ATE273992T1 - Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten - Google Patents
Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheitenInfo
- Publication number
- ATE273992T1 ATE273992T1 AT00938426T AT00938426T ATE273992T1 AT E273992 T1 ATE273992 T1 AT E273992T1 AT 00938426 T AT00938426 T AT 00938426T AT 00938426 T AT00938426 T AT 00938426T AT E273992 T1 ATE273992 T1 AT E273992T1
- Authority
- AT
- Austria
- Prior art keywords
- ascorbic acid
- phytostanols
- phytosterols
- conjugates
- treatment
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 4
- 229960005070 ascorbic acid Drugs 0.000 title abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 title abstract 2
- 239000011668 ascorbic acid Substances 0.000 title abstract 2
- 229940068065 phytosterols Drugs 0.000 title 1
- 208000019553 vascular disease Diseases 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052751 metal Chemical group 0.000 abstract 1
- 239000002184 metal Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- General Preparation And Processing Of Foods (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33990399A | 1999-06-23 | 1999-06-23 | |
| PCT/CA2000/000730 WO2001000653A1 (en) | 1999-06-23 | 2000-06-20 | Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273992T1 true ATE273992T1 (de) | 2004-09-15 |
Family
ID=23331117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00938426T ATE273992T1 (de) | 1999-06-23 | 2000-06-20 | Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020156051A1 (de) |
| EP (2) | EP1420026A3 (de) |
| JP (1) | JP2003522124A (de) |
| KR (1) | KR100711861B1 (de) |
| CN (1) | CN1237071C (de) |
| AT (1) | ATE273992T1 (de) |
| AU (1) | AU5383700A (de) |
| BR (1) | BR0011863A (de) |
| CA (1) | CA2377492A1 (de) |
| DE (1) | DE60013130T2 (de) |
| DK (1) | DK1189924T3 (de) |
| ES (1) | ES2226856T3 (de) |
| HK (1) | HK1049342B (de) |
| NO (1) | NO323774B1 (de) |
| NZ (1) | NZ516349A (de) |
| PT (1) | PT1189924E (de) |
| RU (1) | RU2002101483A (de) |
| SI (1) | SI1189924T1 (de) |
| WO (1) | WO2001000653A1 (de) |
| ZA (1) | ZA200110483B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020026053A (ko) * | 2000-09-30 | 2002-04-06 | 노승권 | 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료 |
| CA2426895A1 (en) * | 2000-10-25 | 2002-05-02 | Forbes Medi-Tech Inc. | Compounds comprising a phytosterol and/or phytostanol moiety and ascorbis acid and use thereof as weight regulating agents |
| KR100396211B1 (ko) * | 2000-10-31 | 2003-09-17 | (주)유진사이언스 | 천연물로 구성된 수용성 식물성 스테롤 유도체 및 이의염과 이들의 제조방법 |
| WO2003009854A1 (en) * | 2001-07-20 | 2003-02-06 | Lonza Ag | Lipid lowering composition comprising carnitine and phytosterol |
| NZ531938A (en) * | 2001-09-26 | 2006-04-28 | Forbes Medi Tech Inc | A method of reducing the in vivo cholesterol ester transfer protein mediated transfer of cholesteryl esters between high density lipoproteins (HDL) and low density lipoproteins (LDL) |
| WO2003063605A1 (en) * | 2002-02-01 | 2003-08-07 | Eugene Science Inc. | Chewing gum composition containing plant sterol for decrease of flood cholesterol levels and prevention of periodontal disease |
| KR20040104513A (ko) * | 2002-03-14 | 2004-12-10 | 포비스 메디-테크 인코포레이티드 | 당뇨병 및 당뇨병의 합병증과 관련된 상태를 포함한당뇨병의 치료방법 |
| CN1289005C (zh) * | 2002-03-20 | 2006-12-13 | 优俊科学公司 | 包含植物甾醇的食物及其制备方法 |
| JP2005520508A (ja) * | 2002-03-20 | 2005-07-14 | ユージーン サイエンス インコーポレイテッド | 植物ステロールと乳化剤の混合粉末及びその製造方法 |
| US20030232797A1 (en) * | 2002-06-06 | 2003-12-18 | Forbes Medi-Tech Inc. | Novel derivatives of androstane and androstene with ascorbic acid and use thereof in treating or preventing various conditions, diseases, and disorders |
| AU2003241478A1 (en) * | 2002-06-10 | 2003-12-22 | Elan Pharma International, Ltd. | Nanoparticulate sterol formulations and sterol combinations |
| DK1549159T3 (da) | 2002-06-12 | 2009-03-02 | Coca Cola Co | Drikkevarer indeholdende plantesteroler |
| US7306819B2 (en) | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
| US20040001874A1 (en) * | 2002-06-24 | 2004-01-01 | Vital Living, Inc. | Safe and effective nutritional supplement formulations and associated regimens adapted to prevent and/or treat targeted diseases or medical or health conditions, and related methods |
| EP1556406A1 (de) * | 2002-09-25 | 2005-07-27 | Forbes Medi-Tech Inc. | Sterol- und/oder stanol- sowie spezifische entzündungshemmende verbindungen enthaltende derivate sowie deren verwendung zur behandlung oder vorbeugung kardiovaskulärer erkrankungen |
| JPWO2004048497A1 (ja) * | 2002-11-22 | 2006-03-30 | 日本水産株式会社 | 高度不飽和脂肪酸、その塩、またはそのエステルを含有する外用組成物 |
| MXPA06000326A (es) * | 2003-07-09 | 2006-03-30 | Forbes Medi Tech Inc | Novedosos compuestos y composiciones que contienen esteroles y/o estanoles e inhibidores de biosintesis de colesterol, y su uso en el tratamiento o prevencion de una variedad de enfermedades y condiciones. |
| WO2005042692A2 (en) * | 2003-10-31 | 2005-05-12 | Forbes Medi-Tech Inc. | A method of inhibiting the expression of genes which mediate cellular cholesterol influx in animal cells and inhibiting the production of proteins resulting from the expression of such genes using cholesterol absorption inhibitors |
| GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| CA2794424C (en) * | 2004-03-29 | 2019-06-04 | Wyeth Llc | Multi-vitamin and mineral nutritional supplements |
| US20050234025A1 (en) * | 2004-04-20 | 2005-10-20 | Forbes Medi-Tech Inc. | Compositions comprising one or more policosanols and/or policosanoic acids combined with sterol and/or steroid based ascorbic acid derivatives, and uses thereof |
| WO2006063219A2 (en) * | 2004-12-09 | 2006-06-15 | Pro-Health, Inc. | Product and method for oral administration of nutraceuticals |
| GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
| CL2009000409A1 (es) * | 2009-02-23 | 2009-05-04 | Rojas Alejandro Markovits | Proceso para obtener una dispersión de fitoesteroles sólidos en agua. |
| JP5657902B2 (ja) * | 2010-03-17 | 2015-01-21 | 株式会社コスモステクニカルセンター | ポリオキシアルキレンステロールエーテル誘導体及び/又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物 |
| MX2014003260A (es) * | 2011-09-16 | 2014-09-08 | Davidson Lopez Llc | Esteroides de plantas y usos de los mismos. |
| KR102816341B1 (ko) * | 2022-01-24 | 2025-06-05 | 연세대학교 산학협력단 | 심혈관계 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56113800A (en) * | 1980-02-14 | 1981-09-07 | Green Cross Corp:The | Water-soluble cholesterol derivative |
| JPH0228189A (ja) * | 1988-04-25 | 1990-01-30 | Takeda Chem Ind Ltd | アスコルビン酸リン酸エステル誘導体およびその製造法 |
| US4939128A (en) * | 1988-04-25 | 1990-07-03 | Takeda Chemical Industries, Ltd. | Ester of ascorbic acid 2-phosphate and pharmaceutical use |
| CA2028759A1 (en) * | 1989-11-22 | 1991-05-23 | Jean-Marie Cassal | Steroids |
| DE4000397A1 (de) * | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
| JPH07252294A (ja) * | 1994-01-28 | 1995-10-03 | Senju Pharmaceut Co Ltd | 副腎皮質ステロイド誘導体 |
| US5866147A (en) * | 1995-05-15 | 1999-02-02 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| US5951990A (en) * | 1995-05-15 | 1999-09-14 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| DE19701264A1 (de) * | 1997-01-16 | 1998-07-23 | Kief Lizenz Verwertungsgesells | Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische |
| FI974648A7 (fi) * | 1997-09-09 | 1999-05-06 | Raisio Benecol Oy | Hydroksihappo-, maitohappo- ja hydroksialkanoaattiesterit ja niiden käyttö |
-
2000
- 2000-06-20 DE DE60013130T patent/DE60013130T2/de not_active Expired - Fee Related
- 2000-06-20 EP EP03025643A patent/EP1420026A3/de not_active Withdrawn
- 2000-06-20 EP EP00938426A patent/EP1189924B1/de not_active Expired - Lifetime
- 2000-06-20 PT PT00938426T patent/PT1189924E/pt unknown
- 2000-06-20 BR BR0011863-0A patent/BR0011863A/pt not_active IP Right Cessation
- 2000-06-20 KR KR1020017016415A patent/KR100711861B1/ko not_active Expired - Fee Related
- 2000-06-20 CN CNB008117985A patent/CN1237071C/zh not_active Expired - Fee Related
- 2000-06-20 SI SI200030497T patent/SI1189924T1/xx unknown
- 2000-06-20 JP JP2001507060A patent/JP2003522124A/ja active Pending
- 2000-06-20 ES ES00938426T patent/ES2226856T3/es not_active Expired - Lifetime
- 2000-06-20 AU AU53837/00A patent/AU5383700A/en not_active Abandoned
- 2000-06-20 CA CA002377492A patent/CA2377492A1/en not_active Abandoned
- 2000-06-20 RU RU2002101483/04A patent/RU2002101483A/ru not_active Application Discontinuation
- 2000-06-20 NZ NZ516349A patent/NZ516349A/xx unknown
- 2000-06-20 AT AT00938426T patent/ATE273992T1/de not_active IP Right Cessation
- 2000-06-20 WO PCT/CA2000/000730 patent/WO2001000653A1/en not_active Ceased
- 2000-06-20 HK HK03101501.7A patent/HK1049342B/zh not_active IP Right Cessation
- 2000-06-20 DK DK00938426T patent/DK1189924T3/da active
-
2001
- 2001-07-25 US US09/916,817 patent/US20020156051A1/en not_active Abandoned
- 2001-12-20 NO NO20016294A patent/NO323774B1/no unknown
- 2001-12-20 ZA ZA200110483A patent/ZA200110483B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1189924E (pt) | 2004-12-31 |
| WO2001000653A1 (en) | 2001-01-04 |
| NO20016294D0 (no) | 2001-12-20 |
| EP1420026A3 (de) | 2004-12-15 |
| CN1370180A (zh) | 2002-09-18 |
| DE60013130D1 (de) | 2004-09-23 |
| NZ516349A (en) | 2004-03-26 |
| EP1189924A1 (de) | 2002-03-27 |
| ES2226856T3 (es) | 2005-04-01 |
| JP2003522124A (ja) | 2003-07-22 |
| US20020156051A1 (en) | 2002-10-24 |
| AU5383700A (en) | 2001-01-31 |
| ZA200110483B (en) | 2003-06-20 |
| EP1189924B1 (de) | 2004-08-18 |
| CN1237071C (zh) | 2006-01-18 |
| NO323774B1 (no) | 2007-07-02 |
| NO20016294L (no) | 2002-02-22 |
| BR0011863A (pt) | 2003-10-14 |
| HK1049342A1 (en) | 2003-05-09 |
| SI1189924T1 (en) | 2005-02-28 |
| CA2377492A1 (en) | 2001-01-04 |
| EP1420026A2 (de) | 2004-05-19 |
| KR100711861B1 (ko) | 2007-04-25 |
| RU2002101483A (ru) | 2003-09-20 |
| HK1049342B (zh) | 2006-04-07 |
| KR20020028907A (ko) | 2002-04-17 |
| DE60013130T2 (de) | 2005-01-05 |
| DK1189924T3 (da) | 2004-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1189924 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |