ATE273992T1 - Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten - Google Patents
Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheitenInfo
- Publication number
- ATE273992T1 ATE273992T1 AT00938426T AT00938426T ATE273992T1 AT E273992 T1 ATE273992 T1 AT E273992T1 AT 00938426 T AT00938426 T AT 00938426T AT 00938426 T AT00938426 T AT 00938426T AT E273992 T1 ATE273992 T1 AT E273992T1
- Authority
- AT
- Austria
- Prior art keywords
- ascorbic acid
- phytostanols
- phytosterols
- conjugates
- treatment
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 4
- 229960005070 ascorbic acid Drugs 0.000 title abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 title abstract 2
- 239000011668 ascorbic acid Substances 0.000 title abstract 2
- 229940068065 phytosterols Drugs 0.000 title 1
- 208000019553 vascular disease Diseases 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052751 metal Chemical group 0.000 abstract 1
- 239000002184 metal Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33990399A | 1999-06-23 | 1999-06-23 | |
| PCT/CA2000/000730 WO2001000653A1 (en) | 1999-06-23 | 2000-06-20 | Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273992T1 true ATE273992T1 (de) | 2004-09-15 |
Family
ID=23331117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00938426T ATE273992T1 (de) | 1999-06-23 | 2000-06-20 | Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020156051A1 (de) |
| EP (2) | EP1189924B1 (de) |
| JP (1) | JP2003522124A (de) |
| KR (1) | KR100711861B1 (de) |
| CN (1) | CN1237071C (de) |
| AT (1) | ATE273992T1 (de) |
| AU (1) | AU5383700A (de) |
| BR (1) | BR0011863A (de) |
| CA (1) | CA2377492A1 (de) |
| DE (1) | DE60013130T2 (de) |
| DK (1) | DK1189924T3 (de) |
| ES (1) | ES2226856T3 (de) |
| HK (1) | HK1049342B (de) |
| NO (1) | NO323774B1 (de) |
| NZ (1) | NZ516349A (de) |
| PT (1) | PT1189924E (de) |
| RU (1) | RU2002101483A (de) |
| SI (1) | SI1189924T1 (de) |
| WO (1) | WO2001000653A1 (de) |
| ZA (1) | ZA200110483B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020026053A (ko) * | 2000-09-30 | 2002-04-06 | 노승권 | 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료 |
| ATE347895T1 (de) * | 2000-10-25 | 2007-01-15 | Forbes Medi Tech Inc | Verbindungen die ein phytosterol- und/oder ein phytostanolteil und ascorbinsäure enthalten und deren verwendung als gewichtsregulatoren |
| KR100396211B1 (ko) * | 2000-10-31 | 2003-09-17 | (주)유진사이언스 | 천연물로 구성된 수용성 식물성 스테롤 유도체 및 이의염과 이들의 제조방법 |
| WO2003009854A1 (en) * | 2001-07-20 | 2003-02-06 | Lonza Ag | Lipid lowering composition comprising carnitine and phytosterol |
| CN1558766A (zh) * | 2001-09-26 | 2004-12-29 | 福布斯梅迪泰克公司 | 降低体内胆固醇酯转移蛋白介导的胆固醇酯在高密度脂蛋白(hdl)和低密度脂蛋白(ldl)之间转移的方法 |
| WO2003063605A1 (en) * | 2002-02-01 | 2003-08-07 | Eugene Science Inc. | Chewing gum composition containing plant sterol for decrease of flood cholesterol levels and prevention of periodontal disease |
| AU2003218547B2 (en) * | 2002-03-14 | 2007-11-01 | Forbes Medi-Tech Inc. | A method of treating diabetes mellitus including conditions associated with diabetes mellitus and complications of diabetes mellitus |
| US20050170064A1 (en) * | 2002-03-20 | 2005-08-04 | Eugene Science Inc. | Plant sterol-containing food, and method for preparing the same |
| EP1538929A4 (de) * | 2002-03-20 | 2009-03-11 | Eugene Science Inc | Pflanzensterol-emulgator-pulvermischung sowie verfahren zu seiner herstellung |
| US20030232797A1 (en) * | 2002-06-06 | 2003-12-18 | Forbes Medi-Tech Inc. | Novel derivatives of androstane and androstene with ascorbic acid and use thereof in treating or preventing various conditions, diseases, and disorders |
| AU2003241478A1 (en) * | 2002-06-10 | 2003-12-22 | Elan Pharma International, Ltd. | Nanoparticulate sterol formulations and sterol combinations |
| US7306819B2 (en) | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
| JP4773720B2 (ja) | 2002-06-12 | 2011-09-14 | ザ・コカ−コーラ・カンパニー | 植物ステロール含有飲料 |
| US20040001874A1 (en) * | 2002-06-24 | 2004-01-01 | Vital Living, Inc. | Safe and effective nutritional supplement formulations and associated regimens adapted to prevent and/or treat targeted diseases or medical or health conditions, and related methods |
| RU2005112247A (ru) * | 2002-09-25 | 2006-01-20 | Форбз Меди-Тек Инк. (Ca) | Новые структуры и композиции, содержащие стеролы и/или станолы и определенные классы противовоспалительных средств, и их применение для лечения или предупреждения сердечно-сосудистого заболевания, лежащих в его основе состояний, включая гиперлипидемию, и других нарушений, при которых воспаление является частью их этиологии или проявления |
| US20060289834A1 (en) * | 2002-11-22 | 2006-12-28 | Nobushige Doisaki | External composition containing Unsaturated fatty acid or its salt or ester |
| KR20060052792A (ko) * | 2003-07-09 | 2006-05-19 | 포비스 메디-테크 인코포레이티드 | 신규 화합물 및 스테롤 및/또는 스탄올 및 콜레스테롤생합성 억제제를 포함하는 조성물 및 다양한 질병 및증상을 치료 또는 예방하기 위한 이들의 용도 |
| WO2005042692A2 (en) * | 2003-10-31 | 2005-05-12 | Forbes Medi-Tech Inc. | A method of inhibiting the expression of genes which mediate cellular cholesterol influx in animal cells and inhibiting the production of proteins resulting from the expression of such genes using cholesterol absorption inhibitors |
| GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| CA2560595C (en) * | 2004-03-29 | 2013-01-22 | Wyeth | Multi-vitamin and mineral nutritional supplements |
| US20050234025A1 (en) * | 2004-04-20 | 2005-10-20 | Forbes Medi-Tech Inc. | Compositions comprising one or more policosanols and/or policosanoic acids combined with sterol and/or steroid based ascorbic acid derivatives, and uses thereof |
| EP1835818B1 (de) * | 2004-12-09 | 2011-08-10 | Eurark, LLC | Produkt und verfahren zur herstellung eines mittels zur oralen verabreichung von nutrazeutika |
| GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
| CL2009000409A1 (es) * | 2009-02-23 | 2009-05-04 | Rojas Alejandro Markovits | Proceso para obtener una dispersión de fitoesteroles sólidos en agua. |
| JP5657902B2 (ja) * | 2010-03-17 | 2015-01-21 | 株式会社コスモステクニカルセンター | ポリオキシアルキレンステロールエーテル誘導体及び/又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物 |
| HK1200358A1 (en) * | 2011-09-16 | 2015-08-07 | 戴维森洛佩兹有限责任公司 | Plant steroids and uses thereof |
| KR102816341B1 (ko) * | 2022-01-24 | 2025-06-05 | 연세대학교 산학협력단 | 심혈관계 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56113800A (en) * | 1980-02-14 | 1981-09-07 | Green Cross Corp:The | Water-soluble cholesterol derivative |
| IL89850A0 (en) * | 1988-04-25 | 1989-12-15 | Takeda Chemical Industries Ltd | Ester of ascorbic acid 2-phosphate |
| JPH0228189A (ja) * | 1988-04-25 | 1990-01-30 | Takeda Chem Ind Ltd | アスコルビン酸リン酸エステル誘導体およびその製造法 |
| CA2028759A1 (en) * | 1989-11-22 | 1991-05-23 | Jean-Marie Cassal | Steroids |
| DE4000397A1 (de) * | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
| JPH07252294A (ja) * | 1994-01-28 | 1995-10-03 | Senju Pharmaceut Co Ltd | 副腎皮質ステロイド誘導体 |
| US5951990A (en) * | 1995-05-15 | 1999-09-14 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| US5866147A (en) * | 1995-05-15 | 1999-02-02 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| DE19701264A1 (de) * | 1997-01-16 | 1998-07-23 | Kief Lizenz Verwertungsgesells | Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische |
| FI974648L (fi) * | 1997-09-09 | 1999-05-06 | Raisio Benecol Oy | Hydroksihappo-, maitohappo- ja hydroksialkanoaattiesterit ja niiden käyttö |
-
2000
- 2000-06-20 ES ES00938426T patent/ES2226856T3/es not_active Expired - Lifetime
- 2000-06-20 PT PT00938426T patent/PT1189924E/pt unknown
- 2000-06-20 RU RU2002101483/04A patent/RU2002101483A/ru not_active Application Discontinuation
- 2000-06-20 AT AT00938426T patent/ATE273992T1/de not_active IP Right Cessation
- 2000-06-20 CA CA002377492A patent/CA2377492A1/en not_active Abandoned
- 2000-06-20 AU AU53837/00A patent/AU5383700A/en not_active Abandoned
- 2000-06-20 EP EP00938426A patent/EP1189924B1/de not_active Expired - Lifetime
- 2000-06-20 SI SI200030497T patent/SI1189924T1/xx unknown
- 2000-06-20 EP EP03025643A patent/EP1420026A3/de not_active Withdrawn
- 2000-06-20 JP JP2001507060A patent/JP2003522124A/ja active Pending
- 2000-06-20 BR BR0011863-0A patent/BR0011863A/pt not_active IP Right Cessation
- 2000-06-20 HK HK03101501.7A patent/HK1049342B/zh not_active IP Right Cessation
- 2000-06-20 DE DE60013130T patent/DE60013130T2/de not_active Expired - Fee Related
- 2000-06-20 WO PCT/CA2000/000730 patent/WO2001000653A1/en not_active Ceased
- 2000-06-20 CN CNB008117985A patent/CN1237071C/zh not_active Expired - Fee Related
- 2000-06-20 KR KR1020017016415A patent/KR100711861B1/ko not_active Expired - Fee Related
- 2000-06-20 NZ NZ516349A patent/NZ516349A/xx unknown
- 2000-06-20 DK DK00938426T patent/DK1189924T3/da active
-
2001
- 2001-07-25 US US09/916,817 patent/US20020156051A1/en not_active Abandoned
- 2001-12-20 NO NO20016294A patent/NO323774B1/no unknown
- 2001-12-20 ZA ZA200110483A patent/ZA200110483B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020028907A (ko) | 2002-04-17 |
| NO323774B1 (no) | 2007-07-02 |
| NZ516349A (en) | 2004-03-26 |
| ES2226856T3 (es) | 2005-04-01 |
| EP1189924B1 (de) | 2004-08-18 |
| EP1189924A1 (de) | 2002-03-27 |
| WO2001000653A1 (en) | 2001-01-04 |
| EP1420026A2 (de) | 2004-05-19 |
| CN1237071C (zh) | 2006-01-18 |
| AU5383700A (en) | 2001-01-31 |
| EP1420026A3 (de) | 2004-12-15 |
| ZA200110483B (en) | 2003-06-20 |
| RU2002101483A (ru) | 2003-09-20 |
| CN1370180A (zh) | 2002-09-18 |
| DE60013130D1 (de) | 2004-09-23 |
| HK1049342A1 (en) | 2003-05-09 |
| US20020156051A1 (en) | 2002-10-24 |
| SI1189924T1 (en) | 2005-02-28 |
| DE60013130T2 (de) | 2005-01-05 |
| KR100711861B1 (ko) | 2007-04-25 |
| PT1189924E (pt) | 2004-12-31 |
| CA2377492A1 (en) | 2001-01-04 |
| NO20016294L (no) | 2002-02-22 |
| BR0011863A (pt) | 2003-10-14 |
| DK1189924T3 (da) | 2004-12-20 |
| JP2003522124A (ja) | 2003-07-22 |
| NO20016294D0 (no) | 2001-12-20 |
| HK1049342B (zh) | 2006-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1189924 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |