| AU2004230209A1 (en) | 2003-04-16 | 2004-10-28 | F. Hoffmann-La Roche Ag | Quinazoline compounds useful as p38 kinase inhibitors |
| WO2004091625A1 (en) | 2003-04-16 | 2004-10-28 | F. Hoffmann-La Roche Ag | (6-(phenoxy)-pyrido`3,4-d! pyrimidin-2-yl)-amine derivatives as p38 kinase inhibitors for the treatment of inflammatoryy conditions such as rheumatois artritis |
| CA2575932A1 (en) * | 2004-08-04 | 2006-02-16 | Schering Corporation | Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases |
| US7766210B2 (en) * | 2006-01-31 | 2010-08-03 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting and fastening instrument with user feedback system |
| EP1991540A1 (en) * | 2006-02-21 | 2008-11-19 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| JP2009528365A (ja) * | 2006-02-28 | 2009-08-06 | アムゲン インコーポレイティッド | ホスホジエステラーゼ１０阻害剤としてのシンノリン及びキナゾリン誘導体 |
| AU2007237904B2 (en) | 2006-04-19 | 2011-03-03 | Novartis Ag | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling |
| GB0608899D0 (en) * | 2006-05-05 | 2006-06-14 | Leuven K U Res & Dev | Novel viral replication inhibitors |
| US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| US20080147082A1 (en) * | 2006-12-13 | 2008-06-19 | Joel Pynson | Injector apparatus for use with intraocular lenses and methods of use |
| EP2112880A4 (en) | 2006-12-14 | 2011-12-21 | Merck Sharp & Dohme | ACYLBIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND TREATMENT METHOD |
| NZ590286A (en) * | 2008-05-27 | 2011-08-26 | Biota Scient Management | Phosphate and sulphate salts of 6-{ 2-[1-(6-methyl-3-pyrazinyl)-4-piperidinyl]ethoxy} -3-ethoxy-1,2-benzisoxazole |
| US20120172329A1 (en) * | 2009-09-14 | 2012-07-05 | Thailand Excellence Center For Tissue Engineering | Phytochemical compositions including xanthones for anti-inflammatory, anti-cytokine storm, and other uses |
| ES2550667T3 (es) | 2010-02-18 | 2015-11-11 | Vtv Therapeutics Llc | Derivados de fenilheteroarilo y métodos de uso de los mismos |
| JP6148618B2 (ja) | 2010-04-15 | 2017-06-14 | バイオウタ サイエンティフィック マネジメント プロプライエタリー リミテッド | 呼吸器の病態又は疾患の治療のための化合物 |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| WO2011133920A1 (en) | 2010-04-23 | 2011-10-27 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| EP2585067B1 (en) | 2010-06-25 | 2017-08-09 | Biota Scientific Management Pty Ltd | Compound for the treatment of enteroviruses |
| SI2595980T1 (sl) | 2010-07-22 | 2014-11-28 | Gilead Sciences, Inc. | Postopki in sestavki za zdravljenje paramyxoviridae virusnih infekcij |
| NZ707955A (en) | 2010-09-23 | 2016-03-31 | Abbvie Bahamas Ltd | Monohydrate of an azaadamantane derivative |
| CN102485717B (zh) * | 2010-12-06 | 2015-12-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑胺衍生物及其作为抗小rna病毒感染药物的用途 |
| BR112013026219A2 (pt) | 2011-04-13 | 2016-07-26 | Gilead Sciences Inc | análogos de n-nucleosídeo 1'-substituída pirimidina para tratamento antiviral |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| EP3157908A4 (en) * | 2014-06-20 | 2017-11-15 | Aviragen Therapeutics, Inc. | Anhydrous crystalline free base form of-{2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-1,2-benzisoxazole |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| SI3349758T1 (sl) | 2015-09-16 | 2022-08-31 | Gilead Sciences, Inc. | Postopki za zdravljenje okužb z virusom arenaviridae |
| US11168068B2 (en) | 2016-07-18 | 2021-11-09 | Janssen Pharmaceutica Nv | Tau PET imaging ligands |
| KR102460968B1 (ko) | 2017-03-14 | 2022-11-01 | 길리애드 사이언시즈, 인코포레이티드 | 고양이 코로나바이러스 감염의 치료 방법 |
| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
| CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| CN114641299A (zh) | 2020-01-27 | 2022-06-17 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| AR121356A1 (es) | 2020-02-18 | 2022-05-11 | Gilead Sciences Inc | Compuestos antivirales |
| TWI884403B (zh) | 2020-02-18 | 2025-05-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN118994170A (zh) | 2020-03-12 | 2024-11-22 | 吉利德科学公司 | 制备1'-氰基核苷的方法 |
| WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| KR20230035518A (ko) * | 2020-04-21 | 2023-03-14 | 노암 코헨 | 선천적 면역 반응을 생성하기 위한 퀴닌과 그의 용도 |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| EP4157272B1 (en) | 2020-05-29 | 2025-07-02 | Gilead Sciences, Inc. | Remdesivir for the treatment of viral infections |
| US11939347B2 (en) | 2020-06-24 | 2024-03-26 | Gilead Sciences, Inc. | 1′-cyano nucleoside analogs and uses thereof |
| CA3188373A1 (en) | 2020-08-24 | 2022-03-03 | Scott E. Lazerwith | Phospholipid compounds and uses thereof |
| SI4204421T1 (sl) | 2020-08-27 | 2024-07-31 | Gilead Sciences, Inc., | Spojine in postopki za zdravljenje virusnih okužb |
| TW202344257A (zh) | 2020-10-16 | 2023-11-16 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| CN112274046B (zh) * | 2020-10-29 | 2022-07-22 | 温州欧迪家居用品有限公司 | 一种抑菌毛巾架及其制备工艺 |
| EP4267574B1 (en) | 2020-12-23 | 2025-04-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| JP2024517807A (ja) * | 2021-05-05 | 2024-04-23 | エモリー ユニバーシティー | ヌクレオチド及びヌクレオシド治療組成物、組合せ、並びにそれらに関連する使用 |
| US12427150B2 (en) | 2021-05-26 | 2025-09-30 | Gilead Sciences, Inc. | Phospholipid formulations of 1′-cyano substituted carba-nucleoside analogs |
| WO2023023527A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2023167938A1 (en) | 2022-03-02 | 2023-09-07 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| EP4320128A1 (en) | 2022-03-02 | 2024-02-14 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| AU2023227850A1 (en) | 2022-03-03 | 2024-09-26 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| KR20240155327A (ko) | 2022-03-03 | 2024-10-28 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 화합물 및 이의 제조와 사용 방법 |
| WO2023239665A1 (en) | 2022-06-06 | 2023-12-14 | Gilead Sciences, Inc. | Methods for treatment of viral infections including sars-cov-2 |
| WO2024006376A1 (en) | 2022-06-29 | 2024-01-04 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| EP4547665A1 (en) | 2022-06-30 | 2025-05-07 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| US20240309028A1 (en) | 2023-02-16 | 2024-09-19 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| TWI898554B (zh) | 2023-04-28 | 2025-09-21 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
| WO2025049699A1 (en) | 2023-08-31 | 2025-03-06 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| US20250084088A1 (en) | 2023-08-31 | 2025-03-13 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| US20250099476A1 (en) | 2023-09-06 | 2025-03-27 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| WO2025072641A1 (en) | 2023-09-28 | 2025-04-03 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3997565A (en) | 1975-09-19 | 1976-12-14 | E. I. Du Pont De Nemours And Company | Acylcrownether oximes and oxime ethers |
| US4268678A (en) | 1979-09-04 | 1981-05-19 | Sterling Drug Inc. | 4-(Arylaliphatic)isoxazoles |
| DE3132335A1 (de) | 1981-08-17 | 1983-03-03 | Bayer Ag, 5090 Leverkusen | Substituierte azolyl-phenoxy-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| US4475416A (en) * | 1982-07-27 | 1984-10-09 | Borg-Warner Corporation | Continuously variable transmission down shift control |
| US4451476A (en) | 1982-12-13 | 1984-05-29 | Sterling Drug Inc. | Isoxazoles as antiviral agents |
| US5002960A (en) | 1983-08-29 | 1991-03-26 | Sterling Drug, Inc. | N-haloalkyl-4-(isoxazol-5-yl)alkoxy benzamides |
| US4843087A (en) | 1983-08-29 | 1989-06-27 | Sterling Drug Inc. | Di-heterocyclic compounds and their use as antiviral agents |
| US4861791A (en) | 1983-08-29 | 1989-08-29 | Sterling Drug Inc. | Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents |
| ZA846525B (en) * | 1983-08-29 | 1985-04-24 | Sterling Drug Inc | (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof |
| US5001125A (en) | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| JPS62252783A (ja) * | 1986-02-13 | 1987-11-04 | ワ−ナ−−ランバ−ト・コンパニ− | ベンズ複素環式化合物 |
| US4861869A (en) | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| DE3618379A1 (de) | 1986-05-31 | 1987-12-03 | Bayer Ag | Verfahren zur herstellung eines azol-derivates |
| US5051437A (en) | 1986-06-24 | 1991-09-24 | Sterling Drug Inc. | Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents |
| DE3716023A1 (de) | 1987-05-14 | 1988-12-08 | Bayer Ag | Azolyl-tetrahydrofuran-2-yliden-methane |
| NZ225045A (en) | 1987-07-01 | 1990-06-26 | Janssen Pharmaceutica Nv | Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent |
| US4992433A (en) | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
| US5231184A (en) | 1987-11-23 | 1993-07-27 | Janssen Pharmaceutica N.V. | Pridazinamine derivatives |
| US5106973A (en) | 1987-11-23 | 1992-04-21 | Janssen Pharmaceutica N.V. | Pyridzainamine derivatives |
| MY104343A (en) * | 1987-11-23 | 1994-03-31 | Janssen Pharmaceutica Nv | Novel pyridizinamine deravatives |
| GB8807275D0 (en) | 1988-03-26 | 1988-04-27 | Synphar Lab Inc | Chemical compounds |
| DE3825170A1 (de) | 1988-07-23 | 1990-01-25 | Hoechst Ag, 65929 Frankfurt | Substituierte 5-(4-(4,5-dihydro-2-oxazolyl)-phenoxyalkylenoxyalkyl)-isoxazole, verfahren sowie 5-(phenoxyalkylenoxyalkyl)-isoxazole als zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von krankheiten, die durch infektion mit viren hervorgerufen wurden |
| WO1990001874A1 (en) | 1988-08-24 | 1990-03-08 | Teijin Limited | Oxime derivatives and herbicides containing the same as an active ingredient |
| JPH02104584A (ja) * | 1988-10-14 | 1990-04-17 | Fujisawa Pharmaceut Co Ltd | 新規キノリン誘導体およびその医薬用途 |
| GB8911158D0 (en) | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
| US5070090A (en) | 1989-05-15 | 1991-12-03 | Janssen Pharmaceutica N.V. | Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers |
| NZ233525A (en) | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions |
| NZ233526A (en) * | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Pyridazine derivatives and their pharmaceutical compositions |
| US5175178A (en) | 1989-08-21 | 1992-12-29 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5110821A (en) | 1989-08-18 | 1992-05-05 | Sterling Drug Inc. | 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US4942241A (en) | 1989-08-21 | 1990-07-17 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US4945164A (en) | 1989-08-18 | 1990-07-31 | Sterling Drug Inc. | 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof |
| ZA9010357B (en) | 1989-12-26 | 1992-08-26 | Janssen Pharmaceutica Nv | Antipicornaviral pyridazinamines |
| JO1645B1 (en) * | 1989-12-26 | 1991-11-27 | شركة جانسين فارماسوتيكا ان. في | Pyridazine compounds are antibacterial viruses |
| JPH05320117A (ja) | 1990-01-25 | 1993-12-03 | Teijin Ltd | オキシム誘導体のｒ光学異性体およびそれを有効成分とする除草剤 |
| US5100893A (en) | 1990-04-18 | 1992-03-31 | Janssen Pharmaceutica N.V. | Antipicornaviral pyridazinamines |
| US5349068A (en) | 1992-04-15 | 1994-09-20 | Sterling Winthrop Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5242924A (en) | 1992-07-02 | 1993-09-07 | Sterling Winthrop Inc. | Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents |
| US5364865A (en) | 1992-12-30 | 1994-11-15 | Sterling Winthrop Inc. | Phenoxy- and phenoxyalkyl-piperidines as antiviral agents |
| AU7275894A (en) * | 1993-08-04 | 1995-02-28 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazolylalkylamine derivative and pharmaceutical composition thereof |
| US5552420A (en) | 1994-05-13 | 1996-09-03 | Sterling Winthrop Inc. | Therapeutic phenoxyalkylazoles and phenoxyalkylazines |
| US5453433A (en) | 1994-05-13 | 1995-09-26 | Sterling Winthrop Inc. | Thiadiazoles and antipicornaviral compositions |
| US5514679A (en) | 1994-05-13 | 1996-05-07 | Sterling Winthrop Inc. | Therapeutic phenoxyalklpyridazines and intermediates therefor |
| CA2188809A1 (en) | 1994-05-13 | 1995-11-23 | Gee-Hong Kuo | Therapeutic phenoxyalkylazoles and phenoxyalkylazines |
| AU704972B2 (en) * | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
| JPH0881314A (ja) | 1994-09-09 | 1996-03-26 | Kumiai Chem Ind Co Ltd | 除草剤組成物 |
| US5523312A (en) | 1994-09-27 | 1996-06-04 | Sterling Winthrop Inc. | Antipicornaviral agents |
| DE19517448A1 (de) | 1995-05-12 | 1996-11-14 | Thomae Gmbh Dr K | Neue Benzothiazole und Benzoxazole, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| US5763461A (en) | 1995-05-26 | 1998-06-09 | Sanofi | Therapeutic phenoxyalkylheterocycles |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| ZA9610745B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| US5891874A (en) * | 1996-06-05 | 1999-04-06 | Eli Lilly And Company | Anti-viral compound |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1998017631A2 (en) | 1996-10-23 | 1998-04-30 | Novartis Ag | Substituted oxime-ethers and their use as pesticides |
| AU7715198A (en) | 1997-06-04 | 1998-12-21 | Eli Lilly And Company | Anti-viral compounds |
| PL340589A1 (en) * | 1997-11-11 | 2001-02-12 | Pfizer Prod Inc | Derivatives of thienepyrimidine and thienepyridine useful as anticarcinogenic agents |
| WO1999055663A1 (en) * | 1998-04-29 | 1999-11-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
| TR200003414T2 (tr) * | 1998-05-20 | 2001-03-21 | Eli Lilly And Company | Anti-viral terkipler |
| AU763669B2 (en) * | 1998-09-29 | 2003-07-31 | Wyeth Holdings Corporation | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
| HK1038564A1 (zh) * | 1998-10-08 | 2002-03-22 | Smithkline Beecham Plc | 用作糖原合酶激酶-3抑制劑的吡咯-2，5-二酮 |
| AUPQ105499A0 (en) * | 1999-06-18 | 1999-07-08 | Biota Scientific Management Pty Ltd | Antiviral agents |
| AUPQ288499A0 (en) | 1999-09-16 | 1999-10-07 | Biota Scientific Management Pty Ltd | Antiviral agents |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| JP2003528043A (ja) * | 1999-11-23 | 2003-09-24 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物 |
| AU3789901A (en) * | 1999-12-17 | 2001-06-25 | Bristol-Myers Squibb Company | Antipsychotic heterocycle compounds |
| ES2261437T3 (es) * | 2000-07-05 | 2006-11-16 | Astellas Pharma Inc. | Derivados de propano-1,3-diona. |
| AUPR213700A0 (en) * | 2000-12-18 | 2001-01-25 | Biota Scientific Management Pty Ltd | Antiviral agents |
| JP5320117B2 (ja) | 2009-03-18 | 2013-10-23 | 積水化学工業株式会社 | 電子部品用接着剤 |
-
2000
- 2000-12-18 AU AUPR2137A patent/AUPR213700A0/en not_active Abandoned
-
2001
- 2001-12-18 EP EP01271365A patent/EP1353911B1/en not_active Expired - Lifetime
- 2001-12-18 AT AT01271365T patent/ATE504579T1/de active
- 2001-12-18 DK DK10178102.9T patent/DK2314582T3/da active
- 2001-12-18 JP JP2002551542A patent/JP4601901B2/ja not_active Expired - Fee Related
- 2001-12-18 ES ES01271365T patent/ES2363234T3/es not_active Expired - Lifetime
- 2001-12-18 EP EP10178102.9A patent/EP2314582B1/en not_active Expired - Lifetime
- 2001-12-18 PT PT01271365T patent/PT1353911E/pt unknown
- 2001-12-18 ES ES10178102.9T patent/ES2477571T3/es not_active Expired - Lifetime
- 2001-12-18 CA CA2431483A patent/CA2431483C/en not_active Expired - Fee Related
- 2001-12-18 AU AU2002221344A patent/AU2002221344C1/en not_active Ceased
- 2001-12-18 DE DE60144392T patent/DE60144392D1/de not_active Expired - Lifetime
- 2001-12-18 US US10/450,005 patent/US7166604B2/en not_active Expired - Fee Related
- 2001-12-18 MX MXPA03005464A patent/MXPA03005464A/es active IP Right Grant
- 2001-12-18 AU AU2134402A patent/AU2134402A/xx active Pending
- 2001-12-18 BR BRPI0116299A patent/BRPI0116299B1/pt not_active IP Right Cessation
- 2001-12-18 DK DK01271365.7T patent/DK1353911T3/da active
- 2001-12-18 WO PCT/AU2001/001627 patent/WO2002050045A1/en not_active Ceased
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2006
- 2006-11-13 US US11/559,253 patent/US7829705B2/en not_active Expired - Fee Related
- 2006-11-13 US US11/559,242 patent/US7579465B2/en not_active Expired - Lifetime
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2008
- 2008-05-01 US US12/113,718 patent/US7951955B2/en not_active Expired - Fee Related
-
2009
- 2009-09-28 JP JP2009223363A patent/JP2010031025A/ja not_active Ceased
-
2010
- 2010-05-06 JP JP2010106686A patent/JP2010189434A/ja active Pending
-
2011
- 2011-05-04 US US13/100,931 patent/US8217171B2/en not_active Expired - Fee Related
- 2011-07-06 CY CY20111100658T patent/CY1111693T1/el unknown
-
2012
- 2012-07-03 US US13/540,865 patent/US8624025B2/en not_active Expired - Lifetime
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2013
- 2013-12-20 US US14/136,106 patent/US9303026B2/en not_active Expired - Fee Related
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