PT1189924E - Conjugados de fitosterol ou fitostanol com acido ascorbico e sua utilizacao no tratamento ou prevencao de doenca cardiovascular - Google Patents
Conjugados de fitosterol ou fitostanol com acido ascorbico e sua utilizacao no tratamento ou prevencao de doenca cardiovascularInfo
- Publication number
- PT1189924E PT1189924E PT00938426T PT00938426T PT1189924E PT 1189924 E PT1189924 E PT 1189924E PT 00938426 T PT00938426 T PT 00938426T PT 00938426 T PT00938426 T PT 00938426T PT 1189924 E PT1189924 E PT 1189924E
- Authority
- PT
- Portugal
- Prior art keywords
- phytosterol
- phytostanol
- ascorbic acid
- cardiovascular disease
- conjugates
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 4
- 208000024172 Cardiovascular disease Diseases 0.000 title abstract 2
- 229960005070 ascorbic acid Drugs 0.000 title abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 title abstract 2
- 239000011668 ascorbic acid Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052751 metal Chemical group 0.000 abstract 1
- 239000002184 metal Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33990399A | 1999-06-23 | 1999-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1189924E true PT1189924E (pt) | 2004-12-31 |
Family
ID=23331117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00938426T PT1189924E (pt) | 1999-06-23 | 2000-06-20 | Conjugados de fitosterol ou fitostanol com acido ascorbico e sua utilizacao no tratamento ou prevencao de doenca cardiovascular |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020156051A1 (pt) |
| EP (2) | EP1189924B1 (pt) |
| JP (1) | JP2003522124A (pt) |
| KR (1) | KR100711861B1 (pt) |
| CN (1) | CN1237071C (pt) |
| AT (1) | ATE273992T1 (pt) |
| AU (1) | AU5383700A (pt) |
| BR (1) | BR0011863A (pt) |
| CA (1) | CA2377492A1 (pt) |
| DE (1) | DE60013130T2 (pt) |
| DK (1) | DK1189924T3 (pt) |
| ES (1) | ES2226856T3 (pt) |
| HK (1) | HK1049342B (pt) |
| NO (1) | NO323774B1 (pt) |
| NZ (1) | NZ516349A (pt) |
| PT (1) | PT1189924E (pt) |
| RU (1) | RU2002101483A (pt) |
| SI (1) | SI1189924T1 (pt) |
| WO (1) | WO2001000653A1 (pt) |
| ZA (1) | ZA200110483B (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020026053A (ko) * | 2000-09-30 | 2002-04-06 | 노승권 | 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료 |
| DK1333838T3 (da) * | 2000-10-25 | 2007-04-10 | Forbes Medi Tech Inc | Forbindelser, der omfatter en phytosterol- og/eller phytostanoldel og ascorbinsyre, og anvendelse deraf som vægtreguleringsmidler |
| KR100396211B1 (ko) * | 2000-10-31 | 2003-09-17 | (주)유진사이언스 | 천연물로 구성된 수용성 식물성 스테롤 유도체 및 이의염과 이들의 제조방법 |
| WO2003009854A1 (en) * | 2001-07-20 | 2003-02-06 | Lonza Ag | Lipid lowering composition comprising carnitine and phytosterol |
| NZ531938A (en) * | 2001-09-26 | 2006-04-28 | Forbes Medi Tech Inc | A method of reducing the in vivo cholesterol ester transfer protein mediated transfer of cholesteryl esters between high density lipoproteins (HDL) and low density lipoproteins (LDL) |
| WO2003063605A1 (en) * | 2002-02-01 | 2003-08-07 | Eugene Science Inc. | Chewing gum composition containing plant sterol for decrease of flood cholesterol levels and prevention of periodontal disease |
| CN1681514A (zh) * | 2002-03-14 | 2005-10-12 | 福布斯梅迪泰克公司 | 一种治疗糖尿病,包括与糖尿病有关的疾病和糖尿病并发症的方法 |
| AU2002241368B2 (en) * | 2002-03-20 | 2009-07-09 | Eugene Science Inc. | Plant sterol-containing food, and method for preparing the same |
| EP1538929A4 (en) * | 2002-03-20 | 2009-03-11 | Eugene Science Inc | POWDER MIXTURE OF VEGETABLE STEROL AND EMULSIFIANT, AND PROCESS FOR PREPARING THE SAME |
| US20030232797A1 (en) * | 2002-06-06 | 2003-12-18 | Forbes Medi-Tech Inc. | Novel derivatives of androstane and androstene with ascorbic acid and use thereof in treating or preventing various conditions, diseases, and disorders |
| CA2488617A1 (en) * | 2002-06-10 | 2003-12-18 | Eugene R. Cooper | Nanoparticulate sterol formulations and sterol combinations |
| US7335389B2 (en) | 2002-06-12 | 2008-02-26 | The Coca-Cola Company | Beverages containing plant sterols |
| US7306819B2 (en) | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
| US20040001874A1 (en) * | 2002-06-24 | 2004-01-01 | Vital Living, Inc. | Safe and effective nutritional supplement formulations and associated regimens adapted to prevent and/or treat targeted diseases or medical or health conditions, and related methods |
| WO2004029068A1 (en) * | 2002-09-25 | 2004-04-08 | Forbes Medi-Tech Inc. | Derivatives comprising sterols and/or stanols and specific classes of anti-inflammatory agents and use thereof in treating or preventing cardiovascular disease |
| ZA200504059B (en) * | 2002-11-22 | 2007-12-27 | Nippon Susan Kaisha Ltd | External composition containing polyunsaturated fatty acid or its salt or ester |
| CA2531836A1 (en) * | 2003-07-09 | 2005-01-20 | Forbes Medi-Tech Inc. | Novel compounds and compositions comprising sterols and/or stanols and cholesterol biosynthesis inhibitors and use thereof in treating or preventing a variety of diseases and conditions. |
| WO2005042692A2 (en) * | 2003-10-31 | 2005-05-12 | Forbes Medi-Tech Inc. | A method of inhibiting the expression of genes which mediate cellular cholesterol influx in animal cells and inhibiting the production of proteins resulting from the expression of such genes using cholesterol absorption inhibitors |
| GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| US20080182801A1 (en) * | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| KR101573316B1 (ko) * | 2004-03-29 | 2015-12-01 | 와이어쓰 엘엘씨 | 종합비타민 및 무기물 영양 보충제 |
| US20050234025A1 (en) * | 2004-04-20 | 2005-10-20 | Forbes Medi-Tech Inc. | Compositions comprising one or more policosanols and/or policosanoic acids combined with sterol and/or steroid based ascorbic acid derivatives, and uses thereof |
| EP1835818B1 (en) * | 2004-12-09 | 2011-08-10 | Eurark, LLC | Product and method for producing a vehicle for oral administration of nutraceuticals |
| GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
| GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| CL2009000409A1 (es) * | 2009-02-23 | 2009-05-04 | Rojas Alejandro Markovits | Proceso para obtener una dispersión de fitoesteroles sólidos en agua. |
| JP5657902B2 (ja) * | 2010-03-17 | 2015-01-21 | 株式会社コスモステクニカルセンター | ポリオキシアルキレンステロールエーテル誘導体及び／又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物 |
| BR112014006222A2 (pt) * | 2011-09-16 | 2017-04-11 | Davidson Lopez Llc | esteroides vegetais e usos dos mesmos |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56113800A (en) * | 1980-02-14 | 1981-09-07 | Green Cross Corp:The | Water-soluble cholesterol derivative |
| US4939128A (en) * | 1988-04-25 | 1990-07-03 | Takeda Chemical Industries, Ltd. | Ester of ascorbic acid 2-phosphate and pharmaceutical use |
| JPH0228189A (ja) * | 1988-04-25 | 1990-01-30 | Takeda Chem Ind Ltd | アスコルビン酸リン酸エステル誘導体およびその製造法 |
| CA2028759A1 (en) * | 1989-11-22 | 1991-05-23 | Jean-Marie Cassal | Steroids |
| DE4000397A1 (de) * | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
| JPH07252294A (ja) * | 1994-01-28 | 1995-10-03 | Senju Pharmaceut Co Ltd | 副腎皮質ステロイド誘導体 |
| US5866147A (en) * | 1995-05-15 | 1999-02-02 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| US5951990A (en) * | 1995-05-15 | 1999-09-14 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| DE19701264A1 (de) * | 1997-01-16 | 1998-07-23 | Kief Lizenz Verwertungsgesells | Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische |
| FI974648A (fi) * | 1997-09-09 | 1999-05-06 | Raisio Benecol Oy | Hydroksihappo-, maitohappo- ja hydroksialkanoaattiesterit ja niiden käyttö |
-
2000
- 2000-06-20 WO PCT/CA2000/000730 patent/WO2001000653A1/en active IP Right Grant
- 2000-06-20 AU AU53837/00A patent/AU5383700A/en not_active Abandoned
- 2000-06-20 CA CA002377492A patent/CA2377492A1/en not_active Abandoned
- 2000-06-20 CN CNB008117985A patent/CN1237071C/zh not_active Expired - Fee Related
- 2000-06-20 AT AT00938426T patent/ATE273992T1/de not_active IP Right Cessation
- 2000-06-20 KR KR1020017016415A patent/KR100711861B1/ko not_active IP Right Cessation
- 2000-06-20 DK DK00938426T patent/DK1189924T3/da active
- 2000-06-20 EP EP00938426A patent/EP1189924B1/en not_active Expired - Lifetime
- 2000-06-20 JP JP2001507060A patent/JP2003522124A/ja active Pending
- 2000-06-20 DE DE60013130T patent/DE60013130T2/de not_active Expired - Fee Related
- 2000-06-20 BR BR0011863-0A patent/BR0011863A/pt not_active IP Right Cessation
- 2000-06-20 PT PT00938426T patent/PT1189924E/pt unknown
- 2000-06-20 EP EP03025643A patent/EP1420026A3/en not_active Withdrawn
- 2000-06-20 RU RU2002101483/04A patent/RU2002101483A/ru not_active Application Discontinuation
- 2000-06-20 SI SI200030497T patent/SI1189924T1/xx unknown
- 2000-06-20 ES ES00938426T patent/ES2226856T3/es not_active Expired - Lifetime
- 2000-06-20 NZ NZ516349A patent/NZ516349A/xx unknown
-
2001
- 2001-07-25 US US09/916,817 patent/US20020156051A1/en not_active Abandoned
- 2001-12-20 NO NO20016294A patent/NO323774B1/no unknown
- 2001-12-20 ZA ZA200110483A patent/ZA200110483B/en unknown
-
2003
- 2003-02-28 HK HK03101501.7A patent/HK1049342B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1049342B (zh) | 2006-04-07 |
| KR100711861B1 (ko) | 2007-04-25 |
| DK1189924T3 (da) | 2004-12-20 |
| BR0011863A (pt) | 2003-10-14 |
| ES2226856T3 (es) | 2005-04-01 |
| NZ516349A (en) | 2004-03-26 |
| AU5383700A (en) | 2001-01-31 |
| CN1237071C (zh) | 2006-01-18 |
| CN1370180A (zh) | 2002-09-18 |
| US20020156051A1 (en) | 2002-10-24 |
| WO2001000653A1 (en) | 2001-01-04 |
| EP1420026A3 (en) | 2004-12-15 |
| RU2002101483A (ru) | 2003-09-20 |
| NO20016294L (no) | 2002-02-22 |
| DE60013130T2 (de) | 2005-01-05 |
| KR20020028907A (ko) | 2002-04-17 |
| CA2377492A1 (en) | 2001-01-04 |
| NO323774B1 (no) | 2007-07-02 |
| SI1189924T1 (en) | 2005-02-28 |
| NO20016294D0 (no) | 2001-12-20 |
| EP1420026A2 (en) | 2004-05-19 |
| EP1189924B1 (en) | 2004-08-18 |
| ZA200110483B (en) | 2003-06-20 |
| DE60013130D1 (de) | 2004-09-23 |
| EP1189924A1 (en) | 2002-03-27 |
| JP2003522124A (ja) | 2003-07-22 |
| HK1049342A1 (en) | 2003-05-09 |
| ATE273992T1 (de) | 2004-09-15 |
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