PT102628A - Novo processo de preparacao de flumetasona e do seu analogo 17-carboxilo androsteno - Google Patents

Novo processo de preparacao de flumetasona e do seu analogo 17-carboxilo androsteno

Info

Publication number
PT102628A
PT102628A PT102628A PT10262801A PT102628A PT 102628 A PT102628 A PT 102628A PT 102628 A PT102628 A PT 102628A PT 10262801 A PT10262801 A PT 10262801A PT 102628 A PT102628 A PT 102628A
Authority
PT
Portugal
Prior art keywords
flumethasone
acetate
preparation
flumethanone
androstene
Prior art date
Application number
PT102628A
Other languages
English (en)
Other versions
PT102628B (pt
Inventor
Joao Emerico Villax
Zita Maria De Mouro Vaz Mendes
Original Assignee
Hovione Farmaciencia Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20086054&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT102628(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hovione Farmaciencia Sa filed Critical Hovione Farmaciencia Sa
Priority to PT102628A priority Critical patent/PT102628B/pt
Priority to US10/162,862 priority patent/US6528666B1/en
Priority to RU2004100309/04A priority patent/RU2260596C1/ru
Priority to PL367843A priority patent/PL206731B1/pl
Priority to JP2003503644A priority patent/JP4095018B2/ja
Priority to CA002450661A priority patent/CA2450661C/en
Priority to DE60235625T priority patent/DE60235625D1/de
Priority to IL15934302A priority patent/IL159343A0/xx
Priority to EP02735607A priority patent/EP1395603B1/en
Priority to CNB028117662A priority patent/CN1244593C/zh
Priority to NZ530536A priority patent/NZ530536A/en
Priority to DK02735607.0T priority patent/DK1395603T3/da
Priority to AT02735607T priority patent/ATE460422T1/de
Priority to AU2002310616A priority patent/AU2002310616B2/en
Priority to PCT/GB2002/002644 priority patent/WO2002100878A1/en
Priority to ES02735607T priority patent/ES2338768T3/es
Publication of PT102628A publication Critical patent/PT102628A/pt
Priority to NO20035517A priority patent/NO326153B1/no
Priority to IL159343A priority patent/IL159343A/en
Priority to ZA200309656A priority patent/ZA200309656B/xx
Priority to CY20101100318T priority patent/CY1109960T1/el
Publication of PT102628B publication Critical patent/PT102628B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Combustion (AREA)
  • Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
PT102628A 2001-06-12 2001-06-12 Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno PT102628B (pt)

Priority Applications (20)

Application Number Priority Date Filing Date Title
PT102628A PT102628B (pt) 2001-06-12 2001-06-12 Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
US10/162,862 US6528666B1 (en) 2001-06-12 2002-06-06 Process of preparation of flumethasone 21-acetate, or flumethasone and its 17-carboxyl androsten analogue
ES02735607T ES2338768T3 (es) 2001-06-12 2002-06-11 Preparacion de flumetasona y su analogo 17-carboxil-androsteno.
NZ530536A NZ530536A (en) 2001-06-12 2002-06-11 Preparation of flumethasone and its 17-carboxyl androsten analogue
DK02735607.0T DK1395603T3 (da) 2001-06-12 2002-06-11 Fremstilling af flumethason og dettes 17-carboxylandrosten-analog
JP2003503644A JP4095018B2 (ja) 2001-06-12 2002-06-11 フルメタゾンおよびその１７−カルボキシルアンドロステン類似体の調製
CA002450661A CA2450661C (en) 2001-06-12 2002-06-11 Preparation of flumethasone and its 17-carboxyl androsten analogue
DE60235625T DE60235625D1 (de) 2001-06-12 2002-06-11 L androsten analog
IL15934302A IL159343A0 (en) 2001-06-12 2002-06-11 Preparation of flumethasone and its 17-carboxyl androsten analogue
EP02735607A EP1395603B1 (en) 2001-06-12 2002-06-11 Preparation of flumethasone and its 17-carboxyl androsten analogue
CNB028117662A CN1244593C (zh) 2001-06-12 2002-06-11 氟米松及其17－羧基雄甾烯类似物的制备
RU2004100309/04A RU2260596C1 (ru) 2001-06-12 2002-06-11 Способ получения флуметазона, соединение
PL367843A PL206731B1 (pl) 2001-06-12 2002-06-11 Sposób wytwarzania flumetazonu , 21-octanu flumetazonu lub jego analogu 17-karboksyloandrostenowego oraz związek pośredni
AT02735607T ATE460422T1 (de) 2001-06-12 2002-06-11 Herstellung von flumethasone und dessen 17- carboxyl androsten analog
AU2002310616A AU2002310616B2 (en) 2001-06-12 2002-06-11 Preparation of flumethasone and its 17-carboxyl androsten analogue
PCT/GB2002/002644 WO2002100878A1 (en) 2001-06-12 2002-06-11 Preparation of flumethasone and its 17-carboxyl androsten analogue
IL159343A IL159343A (en) 2001-06-12 2003-12-11 Preparation of flumethasone and its 17 - carboxyl androsten analogue
NO20035517A NO326153B1 (no) 2001-06-12 2003-12-11 Fremgangsmate for fremstilling av flumetason og dens 17-karboksyl androsten-analoge
ZA200309656A ZA200309656B (en) 2001-06-12 2003-12-12 Preparation of flumethasone and its 17-carboxyl androsten analogue.
CY20101100318T CY1109960T1 (el) 2001-06-12 2010-04-07 Παρασκευη φλουμεθαζονης και του αναλογου αυτης17-καρβοξυλο-ανδροστενιου

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT102628A PT102628B (pt) 2001-06-12 2001-06-12 Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno

Publications (2)

Publication Number Publication Date
PT102628A true PT102628A (pt) 2002-12-31
PT102628B PT102628B (pt) 2010-09-09

Family

ID=20086054

Family Applications (1)

Application Number Title Priority Date Filing Date
PT102628A PT102628B (pt) 2001-06-12 2001-06-12 Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno

Country Status (19)

Country Link
US (1) US6528666B1 (pt)
EP (1) EP1395603B1 (pt)
JP (1) JP4095018B2 (pt)
CN (1) CN1244593C (pt)
AT (1) ATE460422T1 (pt)
AU (1) AU2002310616B2 (pt)
CA (1) CA2450661C (pt)
CY (1) CY1109960T1 (pt)
DE (1) DE60235625D1 (pt)
DK (1) DK1395603T3 (pt)
ES (1) ES2338768T3 (pt)
IL (2) IL159343A0 (pt)
NO (1) NO326153B1 (pt)
NZ (1) NZ530536A (pt)
PL (1) PL206731B1 (pt)
PT (1) PT102628B (pt)
RU (1) RU2260596C1 (pt)
WO (1) WO2002100878A1 (pt)
ZA (1) ZA200309656B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162140A0 (en) * 2001-11-29 2005-11-20 Taro Pharmaceuticals Usa Inc Method for the preparation of l-alpha-fluoro corticosteroids
DE60303687D1 (de) * 2002-12-09 2006-04-27 Sicor Inc Prozess zur herstellung von 6 alpa-fluorierten pregnanen
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法
CN101759761B (zh) * 2008-11-28 2012-08-08 天津金耀集团有限公司 含有6α-F的甾体化合物的制备方法
CN102272304B (zh) 2009-01-07 2013-10-23 三菱化学株式会社 切断固醇侧链的酶蛋白质及其应用
CN101942002A (zh) * 2010-09-24 2011-01-12 岳阳环宇药业有限公司 一种甾体21位酯化物的精制工艺
ITMI20122200A1 (it) 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani
RU2532902C1 (ru) * 2013-07-12 2014-11-20 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) Способ получения 11бета, 17альфа, 21-тригидрокси-16альфа-метил-9альфа-фторпрегна-1,4-диен-3,20-диона (дексаметазона) из фитостерина

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499016A (en) 1958-08-04 1970-03-03 Upjohn Co 6alpha-fluoro-16alpha-methyl derivatives of the pregnane series
US3636010A (en) 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
FR2701262B1 (fr) 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.

Also Published As

Publication number Publication date
US6528666B1 (en) 2003-03-04
DE60235625D1 (de) 2010-04-22
CA2450661C (en) 2008-01-08
AU2002310616A2 (en) 2002-12-23
ES2338768T3 (es) 2010-05-12
AU2002310616B2 (en) 2007-08-30
PL206731B1 (pl) 2010-09-30
RU2260596C1 (ru) 2005-09-20
NZ530536A (en) 2005-05-27
NO20035517D0 (no) 2003-12-11
RU2004100309A (ru) 2005-07-10
EP1395603B1 (en) 2010-03-10
ZA200309656B (en) 2004-06-22
PL367843A1 (en) 2005-03-07
CN1531544A (zh) 2004-09-22
IL159343A0 (en) 2004-06-01
PT102628B (pt) 2010-09-09
ATE460422T1 (de) 2010-03-15
WO2002100878A1 (en) 2002-12-19
JP2004534795A (ja) 2004-11-18
DK1395603T3 (da) 2010-05-10
NO326153B1 (no) 2008-10-06
CY1109960T1 (el) 2014-09-10
IL159343A (en) 2010-11-30
EP1395603A1 (en) 2004-03-10
CA2450661A1 (en) 2002-12-19
JP4095018B2 (ja) 2008-06-04
CN1244593C (zh) 2006-03-08

Similar Documents

Publication Publication Date Title
CY1109960T1 (el) Παρασκευη φλουμεθαζονης και του αναλογου αυτης17-καρβοξυλο-ανδροστενιου
PE20000179A1 (es) Compuestos hipolipidemicos de benzotiazepina
NO20050661L (no) Aripiprazol-komplekspreparat og fremgangsmate
NO164905C (no) Fremgangsmaate for fremstilling av 16,17-acetal-pregnanderivater.
IL80325A (en) Process for the activation of gene technologically produced eukaryotic proteins under reducing conditions followed by oxidative reactivation in the presence of glutathione/glutathione disulphide
MXPA05010402A (es) Oxido nitrico en el tratamiento de la inflamacion.
HUP9903747A2 (hu) Új eljárás mometazon-furoát előállítására
Koca et al. Dissecting cellulitis in a white male: response to isotretinoin.
SE9803761D0 (sv) Method to avoid increased iridial pigmentation during prostaglandin treatment
BR0115220A (pt) Processo para a produção de 16,17-(ciclohexilmetilen)bis(óxi) -11,21-diidróxi-pregna-1,4-dien-3,20-diona ou seu 21-isobutirato por transcetalização
EP1194109A4 (en) TOPICAL FORMULATIONS CONTAINING AGENTS THAT PROMOTE SKIN PENETRATION AND THEIR USE
MY136880A (en) Piperazinyl-or piperidinylamine-sulfamic acid amides as inhibitors of steroid sulfatase
AR015761A1 (es) Un derivado del acido 2-metilpropionico,una composicion farmaceutica que lo incluye, uso de un derivado del acido 2-metilpropionico y un procedimiento parala fabricacion de una composicion farmaceutica para la prevencion o el tratamiento de enfermedades
GB0108865D0 (en) The use of agents to cause intermittent lowering of levels of cortisol and other adrenalhormones as treatment of clinical conditions associated with changes
MXPA03011751A (es) Proceso para preparar 21-acetato de 11b,17a, 21-trihidroxi-6a-metilpregna-1, 4-dieno-3, 20- diona.
NO20054636L (no) Fremgangsmate for fremstilling av steroidale karbotiosyrederivater og -intermediater
GB1367928A (en) Halogenopregnadiene and process for its manufacture
GB903049A (en) Steroid compounds, preparation thereof and compositions thereof
GB1064078A (en) 5-a-pregnano-[3,2-c]pyrazole compounds
GB832325A (en) Hydroxylated steroids and methods for their manufacture
Moriwaki et al. Treatment of Subglottic Stenosis
GB978725A (en) Novel steroid compounds and processes for their perparation
IT1247692B (it) 6 fluoro 6 metilpregn-4-ene-3,20 dioni e 6-fluoro-6-metilpregna-l, 4-diene-3,20-dioni,procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' anti-infiammatoria che li contengono
王仲仁 et al. Principal shearing stress locus theory of axisymmetrically plastic flow
GB1430932A (en) 21-fluoro-pregnanes

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 20010823

BB1A Laying open of patent application

Effective date: 20030618

FG3A Patent granted, date of granting

Effective date: 20100902