BR0115220A - Processo para a produção de 16,17-(ciclohexilmetilen)bis(óxi) -11,21-diidróxi-pregna-1,4-dien-3,20-diona ou seu 21-isobutirato por transcetalização - Google Patents

Processo para a produção de 16,17-(ciclohexilmetilen)bis(óxi) -11,21-diidróxi-pregna-1,4-dien-3,20-diona ou seu 21-isobutirato por transcetalização

Info

Publication number
BR0115220A
BR0115220A BR0115220-3A BR0115220A BR0115220A BR 0115220 A BR0115220 A BR 0115220A BR 0115220 A BR0115220 A BR 0115220A BR 0115220 A BR0115220 A BR 0115220A
Authority
BR
Brazil
Prior art keywords
bis
transcetalization
dien
oxide
production
Prior art date
Application number
BR0115220-3A
Other languages
English (en)
Inventor
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of BR0115220A publication Critical patent/BR0115220A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSO PARA A PRODUçãO DE 16,17-(CICLO-HEXILMETILEN)BIS(óXI)-11,21 -DIIDRóXI-PREGNA-1,4-DIEN-3,20-DIONA OU SEU 21-ISOBUTIRATO POR TRANSCETALIZAçãO". A invenção refere-se a um processo para a preparação de 16,17 [(cicloexilmetileno)bis(óxi)]-11,21-diidroxipregna-1,4-dieno-3,20-dion a [11 beta, 16 alfa(R)] e compostos similares, por reação de um 16,17-cetal apropriado com cicloexanoaldeído.
BR0115220-3A 2000-11-10 2001-11-06 Processo para a produção de 16,17-(ciclohexilmetilen)bis(óxi) -11,21-diidróxi-pregna-1,4-dien-3,20-diona ou seu 21-isobutirato por transcetalização BR0115220A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124626 2000-11-10
PCT/EP2001/012808 WO2002038584A1 (en) 2000-11-10 2001-11-06 Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation

Publications (1)

Publication Number Publication Date
BR0115220A true BR0115220A (pt) 2003-10-07

Family

ID=8170345

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115220-3A BR0115220A (pt) 2000-11-10 2001-11-06 Processo para a produção de 16,17-(ciclohexilmetilen)bis(óxi) -11,21-diidróxi-pregna-1,4-dien-3,20-diona ou seu 21-isobutirato por transcetalização

Country Status (23)

Country Link
US (1) US7468433B2 (pt)
EP (1) EP1335929B1 (pt)
JP (1) JP4456811B2 (pt)
KR (2) KR100809510B1 (pt)
CN (1) CN1264855C (pt)
AT (1) ATE478888T1 (pt)
AU (1) AU2953602A (pt)
BR (1) BR0115220A (pt)
CA (1) CA2430196C (pt)
CZ (1) CZ303885B6 (pt)
DE (1) DE60142920D1 (pt)
EA (1) EA006231B1 (pt)
ES (1) ES2351184T3 (pt)
HK (1) HK1058043A1 (pt)
HU (1) HU228432B1 (pt)
IL (1) IL155274A0 (pt)
MX (1) MXPA03004123A (pt)
NO (1) NO325286B1 (pt)
NZ (1) NZ525707A (pt)
PL (1) PL205674B1 (pt)
SK (1) SK287545B6 (pt)
WO (1) WO2002038584A1 (pt)
ZA (1) ZA200303121B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
CN100404545C (zh) * 2003-03-27 2008-07-23 尼科梅德有限责任公司 具有规定粒径的结晶环缩松的制备方法
CN100338089C (zh) * 2004-08-12 2007-09-19 重庆医药工业研究院有限责任公司 一种哮喘病治疗药物环索奈德的新的制备方法
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
WO2007054974A2 (en) * 2005-09-28 2007-05-18 Arch Pharmalab Limited A green chemistry process for the preparation of pregnadiene esters
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
EP2064227A2 (en) * 2006-09-19 2009-06-03 Cipla Ltd. Processes for the preparation of ciclesonide and its crystal form
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
EP3250211B1 (en) 2015-01-30 2021-12-22 Coral Drugs Pvt. Ltd. Novel process for preparation of glucocorticoid steroids
RU2745748C2 (ru) 2016-06-02 2021-03-31 Эббви Инк. Агонист глюкокортикоидного рецептора и его иммуноконъюгаты
MA49796A (fr) 2017-12-01 2020-06-03 Abbvie Inc Agoniste du récepteur des glucocorticoïdes et immunoconjugués de celui-ci

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880368A (en) * 1983-10-24 1989-11-14 Siegfried C. Hasl In-mold label transfer apparatus
ES8506753A1 (es) 1983-11-24 1985-08-01 Frumtost Zyma S A Procedimiento para la obtencion de un corticoide de accion antipsoriatica
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
FR2675146A1 (fr) 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
DE59407183D1 (de) * 1993-04-02 1998-12-03 Byk Gulden Lomberg Chem Fab Neue prednisolonderivate
DE19635498A1 (de) 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung

Also Published As

Publication number Publication date
HUP0302220A3 (en) 2007-11-28
NO20031964D0 (no) 2003-04-30
MXPA03004123A (es) 2004-09-10
HUP0302220A2 (hu) 2003-10-28
ES2351184T3 (es) 2011-02-01
EP1335929A1 (en) 2003-08-20
EA006231B1 (ru) 2005-10-27
HU228432B1 (hu) 2013-03-28
NO20031964L (no) 2003-04-30
CN1473164A (zh) 2004-02-04
EP1335929B1 (en) 2010-08-25
US7468433B2 (en) 2008-12-23
SK287545B6 (sk) 2011-01-04
CN1264855C (zh) 2006-07-19
DE60142920D1 (de) 2010-10-07
JP2004513181A (ja) 2004-04-30
PL205674B1 (pl) 2010-05-31
WO2002038584A1 (en) 2002-05-16
EA200300504A1 (ru) 2003-12-25
AU2953602A (en) 2002-05-21
ZA200303121B (en) 2004-04-23
HK1058043A1 (en) 2004-04-30
NO325286B1 (no) 2008-03-17
IL155274A0 (en) 2003-11-23
CA2430196C (en) 2010-01-26
ATE478888T1 (de) 2010-09-15
KR20070116185A (ko) 2007-12-06
PL361616A1 (en) 2004-10-04
KR100809510B1 (ko) 2008-03-04
CA2430196A1 (en) 2002-05-16
CZ303885B6 (cs) 2013-06-12
JP4456811B2 (ja) 2010-04-28
KR20030081329A (ko) 2003-10-17
SK5552003A3 (en) 2003-08-05
NZ525707A (en) 2004-11-26
US20050080063A1 (en) 2005-04-14

Similar Documents

Publication Publication Date Title
BR0115220A (pt) Processo para a produção de 16,17-(ciclohexilmetilen)bis(óxi) -11,21-diidróxi-pregna-1,4-dien-3,20-diona ou seu 21-isobutirato por transcetalização
DK243085D0 (da) Fremgangsmaade til fremstilling af 16,17-acetaler af pregnanderivaterog forbindelser fremstillet deraf
BG96166A (bg) Метод за получаване на будезонид
EE03927B1 (et) Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod
FI113543B (fi) Menetelmä uuden terapeuttisesti käyttökelpoisen 16alfa,17-(22R,S)-sykloheksyylimetyleenidioksi-11beta,21-dihydroksipregna-1,4-dieeni-3,20-dionin ja sen epimeerien valmistamiseksi
IE38863L (en) Pregnanes and 19-norpregnanes
DE59408412D1 (de) Medizinisches instrument für atherektomie
DE602004005165D1 (de) Bewehrungsglasfaser für organische sowohl als auch anorganische materialien, verfahren zur herstellung dessen und verwendete zusammensetzung
GB990384A (en) New í¸-16ª‡-methylsteroids and a process for their manufacture
DE60235625D1 (de) L androsten analog
US3065239A (en) Novel 16-halomethyl steroids and processes
US3461144A (en) Novel 16beta-alkyl-17-oxygenated steroids and processes
BR9914521A (pt) Glicuronìdeos de pregnano
GB1269160A (en) New pregnane derivatives
PL358032A1 (en) New application of 22r-(11, 16)-16,17-[butylidene-bis-oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
BR9912206A (pt) 19-nor esteróides 17-halogenados, processo e intermediários de preparo, aplicação como medicamentos e composições farmacêuticas que os contêm
GB806162A (en) Steroidal compounds
MXPA04002758A (es) Transacetalizacion estereoselectiva de acetonido c-22 esteroidal.

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: NYCOMED GMBH (DE)

Free format text: ALTERADO DE: ALTANA PHARMA AG

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.