BR112014006222A2 - esteroides vegetais e usos dos mesmos - Google Patents
esteroides vegetais e usos dos mesmosInfo
- Publication number
- BR112014006222A2 BR112014006222A2 BR112014006222A BR112014006222A BR112014006222A2 BR 112014006222 A2 BR112014006222 A2 BR 112014006222A2 BR 112014006222 A BR112014006222 A BR 112014006222A BR 112014006222 A BR112014006222 A BR 112014006222A BR 112014006222 A2 BR112014006222 A2 BR 112014006222A2
- Authority
- BR
- Brazil
- Prior art keywords
- intestinal
- drug
- conjugate
- diseases
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
abstract plant steroids and uses thereof [0116] the invention relates to a drug conjugate including a drug and a plant steroid. the drug conjugate may target the drug for intestinal cell delivery, and thus may be used to treat diseases, including intestinal diseases, or to affect intestinal metabolism. the invention therefore also relates to treating intestinal diseases and affecting intestinal metabolism with the drug conjugate. ******************************************************** tradução do resumo resumo patente de invenção: "esteroides vegetais e usos dos mesmos". a presente invenção refere-se a um conjugado medicamentoso incluindo uma droga e um esteroide vegetal. o conjugado medicamentoso pode vetorizar a droga para distribuição nas células intestinais, e portanto pode ser usado para tratar doenças, que incluem doenças intestinais, ou para afetar o metabolismo intestinal. a invenção portanto também se refere ao tratamento de doenças intestinais e à afetação do metabolismo intestinal com o cojugado medicamentoso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161535661P | 2011-09-16 | 2011-09-16 | |
US201261675966P | 2012-07-26 | 2012-07-26 | |
PCT/US2012/055549 WO2013040441A1 (en) | 2011-09-16 | 2012-09-14 | Plant steroids and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014006222A2 true BR112014006222A2 (pt) | 2017-04-11 |
Family
ID=47883793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014006222A BR112014006222A2 (pt) | 2011-09-16 | 2012-09-14 | esteroides vegetais e usos dos mesmos |
Country Status (15)
Country | Link |
---|---|
US (2) | US10086082B2 (pt) |
EP (1) | EP2755660B1 (pt) |
JP (2) | JP6035338B2 (pt) |
KR (1) | KR20140093661A (pt) |
CN (2) | CN103987390A (pt) |
AU (1) | AU2012308332A1 (pt) |
BR (1) | BR112014006222A2 (pt) |
CA (1) | CA2848979C (pt) |
EA (1) | EA201490637A1 (pt) |
HK (1) | HK1200358A1 (pt) |
IL (1) | IL231541A0 (pt) |
IN (1) | IN2014CN02688A (pt) |
MX (1) | MX2014003260A (pt) |
SG (1) | SG11201400652UA (pt) |
WO (1) | WO2013040441A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2014225743A1 (en) | 2013-03-08 | 2015-09-24 | Allergan, Inc. | Antibiotic conjugates directly linked with steroid drugs |
KR20150125663A (ko) * | 2013-03-08 | 2015-11-09 | 알러간, 인코포레이티드 | 사이클로스포린 a 스테로이드 켤레물 |
US10077268B2 (en) | 2014-03-13 | 2018-09-18 | Salk Institute For Biological Studies | FXR agonists and methods for making and using |
US10301268B2 (en) | 2014-03-13 | 2019-05-28 | The Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
EP3166613A4 (en) | 2014-07-09 | 2018-02-21 | Duke University | Compositions and methods for the repair of myelin |
US11458146B2 (en) | 2017-01-13 | 2022-10-04 | Duke University | Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders |
KR102139678B1 (ko) * | 2017-11-24 | 2020-07-31 | 전북대학교 산학협력단 | N-아세틸 또는 n-아실 아미노산을 포함하는 아토피 또는 가려움증 치료용 조성물 |
CN110051674A (zh) * | 2018-07-26 | 2019-07-26 | 中国人民解放军空军军医大学第一附属医院 | 豆甾醇在制备治疗胃癌的药物中的用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000052029A1 (en) | 1999-03-04 | 2000-09-08 | Eugene Science Inc. | Water-soluble sterol derivative for inhibiting cholesterol absorption and process for preparing the same |
PT1189924E (pt) * | 1999-06-23 | 2004-12-31 | Forbes Medi Tech Inc | Conjugados de fitosterol ou fitostanol com acido ascorbico e sua utilizacao no tratamento ou prevencao de doenca cardiovascular |
WO2002072035A2 (en) * | 2001-03-14 | 2002-09-19 | Lipogenics, Inc. | Novel anti-inflammatory compositions and methods of use |
CN1531436A (zh) | 2001-05-09 | 2004-09-22 | (株)美大富历寿 | 用于增强粘膜吸收的两亲肝素衍生物制剂 |
SE0103765D0 (sv) * | 2001-11-09 | 2001-11-09 | Astrazeneca Ab | New use |
US20040236125A1 (en) * | 2002-09-25 | 2004-11-25 | Forbes Medi-Tech Inc. | Novel structures and compositions comprising sterols and/or stanols and specific classes of anti-inflammatory agents and use thereof in treating or preventing cardiovascular disease, its underlying conditions including hyperlipidemia and other disorders having inflammation as part of their aetiology or presentation |
WO2004095926A2 (en) * | 2003-04-28 | 2004-11-11 | Monsanto Technology, Llc | Treatment of plants and plant propagation materials with an antioxidant to improve plant health and/or yield |
US20050234025A1 (en) * | 2004-04-20 | 2005-10-20 | Forbes Medi-Tech Inc. | Compositions comprising one or more policosanols and/or policosanoic acids combined with sterol and/or steroid based ascorbic acid derivatives, and uses thereof |
WO2006099445A2 (en) * | 2005-03-14 | 2006-09-21 | Massachusetts Institute Of Technology | Nanocells for diagnosis and treatment of diseases and disorders |
EP2081949B1 (en) | 2006-09-22 | 2014-12-10 | GE Healthcare Dharmacon, Inc. | Tripartite oligonucleotide complexes and methods for gene silencing by rna interference |
JP2010509355A (ja) * | 2006-11-06 | 2010-03-25 | ジャイナ ファーマシューティカルズ,インコーポレーテッド | グッグルリン脂質の方法および組成物 |
US8188060B2 (en) * | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
WO2011109472A1 (en) | 2010-03-02 | 2011-09-09 | Imagenetix, Inc. | Compositions comprising myristic acid and uses thereof |
-
2012
- 2012-09-14 EP EP12832645.1A patent/EP2755660B1/en active Active
- 2012-09-14 BR BR112014006222A patent/BR112014006222A2/pt active Search and Examination
- 2012-09-14 EA EA201490637A patent/EA201490637A1/ru unknown
- 2012-09-14 WO PCT/US2012/055549 patent/WO2013040441A1/en active Application Filing
- 2012-09-14 KR KR1020147009670A patent/KR20140093661A/ko not_active Application Discontinuation
- 2012-09-14 IN IN2688CHN2014 patent/IN2014CN02688A/en unknown
- 2012-09-14 MX MX2014003260A patent/MX2014003260A/es not_active Application Discontinuation
- 2012-09-14 JP JP2014530888A patent/JP6035338B2/ja not_active Expired - Fee Related
- 2012-09-14 SG SG11201400652UA patent/SG11201400652UA/en unknown
- 2012-09-14 AU AU2012308332A patent/AU2012308332A1/en not_active Abandoned
- 2012-09-14 CN CN201280056467.7A patent/CN103987390A/zh active Pending
- 2012-09-14 CN CN201811306193.8A patent/CN109384825A/zh active Pending
- 2012-09-14 CA CA2848979A patent/CA2848979C/en not_active Expired - Fee Related
- 2012-09-14 US US14/345,028 patent/US10086082B2/en not_active Expired - Fee Related
-
2014
- 2014-03-16 IL IL231541A patent/IL231541A0/en unknown
-
2015
- 2015-01-30 HK HK15101045.6A patent/HK1200358A1/xx unknown
-
2016
- 2016-10-31 JP JP2016212948A patent/JP2017019871A/ja active Pending
-
2018
- 2018-08-29 US US16/116,713 patent/US20190083632A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA201490637A1 (ru) | 2014-11-28 |
EP2755660A4 (en) | 2015-03-18 |
JP6035338B2 (ja) | 2016-11-30 |
CA2848979A1 (en) | 2013-03-21 |
CA2848979C (en) | 2019-11-05 |
SG11201400652UA (en) | 2014-09-26 |
JP2017019871A (ja) | 2017-01-26 |
US10086082B2 (en) | 2018-10-02 |
CN103987390A (zh) | 2014-08-13 |
IL231541A0 (en) | 2014-04-30 |
AU2012308332A1 (en) | 2014-04-10 |
EP2755660B1 (en) | 2019-11-06 |
WO2013040441A1 (en) | 2013-03-21 |
US20190083632A1 (en) | 2019-03-21 |
MX2014003260A (es) | 2014-09-08 |
US20150141390A1 (en) | 2015-05-21 |
KR20140093661A (ko) | 2014-07-28 |
CN109384825A (zh) | 2019-02-26 |
HK1200358A1 (en) | 2015-08-07 |
IN2014CN02688A (pt) | 2015-07-03 |
EP2755660A1 (en) | 2014-07-23 |
JP2014526515A (ja) | 2014-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2479 DE 10-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |