DE60013130D1 - Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten - Google Patents
Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheitenInfo
- Publication number
- DE60013130D1 DE60013130D1 DE60013130T DE60013130T DE60013130D1 DE 60013130 D1 DE60013130 D1 DE 60013130D1 DE 60013130 T DE60013130 T DE 60013130T DE 60013130 T DE60013130 T DE 60013130T DE 60013130 D1 DE60013130 D1 DE 60013130D1
- Authority
- DE
- Germany
- Prior art keywords
- ascorbic acid
- phytostanols
- phytosterols
- conjugates
- vascular diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 4
- 229960005070 ascorbic acid Drugs 0.000 title abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 title abstract 2
- 239000011668 ascorbic acid Substances 0.000 title abstract 2
- 229940068065 phytosterols Drugs 0.000 title 1
- 208000019553 vascular disease Diseases 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052751 metal Chemical group 0.000 abstract 1
- 239000002184 metal Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- General Preparation And Processing Of Foods (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33990399A | 1999-06-23 | 1999-06-23 | |
| US339903 | 1999-06-23 | ||
| PCT/CA2000/000730 WO2001000653A1 (en) | 1999-06-23 | 2000-06-20 | Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60013130D1 true DE60013130D1 (de) | 2004-09-23 |
| DE60013130T2 DE60013130T2 (de) | 2005-01-05 |
Family
ID=23331117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60013130T Expired - Fee Related DE60013130T2 (de) | 1999-06-23 | 2000-06-20 | Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020156051A1 (de) |
| EP (2) | EP1420026A3 (de) |
| JP (1) | JP2003522124A (de) |
| KR (1) | KR100711861B1 (de) |
| CN (1) | CN1237071C (de) |
| AT (1) | ATE273992T1 (de) |
| AU (1) | AU5383700A (de) |
| BR (1) | BR0011863A (de) |
| CA (1) | CA2377492A1 (de) |
| DE (1) | DE60013130T2 (de) |
| DK (1) | DK1189924T3 (de) |
| ES (1) | ES2226856T3 (de) |
| HK (1) | HK1049342B (de) |
| NO (1) | NO323774B1 (de) |
| NZ (1) | NZ516349A (de) |
| PT (1) | PT1189924E (de) |
| RU (1) | RU2002101483A (de) |
| SI (1) | SI1189924T1 (de) |
| WO (1) | WO2001000653A1 (de) |
| ZA (1) | ZA200110483B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020026053A (ko) * | 2000-09-30 | 2002-04-06 | 노승권 | 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료 |
| MXPA03003701A (es) * | 2000-10-25 | 2005-07-01 | Forbes Medi Tech Inc | Estructuras novedosas que comprenden fitosterol y/o fitostanol y acido ascorbico y uso de las mismas como agentes de regulacion de peso. |
| KR100396211B1 (ko) * | 2000-10-31 | 2003-09-17 | (주)유진사이언스 | 천연물로 구성된 수용성 식물성 스테롤 유도체 및 이의염과 이들의 제조방법 |
| WO2003009854A1 (en) * | 2001-07-20 | 2003-02-06 | Lonza Ag | Lipid lowering composition comprising carnitine and phytosterol |
| JP2005507890A (ja) * | 2001-09-26 | 2005-03-24 | フォーブス メディ−テック インコーポレーテッド | 生体内のコレステロールエステル転送タンパク質介在の高密度リポタンパク質（ｈｄｌ）と低密度リポタンパク質（ｌｄｌ）の間のコレステリルエステルの転送を減少させる方法 |
| WO2003063605A1 (en) * | 2002-02-01 | 2003-08-07 | Eugene Science Inc. | Chewing gum composition containing plant sterol for decrease of flood cholesterol levels and prevention of periodontal disease |
| JP2005528353A (ja) * | 2002-03-14 | 2005-09-22 | フォーブス メディ−テック インコーポレーテッド | 糖尿病に関連する症状及び糖尿病の合併症を包含する糖尿病の治療方法 |
| US20050118203A1 (en) * | 2002-03-20 | 2005-06-02 | Won-Tae Yoon | Mixing powder of plant sterol and emulsifier, and method for preparing the same |
| EP1653814A4 (de) * | 2002-03-20 | 2009-03-04 | Eugene Science Inc | Pflanzensterolhaltiges naghrungsmittel und verfahren zu seiner herstellung |
| US20030232797A1 (en) * | 2002-06-06 | 2003-12-18 | Forbes Medi-Tech Inc. | Novel derivatives of androstane and androstene with ascorbic acid and use thereof in treating or preventing various conditions, diseases, and disorders |
| EP1511468A1 (de) * | 2002-06-10 | 2005-03-09 | Elan Pharma International Limited | Nanoparticuläre sterolformulierungen und sterolkombinationen |
| US7306819B2 (en) | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
| ATE413820T1 (de) | 2002-06-12 | 2008-11-15 | Coca Cola Co | Pflanzliches sterol enthaltende getränke |
| US20040001874A1 (en) * | 2002-06-24 | 2004-01-01 | Vital Living, Inc. | Safe and effective nutritional supplement formulations and associated regimens adapted to prevent and/or treat targeted diseases or medical or health conditions, and related methods |
| CA2499817A1 (en) * | 2002-09-25 | 2004-04-08 | Forbes Medi-Tech Inc. | Derivatives comprising sterols and/or stanols and specific classes of anti-inflammatory agents and use thereof in treating or preventing cardiovascular disease |
| CN100348184C (zh) * | 2002-11-22 | 2007-11-14 | 日本水产株式会社 | 含有高度不饱和脂肪酸、其盐或其酯的外用组合物 |
| AU2004255285A1 (en) * | 2003-07-09 | 2005-01-20 | Forbes Medi-Tech Inc | Novel compounds and compositions comprising sterols and/or stanols and cholesterol biosynthesis inhibitors and use thereof in treating or preventing a variety of diseases and conditions. |
| WO2005042692A2 (en) * | 2003-10-31 | 2005-05-12 | Forbes Medi-Tech Inc. | A method of inhibiting the expression of genes which mediate cellular cholesterol influx in animal cells and inhibiting the production of proteins resulting from the expression of such genes using cholesterol absorption inhibitors |
| US20080182801A1 (en) * | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| TR201909238T4 (tr) * | 2004-03-29 | 2019-07-22 | Wyeth Llc | Multi-vitamin ve mineral besin takviyeleri. |
| US20050234025A1 (en) * | 2004-04-20 | 2005-10-20 | Forbes Medi-Tech Inc. | Compositions comprising one or more policosanols and/or policosanoic acids combined with sterol and/or steroid based ascorbic acid derivatives, and uses thereof |
| ATE519379T1 (de) * | 2004-12-09 | 2011-08-15 | Eurark Llc | Produkt und verfahren zur herstellung eines mittels zur oralen verabreichung von nutrazeutika |
| GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
| CL2009000409A1 (es) * | 2009-02-23 | 2009-05-04 | Rojas Alejandro Markovits | Proceso para obtener una dispersión de fitoesteroles sólidos en agua. |
| JP5657902B2 (ja) * | 2010-03-17 | 2015-01-21 | 株式会社コスモステクニカルセンター | ポリオキシアルキレンステロールエーテル誘導体及び／又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物 |
| EA201490637A1 (ru) * | 2011-09-16 | 2014-11-28 | ДЭЙВИДСОН ЛОПЕС, ЭлЭлСи | Растительные стероиды и их применения |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56113800A (en) * | 1980-02-14 | 1981-09-07 | Green Cross Corp:The | Water-soluble cholesterol derivative |
| JPH0228189A (ja) * | 1988-04-25 | 1990-01-30 | Takeda Chem Ind Ltd | アスコルビン酸リン酸エステル誘導体およびその製造法 |
| US4939128A (en) * | 1988-04-25 | 1990-07-03 | Takeda Chemical Industries, Ltd. | Ester of ascorbic acid 2-phosphate and pharmaceutical use |
| CA2028759A1 (en) * | 1989-11-22 | 1991-05-23 | Jean-Marie Cassal | Steroids |
| DE4000397A1 (de) * | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
| JPH07252294A (ja) * | 1994-01-28 | 1995-10-03 | Senju Pharmaceut Co Ltd | 副腎皮質ステロイド誘導体 |
| US5951990A (en) * | 1995-05-15 | 1999-09-14 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| US5866147A (en) * | 1995-05-15 | 1999-02-02 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| DE19701264A1 (de) * | 1997-01-16 | 1998-07-23 | Kief Lizenz Verwertungsgesells | Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische |
| FI974648A (fi) * | 1997-09-09 | 1999-05-06 | Raisio Benecol Oy | Hydroksihappo-, maitohappo- ja hydroksialkanoaattiesterit ja niiden käyttö |
-
2000
- 2000-06-20 CA CA002377492A patent/CA2377492A1/en not_active Abandoned
- 2000-06-20 BR BR0011863-0A patent/BR0011863A/pt not_active IP Right Cessation
- 2000-06-20 SI SI200030497T patent/SI1189924T1/xx unknown
- 2000-06-20 AT AT00938426T patent/ATE273992T1/de not_active IP Right Cessation
- 2000-06-20 KR KR1020017016415A patent/KR100711861B1/ko not_active IP Right Cessation
- 2000-06-20 NZ NZ516349A patent/NZ516349A/xx unknown
- 2000-06-20 AU AU53837/00A patent/AU5383700A/en not_active Abandoned
- 2000-06-20 PT PT00938426T patent/PT1189924E/pt unknown
- 2000-06-20 ES ES00938426T patent/ES2226856T3/es not_active Expired - Lifetime
- 2000-06-20 DE DE60013130T patent/DE60013130T2/de not_active Expired - Fee Related
- 2000-06-20 DK DK00938426T patent/DK1189924T3/da active
- 2000-06-20 CN CNB008117985A patent/CN1237071C/zh not_active Expired - Fee Related
- 2000-06-20 WO PCT/CA2000/000730 patent/WO2001000653A1/en active IP Right Grant
- 2000-06-20 JP JP2001507060A patent/JP2003522124A/ja active Pending
- 2000-06-20 EP EP03025643A patent/EP1420026A3/de not_active Withdrawn
- 2000-06-20 RU RU2002101483/04A patent/RU2002101483A/ru not_active Application Discontinuation
- 2000-06-20 EP EP00938426A patent/EP1189924B1/de not_active Expired - Lifetime
-
2001
- 2001-07-25 US US09/916,817 patent/US20020156051A1/en not_active Abandoned
- 2001-12-20 ZA ZA200110483A patent/ZA200110483B/en unknown
- 2001-12-20 NO NO20016294A patent/NO323774B1/no unknown
-
2003
- 2003-02-28 HK HK03101501.7A patent/HK1049342B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002101483A (ru) | 2003-09-20 |
| EP1420026A3 (de) | 2004-12-15 |
| HK1049342B (zh) | 2006-04-07 |
| SI1189924T1 (en) | 2005-02-28 |
| EP1189924B1 (de) | 2004-08-18 |
| BR0011863A (pt) | 2003-10-14 |
| JP2003522124A (ja) | 2003-07-22 |
| WO2001000653A1 (en) | 2001-01-04 |
| DK1189924T3 (da) | 2004-12-20 |
| DE60013130T2 (de) | 2005-01-05 |
| CN1370180A (zh) | 2002-09-18 |
| NO20016294L (no) | 2002-02-22 |
| ZA200110483B (en) | 2003-06-20 |
| AU5383700A (en) | 2001-01-31 |
| EP1420026A2 (de) | 2004-05-19 |
| HK1049342A1 (en) | 2003-05-09 |
| ES2226856T3 (es) | 2005-04-01 |
| NO323774B1 (no) | 2007-07-02 |
| NO20016294D0 (no) | 2001-12-20 |
| KR20020028907A (ko) | 2002-04-17 |
| ATE273992T1 (de) | 2004-09-15 |
| CN1237071C (zh) | 2006-01-18 |
| EP1189924A1 (de) | 2002-03-27 |
| KR100711861B1 (ko) | 2007-04-25 |
| US20020156051A1 (en) | 2002-10-24 |
| PT1189924E (pt) | 2004-12-31 |
| CA2377492A1 (en) | 2001-01-04 |
| NZ516349A (en) | 2004-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |