JPS56113800A - Water-soluble cholesterol derivative - Google Patents
Water-soluble cholesterol derivativeInfo
- Publication number
- JPS56113800A JPS56113800A JP1709280A JP1709280A JPS56113800A JP S56113800 A JPS56113800 A JP S56113800A JP 1709280 A JP1709280 A JP 1709280A JP 1709280 A JP1709280 A JP 1709280A JP S56113800 A JPS56113800 A JP S56113800A
- Authority
- JP
- Japan
- Prior art keywords
- disalt
- chlorophosphate
- mono
- formula
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:A mono- or disalt of 7-keto and 7-hydroxycholesterolphosphoric ester expressed by formula I (R is =O or -OH; X1 and X2 are H or physiologically acceptable cation capable of imparting the water solubility; at least one of X1 and X2 is the cation described above).
EXAMPLE: Disodium salt of 7-ketocholesterolphosphoric ester.
USE: Improved effects on immunosuppressive action, particularly cellular immunosuppressive action and anti-inflammatory action with improved water solubility, and very useful as a medicine.
PROCESS: 7-Ketocholesterol is phosphorylated with a phosphorylating agent containing chlorine, e.g. tetrachloropyrophosphoric acid, to give a chlorophosphate which is a reaction intermediate. The chlorophosphate is then converted into a mono- or disalt by the well-known method to afford the compound of formula II.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1709280A JPS56113800A (en) | 1980-02-14 | 1980-02-14 | Water-soluble cholesterol derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1709280A JPS56113800A (en) | 1980-02-14 | 1980-02-14 | Water-soluble cholesterol derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56113800A true JPS56113800A (en) | 1981-09-07 |
Family
ID=11934339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1709280A Pending JPS56113800A (en) | 1980-02-14 | 1980-02-14 | Water-soluble cholesterol derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56113800A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003522124A (en) * | 1999-06-23 | 2003-07-22 | フォーブス メディ−テック インコーポレーテッド | Complexes of phytosterols or phytostanols with ascorbic acid and their use in treating and preventing cardiovascular disease |
-
1980
- 1980-02-14 JP JP1709280A patent/JPS56113800A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003522124A (en) * | 1999-06-23 | 2003-07-22 | フォーブス メディ−テック インコーポレーテッド | Complexes of phytosterols or phytostanols with ascorbic acid and their use in treating and preventing cardiovascular disease |
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